Deletion of RAGE Causes Hyperactivity and Increased Sensitivity to Auditory Stimuli in Mice
Open accessAbstract
The receptor for advanced glycation end-products (RAGE) is a multi-ligand receptor that belongs to the immunoglobulin superfamily of cell surface receptors. In diabetes and Alzheimer's disease, pathological progression is accelerated by activation of RAGE. However, how RAGE influences gross behavioral activity patterns in basal condition has not been addressed to date. In search for a functional role of RAGE in normal mice, a series of standard behavioral tests were performed on adult RAGE knockout (KO) mice. We observed a solid increase of home cage activity in RAGE KO. In addition, auditory startle response assessment resulted in a higher sensitivity to auditory signal and increased prepulse inhibition in KO mice. There were no significant differences between KO and wild types in behavioral tests for spatial memory and anxiety, as tested by Morris water maze, classical fear conditioning, and elevated plus maze. Our results raise a possibility that systemic therapeutic treatments to occlude RAGE activation may have adverse effects on general activity levels or sensitivity to auditory stimuli.
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Ager−/− male mice are known to be hyperactive, with greater speeds and distances travelled during both light-dark transition and open field tests.
“Ager−/− male mice are also known to be hyperactive, with greater speeds and distances travelled during both light-dark transition and open field tests58.”
From Vascular RAGE transports oxytocin into the brain to elicit its maternal bonding behaviour in mice (2019) · cites this paper as [58]
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- Authors
- Sakatani, S., Yamada, K., Homma, C., Munesue, S., Yamamoto, Y., Yamamoto, H., & Hirase, H.
- Affiliations
- RIKEN Center for Brain Science (JP)
- Kanazawa University (JP)
- Corresponding author
- Hirase, Hajime
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2009-12-15
- Volume
- 4
- Issue
- 12
- Pages
- e8309
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC2788702
- OpenAlex
- W2019300513
- Cited by
- 42
- References
- 30
- Citations by year
- 2026: 1 · 2025: 1 · 2023: 3 · 2022: 5 · 2021: 1 · 2020: 4 · 2019: 2 · 2018: 1 · 2017: 2 · 2016: 2 · 2015: 1 · 2014: 1 · 2013: 5 · 2012: 5
- FWCI
- 2.77
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- PLoS ONE (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Japan Society for the Promotion of Science (21700368, 19390085)
- RIKEN
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Advanced Glycation End Products research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- receptor for advanced glycation end products, RAGE knockout mice, hyperactivity, home cage activity, acoustic startle response, prepulse inhibition, auditory sensitivity, spatial memory, anxiety, diabetes mellitus, Alzheimer's disease, RAGE antagonists
- MeSH terms
- Receptor for Advanced Glycation End Products, Acoustic Stimulation, Animals, Cues, Gene Expression Regulation, Hyperkinesis, Receptors, Immunologic, Reflex, Startle, Reproducibility of Results, Gene Deletion, Mice, Knockout, Mice
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