Mitochondrial diseases in man and mouse

Mitochondria and Apoptosis

Green, D. R., & Reed, J. C. (1998) · Science · doi:10.1126/science.281.5381.1309 · Cited by 8,998 · see citing works

Oxidants, antioxidants, and the degenerative diseases of aging.

Ames, B. N., Shigenaga, M. K., & Hagen, T. M. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.17.7915 · Cited by 5,958 · see citing works

Induction of Apoptotic Program in Cell-Free Extracts: Requirement for dATP and Cytochrome c

Liu, X., Kim, C. N., Yang, J., Jemmerson, R., & Wang, X. (1996) · Cell · doi:10.1016/s0092-8674(00)80085-9 · Cited by 5,167 · see citing works

Molecular characterization of mitochondrial apoptosis-inducing factor

Susin, S. A., Lorenzo, H. K., Zamzami, N., Marzo, I., Snow, B. E., Brothers, G. M., Mangion, J., Jacotot, E., Costantini, P., Loeffler, M., et al. (1999) · Nature · doi:10.1038/17135 · Cited by 4,060 · see citing works

Mitochondrial DNA mutation associated with Leber’s hereditary optic neuropathy

Wallace, D. C., Singh, G., Lott, M. T., Hodge, J. A., Schurr, T. G., Lezza, A. M. S., Elsas, L. J., & Nikoskelainen, E. K. (1988) · Science · doi:10.1126/science.3201231 · Cited by 2,440 · see citing works

The mitochondrial permeability transition

Zoratti, M., & Szabó, I. (1995) · Biochimica et Biophysica Acta (BBA) - Reviews on Biomembranes · doi:10.1016/0304-4157(95)00003-a · Cited by 2,395 · see citing works

A mutation in the tRNALeu(UUR) gene associated with the MELAS subgroup of mitochondrial encephalomyopathies

Goto, Y.-I., Nonaka, I., & Horai, S. (1990) · Nature · doi:10.1038/348651a0 · Cited by 2,070 · see citing works

Deletions of muscle mitochondrial DNA in patients with mitochondrial myopathies

Holt, I. J., Harding, A. E., & MORGAN-HUGHES, J. A. (1988) · Nature · doi:10.1038/331717a0 · Cited by 1,845 · see citing works

Dilated cardiomyopathy and neonatal lethality in mutant mice lacking manganese superoxide dismutase

Li, Y., Huang, T.-T., Carlson, E. J., Melov, S., Ursell, P. C., Olson, J. L., Noble, L. J., Yoshimura, M. P., Berger, C., Chan, P. H., et al. (1995) · Nature Genetics · doi:10.1038/ng1295-376 · Cited by 1,789 · see citing works

The genome sequence of Rickettsia prowazekii and the origin of mitochondria

Andersson, S. G. E., Zomorodipour, A., Andersson, J. O., Sicheritz-Pontén, T., Alsmark, U. C. M., Podowski, R. M., Näslund, A. K., Eriksson, A.-S., Winkler, H. H., & Kurland, C. G. (1998) · Nature · doi:10.1038/24094 · Cited by 1,697 · see citing works

Human Cells Lacking mtDNA: Repopulation with Exogenous Mitochondria by Complementation

King, M. P., & Attardi, G. M. (1989) · Science · doi:10.1126/science.2814477 · Cited by 1,659 · see citing works

Mitochondrial transcription factor A is necessary for mtDNA maintance and embryogenesis in mice

Larsson, N.-G., Wang, J., Wilhelmsson, H., Oldfors, A., Rustin, P., Lewandoski, M., Barsh, G. S., & Clayton, D. A. (1998) · Nature Genetics · doi:10.1038/ng0398-231 · Cited by 1,594 · see citing works

Human cells lacking mtDNA: repopulation with exogenous mitochondria by complementation

(1990) · Trends in Genetics · doi:10.1016/0168-9525(90)90040-d · Cited by 1,386 · see citing works

Bax and Adenine Nucleotide Translocator Cooperate in the Mitochondrial Control of Apoptosis

Marzo, I., Brenner, C., Zamzami, N., Jürgensmeier, J. M., Susin, S. A., Vieira, H. L. A., Prévost, M.-C., Xie, Z., Matsuyama, S., Reed, J. C., et al. (1998) · Science · doi:10.1126/science.281.5385.2027 · Cited by 1,168 · see citing works

Oxidative damage to mitochondrial DNA is increased in Alzheimer’s disease

Mecocci, P., MacGarvey, U., & Beal, M. F. (1994) · Annals of Neurology · doi:10.1002/ana.410360510 · Cited by 1,037 · see citing works

Neurodegeneration, myocardial injury, and perinatal death in mitochondrial superoxide dismutase-deficient mice

Lebovitz, R. M., Zhang, H., Vogel, H., Cartwright, J., Dionne, L., Lu, N., Huang, S., & Matzuk, M. M. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.18.9782 · Cited by 1,023 · see citing works

A new mitochondrial disease associated with mitochondrial DNA heteroplasmy.

Holt, I. J., Harding, A. E., Petty, R., & MORGAN-HUGHES, J. A. (1990) · PubMed · Cited by 996 · see citing works

A CASE OF SEVERE HYPERMETABOLISM OF NONTHYROID ORIGIN WITH A DEFECT IN THE MAINTENANCE OF MITOCHONDRIAL RESPIRATORY CONTROL: A CORRELATED CLINICAL, BIOCHEMICAL, AND MORPHOLOGICAL STUDY

Luft, R., Ikkos, D., Palmieri, G. M. A., Ernster, L., & Afzelius, B. A. (1962) · Journal of Clinical Investigation · doi:10.1172/jci104637 · Cited by 981 · see citing works

Thymidine Phosphorylase Gene Mutations in MNGIE, a Human Mitochondrial Disorder

Nishino, I., Spinazzola, A., & Hirano, M. (1999) · Science · doi:10.1126/science.283.5402.689 · Cited by 899 · see citing works

Mitochondrial DNA deletions in human brain: regional variability and increase with advanced age

Corral-Debrinski, M., Horton, T., Lott, M. T., Shoffner, J. M., Flint Beal, M., & Wallace, D. C. (1992) · Nature Genetics · doi:10.1038/ng1292-324 · Cited by 890 · see citing works

Somatic mutations of the mitochondrial genome in human colorectal tumours

Polyák, K., Li, Y., Zhu, H., Christoph Lengauer, C., Willson, J. K. V., Markowitz, S. D., Trush, M. A., Kinzler, K. W., & Vogelstein, B. (1998) · Nature Genetics · doi:10.1038/3108 · Cited by 834 · see citing works

Spastic Paraplegia and OXPHOS Impairment Caused by Mutations in Paraplegin, a Nuclear-Encoded Mitochondrial Metalloprotease

Casari, G., Fusco, M. D., Ciarmatori, S., Zeviani, M., Mora, M., Fernández‐Silva, P., Michele, G. D., Filla, A., Cocozza, S., Marconi, R., et al. (1998) · Cell · doi:10.1016/s0092-8674(00)81203-9 · Cited by 826 · see citing works

Oxidative damage to mitochondrial DNA shows marked age-dependent increases in human brain

Mecocci, P., MacGarvey, U., Kaufman, A. E., Koontz, D., Shoffner, J. M., Wallace, D. C., & Beal, M. F. (1993) · Annals of Neurology · doi:10.1002/ana.410340416 · Cited by 757 · see citing works

[42]Assessment of mitochondrial oxidative phosphorylation in patient muscle biopsies, lymphoblasts, and transmitochondrial cell lines

Trounce, I. A., Kim, Y. L., Jun, A. S., & Wallace, D. C. (1996) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(96)64044-0 · Cited by 749 · see citing works

Mutation of a nuclear succinate dehydrogenase gene results in mitochondrial respiratory chain deficiency

Bourgeron, T., Rustin, P., Chretien, D., Birch-Machin, M., Bourgeois, M., Viegas-Péquignot, E., Munnich, A., & Rötig, A. (1995) · Nature Genetics · doi:10.1038/ng1095-144 · Cited by 730 · see citing works

Decline in skeletal muscle mitochondrial respiratory chain function: possible factor in ageing

Trounce, I., Byrne, E., & Marzuki, S. (1989) · The Lancet · doi:10.1016/s0140-6736(89)92143-0 · Cited by 730 · see citing works

SURF1, encoding a factor involved in the biogenesis of cytochrome c oxidase, is mutated in Leigh syndrome

Zhu, Z., Yao, J., Johns, T., Fu, K., Bie, I. D., Macmillan, C., Cuthbert, A. P., Newbold, R. F., Wang, J., Chevrette, M., et al. (1998) · Nature Genetics · doi:10.1038/3804 · Cited by 620 · see citing works

Maternally transmitted diabetes and deafness associated with a 10.4 kb mitochondrial DNA deletion

Ballinger, S. W., Shoffner, J. M., Hedaya, E. V., Trounce, I. A., Polak, M. A., Koontz, D. A., & Wallace, D. C. (1992) · Nature Genetics · doi:10.1038/ng0492-11 · Cited by 606 · see citing works

Random genetic drift in the female germline explains the rapid segregation of mammalian mitochondrial DNA

Jenuth, J. P., Peterson, A. C., Fu, K., & Shoubridge, E. A. (1996) · Nature Genetics · doi:10.1038/ng1096-146 · Cited by 591 · see citing works

Mitochondrial disease in superoxide dismutase 2 mutant mice

Melov, S., Coskun, P., Patel, M., Tuinstra, R., Cottrell, B., Jun, A. S., Zastawny, T. H., Dizdaroglu, M., Goodman, S. I., Huang, T.-T., et al. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.3.846 · Cited by 581 · see citing works

A mouse model for mitochondrial myopathy and cardiomyopathy resulting from a deficiency in the heart/muscle isoform of the adenine nucleotide translocator

Graham, B. H., Waymire, K. G., Cottrell, B. A., Trounce, I. A., MacGregor, G. R., & Wallace, D. C. (1997) · Nature Genetics · doi:10.1038/ng0797-226 · Cited by 556 · see citing works

Familial mitochondrial encephalomyopathy (MERRF): Genetic, pathophysiological, and biochemical characterization of a mitochondrial DNA disease

Wallace, D. C., Zheng, X., Lott, M. T., Shoffner, J. M., Hodge, J. A., Kelley, R. I., Epstein, C. M., & Hopkins, L. C. (1988) · Cell · doi:10.1016/0092-8674(88)90218-8 · Cited by 537 · see citing works

Mutations of SURF-1 in Leigh Disease Associated with Cytochrome c Oxidase Deficiency

Tiranti, V., Hoertnagel, K., Carrozzo, R., Galimberti, C., Munaro, M., Granatiero, M., Zelante, L., Gasparini, P., Marzella, R., Rocchi, M., et al. (1998) · The American Journal of Human Genetics · doi:10.1086/302150 · Cited by 526 · see citing works

MITOMAP: a human mitochondrial genome database

Kogelnik, A. M. (1996) · Nucleic Acids Research · doi:10.1093/nar/24.1.177 · Cited by 524 · see citing works

Emery and Rimoin's Principles and Practice of Medical Genetics

Rimoin, D. L. (1997) · Cited by 523 · see citing works

Mitochondria and programmed cell death: back to the future

PETIT, P. X., Susín, S. A., Zamzami, N., Mignotte, B., & Kroemer, G. (1996) · FEBS Letters · doi:10.1016/0014-5793(96)00988-x · Cited by 503 · see citing works

MELAS mutation in mtDNA binding site for transcription termination factor causes defects in protein synthesis and in respiration but no change in levels of upstream and downstream mature transcripts.

Chomyn, A., Martinuzzi, A., Yoneda, M., Daga, A., Hurko, O., Johns, D. R., Lai, S. T., Nonaka, I., Angelini, C. I., & Attardi, G. M. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.10.4221 · Cited by 491 · see citing works

A novel neurological phenotype in mice lacking mitochondrial manganese superoxide dismutase

Melov, S., Schneider, J. A., Day, B. J., Hinerfeld, D. A., Coskun, P. E., Mirra, S. S., Crapo, J. D., & Wallace, D. C. (1998) · Nature Genetics · doi:10.1038/ng0298-159 · Cited by 487 · see citing works

Heteroplasmic mtDNA mutation (T----G) at 8993 can cause Leigh disease when the percentage of abnormal mtDNA is high.

Tatuch, Y., Christodoulou, J., Feigenbaum, A., Clarke, J. T. R., Wherret, J., Smith, C., Rudd, N., Petrova-Benedict, R., & Robinson, B. H. (1992) · PubMed · Cited by 483 · see citing works

Increased Oxidative Damage Is Correlated to Altered Mitochondrial Function in Heterozygous Manganese Superoxide Dismutase Knockout Mice

Williams, M. D., Remmen, H. V., Conrad, C. C., Huang, T., Epstein, C. J., & Richardson, A. G. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.43.28510 · Cited by 453 · see citing works

Mitochondrial DNA Variants Observed in Alzheimer Disease and Parkinson Disease Patients

Shoffner, J. M., Brown, M. D., Torroni, A., Lott, M. T., Cabell, M. F., Mirra, S. S., Beal, M. F., Yang, C.-C., Gearing, M., Salvo, R., et al. (1993) · Genomics · doi:10.1006/geno.1993.1299 · Cited by 450 · see citing works

Mitochondrial ADP/ATP Carrier Can Be Reversibly Converted into a Large Channel by Ca 2+

Brustovetsky, N., & Klingenberg, M. (1996) · Biochemistry · doi:10.1021/bi960833v · Cited by 423 · see citing works

Tissue-specific selection for different mtDNA genotypes in heteroplasmic mice

Jenuth, J. P., Peterson, A. C., & Shoubridge, E. A. (1997) · Nature Genetics · doi:10.1038/ng0597-93 · Cited by 415 · see citing works

Mitochondrial complex I deficiency leads to increased production of superoxide radicals and induction of superoxide dismutase.

Pitkanen, S., & Robinson, B. H. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118798 · Cited by 388 · see citing works

Association of mitochondrial DNA damage with aging and coronary atherosclerotic heart disease

Corral‐Debrinski, M., Shoffner, J. M., Lott, M. T., & Wallace, D. C. (1992) · Mutation Research/DNAging · doi:10.1016/0921-8734(92)90021-g · Cited by 360 · see citing works

The Molecular and Genetic Basis of Neurological Disease

Trojanowski, J. Q. (1993) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-199309000-00013 · Cited by 341 · see citing works

A mitochondrial DNA mutation at nucleotide pair 14459 of the NADH dehydrogenase subunit 6 gene associated with maternally inherited Leber hereditary optic neuropathy and dystonia.

Jun, A. S., Brown, M. D., & Wallace, D. C. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.13.6206 · Cited by 316 · see citing works

Marked changes in mitochondrial DNA deletion levels in Alzheimer brains

Corral-Debrinski, M., Horton, T., Lott, M. T., Shoffner, J. M., McKee, A. C., Beal, M. F., Graham, B. H., & Wallace, D. C. (1994) · Genomics · doi:10.1006/geno.1994.1525 · Cited by 309 · see citing works

In Vitro Genetic Transfer of Protein Synthesis and Respiration Defects to Mitochondrial DNA-Less Cells with Myopathy-Patient Mitochondria

Chomyn, A., Meola, G., Bresolin, N., Lai, S. T., Scarlato, G., & Attardi, G. M. (1991) · Molecular and Cellular Biology · doi:10.1128/mcb.11.4.2236 · Cited by 301 · see citing works

The First Nuclear-Encoded Complex I Mutation in a Patient with Leigh Syndrome

Loeffen, J. L. C., Smeitink, J. A. M., Triepels, R. H., Smeets, R., Schuelke, M., Sengers, R. C. A., Trijbels, F. J. M., Hamel, B. C. J., Mullaart, R. A., & van den Heuvel, L. (1998) · The American Journal of Human Genetics · doi:10.1086/302154 · Cited by 283 · see citing works

Marked increase in the number and variety of mitochondrial DNA rearrangements in aging human skeletal muscle

Melov, S., Shoffner, J. M., Kaufman, A. E., & Wallace, D. C. (1995) · Nucleic Acids Research · doi:10.1093/nar/23.20.4122 · Cited by 271 · see citing works

The Protein Import System of Mitochondria

Schatz, G. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.50.31763 · Cited by 263 · see citing works

Demonstration of a New Pathogenic Mutation in Human Complex I Deficiency: A 5-bp Duplication in the Nuclear Gene Encoding the 18-kD (AQDQ) Subunit

van den Heuvel, L., Ruitenbeek, W., Smeets, R., Gelman-Kohan, Z., Elpeleg, O. N., Loeffen, J. L. C., Trijbels, F. J. M., Mariman, E. C. M., de Bruijn, D. R. H., & Smeitink, J. A. M. (1998) · The American Journal of Human Genetics · doi:10.1086/301716 · Cited by 260 · see citing works

MITOCHONDRIAL DNA DELETION IN PEARSON'S MARROW/PANCREAS SYNDROME

Rötig, A., Colonna, M., Bonnefont, J., Blanche, S., Fischer, A., Saudubray, J., & Münnich, A. (1989) · The Lancet · doi:10.1016/s0140-6736(89)92897-3 · Cited by 260 · see citing works

Deletion mutants are functionally dominant over wild-type mitochondrial genomes in skeletal muscle fiber segments in mitochondrial disease

Shoubridge, E. A., Karpati, G., & Hastings, K. E. M. (1990) · Cell · doi:10.1016/0092-8674(90)90238-a · Cited by 245 · see citing works

An autosomal locus predisposing to deletions of mitochondrial DNA

Suomalainen, A., Kaukonen, J., Amati‐Bonneau, P., Timonen, R., Haltia, M., Weissenbach, J., Zeviani, M., Somer, H., & Peltonen, L. (1995) · Nature Genetics · doi:10.1038/ng0295-146 · Cited by 238 · see citing works

Mitochondrial diabetes mellitus: a review

Gerbitz, K.-D., van den Ouweland, J. M. W., Maassen, J. A., & Jaksch, M. (1995) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/0925-4439(95)00036-4 · Cited by 220 · see citing works

Ancient mtDNA sequences in the human nuclear genome: A potential source of errors in identifying pathogenic mutations

Wallace, D. C., Stugard, C., Murdock, D. G., Schurr, T. G., & Brown, M. D. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.26.14900 · Cited by 219 · see citing works

Detection of "deleted" mitochondrial genomes in cytochrome-c oxidase-deficient muscle fibers of a patient with Kearns-Sayre syndrome.

Mita, S., Schmidt, B., Schon, E. A., DiMauro, S., & Bonilla, E. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.23.9509 · Cited by 211 · see citing works

Cytoplasmic transfer of the mtDNA nt 8993 T-->G (ATP6) point mutation associated with Leigh syndrome into mtDNA-less cells demonstrates cosegregation with a decrease in state III respiration and ADP/O ratio.

Trounce, I. A., Neill, S. G., & Wallace, D. C. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.18.8334 · Cited by 190 · see citing works

Cytoplasmic Inheritance of Chloramphenicol Resistance in Mouse Tissue Culture Cells

Bunn, C. L., Wallace, D. C., & Eisenstadt, J. M. (1974) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.71.5.1681 · Cited by 183 · see citing works

A mitochondrial DNA clone is associated with increased risk for Alzheimer disease.

Hutchin, T. P., & Cortopassi, G. A. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.15.6892 · Cited by 183 · see citing works

Compilation of somatic mutations of theCDKN2 gene in human cancers: Non-random distribution of base substitutions

Pollock, P. M., Pearson, J. V., & Hayward, N. K. (1996) · Genes Chromosomes and Cancer · doi:10.1002/(sici)1098-2264(199602)15:2 · Cited by 173 · see citing works

Techniques in Somatic Cell Genetics

Shay, J. W. (1982) · Springer eBooks · doi:10.1007/978-1-4684-4271-7 · Cited by 173 · see citing works

Structure and evolution of organelle genomes

Wallace, D. C. (1982) · Microbiological Reviews · doi:10.1128/mr.46.2.208-240.1982 · Cited by 171 · see citing works

Cytoplasmic transfer of chloramphenicol resistance in human tissue culture cells.

Wallace, D. C., Bunn, C. L., & Eisenstadt, J. M. (1975) · The Journal of Cell Biology · doi:10.1083/jcb.67.1.174 · Cited by 166 · see citing works

Use of Transmitochondrial Cybrids To Assign a Complex I Defect to the Mitochondrial DNA-Encoded NADH Dehydrogenase Subunit 6 Gene Mutation at Nucleotide Pair 14459 That Causes Leber Hereditary Optic Neuropathy and Dystonia

Jun, A. S., Trounce, I. A., Brown, M. D., Shoffner, J. M., & Wallace, D. C. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.3.771 · Cited by 158 · see citing works

Microsatellite instability in the mitochondrial DNA of colorectal carcinomas: Evidence for mismatch repair systems in mitochondrial genome

Habano, W., Nakamura, S., & Sugai, T. (1998) · Oncogene · doi:10.1038/sj.onc.1202112 · Cited by 155 · see citing works

Subacute necrotizing encephalopathy

Shoffner, J. M., Fernhoff, P. M., Krawiecki, N., Caplan, D. B., Holt, P., Koontz, D. A., Takei, Y., Newman, N. J., Ortiz, R. G., Polak, M., et al. (1992) · Neurology · doi:10.1212/wnl.42.11.2168 · Cited by 154 · see citing works

Leber's disease and dystonia

Novotny, E. J., Singh, G., Wallace, D. C., Dorfman, L. J., Louis, A. A., Sogg, R. L., & Steinman, L. (1986) · Neurology · doi:10.1212/wnl.36.8.1053 · Cited by 150 · see citing works

Mitochondrial Genotype Segregation During Preimplantation Development in Mouse Heteroplasmic Embryos

Meirelles, F. V., & Smith, L. C. (1998) · Genetics · doi:10.1093/genetics/148.2.877 · Cited by 132 · see citing works

Detection of hydroxyl radical in the mitochondria of ischemic-reperfused myocardium by trapping with salicylate

Das, D. K., George, A., Liu, X., & Rao, P. S. (1989) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(89)92702-2 · Cited by 123 · see citing works

Nuclear complementation restores mtDNA levels in cultured cells from a patient with mtDNA depletion.

Bodnar, A. G., Cooper, J. M., Holt, I. J., et al. (1993) · PubMed · Cited by 118 · see citing works

Leber's hereditary optic neuropathy plus dystonia is caused by a mitochondrial DNA point mutation

Shoffner, J. M., Brown, M. D., Stugard, C., et al. (1995) · Annals of Neurology · doi:10.1002/ana.410380207 · Cited by 114 · see citing works

Multi-Organ Characterization of Mitochondrial Genomic Rearrangements in Ad Libitum and Caloric Restricted Mice Show Striking Somatic Mitochondrial DNA Rearrangements with Age

Melov, S., Hinerfeld, D. A., Esposito, L., & Wallace, D. C. (1997) · Nucleic Acids Research · doi:10.1093/nar/25.5.974 · Cited by 113 · see citing works

In Vitro Analysis of Mutations Causing Myoclonus Epilepsy with Ragged-Red Fibers in the Mitochondrial tRNALys Gene: Two Genotypes Produce Similar Phenotypes

Masucci, J. P., Davidson, M. M., Koga, Y., Schon, E. A., & King, M. P. (1995) · Molecular and Cellular Biology · doi:10.1128/mcb.15.5.2872 · Cited by 111 · see citing works

Progressive loss of cytochrome c oxidase in the human extraocular muscles in ageing — a cytochemical-immunohistochemical study

Müller‐Höcker, J., Schneiderbanger, K., Stefani, F. H., & Kadenbach, B. (1992) · Mutation Research/DNAging · doi:10.1016/0921-8734(92)90016-i · Cited by 111 · see citing works

Mitochondrial DNA expression in mitochondrial myopathies and coordinated expression of nuclear genes involved in ATP production

Heddi, A., Lestienne, P. P., Wallace, D. C., & Stepien, G. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)50321-0 · Cited by 108 · see citing works

Mitochondria transfer into mouse ova by microinjection

Pinkert, C. A., Irwin, M. H., JOHNSON, L. W., & Moffatt, R. J. (1997) · Transgenic Research · doi:10.1023/a:1018431316831 · Cited by 106 · see citing works

Marked increase in mitochondrial DNA deletion levels in the cerebral cortex of Huntington's disease patients

Horton, T. M., Graham, B. H., Corral‐Debrinski, M., Shoffner, J. M., Kaufman, A. E., Beal, M. F., & Wallace, D. C. (1995) · Neurology · doi:10.1212/wnl.45.10.1879 · Cited by 106 · see citing works

Clinical features of melas and mitochondrial DNA mutations

Goto, Y. (1995) · Muscle & Nerve · doi:10.1002/mus.880181422 · Cited by 96 · see citing works

Molecular genetic characterization of an X‐linked form of Leigh's syndrome

Matthews, P. M., Marchington, D. R., Squier, M. V., et al. (1993) · Annals of Neurology · doi:10.1002/ana.410330616 · Cited by 85 · see citing works

Variable Retinal and Neurologic Manifestations in Patients Harboring the Mitochondrial DNA 8993 Mutation

Ortiz, R. G. (1993) · Archives of Ophthalmology · doi:10.1001/archopht.1993.01090110091031 · Cited by 80 · see citing works

Teratocarcinoma cells as vehicles for introducing specific mutant mitochondrial genes into mice

Watanabe, T., Dewey, M. J., & Mintz, B. (1978) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.75.10.5113 · Cited by 48 · see citing works

Superoxide dismutases of muscle in mitochondrial encephalomyopathies

Ohkoshi, N., Mizusawa, H., Shiraiwa, N., et al. (1995) · Muscle & Nerve · doi:10.1002/mus.880181108 · Cited by 39 · see citing works

Steady state levels of mitochondrial and nuclear oxidative phosphorylation transcripts in Kearns-Sayre syndrome

Heddi, A., Lestienne, P. P., Wallace, D. C., et al. (1994) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/0925-4439(94)90030-2 · Cited by 33 · see citing works

Searching for genes affecting the structural integrity of the mitochondrial genome

Zeviani, M., Amati‐Bonneau, P., Comi, G. P., Fratta, G. M., Mariotti, C., & Tiranti, V. (1995) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/0925-4439(95)00022-v · Cited by 27 · see citing works

Cytoplasmic Inheritance of Chloramphenicol Resistance in Mammalian Cells

Wallace, D. C. (1982) · Springer eBooks · doi:10.1007/978-1-4684-4271-7_12 · Cited by 21 · see citing works

Alzheimer’s disease

Querfurth, H. W., & LaFerla, F. M. (2010) · New England Journal of Medicine · doi:10.1056/nejmra0909142 · Cited by 4,569 · see citing works

Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1

Wu, Z., Puigserver, P., Andersson, U., Zhang, C., Adelmant, G., Mootha, V., Troy, A., Cinti, S., Lowell, B., Scarpulla, R. C., et al. (1999) · Cell · doi:10.1016/s0092-8674(00)80611-x · Cited by 4,139 · see citing works

A Mitochondrial Paradigm of Metabolic and Degenerative Diseases, Aging, and Cancer: A Dawn for Evolutionary Medicine

Wallace, D. C. (2005) · Annual Review of Genetics · doi:10.1146/annurev.genet.39.110304.095751 · Cited by 3,185 · see citing works

Mitochondrial control of cell death

Kroemer, G., & Reed, J. C. (2000) · Nature Medicine · doi:10.1038/74994 · Cited by 3,103 · see citing works

Suppression of Reactive Oxygen Species and Neurodegeneration by the PGC-1 Transcriptional Coactivators

St-Pierre, J., Drori, S., Uldry, M., Silvaggi, J. M., Rhee, J., Jäger, S., Handschin, C., Zheng, K., Lin, J., Yang, W., et al. (2006) · Cell · doi:10.1016/j.cell.2006.09.024 · Cited by 2,233 · see citing works

Understanding the odd science of aging

Kirkwood, T. B. L. (2005) · Cell · doi:10.1016/j.cell.2005.01.027 · Cited by 1,984 · see citing works

Oxidative Stress and Vascular Disease

Madamanchi, N. R., Vendrov, A., & Runge, M. S. (2005) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.0000150649.39934.13 · Cited by 1,618 · see citing works

An essential role of the mitochondrial electron transport chain in cell proliferation is to enable aspartate synthesis

Birsoy, K., Wang, T., Chen, W. W., Freinkman, E., Abu-Remaileh, M., & Sabatini, D. M. (2015) · Cell · doi:10.1016/j.cell.2015.07.016 · Cited by 1,388 · see citing works

ROS-Generating Mitochondrial DNA Mutations Can Regulate Tumor Cell Metastasis

Ishikawa, K., Takenaga, K., Akimoto, M., Koshikawa, N., Yamaguchi, A., Imanishi, H., Nakada, K., Honma, Y., & Hayashi, J.-I. (2008) · Science · doi:10.1126/science.1156906 · Cited by 1,444 · see citing works

Peroxisome proliferator–activated receptor γ coactivator-1 promotes cardiac mitochondrial biogenesis

Lehman, J. J., Barger, P. M., Kovacs, A., Saffitz, J. E., Medeiros, D. M., & Kelly, D. P. (2000) · Journal of Clinical Investigation · doi:10.1172/jci10268 · Cited by 1,285 · see citing works

Generation of reactive oxygen species by the mitochondrial electron transport chain

Liu, Y., Fiskum, G., & Schubert, D. (2002) · Journal of Neurochemistry · doi:10.1046/j.0022-3042.2002.00744.x · Cited by 1,260 · see citing works

Radical-free biology of oxidative stress

Jones, D. P. (2008) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00283.2008 · Cited by 1,213 · see citing works

Electron transfer between cytochrome c and p66Shc generates reactive oxygen species that trigger mitochondrial apoptosis

Giorgio, M., Migliaccio, E., Orsini, F., Paolucci, D., Moroni, M., Contursi, C., Pelliccia, G., Luzi, L., Minucci, S., Marcaccio, M., et al. (2005) · Cell · doi:10.1016/j.cell.2005.05.011 · Cited by 1,176 · see citing works

Targeting Antioxidants to Mitochondria by Conjugation to Lipophilic Cations

Murphy, M. P., & Smith, R. A. J. (2007) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.47.120505.105110 · Cited by 1,173 · see citing works

Selective Targeting of a Redox-active Ubiquinone to Mitochondria within Cells

Kelso, G. F., Porteous, C. M., Coulter, C. V., Hughes, G., Porteous, W. K., Ledgerwood, E. C., Smith, R. A. J., & Murphy, M. P. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m009093200 · Cited by 1,091 · see citing works

Current concepts in the pathogenesis of age-related macular degeneration

Zarbin, M. A. (2004) · Archives of Ophthalmology · doi:10.1001/archopht.122.4.598 · Cited by 1,006 · see citing works

A systematic RNAi screen identifies a critical role for mitochondria in C. elegans longevity

Lee, S. S., Lee, R. Y. N., Fraser, A. G., Kamath, R. S., Ahringer, J., & Ruvkun, G. (2003) · Nature Genetics · doi:10.1038/ng1056 · Cited by 969 · see citing works

Mitochondrial fusion protects against neurodegeneration in the cerebellum

Chen, H., McCaffery, J. M., & Chan, D. C. (2007) · Cell · doi:10.1016/j.cell.2007.06.026 · Cited by 924 · see citing works

Mitophagy and Alzheimer’s Disease: Cellular and Molecular Mechanisms

Kerr, J. S., Adriaanse, B. A., Greig, N. H., Mattson, M. P., Cader, M. Z., Bohr, V. A., & Fang, E. F. (2017) · Trends in Neurosciences · doi:10.1016/j.tins.2017.01.002 · Cited by 870 · see citing works

Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria.

Mootha, V. K., Bunkenborg, J., Olsen, J. V., Hjerrild, M., Wisniewski, J. R., Stahl, E., Bolouri, M. S., Ray, H. N., Sihag, S., Kamal, M., et al. (2003) · Cell · doi:10.1016/s0092-8674(03)00926-7 · Cited by 889 · see citing works

Cell and tissue autofluorescence research and diagnostic applications

Monici, M. (2005) · Biotechnology Annual Review · doi:10.1016/s1387-2656(05)11007-2 · Cited by 887 · see citing works

Amyloid-β overproduction causes abnormal mitochondrial dynamics via differential modulation of mitochondrial fission/fusion proteins

Wang, X., Su, B., Siedlak, S. L., Moreira, P. I., Fujioka, H., Wang, Y., Casadesus, G., & Zhu, X. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0804871105 · Cited by 835 · see citing works

Oxidative Stress in Neurodegenerative Diseases: From Molecular Mechanisms to Clinical Applications

Liu, Z., Zhou, T., Ziegler, A. C., Dimitrion, P., & Zuo, L. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/2525967 · Cited by 810 · see citing works

Reactive oxygen species in health and disease

Alfadda, A. A., & Sallam, R. M. (2012) · Journal of Biomedicine and Biotechnology · doi:10.1155/2012/936486 · Cited by 824 · see citing works

Defective hepatic mitochondrial respiratory chain in patients with nonalcoholic steatohepatitis.

Pérez-Carreras, M., Del Hoyo, P., Martín, M. A., Rubio, J. C., Martín, A., Castellano, G., Colina, F., Arenas, J., & Solis-Herruzo, J. A. (2003) · Hepatology · doi:10.1002/hep.1840380426 · Cited by 734 · see citing works

Targeting an antioxidant to mitochondria decreases cardiac ischemia-reperfusion injury

Adlam, V. J., Harrison, J. C., Porteous, C. M., James, A. M., Smith, R. A. J., Murphy, M. P., & Sammut, I. A. (2005) · The FASEB Journal · doi:10.1096/fj.05-3718com · Cited by 618 · see citing works

Free Radical Theory of Aging: An Update: Increasing the Functional Life Span

HARMAN, D. (2006) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1354.003 · Cited by 601 · see citing works

Mitochondrial transcription factors B1 and B2 activate transcription of human mtDNA

Falkenberg, M., Gaspari, M., Rantanen, A., Trifunovic, A., Larsson, N.-G., & Gustafsson, C. M. (2002) · Nature Genetics · doi:10.1038/ng909 · Cited by 598 · see citing works

Alcohol and mitochondria: a dysfunctional relationship

Hoek, J. B., Cahill, A., & Pastorino, J. G. (2002) · Gastroenterology · doi:10.1053/gast.2002.33613 · Cited by 553 · see citing works

Development of insulin resistance and obesity in mice overexpressing cellular glutathione peroxidase

McClung, J. P., Roneker, C. A., Mu, W., Lisk, D. J., Langlais, P., Liu, F., & Lei, X. G. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0308096101 · Cited by 536 · see citing works

Multiple organ pathology, metabolic abnormalities and impaired homeostasis of reactive oxygen species in Epas1−/− mice.

Scortegagna, M., Ding, K., Oktay, Y., Gaur, A., Thurmond, F., Yan, L.-J., Marck, B. T., Matsumoto, A. M., Shelton, J. M., Richardson, J. A., et al. (2003) · Nature Genetics · doi:10.1038/ng1266 · Cited by 496 · see citing works

Mitochondrial biogenesis by NO yields functionally active mitochondria in mammals

Nisoli, E., Falcone, S., Tonello, C., Cozzi, V., Palomba, L., Fiorani, M., Pisconti, A., Brunelli, S., Cardile, A., Francolini, M., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0405432101 · Cited by 495 · see citing works

Mitochondrial Diabetes

Maassen, J. A., ‘t Hart, L. M., van Essen, E., Heine, R. J., Nijpels, G., Jahangir Tafrechi, R. S., Raap, A. K., Janssen, G. M. C., & Lemkes, H. H. P. J. (2004) · Diabetes · doi:10.2337/diabetes.53.2007.s103 · Cited by 439 · see citing works

Impaired insulin secretion and β-cell loss in tissue-specific knockout mice with mitochondrial diabetes

Silva, J. P., Köhler, M., Graff, C., Oldfors, A., Magnuson, M. A., Berggren, P.-O., & Larsson, N.-G. (2000) · Nature Genetics · doi:10.1038/81649 · Cited by 433 · see citing works

Intercellular mitochondrial transfer as a means of tissue revitalization

Liu, D., Gao, Y., Liu, J., Huang, Y., Yin, J., Feng, Y., Shi, L., Meloni, B. P., Zhang, C., Zheng, M., et al. (2021) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-020-00440-z · Cited by 403 · see citing works

Receptor-mediated mitophagy in yeast and mammalian systems

Liu, L., Sakakibara, K., Chen, Q., & Okamoto, K. (2014) · Cell Research · doi:10.1038/cr.2014.75 · Cited by 421 · see citing works

Targeted deletion of AIF decreases mitochondrial oxidative phosphorylation and protects from obesity and diabetes

Pospisilik, J. A., Knauf, C., Joza, N., Benit, P., Orthofer, M., Cani, P. D., Ebersberger, I., Nakashima, T., Sarao, R., Neely, G., et al. (2007) · Cell · doi:10.1016/j.cell.2007.08.047 · Cited by 404 · see citing works

Mitochondrial dysfunction in cardiovascular disease

Ballinger, S. W. (2005) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2005.02.014 · Cited by 405 · see citing works

Mitochondria-Targeted Small Molecule Therapeutics and Probes

Smith, R. A. J., Hartley, R. C., & Murphy, M. P. (2011) · Antioxidants & Redox Signaling · doi:10.1089/ars.2011.3969 · Cited by 399 · see citing works

Cardiac-specific induction of the transcriptional coactivator peroxisome proliferator-activated receptor γ coactivator-1α promotes mitochondrial biogenesis and reversible cardiomyopathy in a developmental stage-dependent manner.

Russell, L. K., Mansfield, C. M., Lehman, J. J., Kovacs, A., Courtois, M., Saffitz, J. E., Medeiros, D. M., Valencik, M. L., McDonald, J. A., & Kelly, D. P. (2004) · Circulation Research · doi:10.1161/01.res.0000117088.36577.eb · Cited by 402 · see citing works

Mitochondrial dysfunction and pathology in bipolar disorder and schizophrenia

Clay, H. B., Daws, S., & Konradi, C. (2011) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2010.08.007 · Cited by 399 · see citing works

Abnormal mitochondrial dynamics and synaptic degeneration as early events in Alzheimer’s disease: Implications to mitochondria-targeted antioxidant therapeutics

Reddy, P. H., Tripathi, R., Troung, Q., Tirumala, K., Reddy, T. P., Anekonda, V., Shirendeb, U. P., Calkins, M. J., Reddy, A. P., Mao, P., et al. (2012) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2011.10.011 · Cited by 394 · see citing works

Genome-wide responses to mitochondrial dysfunction

Epstein, C. B., Waddle, J. A., Hale, W., Davé, V., Thornton, J., Macatee, T. L., Garner, H. R., & Butow, R. A. (2001) · Molecular Biology of the Cell · doi:10.1091/mbc.12.2.297 · Cited by 389 · see citing works

Peroxiredoxin III, a Mitochondrion-specific Peroxidase, Regulates Apoptotic Signaling by Mitochondria

Chang, T.-S., Cho, C.-S., Park, S., Yu, S., Kang, S. W., & Rhee, S. G. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m407707200 · Cited by 388 · see citing works

Nuclear DNA damage signalling to mitochondria in ageing

Fang, E. F., Scheibye-Knudsen, M., Chua, K. F., Mattson, M. P., Croteau, D. L., & Bohr, V. A. (2016) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2016.14 · Cited by 387 · see citing works

Pharmacological approaches to restore mitochondrial function

Andreux, P. A., Houtkooper, R. H., & Auwerx, J. (2013) · Nature Reviews Drug Discovery · doi:10.1038/nrd4023 · Cited by 383 · see citing works

The Role of Mitochondria in Neurodegenerative Diseases: the Lesson from Alzheimer’s Disease and Parkinson’s Disease

Monzio Compagnoni, G., Di Fonzo, A., Corti, S., Comi, G. P., Bresolin, N., & Masliah, E. (2020) · Molecular Neurobiology · doi:10.1007/s12035-020-01926-1 · Cited by 378 · see citing works

Caloric restriction decreases mitochondrial free radical generation at complex I and lowers oxidative damage to mitochondrial DNA in the rat heart

Gredilla, R., Sanz, A., Lopez-Torres, M., & Barja, G. (2001) · The FASEB Journal · doi:10.1096/fj.00-0764fje · Cited by 372 · see citing works

Hepatocellular carcinoma in the setting of alcohol-related liver disease

Ganne-Carrié, N., & Nahon, P. (2019) · Journal of Hepatology · doi:10.1016/j.jhep.2018.10.008 · Cited by 360 · see citing works

Ultra-sensitive sequencing reveals an age-related increase in somatic mitochondrial mutations that are inconsistent with oxidative damage

Kennedy, S. R., Salk, J. J., Schmitt, M. W., & Loeb, L. A. (2013) · PLoS Genetics · doi:10.1371/journal.pgen.1003794 · Cited by 363 · see citing works

Mitophagy in neurodegeneration and aging

Fivenson, E. M., Lautrup, S., Sun, N., Scheibye-Knudsen, M., Stevnsner, T., Nilsen, H., Bohr, V. A., & Fang, E. F. (2017) · Neurochemistry International · doi:10.1016/j.neuint.2017.02.007 · Cited by 364 · see citing works

Glycation of mitochondrial proteins from diabetic rat kidney is associated with excess superoxide formation

Rosca, M. G., Mustata, T. G., Kinter, M. T., Ozdemir, A. M., Kern, T. S., Szweda, L. I., Brownlee, M., Monnier, V. M., & Weiss, M. F. (2005) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00415.2004 · Cited by 354 · see citing works

Proteomic method identifies proteins nitrated <i>in vivo</i> during inflammatory challenge

Aulak, K. S., Miyagi, M., Yan, L., West, K. A., Massillon, D., Crabb, J. W., & Stuehr, D. J. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.221269198 · Cited by 350 · see citing works

Random intracellular drift explains the clonal expansion of mitochondrial DNA mutations with age

Elson, J. L., Samuels, D. C., Turnbull, D. M., & Chinnery, P. F. (2001) · The American Journal of Human Genetics · doi:10.1086/318801 · Cited by 340 · see citing works

Foxo1 integrates insulin signaling with mitochondrial function in the liver

Cheng, Z., Guo, S., Copps, K., Dong, X., Kollipara, R., Rodgers, J. T., Depinho, R. A., Puigserver, P., & White, M. F. (2009) · Nature Medicine · doi:10.1038/nm.2049 · Cited by 321 · see citing works

Detection and quantification of mitochondrial DNA deletions in individual cells by real-time PCR

He, L. (2002) · Nucleic Acids Research · doi:10.1093/nar/gnf067 · Cited by 320 · see citing works

Increased mitochondrial mass in mitochondrial myopathy mice

Wredenberg, A., Wibom, R., Wilhelmsson, H., Graff, C., Wiener, H. H., Burden, S. J., Oldfors, A., Westerblad, H., & Larsson, N.-G. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.232591499 · Cited by 302 · see citing works

DNA Polymerase γ in Mitochondrial DNA Replication and Repair

Graziewicz, M. A., Longley, M. J., & Copeland, W. C. (2006) · Chemical Reviews · doi:10.1021/cr040463d · Cited by 301 · see citing works

Physiological diversity of mitochondrial oxidative phosphorylation

Benard, G., Faustin, B., Passerieux, E., Galinier, A., Rocher, C., Bellance, N., Delage, J.-P., Casteilla, L., Letellier, T., & Rossignol, R. (2006) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00195.2006 · Cited by 297 · see citing works

Antioxidant and prooxidant properties of mitochondrial Coenzyme Q

James, A. M., Smith, R. A. J., & Murphy, M. P. (2004) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2003.12.025 · Cited by 292 · see citing works

A defect in the cytochrome b large subunit in complex II causes both superoxide anion overproduction and abnormal energy metabolism in Caenorhabditis elegans

Senoo-Matsuda, N., Yasuda, K., Tsuda, M., Ohkubo, T., Yoshimura, S., Nakazawa, H., Hartman, P. S., & Ishii, N. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m104718200 · Cited by 271 · see citing works

The Fidelity of Human DNA Polymerase γ with and without Exonucleolytic Proofreading and the p55 Accessory Subunit

Longley, M. J., Nguyen, D., Kunkel, T. A., & Copeland, W. C. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m105230200 · Cited by 270 · see citing works

PGC-1β controls mitochondrial metabolism to modulate circadian activity, adaptive thermogenesis, and hepatic steatosis

Sonoda, J., Mehl, I. R., Chong, L.-W., Nofsinger, R. R., & Evans, R. M. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0611623104 · Cited by 266 · see citing works

Mitochondrial involvement in brain function and dysfunction: relevance to aging, neurodegenerative disorders and longevity

Calabrese, V., Scapagnini, G., Giuffrida Stella, A. M., Bates, T. E., & Clark, J. B. (2001) · Neurochemical Research · doi:10.1023/a:1010955807739 · Cited by 263 · see citing works

Increased oxidative damage in nuclear and mitochondrial DNA in mild cognitive impairment

Wang, J., Markesbery, W. R., & Lovell, M. A. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2005.03615.x · Cited by 260 · see citing works

Effect of denervation on mitochondrially mediated apoptosis in skeletal muscle.

Adhihetty, P. J., O'Leary, M. F. N., Chabi, B., Wicks, K. L., & Hood, D. A. (2007) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00768.2006 · Cited by 240 · see citing works

Supplementation of Endothelial Cells with Mitochondria-targeted Antioxidants Inhibit Peroxide-induced Mitochondrial Iron Uptake, Oxidative Damage, and Apoptosis

Dhanasekaran, A., Kotamraju, S., Kalivendi, S. V., Matsunaga, T., Shang, T., Keszler, A., Joseph, J., & Kalyanaraman, B. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m404003200 · Cited by 241 · see citing works

Mitochondrial dysfunction leads to telomere attrition and genomic instability

Liu, L., Trimarchi, J. R., Smith, P. J. S., & Keefe, D. L. (2002) · Aging Cell · doi:10.1046/j.1474-9728.2002.00004.x · Cited by 237 · see citing works

Modulation of Lon protease activity and aconitase turnover during aging and oxidative stress

Bota, D. A., Van Remmen, H., & Davies, K. J. A. (2002) · FEBS Letters · doi:10.1016/s0014-5793(02)03638-4 · Cited by 233 · see citing works

Mitochondrial Medicine for Aging and Neurodegenerative Diseases

Reddy, P. H. (2008) · NeuroMolecular Medicine · doi:10.1007/s12017-008-8044-z · Cited by 230 · see citing works

Mitochondrial oxidative stress in mice lacking the glutathione peroxidase-1 gene

Esposito, L. A., Kokoszka, J. E., Waymire, K. G., Cottrell, B., MacGregor, G. R., & Wallace, D. C. (2000) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(00)00161-1 · Cited by 228 · see citing works

The Mitochondrial p55 Accessory Subunit of Human DNA Polymerase γ Enhances DNA Binding, Promotes Processive DNA Synthesis, and Confers N-Ethylmaleimide Resistance

Lim, S. E., Longley, M. J., & Copeland, W. C. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.53.38197 · Cited by 226 · see citing works

A switch in metabolism precedes increased mitochondrial biogenesis in respiratory chain-deficient mouse hearts

Hansson, A., Hance, N., Dufour, E., Rantanen, A., Hultenby, K., Clayton, D. A., Wibom, R., & Larsson, N.-G. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0308710100 · Cited by 220 · see citing works

After Cellular Internalization, Quercetin Causes Nrf2 Nuclear Translocation, Increases Glutathione Levels, and Prevents Neuronal Death against an Oxidative Insult

Arredondo, F., Echeverry, C., Abin-Carriquiry, J. A., Blasina, F., Antúnez, K., Jones, D. P., Go, Y.-M., Liang, Y.-L., & Dajas, F. (2010) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2010.05.020 · Cited by 220 · see citing works

Nox enzymes as novel targets for drug development

Lambeth, J. D., Krause, K.-H., & Clark, R. A. (2008) · Seminars in Immunopathology · doi:10.1007/s00281-008-0123-6 · Cited by 212 · see citing works

(–)-Epicatechin enhances fatigue resistance and oxidative capacity in mouse muscle

Nogueira, L., Ramirez‐Sanchez, I., Perkins, G. A., Murphy, A., Taub, P. R., Ceballos, G., Villarreal, F. J., Hogan, M. C., & Malek, M. H. (2011) · The Journal of Physiology · doi:10.1113/jphysiol.2011.209924 · Cited by 205 · see citing works

Accumulation of mitochondrial DNA deletion mutations in aged muscle fibers: evidence for a causal role in muscle fiber loss

Herbst, A., Pak, J. W., McKenzie, D., Bua, E., Bassiouni, M., & Aiken, J. M. (2007) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/62.3.235 · Cited by 200 · see citing works

Leber hereditary optic neuropathy: current perspectives.

McClelland, C., Meyerson, C., & Van Stavern, G. (2015) · Clinical Ophthalmology · doi:10.2147/opth.s62021 · Cited by 196 · see citing works

Induction of the Photoaging-Associated Mitochondrial Common Deletion In Vivo in Normal Human Skin

Berneburg, M., Plettenberg, H., Medve-König, K., Pfahlberg, A., Gers-Barlag, H., Gefeller, O., & Krutmann, J. (2004) · Journal of Investigative Dermatology · doi:10.1111/j.0022-202x.2004.22502.x · Cited by 193 · see citing works

Mitochondrial dysfunction and complications associated with diabetes

Blake, R., & Trounce, I. A. (2014) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2013.11.007 · Cited by 190 · see citing works

Lipopolysaccharide Stimulates Mitochondrial Biogenesis via Activation of Nuclear Respiratory Factor-1

Suliman, H. B., Carraway, M. S., Welty-Wolf, K. E., Whorton, A. R., & Piantadosi, C. A. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m304719200 · Cited by 189 · see citing works

Genetic modification of survival in tissue-specific knockout mice with mitochondrial cardiomyopathy

Li, H., Wang, J., Wilhelmsson, H., Hansson, A., Thorén, P., Duffy, J., Rustin, P., & Larsson, N.-G. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.7.3467 · Cited by 185 · see citing works

Role of the mitochondrial DNA replication machinery in mitochondrial DNA mutagenesis, aging and age-related diseases

DeBalsi, K. L., Hoff, K. E., & Copeland, W. C. (2017) · Ageing Research Reviews · doi:10.1016/j.arr.2016.04.006 · Cited by 180 · see citing works

Mitochondrial DNA deletion mutations are concomitant with ragged red regions of individual, aged muscle fibers: Analysis by laser-capture microdissection

Cao, Z. (2001) · Nucleic Acids Research · doi:10.1093/nar/29.21.4502 · Cited by 170 · see citing works

Gene therapy for progeny of mito-mice carrying pathogenic mtDNA by nuclear transplantation

Sato, A., Kono, T., Nakada, K., Ishikawa, K., Inoue, S.-I., Yonekawa, H., & Hayashi, J.-I. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0506197102 · Cited by 171 · see citing works

Late-onset corticohippocampal neurodepletion attributable to catastrophic failure of oxidative phosphorylation in MILON mice

Sörensen, L., Ekstrand, M., Silva, J., Lindqvist, E., Xu, B., Rustin, P., Olson, L., & Larsson, N.-G. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-20-08082.2001 · Cited by 167 · see citing works

Role of glutathione in neuroprotective effects of mood stabilizing drugs lithium and valproate

Cui, J., Shao, L., Young, L. T., & Wang, J.-F. (2007) · Neuroscience · doi:10.1016/j.neuroscience.2006.11.010 · Cited by 160 · see citing works

Coordinated patterns of gene expression for substrate and energy metabolism in skeletal muscle of diabetic mice

Yechoor, V. K., Patti, M.-E., Saccone, R., & Kahn, C. R. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.142301999 · Cited by 156 · see citing works

Nuclear DNA-encoded tRNAs targeted into mitochondria can rescue a mitochondrial DNA mutation associated with the MERRF syndrome in cultured human cells

Kolesnikova, O. A., Entelis, N. S., Jacquin-Becker, C., Goltzene, F., Chrzanowska-Lightowlers, Z. M., Lightowlers, R. N., Martin, R. P., & Tarassov, I. (2004) · Human Molecular Genetics · doi:10.1093/hmg/ddh267 · Cited by 157 · see citing works

Active Site Mutation in DNA Polymerase γ Associated with Progressive External Ophthalmoplegia Causes Error-prone DNA Synthesis

Ponamarev, M. V., Longley, M. J., Nguyen, D., Kunkel, T. A., & Copeland, W. C. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.c200100200 · Cited by 156 · see citing works

HSP72 Is a Mitochondrial Stress Sensor Critical for Parkin Action, Oxidative Metabolism, and Insulin Sensitivity in Skeletal Muscle

Drew, B. G., Ribas, V., Le, J. A., Henstridge, D. C., Phun, J., Zhou, Z., Soleymani, T., Daraei, P., Sitz, D., Vergnes, L., et al. (2014) · Diabetes · doi:10.2337/db13-0665 · Cited by 145 · see citing works

Origins of human mitochondrial point mutations as DNA polymerase γ-mediated errors

Zheng, W., Khrapko, K., Coller, H. A., Thilly, W. G., & Copeland, W. C. (2006) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2005.12.012 · Cited by 141 · see citing works

Familial multisystem degeneration with parkinsonism associated with the 11778 mitochondrial DNA mutation

Simon, D. K., Pulst, S. M., Sutton, J. P., Browne, S. E., Beal, M. F., & Johns, D. R. (1999) · Neurology · doi:10.1212/wnl.53.8.1787 · Cited by 141 · see citing works

In beta-cells, mitochondria integrate and generate metabolic signals controlling insulin secretion

Maechler, P., Carobbio, S., & Rubi, B. (2006) · The International Journal of Biochemistry &amp; Cell Biology · doi:10.1016/j.biocel.2005.12.006 · Cited by 140 · see citing works

l-2-Hydroxyglutaric aciduria: identification of a mutant gene C14orf160, localized on chromosome 14q22.1

Topçu, M., Jobard, F., Halliez, S., Coskun, T., Yalçinkayal, C., Gerceker, F. O., Wanders, R. J. A., Prud'homme, J.-F., Lathrop, M., Özguc, M., et al. (2004) · Human Molecular Genetics · doi:10.1093/hmg/ddh300 · Cited by 133 · see citing works

Structure-function defects of human mitochondrial DNA polymerase in autosomal dominant progressive external ophthalmoplegia

Graziewicz, M. A., Longley, M. J., Bienstock, R. J., Zeviani, M., & Copeland, W. C. (2004) · Nature Structural &amp; Molecular Biology · doi:10.1038/nsmb805 · Cited by 131 · see citing works

A two-channel responsive fluorescent probe with AIE characteristics and its application for selective imaging of superoxide anions in living cells

Gao, X., Feng, G., Manghnani, P. N., Hu, F., Jiang, N., Liu, J., Liu, B., Sun, J. Z., & Tang, B. Z. (2017) · Chemical Communications · doi:10.1039/c6cc09307h · Cited by 121 · see citing works

Increased Vulnerability of Brain Mitochondria in Diabetic (Goto-Kakizaki) Rats With Aging and Amyloid-β Exposure

Moreira, P. I., Santos, M. S., Moreno, A. M., Seiça, R., & Oliveira, C. R. (2003) · Diabetes · doi:10.2337/diabetes.52.6.1449 · Cited by 117 · see citing works

The sensitivity of pancreatic β-cells to mitochondrial injuries triggered by lipotoxicity and oxidative stress.

Li, N., Frigerio, F., & Maechler, P. (2008) · Biochemical Society Transactions · doi:10.1042/bst0360930 · Cited by 114 · see citing works

Mitochondrial DNA Polymorphism A4917G Is Independently Associated with Age-Related Macular Degeneration

Canter, J. A., Olson, L. M., Spencer, K., Schnetz-Boutaud, N., Anderson, B., Hauser, M. A., Schmidt, S., Postel, E. A., Agarwal, A., Pericak-Vance, M. A., et al. (2008) · PLoS ONE · doi:10.1371/journal.pone.0002091 · Cited by 110 · see citing works

Oxidative Damage in Mitochondrial DNA Is Not Extensive

Lim, K. S., Jeyaseelan, K., Whiteman, M., Jenner, A. M., & Halliwell, B. B. (2005) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1338.023 · Cited by 49 · see citing works

Large Mitochondrial DNA Deletion in an Infant with Addison Disease

Duran, G. P., Martínez‐Aguayo, A., Helena Poggi, M., Marcela Lagos, L., Gutiérrez, D. A., & Harris, P. R. (2011) · JIMD Reports · doi:10.1007/8904_2011_33 · Cited by 14 · see citing works

Measurement of ATP production in mitochondrial disorders

Shepherd, R., Checcarelli, N., Naini, A., Vivo, D. C. D., DiMauro, S., & Sue, C. M. (2006) · Journal of Inherited Metabolic Disease · doi:10.1007/s10545-006-0148-8 · Cited by 37 · see citing works

Mitochondrial DNA Oxidation

Richter, C. (1999) · Rejuvenation Research · doi:10.1089/rej.1.1999.2.217

Genome editing to treat mitochondrial DNA disorders

Avaria, M. A., & Kleinsteuber, K. (2015) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2015.09.310