The roles of Polycomb group proteins in hematopoietic stem cells and hematological malignancies

Epigenetic Regulations of GABAergic Neurotransmission: Relevance for Neurological Disorders and Epigenetic Therapy

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Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals

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A gene complex controlling segmentation in Drosophila

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Role of Histone H3 Lysine 27 Methylation in Polycomb-Group Silencing

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Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells.

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EZH2 inhibition as a therapeutic strategy for lymphoma with EZH2-activating mutations

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Role of histone H2A ubiquitination in Polycomb silencing

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Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large B-cell lymphomas of germinal-center origin

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The genetic basis of early T-cell precursor acute lymphoblastic leukaemia

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Drosophila Enhancer of Zeste/ESC Complexes Have a Histone H3 Methyltransferase Activity that Marks Chromosomal Polycomb Sites

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Bmi-1 determines the proliferative capacity of normal and leukaemic stem cells.

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Polycomb silencers control cell fate, development and cancer

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Role of the polycomb protein EED in the propagation of repressive histone marks

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Inactivating mutations of the histone methyltransferase gene EZH2 in myeloid disorders

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Bmi-1 collaborates with c-Myc in tumorigenesis by inhibiting c-Myc-induced apoptosis via INK4a/ARFPreprint

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Genomewide Analysis of PRC1 and PRC2 Occupancy Identifies Two Classes of Bivalent Domains

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Molecular basis for the discrimination of repressive methyl-lysine marks in histone H3 by Polycomb and HP1 chromodomainsPreprint

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The Polycomb-Group GeneEzh2 Is Required for Early Mouse Development

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PCGF Homologs, CBX Proteins, and RYBP Define Functionally Distinct PRC1 Family Complexes

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Chromatin Compaction by a Polycomb Group Protein Complex

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SUZ12 Is Required for Both the Histone Methyltransferase Activity and the Silencing Function of the EED-EZH2 Complex

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Identification of cooperating oncogenes in Eμ-myc transgenic mice by provirus tagging

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Somatic mutations of the histone methyltransferase gene EZH2 in myelodysplastic syndromes

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Variant PRC1 Complex-Dependent H2A Ubiquitylation Drives PRC2 Recruitment and Polycomb Domain Formation

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Coordinated activities of wild-type plus mutant EZH2 drive tumor-associated hypertrimethylation of lysine 27 on histone H3 (H3K27) in human B-cell lymphomas

Sneeringer, C. J., Scott, M. P., Kuntz, K. W., Knutson, S. K., Pollock, R. M., Richon, V. M., & Copeland, R. A. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1012525107 · Cited by 691 · see citing works

Polycomb Group Proteins: Multi-Faceted Regulators of Somatic Stem Cells and Cancer

Sauvageau, M., & Sauvageau, G. (2010) · Cell stem cell · doi:10.1016/j.stem.2010.08.002 · Cited by 676 · see citing works

Ring1-mediated ubiquitination of H2A restrains poised RNA polymerase II at bivalent genes in mouse ES cells

Stock, J. K., Giadrossi, S., Casanova, M., Brookes, E., Vidal, M., Koseki, H., Brockdorff, N., Fisher, A. G., & Pombo, A. (2007) · Nature Cell Biology · doi:10.1038/ncb1663 · Cited by 650 · see citing works

Chromatin Signatures in Multipotent Human Hematopoietic Stem Cells Indicate the Fate of Bivalent Genes during Differentiation

Cui, K., Zang, C., Roh, T., Schones, D. E., Childs, R. W., Peng, W., & Zhao, K. (2009) · Cell stem cell · doi:10.1016/j.stem.2008.11.011 · Cited by 620 · see citing works

Ezh2 controls B cell development through histone H3 methylation and Igh rearrangement

Su, I.-H., Basavaraj, A., Krutchinsky, A. N., Hobert, O., Ullrich, A., Chait, B. T., & Tarakhovsky, A. (2002) · Nature Immunology · doi:10.1038/ni876 · Cited by 614 · see citing works

RYBP-PRC1 Complexes Mediate H2A Ubiquitylation at Polycomb Target Sites Independently of PRC2 and H3K27me3

Tavares, L., Dimitrova, E., Oxley, D., Webster, J. A., Poot, R. A., Demmers, J., Bezstarosti, K., Taylor, S., Ura, H., Koide, H., et al. (2012) · Cell · doi:10.1016/j.cell.2011.12.029 · Cited by 558 · see citing works

Selective Inhibition of EZH2 by EPZ-6438 Leads to Potent Antitumor Activity in EZH2 -Mutant Non-Hodgkin Lymphoma

Knutson, S. K., Kawano, S., Minoshima, Y., Warholic, N. M., Huang, K., Xiao, Y., Kadowaki, T., Uesugi, M., Kuznetsov, G., Kumar, N., et al. (2014) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-13-0773 · Cited by 529 · see citing works

Genetic inactivation of the polycomb repressive complex 2 in T cell acute lymphoblastic leukemia

Ntziachristos, P., Tsirigos, A., Vlierberghe, P. V., Nedjic, J., Trimarchi, T., Flaherty, M. S., Ferrés-Marcó, D., Ros, V. G. D., Tang, Z., Siegle, J., et al. (2012) · Nature Medicine · doi:10.1038/nm.2651 · Cited by 528 · see citing works

Non-coding RNAs as direct and indirect modulators of epigenetic regulation

Peschansky, V. J., & Wahlestedt, C. (2013) · Epigenetics · doi:10.4161/epi.27473 · Cited by 516 · see citing works

Enhanced self-renewal of hematopoietic stem cells mediated by the polycomb gene product Bmi-1

Iwama, A., Oguro, H., Negishi, M., Kato, Y., Morita, Y., Tsukui, H., Ema, H., Kamijo, T., Katoh-Fukui, Y., Koseki, H., et al. (2004) · Immunity · doi:10.1016/j.immuni.2004.11.004 · Cited by 515 · see citing works

Mutation of A677 in histone methyltransferase EZH2 in human B-cell lymphoma promotes hypertrimethylation of histone H3 on lysine 27 (H3K27)

McCabe, M. T., Graves, A. P., Ganji, G., Diaz, E., Halsey, W. S., Jiang, Y., Smitheman, K. N., Ott, H. M., Pappalardi, M. B., Allen, K. E., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1116418109 · Cited by 493 · see citing works

Epigenetics and cancer

Lund, A. H., & van Lohuizen, M. (2004) · Genes & Development · doi:10.1101/gad.1232504 · Cited by 489 · see citing works

Histone H2A monoubiquitination promotes histone H3 methylation in Polycomb repression

Kalb, R., Latwiel, S., Baymaz, H. I., Jansen, P. W. T. C., Müller, C. W., Vermeulen, M., & Müller, J. (2014) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.2833 · Cited by 451 · see citing works

Structure and E3‐ligase activity of the Ring–Ring complex of Polycomb proteins Bmi1 and Ring1b

Buchwald, G., van der Stoop, P. P. M., Weichenrieder, O., Anastassis Perrakis, A., van Lohuizen, M., & Sixma, T. K. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7601144 · Cited by 438 · see citing works

The polycomb group gene Ezh2 prevents hematopoietic stem cell exhaustion

Kamminga, L. M., Bystrykh, L. V., de Boer, A., Houwer, S., Douma, J., Weersing, E., Dontje, B., & de Haan, G. (2006) · Blood · doi:10.1182/blood-2005-09-3585 · Cited by 376 · see citing works

Targeted Disruption of the EZH2/EED Complex Inhibits EZH2-dependent Cancer

Kim, W., Bird, G. H., Neff, T., Guo, G., Kerényi, M., Walensky, L., & Orkin, S. (2013) · Nature Chemical Biology · doi:10.1038/nchembio.1331 · Cited by 357 · see citing works

Polycomb Repressive Complex 2 Regulates Normal Hematopoietic Stem Cell Function in a Developmental-Stage-Specific Manner

Xie, H., Xu, J., Hsu, J. H.-R., Nguyen, M., Fujiwara, Y., Peng, C., & Orkin, S. H. (2013) · Cell stem cell · doi:10.1016/j.stem.2013.10.001 · Cited by 320 · see citing works

Polycomb group proteins Ring1A/B are functionally linked to the core transcriptional regulatory circuitry to maintain ES cell identity

Endoh, M., Endo, T. A., Endoh, T., Fujimura, Y., Ohara, O., Toyoda, T., Otte, A. P., Okano, M., Brockdorff, N., Vidal, M., et al. (2008) · Development · doi:10.1242/dev.014340 · Cited by 286 · see citing works

BMI-1 gene amplification and overexpression in hematological malignancies occur mainly in mantle cell lymphomas.

Beà, S., Tort, F., Pinyol, M., Puig, X., Hernández, L., Hernandez, S. F., Fernández, P. L., van Lohuizen, M., Colomer, D., & Campo, E. (2001) · PubMed · Cited by 281 · see citing works

Altered cellular proliferation and mesoderm patterning in Polycomb-M33-deficient mice

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Coexpression of BMI-1 and EZH2 polycomb-group proteins is associated with cycling cells and degree of malignancy in B-cell non-Hodgkin lymphoma

van Kemenade, F. J., Raaphorst, F. M., Blokzijl, T., Fieret, E. J. H., Hamer, K. M., Satijn, D. P. E., Otte, A. P., & Meijer, C. J. L. M. (2001) · Blood · doi:10.1182/blood.v97.12.3896 · Cited by 267 · see citing works

A key role for <i>EZH2</i> and associated genes in mouse and human adult T-cell acute leukemia

Simon, C., Chagraoui, J., Krosl, J., Gendron, P., Wilhelm, B., Lemieux, S., Boucher, G., Chagnon, P., Drouin, S., Lambert, R., et al. (2012) · Genes &amp; Development · doi:10.1101/gad.186411.111 · Cited by 264 · see citing works

Stem cell regulation by polycomb repressors: postponing commitment

Pietersen, A. M., & van Lohuizen, M. (2008) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2008.01.004 · Cited by 248 · see citing works

A Vertebrate Polycomb Response Element Governs Segmentation of the Posterior Hindbrain

Sing, A., Pannell, D., Karaiskakis, A., Sturgeon, K., Djabali, M., Ellis, J., Lipshitz, H. D., & Cordes, S. P. (2009) · Cell · doi:10.1016/j.cell.2009.08.020 · Cited by 237 · see citing works

The Polycomb group protein EZH2 is upregulated in proliferating, cultured human mantle cell lymphoma

Visser, H. P. J., Gunster, M. J., Kluin‐Nelemans, H. C., Manders, E. M. M., Raaphorst, F. M., Meijer, C. J. L. M., Willemze, R., & Otte, A. P. (2001) · British Journal of Haematology · doi:10.1046/j.1365-2141.2001.02641.x · Cited by 236 · see citing works

Polycomb repressive complex 2 is required for MLL-AF9 leukemia

Neff, T., Sinha, A. U., Kluk, M., Zhu, N., Khattab, M. H., Stein, L., Xie, H., Orkin, S. H., & Armstrong, S. A. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1202258109 · Cited by 228 · see citing works

Differential impact of Ink4a and Arf on hematopoietic stem cells and their bone marrow microenvironment in Bmi1-deficient mice

Oguro, H., Iwama, A., Morita, Y., Kamijo, T., van Lohuizen, M., & Nakauchi, H. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20052477 · Cited by 227 · see citing works

Ezh1 Is Required for Hematopoietic Stem Cell Maintenance and Prevents Senescence-like Cell Cycle Arrest

Hidalgo, I., Herrera-Merchan, A., Ligos, J. M., Carramolino, L., Nuñez, J., Martinez, F., Dominguez, O., Torres, M., & Gonzalez, S. (2012) · Cell Stem Cell · doi:10.1016/j.stem.2012.08.001 · Cited by 222 · see citing works

Direct Recruitment of Polycomb Repressive Complex 1 to Chromatin by Core Binding Transcription Factors

Yu, M., Mazor, T., Huang, H., Huang, H.-T., Kathrein, K. L., Woo, A. J., Chouinard, C. R., Labadorf, A. T., Akie, T. E., Moran, T. B., et al. (2012) · Molecular Cell · doi:10.1016/j.molcel.2011.11.032 · Cited by 215 · see citing works

Dependency on the polycomb gene Ezh2 distinguishes fetal from adult hematopoietic stem cells

Mochizuki‐Kashio, M., Mishima, Y., Miyagi, S., Negishi, M., Saraya, A., Konuma, T., Shinga, J., Koseki, H., & Iwama, A. (2011) · Blood · doi:10.1182/blood-2011-03-340554 · Cited by 211 · see citing works

Ezh2 augments leukemogenicity by reinforcing differentiation blockage in acute myeloid leukemia.

Tanaka, S., Miyagi, S., Sashida, G., Chiba, T., Yuan, J., Mochizuki-Kashio, M., Suzuki, Y., Sugano, S., Nakaseko, C., Yokote, K., et al. (2012) · Blood · doi:10.1182/blood-2011-11-394932 · Cited by 201 · see citing works

RYBP and Cbx7 define specific biological functions of polycomb complexes in mouse embryonic stem cells

Morey, L., Aloia, L., Cozzuto, L., Benitah, S. A., & Di Croce, L. (2013) · Cell Reports · doi:10.1016/j.celrep.2012.11.026 · Cited by 201 · see citing works

Poised Lineage Specification in Multipotential Hematopoietic Stem and Progenitor Cells by the Polycomb Protein Bmi1

Oguro, H., Yuan, J., Ichikawa, H., Ikawa, T., Yamazaki, S., Kawamoto, H., Nakauchi, H., & Iwama, A. (2010) · Cell stem cell · doi:10.1016/j.stem.2010.01.005 · Cited by 186 · see citing works

Polycomb Group Gene rae28 Is Required for Sustaining Activity of Hematopoietic Stem Cells

Ohta, H., Sawada, A., Kim, J. Y., Tokimasa, S., Nishiguchi, S., Humphries, R. K., Hara, J., & Takihara, Y. (2002) · The Journal of Experimental Medicine · doi:10.1084/jem.20011911 · Cited by 182 · see citing works

Concurrent loss of Ezh2 and Tet2 cooperates in the pathogenesis of myelodysplastic disorders

Muto, T., Sashida, G., Oshima, M., Wendt, G. R., Mochizuki‐Kashio, M., Nagata, Y., Sanada, M., Miyagi, S., Saraya, A., Kamio, A., et al. (2013) · The Journal of Experimental Medicine · doi:10.1084/jem.20131144 · Cited by 179 · see citing works

Inactivation of polycomb repressive complex 2 components in myeloproliferative and myelodysplastic/myeloproliferative neoplasms

Score, J., Hidalgo-Curtis, C., Jones, A. V., Winkelmann, N., Skinner, A., Ward, D., Zoi, K., Ernst, T., Stegelmann, F., Döhner, K., et al. (2012) · Blood · doi:10.1182/blood-2011-07-367243 · Cited by 177 · see citing works

Role of the chromobox protein CBX7 in lymphomagenesis

Scott, C. L., Gil, J., Hernando, E., Teruya‐Feldstein, J., Narita, M., Martínez, D., Visakorpi, T., Mu, D., Cordon‐Cardo, C., Peters, G. G., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0608721104 · Cited by 174 · see citing works

REST–Mediated Recruitment of Polycomb Repressor Complexes in Mammalian Cells

Dietrich, N., Lerdrup, M., Landt, E., Singh, S. A., Bak, M., Tommerup, N., Rappsilber, J., Södersten, E., & Hansen, K. H. (2012) · PLoS Genetics · doi:10.1371/journal.pgen.1002494 · Cited by 173 · see citing works

CBX8, a Polycomb Group Protein, Is Essential for MLL-AF9-Induced Leukemogenesis

Tan, J., Jones, M., Koseki, H., Nakayama, M., Muntean, A. G., Maillard, I. P., & Hess, J. L. (2011) · Cancer Cell · doi:10.1016/j.ccr.2011.09.008 · Cited by 172 · see citing works

Coexpression of BMI-1 and EZH2 Polycomb Group Genes in Reed-Sternberg Cells of Hodgkin’s Disease

Raaphorst, F. M., van Kemenade, F. J., Blokzijl, T., Fieret, E. J. H., Hamer, K. M., Satijn, D. P. E., Otte, A. P., & Meijer, C. J. L. M. (2000) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)64583-x · Cited by 166 · see citing works

Stage-Specific Expression of Polycomb Group Genes in Human Bone Marrow Cells

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Ezh2 loss in hematopoietic stem cells predisposes mice to develop heterogeneous malignancies in an Ezh1-dependent manner

Mochizuki‐Kashio, M., Aoyama, K., Sashida, G., Oshima, M., Tomioka, T., Muto, T., Wang, C., & Iwama, A. (2015) · Blood · doi:10.1182/blood-2015-03-634428 · Cited by 141 · see citing works

The polycomb group BMI1 gene is a molecular marker for predicting prognosis of chronic myeloid leukemia

Mohty, M., Yong, A. S. M., Szydlo, R., Apperley, J. F., & Melo, J. V. (2007) · Blood · doi:10.1182/blood-2006-12-065599 · Cited by 134 · see citing works

Bmi-1 is useful as a novel molecular marker for predicting progression of myelodysplastic syndrome and patient prognosis

Mihara, K., Chowdhury, M., Nakaju, N., Hidani, S., Ihara, A., Hyodo, H., Yasunaga, S., Takihara, Y., & Kimura, A. (2005) · Blood · doi:10.1182/blood-2005-06-2393 · Cited by 129 · see citing works

EPZ011989, A Potent, Orally-Available EZH2 Inhibitor with Robust in Vivo Activity

Campbell, J. E., Kuntz, K. W., Knutson, S. K., Warholic, N. M., Keilhack, H., Wigle, T. J., Raimondi, A., Klaus, C. R., Rioux, N., Yokoi, A., et al. (2015) · ACS Medicinal Chemistry Letters · doi:10.1021/acsmedchemlett.5b00037 · Cited by 129 · see citing works

Inactivation of the Polycomb Group Protein Ring1B Unveils an Antiproliferative Role in Hematopoietic Cell Expansion and Cooperation with Tumorigenesis Associated with Ink4a Deletion

Cales, C., Román-Trufero, M., Pavón, L., Serrano, I., Melgar, T., Endoh, M., Pérez, C., Koseki, H., & Vidal, M. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.01136-07 · Cited by 116 · see citing works

The Role of mel-18, a Mammalian Polycomb Group Gene, during IL-7–Dependent Proliferation of Lymphocyte Precursors

Akasaka, T., Tsuji, K., Kawahira, H., Kanno, M., Harigaya, K., Hu, L., Ebihara, Y., Nakahata, T., Tetsu, O., Taniguchi, M., et al. (1997) · Immunity · doi:10.1016/s1074-7613(00)80516-6 · Cited by 110 · see citing works

Polycomb repressive complex 2 component Suz12 is required for hematopoietic stem cell function and lymphopoiesis

Lee, S. C.-W., Miller, S., Hyland, C. D., Kauppi, M., Lebois, M., Rago, L. D., Metcalf, D., Kinkel, S., Josefsson, E. C., Blewitt, M. E., et al. (2015) · Blood · doi:10.1182/blood-2014-12-615898 · Cited by 105 · see citing works

Overexpression of enhancer of zeste homolog 2 with trimethylation of lysine 27 on histone H3 in adult T-cell leukemia/lymphoma as a target for epigenetic therapy

Sasaki, D., Imaizumi, Y., Hasegawa, H., Osaka, A., Tsukasaki, K., Choi, Y. L., Mano, H., Márquez, V. E., Hayashi, T., Yanagihara, K., et al. (2011) · Haematologica · doi:10.3324/haematol.2010.028605 · Cited by 104 · see citing works

Overexpression of the EZH2, RING1 and BMI1 genes is common in myelodysplastic syndromes: relation to adverse epigenetic alteration and poor prognostic scoring

Xu, F., Li, X., Wu, L., Zhang, Q., Yang, R., Yang, Y., Zhang, Z., He, Q., & Chang, C. (2010) · Annals of Hematology · doi:10.1007/s00277-010-1128-5 · Cited by 103 · see citing works

Polycomb group gene mel-18 modulates the self-renewal activity and cell cycle status of hematopoietic stem cells

Kajiume, T., Ninomiya, Y., Ishihara, H., Kanno, R., & Kanno, M. (2004) · Experimental Hematology · doi:10.1016/j.exphem.2004.03.001 · Cited by 103 · see citing works

Expression of Polycomb-group (PcG) protein BMI-1 predicts prognosis in patients with acute myeloid leukemia

Chowdhury, M., Mihara, K., Yasunaga, S., Ohtaki, M., Takihara, Y., & Kimura, A. (2007) · Leukemia · doi:10.1038/sj.leu.2404623 · Cited by 97 · see citing works

Bmi-1 Regulation of INK4A-ARF Is a Downstream Requirement for Transformation of Hematopoietic Progenitors by E2a-Pbx1

Smith, K. S., Chanda, S. K., Lingbeek, M., Ross, D. T., Botstein, D., van Lohuizen, M., & Cleary, M. L. (2003) · Molecular Cell · doi:10.1016/s1097-2765(03)00277-6 · Cited by 89 · see citing works

BMI1 collaborates with BCR-ABL in leukemic transformation of human CD34+ cells

Rizo, A., Horton, S. J., Olthof, S. G. M., Dontje, B., Ausema, A., van Os, R. P., van den Boom, V., Vellenga, E., de Haan, G., & Schuringa, J. J. (2010) · Blood · doi:10.1182/blood-2010-02-270660 · Cited by 82 · see citing works

A transgenic mouse model demonstrating the oncogenic role of mutations in the polycomb-group gene EZH2 in lymphomagenesis

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Bmi1 is essential for leukemic reprogramming of myeloid progenitor cells

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Polycomb-group genes as regulators of mammalian lymphopoiesis

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Polycomb proteins in hematologic malignancies

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GATA-1 Utilizes Ikaros and Polycomb Repressive Complex 2 To Suppress Hes1 and To Promote Erythropoiesis

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Hypermethylated in Cancer 1 (HIC1) Recruits Polycomb Repressive Complex 2 (PRC2) to a Subset of Its Target Genes through Interaction with Human Polycomb-like (hPCL) Proteins

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Defective long‐term repopulating ability in hematopoietic stem cells lacking the Polycomb‐group gene rae28

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BMI1 gene expression in myeloid leukemias and its impact on prognosis

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Expression of the polycomb-group gene BMI1 is related to an unfavourable prognosis in primary nodal DLBCL

van Galen, J. C., Muris, J. J. F., Oudejans, J. J., Vos, W., Giroth, C., Ossenkoppele, G. J., Otte, A. P., Raaphorst, F. M., & Meijer, C. J. L. M. (2006) · Journal of Clinical Pathology · doi:10.1136/jcp.2006.038752 · Cited by 46 · see citing works

Epigenetics of hematopoietic stem cell aging and disease

Oshima, M., & Iwama, A. (2014) · International Journal of Hematology · doi:10.1007/s12185-014-1647-2 · Cited by 39 · see citing works

Bmi1 reprograms CML B-lymphoid progenitors to become B-ALL–initiating cells

Sengupta, A., Ficker, A. M., Dunn, S. K., Madhu, M., & Cancelas, J. A. (2011) · Blood · doi:10.1182/blood-2011-06-359232 · Cited by 34 · see citing works

UBAP2L is a novel BMI1-interacting protein essential for hematopoietic stem cell activity

Bordeleau, M.-È., Aucagne, R., Chagraoui, J., Girard, S., Mayotte, N., Bonneil, É., Thibault, P., Pabst, C., Bergeron, A., Barabé, F., et al. (2014) · Blood · doi:10.1182/blood-2014-01-548651 · Cited by 32 · see citing works

Improved outcome following allogeneic stem cell transplantation in chronic myeloid leukemia is associated with higher expression of BMI-1 and immune responses to BMI-1 protein

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BMI1, The polycomb‐group gene, is recurrently targeted by genomic rearrangements in progressive B‐cell leukemia/lymphoma

Rouhi, L., Ferreiro, J. F., Put, N., Michaux, L., Tousseyn, T., Lefebvre, C., Gardiner, A. C., Kelver, W. D., Demuynck, H., Verschuere, J., et al. (2013) · Genes Chromosomes and Cancer · doi:10.1002/gcc.22088 · Cited by 27 · see citing works

Variations in Chromosomes 9 and 6p21.3 with Risk of Non–Hodgkin Lymphoma

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Mechanisms of Polycomb group protein function in cancer

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Novel orally bioavailable EZH1/2 dual inhibitors with greater antitumor efficacy than an EZH2 selective inhibitor

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Proteolysis targeting chimeras (PROTACs) are emerging therapeutics for hematologic malignancies

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Emerging EZH2 Inhibitors and Their Application in Lymphoma

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Multifaceted role of the polycomb-group gene EZH2 in hematological malignancies

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Epigenetics in normal and malignant hematopoiesis: An overview and update 2017

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Epigenetic regulation of HIV-1 latency: focus on polycomb group (PcG) proteins

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PRC2 loss of function confers a targetable vulnerability to BET proteins in T-ALL

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Polycomb‐mediated gene regulation in human brain development and neurodevelopmental disorders

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Functional Toll-Like Receptors (TLRs) Are Expressed by a Majority of Primary Human Acute Myeloid Leukemia Cells and Inducibility of the TLR Signaling Pathway Is Associated with a More Favorable Phenotype

Brenner, A. K., & Bruserud, Ø. (2019) · Cancers · doi:10.3390/cancers11070973 · Cited by 33 · see citing works

Ring1A and Ring1B inhibit expression of Glis2 to maintain murine MOZ-TIF2 AML stem cells.

Shima, H., Takamatsu-Ichihara, E., Shino, M., Yamagata, K., Katsumoto, T., Aikawa, Y., Fujita, S., Koseki, H., & Kitabayashi, I. (2018) · Blood · doi:10.1182/blood-2017-05-787226 · Cited by 27 · see citing works

MiR-203 Interplays with Polycomb Repressive Complexes to Regulate the Proliferation of Neural Stem/Progenitor Cells

Liu, P., Tang, G.-B., Xu, Y., Zeng, Y.-Q., Zhang, S.-F., Du, H., Teng, Z., & Liu, C.-M. (2017) · Stem Cell Reports · doi:10.1016/j.stemcr.2017.05.007 · Cited by 29 · see citing works

ENL: structure, function, and roles in hematopoiesis and acute myeloid leukemia

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Structural heterogeneity of the mammalian polycomb repressor complex in immune regulation

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Disrupting the Code: Epigenetic Dysregulation of Lymphocyte Function during Infectious Disease and Lymphoma Development

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Phc2 controls hematopoietic stem and progenitor cell mobilization from bone marrow by repressing Vcam1 expression

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EZH2 regulates oncomiR-200c and EMT markers in esophageal squamous cell carcinomas

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Drosophila Hox genes induce melanized pseudo-tumors when misexpressed in hemocytes

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Therapeutic implications of signaling pathways and tumor microenvironment interactions in esophageal cancer

Khan, I. R., Sadida, H. Q., Hashem, S., Singh, M. K., Macha, M. A., Akil, A. S. A.-S., Khurshid, I., & Bhat, A. A. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.116873 · Cited by 11 · see citing works

High expression of ABCG2 induced by EZH2 disruption has pivotal roles in MDS pathogenesis

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Polycomb protein RING1A limits hematopoietic differentiation in myelodysplastic syndromes

Palau, A., Garz, A.-K., Diesch, J., Zwick, A., Malinverni, R., Valero, V., Lappin, K. M., Casquero, R., Lennartsson, A., Zuber, J. A., et al. (2017) · Oncotarget · doi:10.18632/oncotarget.22839 · Cited by 7 · see citing works

PROTACs: Walking through hematological malignancies

Malhab, L. J. B., AlSafar, H. S., Ibrahim, S. M., & Rahmani, M. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1086946 · Cited by 6 · see citing works

Exploring Epigenetic Complexity in Regulation of Hematopoietic Stem Cells Niche: A Mechanistic Journey from Normal to Malignant Hematopoiesis

Yusoff, N. A., Hamid, Z. A., Taib, I. S., Razak, S. R. A., & Budin, S. B. (2025) · Advances in experimental medicine and biology · doi:10.1007/5584_2024_846 · Cited by 2 · see citing works

Guest editorial: Cooperative networks for stem cell homeostasis in normal and malignant hematopoiesis: from metabolism to epigenetics

Hirao, A. (2016) · International Journal of Hematology · doi:10.1007/s12185-016-2012-4 · Cited by 1 · see citing works

DNA and Histone Methylation in Hematopoietic Malignancy

Kawabata, K. C., & Kitamura, T. (2017) · Cancer drug discovery and develogment/Cancer drug discovery and development · doi:10.1007/978-3-319-59786-7_14

Drosophila Hox genes induce melanised pseudo-tumours when misexpressed in hemocytesPreprint

Ponratnam, T., Saini, R., & Mishra, R. K. (2020) · doi:10.21203/rs.2.20010/v2

Drosophila Hox genes induce melanised pseudo-tumours when misexpressed in hemocytesPreprint

Ponratnam, T., Saini, R., & Mishra, R. K. (2020) · doi:10.21203/rs.2.20010/v1

BindingDB Entry 50022486: Novel orally bioavailable EZH1/2 dual inhibitors with greater antitumor efficacy than an EZH2 selective inhibitor.

BindingDB (2025) · UC San Diego · doi:10.7270/q23j3jq7

Polycomb proteins in hematologic malignancies

Martin-Perez, D., Piris, M. A., & Sanchez-Beato, M. (2010) · Blood · doi:10.1182/blood-2010-05-267096 · Cited by 65 · see citing works

Polycomb-group proteins in hematopoietic stem cell regulation and hematopoietic neoplasms

Radulović, V., de Haan, G., & Klauke, K. (2013) · Leukemia · doi:10.1038/leu.2012.368 · Cited by 71 · see citing works

Polycomb Proteins in Hematopoiesis and Hematologic Malignancie

Li, J. (2017) · International Journal of Blood Research and Disorders · doi:10.23937/2469-5696/1410025 · Cited by 1 · see citing works

Polycomb complexes in normal and malignant hematopoiesis

Carlo, V. D., Mocavini, I., & Croce, L. D. (2018) · The Journal of Cell Biology · doi:10.1083/jcb.201808028 · Cited by 61 · see citing works

Polycomb group genes as epigenetic regulators of normal and leukemic hemopoiesis

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