Role of RAGE in the Pathogenesis of Neurological Disorders
Open accessAbstract
This review reflects upon our own as well as other investigators' studies on the role of receptor for advanced glycation end-products (RAGE), bringing up the latest information on RAGE in physiology and pathology of the nervous system. Over the last ten years, major progress has been made in uncovering many of RAGE-ligand interactions and signaling pathways in nervous tissue; however, the translation of these discoveries into clinical practice has not come to fruition yet. This is likely, in part to be the result of our incomplete understanding of this crucial signaling pathway. Clinical trials examining the therapeutic efficacy of blocking RAGE-external ligand interactions by genetically engineered soluble RAGE or an endogenous RAGE antagonist, has not stood up to its promise; however, other trials with different blocking agents are being considered with hope for therapeutic success in diseases of the nervous system.
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RAGE belongs to the group of PRR receptors that can interact with DAMPs or PAMPs to induce an innate immune response.
“RAGE belongs to the group of PRR receptors that can interact with DAMPs or PAMPs to induce an innate immune response.323”
From Role of neuroinflammation in neurodegeneration development (2023) · cites this paper as [323]
Cites
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Radical roles for RAGE in the pathogenesis of oxidative stress in cardiovascular diseases and beyond
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Vascular RAGE transports oxytocin into the brain to elicit its maternal bonding behaviour in mice
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“Deletion of RAGE in mice increases their sensitivity to auditory stimuli [129], indicating a physiological role of RAGE in auditory sensation.”
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Role of neuroinflammation in neurodegeneration development
Zhang, W., Xiao, D., Mao, Q., & Xia, H. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01486-5 · Cited by 1,668 · see citing works
“RAGE signaling pathway RAGE belongs to the group of PRR receptors that can interact with DAMPs or PAMPs to induce an innate immune response.(323) In the CNS, RAGE is expressed by multiple cell types, including microglia, astrocytes, neurons, pericytes and endothelial cells.”
Background
- Authors
- Juranek, J., Mukherjee, K., Kordas, B., Załęcki, M., Korytko, A., Zglejc-Waszak, K., Szuszkiewicz, J., & Banach, M.
- Affiliations
- University of Warmia and Mazury in Olsztyn (PL)
- Virginia Tech (US)
- Jagiellonian University (PL)
- Corresponding author
- Juranek, Judyta
- Banach, Marta
- ORCID
- Venue
- Neuroscience Bulletin
- Published
- 2022-06-21
- Volume
- 38
- Issue
- 10
- Pages
- 1248-1262
- ISSN
- 1995-8218 (ISSN-L)
- 1673-7067
- PMC
- PMC9554177
- OpenAlex
- W4283264051
- Cited by
- 45
- References
- 8
- Citations by year
- 2026: 5 · 2025: 17 · 2024: 12 · 2023: 9 · 2022: 2
- FWCI
- 1.21
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Neuroscience Bulletin (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Homo Politicus (Academy of Humanities and Economics in Lodz) (submittedVersion, cc-by-nc-nd)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Advanced Glycation End Products research
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Keywords
- receptor for advanced glycation end products, RAGE, neurological disorders, signaling pathways, soluble RAGE, RAGE antagonists, neuroprotection, clinical trials
- MeSH terms
- Receptor for Advanced Glycation End Products, Humans, Ligands, Nervous System Diseases, Signal Transduction
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