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In vivo effects of dietary quercetin and quercetin-rich red onion extract on skeletal muscle mitochondria, metabolism, and insulin sensitivity
Open accessAbstract
Red onions and low doses of the flavonoid, quercetin, increase insulin sensitivity and improve glucose tolerance. We hypothesized that dietary supplementation with red onion extract (RO) would attenuate high fat diet (HFD)-induced obesity and insulin resistance similar to quercetin supplementation by increasing energy expenditure through a mechanism involving skeletal muscle mitochondrial adaptations. To test this hypothesis, C57BL/6J mice were randomized into four groups and fed either a low fat diet (LF), HFD (HF), HFD + quercetin (HF + Q), or HFD + RO (HF + RO) for 9 weeks. Food consumption and body weight and composition were measured weekly. Insulin sensitivity was assessed by insulin and glucose tolerance tests. Energy expenditure and physical activity were measured by indirect calorimetry. Skeletal muscle incomplete beta oxidation, mitochondrial number, and mtDNA-encoded gene expression were measured. Quercetin and RO supplementation decreased HFD-induced fat mass accumulation and insulin resistance (measured by insulin tolerance test) and increased energy expenditure; however, only HF + Q showed an increase in physical activity levels. Although quercetin and RO similarly increased skeletal muscle mitochondrial number and decreased incomplete beta oxidation, establishing mitochondrial function similar to that seen in LF, only HF + Q exhibited consistently lower mRNA levels of mtDNA-encoded genes necessary for complexes IV and V compared to LF. Quercetin- and RO-induced improvements in adiposity, insulin resistance, and energy expenditure occur through differential mechanisms, with quercetin-but not RO-induced energy expenditure being related to increases in physical activity. While both treatments improved skeletal muscle mitochondrial number and function, mtDNA-encoded transcript levels suggest that the antiobesogenic, insulin-sensitizing effects of purified quercetin aglycone, and RO may occur through differential mechanisms.
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“In this study, 17 mg/kg of quercetin aglycone treatment for nine weeks increased skeletal muscle mitochondria number and decreases incomplete β-oxidation, establishing mitochondrial function comparable to that of lean counterparts [98].”
From Mitochondrial Adaptation in Skeletal Muscle: Impact of Obesity, Caloric Restriction, and Dietary Compounds (2024) · cites this paper as [98]
Experimental — accuracy not yet measuredIn the citing paper
“Similarly, dietary quercetin supplementation was reported to decrease high-fat diet-induced fat accumulation and insulin resistance [98].”
From Mitochondrial Adaptation in Skeletal Muscle: Impact of Obesity, Caloric Restriction, and Dietary Compounds (2024) · cites this paper as [98]
In the citing paper
“Similarly, dietary quercetin supplementation was reported to decrease high-fat diet-induced fat accumulation and insulin resistance [98].”
From Mitochondrial Adaptation in Skeletal Muscle: Impact of Obesity, Caloric Restriction, and Dietary Compounds (2024) · cites this paper as [98]
In the citing paper
“In this study, 17 mg/kg of quercetin aglycone treatment for nine weeks increased skeletal muscle mitochondria number and decreases incomplete β-oxidation, establishing mitochondrial function comparable to that of lean counterparts [98].”
From Mitochondrial Adaptation in Skeletal Muscle: Impact of Obesity, Caloric Restriction, and Dietary Compounds (2024) · cites this paper as [98]
In the citing paper
“In this study, 17 mg/kg of quercetin aglycone treatment for nine weeks increased skeletal muscle mitochondria number and decreases incomplete β-oxidation, establishing mitochondrial function comparable to that of lean counterparts [98].”
From Mitochondrial Adaptation in Skeletal Muscle: Impact of Obesity, Caloric Restriction, and Dietary Compounds (2024) · cites this paper as [98]
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Citations
Cites
Mitochondrial diseases in man and mouse
Wallace, D. C. (1999) · Science · doi:10.1126/science.283.5407.1482 · Cited by 3,060
Mitochondrial dysfunction and type 2 diabetes
Lowell, B. B., & Shulman, G. I. (2005) · Science · doi:10.1126/science.1104343 · Cited by 2,070
Koves, T. R., Ussher, J. R., Noland, R. C., Slentz, D., Mosedale, M., Ilkayeva, O., Bain, J., Stevens, R., Dyck, J. R. B., Newgard, C. B., et al. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2007.10.013 · Cited by 1,990
Self-citationBiomarkers of mitochondrial content in skeletal muscle of healthy young human subjects
Larsen, S., Nielsen, J., Hansen, C. N., Nielsen, L. B., Wibrand, F., Stride, N., Schroder, H. D., Boushel, R., Helge, J. W., Dela, F., et al. (2012) · The Journal of Physiology · doi:10.1113/jphysiol.2012.230185 · Cited by 1,180 · cited 2×
“…measure of mitochondrial content (Casuso et al. 2013; Chang et al. 2012; Davis et al. 2009; Drew et al. 2014), it is not a direct measure of mitochondrial number and a recent study in humans shows that mtDNA does not correlate with other measures of mitochondrial number (Larsen et al. 2012).”
Determinants of 24-hour energy expenditure in man. Methods and results using a respiratory chamber.
Ravussin, E., Lillioja, S., Anderson, T. E., Christin, L., & Bogardus, C. (1986) · Journal of Clinical Investigation · doi:10.1172/jci112749 · Cited by 1,166
Absorption of dietary quercetin glycosides and quercetin in healthy ileostomy volunteers
Hollman, P. C. H., de Vries, J., van Leeuwen, S., Mengelers, M. J. B., & Katan, M. (1995) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/62.6.1276 · Cited by 956
Sparks, L. M., Xie, H., Koza, R. A., Mynatt, R., Hulver, M. W., Bray, G. A., & Smith, S. R. (2005) · Diabetes · doi:10.2337/diabetes.54.7.1926 · Cited by 629 · cited 4×
“Improvements in energy expenditure and insulin sensitivity are associated with beneficial skeletal muscle mitochondrial adaptations (Asmann et al. 2006; Carrasco-Pozo et al. 2012; Davis et al. 2009; Henagan et al. 2014; Rayamajhi et al. 2013; Sparks et al. 2005; Stewart et al. 2008).”
InfluentialThe role of mitochondria in insulin resistance and type 2 diabetes mellitus
Szendroedi, J., Phielix, E., & Roden, M. (2012) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2011.138 · Cited by 600 · cited 1×
“High fat diet (HFD)-induced obesity is associated with the development of insulin resistance mediated partially by decreased mitochondrial number and promotion of mitochondrial dysfunction (Jia et al. 2014; Lowell and Shulman 2005; Szendroedi et al. 2012).”
High-fat diets cause insulin resistance despite an increase in muscle mitochondria
Hancock, C. R., Han, D.-H., Chen, M., Terada, S., Yasuda, T., Wright, D. C., & Holloszy, J. O. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0802057105 · Cited by 538 · cited 1×
“HFD has been shown to have varying effects on mitochondrial biogenesis that may occur independently of differences in mitochondrial function and insulin sensitivity and may be dependent on the duration of feeding and type and level of dietary fat (Hancock et al. 2008; Holloszy 2013).”
Biochemical study on the hypoglycemic effects of onion and garlic in alloxan-induced diabetic rats
El-Demerdash, F. M., Yousef, M. I., & El-Naga, N. I. A. (2004) · Food and Chemical Toxicology · doi:10.1016/j.fct.2004.08.012 · Cited by 495
Quercetin increases brain and muscle mitochondrial biogenesis and exercise tolerance
Davis, J. M., Murphy, E. A., Carmichael, M. D., & Davis, B. (2009) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.90925.2008 · Cited by 486
Egert, S., Wolffram, S., Bosy‐Westphal, A., Boesch, C., Wagner, A. E., Frank, J., Rimbach, G. H., & Mueller, M. J. (2008) · Journal of Nutrition · doi:10.1093/jn/138.9.1615 · Cited by 335
Noland, R. C., Koves, T. R., Seiler, S. E., Lum, H., Lust, R. M., Ilkayeva, O., Stevens, R. D., Hegardt, F. G., & Muoio, D. M. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.032888 · Cited by 317
Self-citationJeong, S.-M., Kang, M.-J., Choi, H., Kim, J., & Kim, J.-I. (2012) · Nutrition Research and Practice · doi:10.4162/nrp.2012.6.3.201 · Cited by 266
Stewart, L. K., Soileau, J. L., Ribnicky, D., Wang, Z. Q., Raskin, I., Poulev, A., Majewski, M., Cefalu, W. T., & Gettys, T. W. (2008) · Metabolism · doi:10.1016/j.metabol.2008.03.003 · Cited by 220
Self-citationEid, H. M., Martineau, L. C., Saleem, A., Muhammad, A., Vallerand, D., Benhaddou-Andaloussi, A., Nistor, L., Afshar, A., Arnason, J. T., & Haddad, P. S. (2010) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200900218 · Cited by 218
Asmann, Y. W., Stump, C. S., Short, K. R., Coenen-Schimke, J. M., Guo, Z., Bigelow, M. L., & Nair, K. S. (2006) · Diabetes · doi:10.2337/db05-1230 · Cited by 207
Jung, J. Y., Lim, Y., Moon, M. S., Kim, J. Y., & Kwon, O. (2011) · Nutrition & Metabolism · doi:10.1186/1743-7075-8-18 · Cited by 180
Carrasco‐Pozo, C., Mizgier, M. L., Speisky, H., & Gotteland, M. (2011) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2011.12.007 · Cited by 146
Drew, B. G., Ribas, V., Le, J. A., Henstridge, D. C., Phun, J., Zhou, Z., Soleymani, T., Daraei, P., Sitz, D., Vergnes, L., et al. (2014) · Diabetes · doi:10.2337/db13-0665 · Cited by 145
Variation in the Quercetin Content in Different Colored Onions (Allium cepa L.)
Patil, B. S., Pike, L. M., & Yoo, K. S. (1995) · Journal of the American Society for Horticultural Science · doi:10.21273/jashs.120.6.909 · Cited by 138
Dietary fat increases quercetin bioavailability in overweight adults
Guo, Y. C., Mah, E., Davis, C. G., Jalili, T., Ferruzzi, M. G., Chun, O. K., & Bruno, R. S. (2013) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201200619 · Cited by 128
Marchi, U. D., Biasutto, L., Garbisa, S., Toninello, A., & Zoratti, M. (2009) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2009.06.002 · Cited by 119
Eldin, I. M. T., Ahmed, E. M., & Elwahab, H. M. (2010) · Environmental Health Insights · doi:10.4137/ehi.s5540 · Cited by 114
“Deficiency” of Mitochondria in Muscle Does Not Cause Insulin Resistance
Holloszy, J. O. (2013) · Diabetes · doi:10.2337/db12-1107 · Cited by 111
Kumari, K., & Augusti, K. T. (2002) · PubMed · Cited by 105
Quercetin Induces Mitochondrial Biogenesis through Activation of HO-1 in HepG2 Cells
Rayamajhi, N., Kim, S., Go, H., Joe, Y., Callaway, Z., Kang, J., Ryter, S. W., & Chung, H. (2013) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2013/154279 · Cited by 87
Anhê, G. F., Okamoto, M. M., Kinote, A. P. B. D. M., Sollon, C. S., Lellis‐Santos, C., Anhê, F. F., Lima, G. A., Hirabara, S. M., Velloso, L. A., Bordin, S. A., et al. (2012) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2012.06.007 · Cited by 85
Chang, J. S., Fernand, V. E., Zhang, Y., Shin, J., Jun, H., Joshi, Y., & Gettys, T. W. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.320200 · Cited by 75
Self-citationHenagan, T. M., Lenard, N. R., Gettys, T. W., & Stewart, L. K. (2014) · PLoS ONE · doi:10.1371/journal.pone.0089365 · Cited by 74
Self-citationPeroxisomal-mitochondrial oxidation in a rodent model of obesity-associated insulin resistance
Noland, R. C., Woodlief, T., Whitfield, B. R., Manning, S. M., Evans, J. R., Dudek, R. W., Lust, R. M., & Cortright, R. N. (2007) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00399.2006 · Cited by 68
Self-citationJia, H., Aw, W., Egashira, K., Takahashi, S., Aoyama, S., Saito, K., Kishimoto, Y., & Kato, H. (2014) · Genes & Nutrition · doi:10.1007/s12263-014-0389-3 · Cited by 47
Xu, M., Hu, J., Zhao, W., Gao, X., Jiang, C., Liu, K., Liu, B., & Huang, F. (2013) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201300510 · Cited by 40
Oral quercetin supplementation hampers skeletal muscle adaptations in response to exercise training
Casuso, R. A., López, E. J. M., Nordsborg, N. B., Hita‐Contreras, F., Martínez‐Romero, R., Cañuelo, A., & Martínez‐Amat, A. (2013) · Scandinavian Journal of Medicine and Science in Sports · doi:10.1111/sms.12136 · Cited by 34
Research works printed but not linked: 1
- Noland RC, Koves TR, Seiler SE, Lum H, Lust RM, Ilkayeva O, Stevens RD, Hegardt FG, Muoio DM (2009b) Carnitine insufficiency caused by aging and overnutrition compromises mitochondrial performance and metabolic control. J Biol Chem 284:22840–22852 · DOI · Paper page
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Salehi, B., Machín, L., Monzote, L., Sharifi‐Rad, J., Ezzat, S. M., Salem, M. A., Merghany, R. M., Elsayyad, N. M. E., Kılıç, C. S., Sytar, O., et al. (2020) · ACS Omega · doi:10.1021/acsomega.0c01818 · Cited by 744
Neuroprotective Effects of Quercetin in Alzheimer’s Disease
Khan, H. Z., Ullah, H., Aschner, M., Cheang, W. S., & Akkol, E. K. (2019) · Biomolecules · doi:10.3390/biom10010059 · Cited by 563
Shi, G., Li, Y., Cao, Q., Wu, H., Tang, X., Gao, X., Yu, J., Chen, Z., & Yang, Y. (2018) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.10.130 · Cited by 302
Mechanistic insights and perspectives involved in neuroprotective action of quercetin
Grewal, A. K., Singh, T. G., Sharma, D., Sharma, V., Singh, M., Rahman, M. H., Najda, A., Walasek-Janusz, M., Kamel, M. S., Albadrani, G. M., et al. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.111729 · Cited by 295
Quercetin and the mitochondria: A mechanistic view
de Oliveira, M. R., Nabavi, S. M., Braidy, N., Setzer, W. N., Ahmed, T., & Nabavi, S. F. (2015) · Biotechnology Advances · doi:10.1016/j.biotechadv.2015.12.014 · Cited by 253
Metadata
- Authors
- Henagan, T. M., Cefalu, W. T., Ribnicky, D. M., Noland, R. C., Dunville, K., Campbell, W. W., Stewart, L. K., Forney, L. A., Gettys, T. W., Chang, J. S., & Morrison, C. D.
- Affiliations
- Purdue University West Lafayette (US)
- Pennington Biomedical Research Center (US)
- Rutgers, The State University of New Jersey (US)
- University of Northern Colorado (US)
- ORCID
- Venue
- Genes & Nutrition
- Published
- 2014-12-27
- Volume
- 10
- Issue
- 1
- Pages
- 451-451
- ISSN
- 1555-8932 (ISSN-L)
- 1865-3499
- PMC
- PMC4277553
- OpenAlex
- W2023989068
- Cited by
- 102
- References
- 34
- Citations by year
- 2026: 4 · 2025: 3 · 2024: 11 · 2023: 10 · 2022: 7 · 2021: 11 · 2020: 13 · 2019: 9 · 2018: 10 · 2017: 11 · 2016: 8 · 2015: 5
- FWCI
- 5.32
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Genes & Nutrition (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (DK072476)
- National Institute of General Medical Sciences (P20GM103528, P30GM118430)
- National Institute of Diabetes and Digestive and Kidney Diseases (DK072476, DK064584, 8P20-GM103528-07, R01DK096311, 5T32-DK064584-09, T32DK064584, P30DK072476)
- National Center for Complementary and Alternative Medicine
- National Center for Research Resources (P20RR021945)
- National Center for Complementary and Integrative Health (P50AT002776)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Natural Antidiabetic Agents Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Keywords
- quercetin, red onion extract, dietary flavonoids, insulin resistance, insulin sensitivity, high-fat diet, obesity, energy expenditure, skeletal muscle mitochondria, mitochondrial biogenesis, physical activity, glucose tolerance, fat mass
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