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Cited by 330Diabetes Management and EducationDiabetes, Cardiovascular Risks, and LipoproteinsCardiac Health and Mental Health

The role of depression and anxiety in onset of diabetes in a large population-based study

Engum, Anne·2007·Journal of Psychosomatic Research
DOI 10.1016/j.jpsychores.2006.07.009
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Abstract

Objective Recent research has shown that depression may predict incident diabetes. The aims of the study are to investigate if symptoms of depression and anxiety precede the onset of diabetes or vice versa and to examine if mediating factors may explain such associations. Methods A prospective population-based study (N=37,291) investigating the associations between symptoms of depression/anxiety and diabetes was conducted. Results Individuals reporting symptoms of depression and anxiety at baseline had increased risk of onset of type 2 diabetes at 10-year follow-up. No gender differences were found. The analyses did not reveal underlying factors that mediated the association. Baseline diagnosis of diabetes was not associated with subsequent symptoms of anxiety or depression among males or females. Conclusion Diabetes did not predict symptoms of depression or anxiety. Symptoms of depression and anxiety emerged as significant risk factors for onset of type 2 diabetes independent of established risk factors for diabetes, such as socioeconomic factors, lifestyle factors, and markers of the metabolic syndrome. The comorbidity between depression and anxiety may be the most important factor.

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Crossref · 10.1016/j.jpsychores.2006.07.009

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  • Reported links between anxiety and new onset diabetes mellitus are equivocal.

    “Anxiety is not as well researched as depression, and reported links with new onset diabetes mellitus have been equivocal 69-74”

    From Type 2 diabetes mellitus and psychological stress — a modifiable risk factor (2017) · cites this paper as [69]

  • In a Norwegian cohort (n=37,291; 10 year follow-up), anxiety measured by HADS is associated with diabetes risk (OR 1.5, 95% CI 1.3-1.8).

    “| Norwegian cohort ( n = 37,291; 10 year follow- up) | Anxiety using the hospital anxiety and depression scale, seven-items for anxiety | OR 1.5 (95% CI 1.3- 1.8) ‡ Did not control for depression. |”

    From Type 2 diabetes mellitus and psychological stress — a modifiable risk factor (2017) · cites this paper as Engum (2007) 63

  • The association between anxiety and diabetes risk in the Norwegian cohort did not control for depression.

    “Did not control for depression.”

    From Type 2 diabetes mellitus and psychological stress — a modifiable risk factor (2017) · cites this paper as Engum (2007) 63

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Authors
Engum, A.
Affiliations
Norwegian University of Science and Technology (NO)
Corresponding author
Engum, Anne
ORCID
Engum, Anne
Venue
Journal of Psychosomatic Research
Publisher
Elsevier BV
Published
2007-01
Volume
62
Issue
1
Pages
31-38
ISSN
0022-3999 (ISSN-L)
DOI
10.1016/j.jpsychores.2006.07.009
OpenAlex
W2082437852
Cited by
330
References
34
Citations by year
2026: 2 · 2025: 8 · 2024: 9 · 2023: 18 · 2022: 10 · 2021: 14 · 2020: 16 · 2019: 13 · 2018: 17 · 2017: 21 · 2016: 22 · 2015: 30 · 2014: 20 · 2013: 28 · 2012: 26
FWCI
9.32
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Journal of Psychosomatic Research (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Education
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Health and Mental Health
Keywords
depression, anxiety, type 2 diabetes, diabetes onset, incident diabetes risk, comorbid depression and anxiety, mediation, psychosocial risk factors, metabolic syndrome
MeSH terms
Adult, Aged, Aged, 80 and over, Anxiety Disorders, Depressive Disorder, Diabetes Mellitus, Type 2, Female, Health Surveys, Humans, Longitudinal Studies, Male, Middle Aged, Norway, Prospective Studies, Statistics as Topic, Comorbidity, Metabolic Syndrome

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