Psychosocial Stress Predicts Abnormal Glucose Metabolism: The Australian Diabetes, Obesity and Lifestyle (AusDiab) Study
Open accessAbstract
BACKGROUND: The evidence supporting a relationship between stress and diabetes has been inconsistent. PURPOSE: This study examined the effects of stress on abnormal glucose metabolism, using a population-based sample of 3,759, with normoglycemia at baseline, from the Australian Diabetes, Obesity and Lifestyle study. METHODS: Perceived stress and stressful life events were measured at baseline, with health behavior and anthropometric information also collected. Oral glucose tolerance tests were undertaken at baseline and 5-year follow-up. The primary outcome was the development of abnormal glucose metabolism (impaired fasting glucose, impaired glucose tolerance, and type 2 diabetes), according to WHO 1999 criteria. RESULTS: Perceived stress predicted incident abnormal glucose metabolism in women but not men, after multivariate adjustment. Life events showed an inconsistent relationship with abnormal glucose metabolism. CONCLUSIONS: Perceived stress predicted abnormal glucose metabolism in women. Healthcare professionals should consider psychosocial adversity when assessing risk factor profiles for the development of diabetes.
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The association between perceived stress and T2DM varies by sex or socioeconomic status in some studies.
“However, this association has been shown in some studies to vary by sex or socioeconomic status (as measured by occupational status), which indicates that these factors might moderate this relationship.”
From Type 2 diabetes mellitus and psychological stress — a modifiable risk factor (2017) · cites this paper as [83]
A link exists between perceived stress and development of T2DM.
“Considering the evidence as a whole, a link seems to exist between perceived stress and development of T2DM.”
From Type 2 diabetes mellitus and psychological stress — a modifiable risk factor (2017) · cites this paper as [83]
In Australian adults (n=3,759; 5-year follow-up), perceived stress in a 30-item questionnaire was associated with abnormal glucose tolerance rather than overt diabetes mellitus, only in women (OR 1.72...).
“Australian adults ( n = 3,759; 5 year follow- up) | Perceived stress in 30-item questionnaire | ‡ Outcome was abnormal glucose tolerance rather than overt diabetes mellitus. Association only in women OR 1.72”
From Type 2 diabetes mellitus and psychological stress — a modifiable risk factor (2017) · cites this paper as Williams (2013) 76
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- Authors
- Williams, E. D., Magliano, D. J., Tapp, R. J., Oldenburg, B. F., & Shaw, J. E.
- Affiliations
- The Alfred Hospital (AU)
- Baker Heart and Diabetes Institute (AU)
- Australian College of Optometry (AU)
- Corresponding author
- Williams, Emily D.
- Venue
- Annals of Behavioral Medicine
- Publisher
- Oxford University Press (OUP)
- Published
- 2013-02-07
- Volume
- 46
- Issue
- 1
- Pages
- 62-72
- ISSN
- 0742-5554 (ISSN-L)
- 0883-6612
- 1532-4796
- OpenAlex
- W1979981107
- Cited by
- 68
- References
- 11
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 7 · 2023: 6 · 2022: 8 · 2021: 3 · 2020: 5 · 2019: 2 · 2018: 7 · 2017: 6 · 2016: 10 · 2015: 5 · 2014: 6 · 2013: 1
- FWCI
- 5.78
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Annals of Behavioral Medicine (publishedVersion)
- PubMed (publishedVersion)
- Minerva Access (University of Melbourne) (submittedVersion)
- Open Research (University of Surrey) (submittedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Funders
- U.S. Department of Health and Human Services
- Bristol-Myers Squibb
- Eli Lilly and Company
- Pfizer
- AstraZeneca
- GlaxoSmithKline
- Sanofi
- Victorian Cancer Agency
- Queensland Health
- Pratt Foundation
- Australian Government
- Diabetes UK (09/0003833)
- Diabetes Australia
- Kidney Health Australia
- Novo Nordisk
- State Government of Victoria
- Menzies Institute for Medical Research
- Eli Lilly Australia
- Medical Research Council
- National Health and Medical Research Council (586623, 233200, NHMRC grant 233200)
- Cilag
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Education
- Keywords
- psychosocial stress, perceived stress, life events, abnormal glucose metabolism, type 2 diabetes, impaired glucose tolerance, impaired fasting glucose, sex differences, diabetes risk factors, oral glucose tolerance test, AusDiab
- MeSH terms
- Adult, Australia, Blood Glucose, Diabetes Mellitus, Type 2, Female, Glucose Tolerance Test, Humans, Insulin Resistance, Life Change Events, Life Style, Male, Obesity, Perception, Prediabetic State, Risk Factors, Stress, Psychological, Health Behavior, Glucose Intolerance
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