Antiviral activity of Bifidobacterium adolescentis SPM0212 against Hepatitis B virus
Abstract
Bifidobacteria are considered one of the most beneficial probiotics and have been widely studied for their effects in preventing and treating specific pathological conditions. The present study explored the antiviral activity of Bifidobacterium adolescentis SPM0212 isolated from healthy Koreans against hepatitis B virus (HBV) and its mechanism of action. To determine the effect of B. adolescentis SPM0212 against HBV, the level of HBV surface antigen (HBsAg) in the culture medium and the levels of viral transcripts in HepG2.2.15 cells were measured by enzyme-linked immunosorbent assay and reverse transcription-quantitative PCR (RT-qPCR), respectively. To clarify the mechanism, we performed RT-qPCR using specific primers for genes encoding Interferon (IFN)-signaling components and IFN-inducible antiviral effectors. The cell extract of B. adolescentis SPM0212 dose-dependently decreased the extracellular HBsAg level by up to 50 %. Its gene expression in HepG2.2.15 cells was also inhibited by 40 %. This extract significantly increased the expression level of myxovirus resistance A, which is an IFN-inducible antiviral effector. Furthermore, the antiviral activity was observed in the fraction of compound(s) with molecular weights under 30 kDa. Thus, the cell extract of B. adolescentis SPM0212 inhibits HBV and its antiviral mechanism is associated with the Mx GTPase pathway.
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In in vitro cell model HepG2.2.15, cell extract of B. adolescentis SPM0212 inhibited HBV, and its antiviral mechanism was associated with the Mx GTPase pathway.
“Lee et al. [162] reported that in the in vitro cell model HepG2.2.15, containing integrated HBV DNA and secreting hepatitis B virus surface antigen-AgHBs, the cell extract of B. adolescentis SPM0212 inhibited HBV, and its antiviral mechanism was associated with the Mx GTPase pathway.”
From The Potential Impact of Probiotics on Human Health: An Update on Their Health-Promoting Properties (2024) · cites this paper as [162]
Cites
Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method
Livak, K. J., & Schmittgen, T. D. (2001) · Methods · doi:10.1006/meth.2001.1262 · Cited by 180,860 · see citing works
Lavanchy, D. (2004) · Journal of Viral Hepatitis · doi:10.1046/j.1365-2893.2003.00487.x · Cited by 2,649 · see citing works
Trypan Blue Exclusion Test of Cell Viability
Strober, W. (2015) · Current Protocols in Immunology · doi:10.1002/0471142735.ima03bs111 · Cited by 2,623 · see citing works
Interferon-inducible antiviral effectors
Sadler, A. J., & Williams, B. R. G. (2008) · Nature Reviews Immunology · doi:10.1038/nri2314 · Cited by 2,160 · see citing works
Journal of Microbiology and Biotechnology
(2013) · Journal of Microbiology and Biotechnology · doi:10.4014/jmb · Cited by 1,469 · see citing works
Probiotics and their fermented food products are beneficial for health
Parvez, S., Malik, K. A., Ah Kang, S., & Kim, H.-Y. (2006) · Journal of Applied Microbiology · doi:10.1111/j.1365-2672.2006.02963.x · Cited by 1,435 · see citing works
Trypan Blue Exclusion Test of Cell Viability
Strober, W. (1997) · Current Protocols in Immunology · doi:10.1002/0471142735.ima03bs21 · Cited by 1,349 · see citing works
Sells, M. A., Chen, M. L., & Acs, G. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.4.1005 · Cited by 1,121 · see citing works
Global control of hepatitis B virus infection
Kao, J., & Chen, D. (2002) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(02)00315-8 · Cited by 817 · see citing works
Wang, G., Shi, L., Ren, Y., Liu, Q., Liu, H., Zhang, R., Li, Z., Zhu, F., He, P., Tang, W., et al. (2009) · Antiviral Research · doi:10.1016/j.antiviral.2009.05.002 · Cited by 404 · see citing works
Miettinen, M., Vuopio‐Varkila, J., & Varkila, K. (1996) · Infection and Immunity · doi:10.1128/iai.64.12.5403-5405.1996 · Cited by 402 · see citing works
Probiotics and human health: a clinical perspective
Gill, H. S., & Guarner, F. (2004) · Postgraduate Medical Journal · doi:10.1136/pgmj.2003.008664 · Cited by 334 · see citing works
Yuen, M., Wong, D. K.-H., Sablon, E., Tse, E., Ng, I. O., Yuan, H., Siu, C., Sander, T. J., Bourne, E. J., Hall, J. G., et al. (2004) · Hepatology · doi:10.1002/hep.20240 · Cited by 242 · see citing works
Risk and Predictors of Mortality Associated With Chronic Hepatitis B Infection
Iloeje, U. H., Yang, H., Jen, C., Su, J., Wang, L., You, S., & Chen, C. (2007) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2007.06.015 · Cited by 231 · see citing works
Inhibition of Hepatitis B Virus Replication by the Interferon-Inducible MxA Protein
Gordien, E., Rosmorduc, O., Peltekian, C., Garreau, F., Bréchot, C., & Kremsdorf, D. (2001) · Journal of Virology · doi:10.1128/jvi.75.6.2684-2691.2001 · Cited by 190 · see citing works
Human MxA Protein Inhibits the Replication of Crimean-Congo Hemorrhagic Fever Virus
Andersson, I., Bladh, L., Mousavi‐Jazi, M., Magnusson, K., Lundkvist, Å., Haller, O., & Mirazimi, A. (2004) · Journal of Virology · doi:10.1128/jvi.78.8.4323-4329.2004 · Cited by 139 · see citing works
Arase, Y., Ikeda, K., Suzuki, F., Suzuki, Y., Saitoh, S., Kobayashi, M., Akuta, N., Someya, T., Hosaka, T., Sezaki, H., et al. (2006) · The American Journal of Medicine · doi:10.1016/j.amjmed.2005.02.033 · Cited by 138 · see citing works
Lee, D. K., Jang, S., Baek, E. H., Kim, M. J., Lee, K. S., Shin, H. S., Chung, M. J., Kim, J. E., Lee, K. O., & Ha, N. J. (2009) · Lipids in Health and Disease · doi:10.1186/1476-511x-8-21 · Cited by 131 · see citing works
Lee, D. K., Jang, S., Kim, M. J., Kim, J. H., Chung, M. J., Kim, K. J., & Ha, N. J. (2008) · BMC Cancer · doi:10.1186/1471-2407-8-310 · Cited by 130 · see citing works
Shin, H. S., Park, S.-Y., Lee, D. K., Kim, S. A., An, H. M., Kim, J. R., Kim, M. J., Gyeong, M., Lee, S. W., Kim, K., et al. (2010) · Archives of Pharmacal Research · doi:10.1007/s12272-010-0917-7 · Cited by 116 · see citing works
A cell culture assay for compounds which inhibit hepatitis B virus replication
Korba, B. E., & Milman, G. (1991) · Antiviral Research · doi:10.1016/0166-3542(91)90068-3 · Cited by 103 · see citing works
Probiotics can treat hepatic encephalopathy
Solga, S. F. (2003) · Medical Hypotheses · doi:10.1016/s0306-9877(03)00192-0 · Cited by 96 · see citing works
Antiviral activity of Bifidobacterium adolescentisSPM1005-A on human papillomavirus type 16
Cha, M.-K., Lee, D., An, H.-M., Lee, S., Shin, S. H., Kwon, J.-H., Kim, K.-J., & Ha, N. (2012) · BMC Medicine · doi:10.1186/1741-7015-10-72 · Cited by 95 · see citing works
Su, T., Hsu, C., Chen, C., Liu, C., Huang, Y., Tseng, T., Liu, C., Chen, P., Lai, M., Chen, D., et al. (2010) · Antiviral Therapy · doi:10.3851/imp1696 · Cited by 91 · see citing works
Current Treatment of Chronic Hepatitis B: Benefits and Limitations
Perrillo, R. P. (2005) · Seminars in Liver Disease · doi:10.1055/s-2005-915647 · Cited by 82 · see citing works
Nosova, T. (2000) · Alcohol and Alcoholism · doi:10.1093/alcalc/35.6.561 · Cited by 75 · see citing works
Chen, C., Lee, C., Wang, J., Tung, H., Hung, C., & Lu, S. (2004) · European Journal of Gastroenterology & Hepatology · doi:10.1097/00042737-200411000-00021 · Cited by 68 · see citing works
Inhibition of Coxsackievirus B4 Replication in Stably Transfected Cells Expressing Human MxA Protein
Chieux, V., Chehadeh, W., Harvey, J. P., Haller, O., Wattré, P., & Hober, D. (2001) · Virology · doi:10.1006/viro.2001.0877 · Cited by 64 · see citing works
Hepatoma cell line HepG2.2.15 demonstrates distinct biological features compared with parental HepG2
Zhao, R. (2011) · World Journal of Gastroenterology · doi:10.3748/wjg.v17.i9.1152 · Cited by 48 · see citing works
Jansen, R. W., Johnson, L. C., & Averett, D. R. (1993) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.37.3.441 · Cited by 46 · see citing works
Kruining, J., Heijtink, R. A., & Schalm, S. W. (1995) · Journal of Hepatology · doi:10.1016/0168-8278(95)80277-0 · Cited by 36 · see citing works
Cholesterol requirement of hepatitis B surface antigen (HBsAg) secretion
Lin, Y., Shiao, M., Mettling, C., & Chou, C. (2003) · Virology · doi:10.1016/s0042-6822(03)00403-3 · Cited by 33 · see citing works
Korean Journal of Medicinal Crop Science
(2017) · Korean Journal of Medicinal Crop Science · doi:10.7783/kjmcs · Cited by 33 · see citing works
Lee, D. K., Park, S.-Y., Jang, S., Baek, E. H., Kim, M. J., Huh, S. M., Choi, K. S., Chung, M. J., Kim, J. E., Lee, K. O., et al. (2011) · Archives of Pharmacal Research · doi:10.1007/s12272-011-0102-7 · Cited by 30 · see citing works
Probiotics for the hemodynamic alterations of patients with liver cirrhosis
Santis, A. D., Famularo, G., & Simone, C. D. (2000) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2000.01726.x · Cited by 30 · see citing works
Drugs in Development for Hepatitis B
Buti, M., & Esteban, R. (2005) · Drugs · doi:10.2165/00003495-200565110-00001 · Cited by 22 · see citing works
Fang, J., Zhang, Y., & Liu, C. (2006) · Journal of Biotechnology · doi:10.1016/j.jbiotec.2006.09.007 · Cited by 16 · see citing works
Probiotics for the hemodynamic alterations of patients with liver cirrhosis
Santis, A. D. (2000) · The American Journal of Gastroenterology · doi:10.1016/s0002-9270(99)00785-6 · Cited by 11 · see citing works
Hepatoprotective Effect of Lactic Acid Bacteria
Song-Vi, B., Chul-Sung, H., Ahn, Y., Lim, K., Baek, Y.-J., & Dong-Hyun, K. (2005) · Journal of Microbiology and Biotechnology · Cited by 9 · see citing works
Han, S., Cho, K., Lee, C., Song, Y., Hee, P. S., Ha, N., & Kim, K. (2005) · Biomolecules & Therapeutics · Cited by 7 · see citing works
Analysis of the cost-effectiveness of antiviral therapies in chronic hepatitis B patients in Korea
Kim, B. K., Kwon, S. Y., Lee, C. H., Choe, W. H., Choi, H. M., & Koo, H. W. (2009) · The Korean Journal of Hepatology · doi:10.3350/kjhep.2009.15.1.25 · Cited by 7 · see citing works
Nelumbo nucifera Leaves Extract Reduced the Production of Hepatitis B Surface Antigen on HepG2.2.15
Lee, Y., Kang, L., & Lee, S.-G. (2009) · Korean Journal of Medicinal Crop Science · Cited by 2 · see citing works
Cho, Y., & Song, B. (2011) · Korean Journal of Gastroenterology · doi:10.4166/kjg.2011.57.3.144 · Cited by 2 · see citing works
[Action mechanism in immunopathogenesis and clearance of HBV].
Im, S. J., & Sung, Y. C. (2006) · PubMed · Cited by 2 · see citing works
Flagged first, then by citations
1 of the 45 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
The Potential Impact of Probiotics on Human Health: An Update on Their Health-Promoting Properties
Maftei, N.-M., Raileanu, C. R., Balta, A. A., Ambrose, L., Boev, M., Marin, D. B., & Lisa, E. L. (2024) · Microorganisms · doi:10.3390/microorganisms12020234 · Cited by 381 · see citing works
Fan, L., Qi, Y., Qu, S., Chen, X., Li, A., Maher, H., Xu, C., Wang, L., Hou, T., Si, J., et al. (2021) · Gut Microbes · doi:10.1080/19490976.2020.1826746 · Cited by 244 · see citing works
Viral Infections, the Microbiome, and Probiotics
Harper, A., Vijayakumar, V., Ouwehand, A. C., ter Haar, J., Obis, D., Espadaler, J., Binda, S., Desiraju, S., & Day, R. (2021) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2020.596166 · Cited by 177 · see citing works
Probiotics in Prevention and Treatment of COVID-19: Current Perspective and Future Prospects
Kurian, S. J., Unnikrishnan, M. K., Miraj, S. S., Bagchi, D., Banerjee, M., Reddy, B. S., Rodrigues, G. S., Manu, M. K., Saravu, K., Mukhopadhyay, C., et al. (2021) · Archives of Medical Research · doi:10.1016/j.arcmed.2021.03.002 · Cited by 85 · see citing works
Abdelhamid, A. G., El-Masry, S., & Dougdoug, N. K. E. (2019) · The EPMA Journal · doi:10.1007/s13167-019-00184-z · Cited by 80 · see citing works
Olaya-Galán, N. N., Ulloa, J. C., Reyes, F. A. V., Duarte, K. P. F., Salas-Cárdenas, S. P., & Fernández, M. F. G. (2016) · Journal of Applied Microbiology · doi:10.1111/jam.13069 · Cited by 68 · see citing works
Kumova, O. K., Fike, A. J., Thayer, J. L., Nguyen, L. T., Mell, J. C., Pascasio, J. M., Stairiker, C. J., León, L. G., Katsikis, P. D., & Carey, A. J. (2019) · PLoS Pathogens · doi:10.1371/journal.ppat.1008072 · Cited by 62 · see citing works
Kang, J. Y., Lee, D. K., Ha, N. J., & Shin, H. S. (2015) · The Journal of Microbiology · doi:10.1007/s12275-015-5302-2 · Cited by 60 · see citing works
Exploring the potential impact of probiotic use on drug metabolism and efficacy
Purdel, C. N., Ungurianu, A., Adam-Dima, I., & Margina, D. M. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.114468 · Cited by 63 · see citing works
Mechanisms by Which Probiotic Bacteria Attenuate the Risk of Hepatocellular Carcinoma
Thilakarathna, W. P. D. W., Rupasinghe, H. P. V., & Ridgway, N. D. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22052606 · Cited by 57 · see citing works
Dysbiosis of vaginal microbiota associated with persistent high-risk human papilloma virus infection
Mei, L., Wang, T., Chen, Y., Wei, D., Zhang, Y., Cui, T., Meng, J., Zhang, X., Liu, Y., Ding, L., et al. (2022) · Journal of Translational Medicine · doi:10.1186/s12967-021-03201-w · Cited by 56 · see citing works
Hepatocellular Carcinoma Immunotherapy and the Potential Influence of Gut Microbiome
Temraz, S. N., Nassar, F. J., Kreidieh, F., Mukherji, D., Shamseddine, A. I., & Nasr, R. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22157800 · Cited by 56 · see citing works
Interplay between viruses and bacterial microbiota in cancer development
Vyshenska, D., Lam, K. C., Shulzhenko, N., & Morgun, A. (2017) · Seminars in Immunology · doi:10.1016/j.smim.2017.05.003 · Cited by 49 · see citing works
Manna, S., Chowdhury, T., Chakraborty, R., & Mandal, S. M. (2020) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-020-09727-7 · Cited by 44 · see citing works
Bifidobacterium adolescentis – a beneficial microbe
Leser, T. D., & Baker, A. (2017) · Beneficial Microbes · doi:10.1163/18762891-20230030 · Cited by 42 · see citing works
Antiviral activity ofBifidobacterium adolescentisSPM1605 against Coxsackievirus B3
Kim, M. J., Lee, D. K., Park, J. E., Park, I.-H., Seo, J. G., & Ha, N. J. (2014) · Biotechnology & Biotechnological Equipment · doi:10.1080/13102818.2014.945237 · Cited by 38 · see citing works
Current evidence on the use of probiotics in liver diseases
Chávez-Tapia, N. C., González-Rodríguez, L., Jeong, M., López-Ramírez, Y., Barbero-Becerra, V. J., Juárez-Hernández, E., Romero-Flores, J. L., Arrese, M. A., Méndez‐Sánchez, N., & Uribe, M. (2015) · Journal of Functional Foods · doi:10.1016/j.jff.2015.05.009 · Cited by 38 · see citing works
Fernandez, K. P., Olaya-Galán, N. N., Salas-Cárdenas, S. P., Lopez-Rozo, J., & Fernández, M. F. G. (2017) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-017-9277-7 · Cited by 37 · see citing works
Probiotics: Supplements, Food, Pharmaceutical Industry
Putta, S., Yarla, N. S., Lakkappa, D. B., Imandi, S. B., Malla, R. R., Amajala, K. C., Chari, B. P. V., Saka, S., Vechalapu, R. R., Kamal, M. A., et al. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-814625-5.00002-9 · Cited by 37 · see citing works
Probiotic, Prebiotic and Synbiotic Products in Human Health
Maftei, N.-M. (2019) · IntechOpen eBooks · doi:10.5772/intechopen.81553 · Cited by 37 · see citing works
Singh, D., Khan, M. A., & Siddique, H. R. (2021) · Life Sciences · doi:10.1016/j.lfs.2021.120008 · Cited by 36 · see citing works
Crucial functions of gut microbiota on gut–liver repair
Wang, Y., Yan, H., Zheng, Q., & Sun, X. (2025) · hLife · doi:10.1016/j.hlife.2025.01.001 · Cited by 34 · see citing works
Probiotics in hepatology: An update
Maslennikov, R. V., Ivashkin, V. T., Efremova, I., Poluektova, E. A., & Shirokova, E. N. (2021) · World Journal of Hepatology · doi:10.4254/wjh.v13.i9.1154 · Cited by 35 · see citing works
Prebiotic role of softwood hemicellulose in healthy mice model
Deloule, V., Boisset, C., Hannani, D., Suau, A., Gouëllec, A. L., Chroboczek, J., Botté, C. Y., Yamaryo‐Botté, Y., Chirat, C., & Toussaint, B. (2019) · Journal of Functional Foods · doi:10.1016/j.jff.2019.103688 · Cited by 31 · see citing works
Xiang, Z., Wu, J., Li, J., Zheng, S., Wei, X., & Xu, X. (2023) · Engineering · doi:10.1016/j.eng.2022.12.012 · Cited by 27 · see citing works
Probiotics, prebiotics, and synbiotics: Current status and future uses for human health
Kumari, R., Singh, A., Yadav, A. N., Mishra, S. K., Sachan, A., & Sachan, S. G. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-820528-0.00012-0 · Cited by 24 · see citing works
Quintero-Gil, C., Parra-Suescún, J., Herrera, A. L., & Ordúz, S. (2017) · VirusDisease · doi:10.1007/s13337-017-0383-7 · Cited by 21 · see citing works
Immunomodulation by probiotics and prebiotics in hepatocellular carcinoma
Russo, E., Fiorindi, C., Giudici, F., & Amedei, A. (2022) · World Journal of Hepatology · doi:10.4254/wjh.v14.i2.372 · Cited by 20 · see citing works
Shi, K., Zhang, Q., Zhang, Y., Bi, Y., Zeng, X., & Wang, X. (2023) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2022.1104399 · Cited by 20 · see citing works
Li, B., Wang, H.-Y., Wang, M., Liang, H.-W., Hu, T.-Y., Yang, J.-L., Li, S.-Y., You, X., Xia, B., Yuan, Y., et al. (2025) · Frontiers in Microbiology · doi:10.3389/fmicb.2024.1496280 · Cited by 19 · see citing works
Bile acid–microbiota crosstalk in hepatitis B virus infection
Wang, J., Xu, H., Liu, Z., Cao, Y., Chen, S., Hou, R., Zhou, Y., & Wang, Y. (2024) · Journal of Gastroenterology and Hepatology · doi:10.1111/jgh.16604 · Cited by 19 · see citing works
Stenico, V., Baffoni, L., Gaggìa, F., & Biavati, B. (2014) · Anaerobe · doi:10.1016/j.anaerobe.2014.03.004 · Cited by 17 · see citing works
Sasaki, K., Sasaki, K., Sasaki, K., Nishidono, Y., Yamamori, A., Tanaka, K., & Kondo, A. (2021) · Scientific Reports · doi:10.1038/s41598-021-84167-z · Cited by 16 · see citing works
Montazeri‐Najafabady, N., Kazemi, K., & Gholami, A. (2022) · Biologia · doi:10.1007/s11756-022-01147-y · Cited by 16 · see citing works
Is it time for microbiome-based therapies in viral infections?
Sadiq, F. A. (2020) · Virus Research · doi:10.1016/j.virusres.2020.198203 · Cited by 15 · see citing works
Probiotics against Viral Infections: Current Clinical Trials and Future Perspectives
Reyes-Castillo, P. A., Gónzalez-Vázquez, R., Torres-Maravilla, E., Tello, M., Bermúdez‐Humarán, L. G., & Mayorga-Reyes, L. (2021) · Immuno · doi:10.3390/immuno1040034 · Cited by 14 · see citing works
El‐Saadony, M. T., Saad, A. M., Sitohy, M. Z., Alkafaas, S. S., Dladla, M., Ghosh, S., Mohammed, D. M., Ibrahim, E. H., Fahmy, M. A., Elkelish, A., et al. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1713426 · Cited by 13 · see citing works
Yang, J., Gao, H., Zhang, T., Fan, Y., Wu, Y., Zhao, X., Li, Y., Wu, L., Zhao, H. J., Yang, L., et al. (2024) · Nutrients · doi:10.3390/nu16050600 · Cited by 11 · see citing works
Xia, Q., Lei, Y., Wang, J., & Wang, Q. (2023) · Open Life Sciences · doi:10.1515/biol-2022-0741 · Cited by 8 · see citing works
Velikova, T. V., Ali, H., Batselova, H., Chervenkov, L., Miteva, D., Peruhova, M., Gulinac, M., Tomov, L., Mitova-Mineva, Y. I., & Velev, V. R. (2026) · World Journal of Gastroenterology · doi:10.3748/wjg.v32.i3.112437 · Cited by 5 · see citing works
Lee, D., Park, J.-E., Kim, M., Lee, Y. J., Seo, J., Ha, N.-J., & Kim, K. (2015) · The Korean Journal of Microbiology · doi:10.7845/kjm.2015.5031 · Cited by 5 · see citing works
Integrating the microbiome into the barrier theory of cancer
Ewald, H. A. S., & Ewald, P. W. (2020) · Evolutionary Applications · doi:10.1111/eva.13066 · Cited by 5 · see citing works
Ni, J., Wang, F., Wu, Y., Shen, J., Zhou, Z., Xu, L., Lou, Z., Shen, Y., Qiu, B., Xiang, Q., et al. (2025) · npj Science of Food · doi:10.1038/s41538-025-00613-6 · Cited by 3 · see citing works
A review on antiviral efficacy of Bifidobacterium species
Abdi, M., & Ranjbar, R. (2021) · Reviews in Medical Microbiology · doi:10.1097/mrm.0000000000000295 · Cited by 3 · see citing works
Bhuyan, A. A., Bhuiyan, A. A., Memon, A. M., Zhang, B., Alam, J., & He, Q. (2021) · Animal Biotechnology · doi:10.1080/10495398.2021.1967964 · Cited by 2 · see citing works
Gut Microbiota Modulation: Probiotics and Prebiotics in GI Cancer
Au-Doung, P. L. W., Chan, R. H., Wu, W. K. K., & Li, Q. (2023) · Springer eBooks · doi:10.1007/978-981-19-4492-5_14 · Cited by 2 · see citing works
Hernández, M., Sieger, M., Barreto, A., Guerrero, C., & Ulloa, J. C. (2023) · Pathogens · doi:10.3390/pathogens13010017 · Cited by 2 · see citing works
Mucosal microbiota signatures reveal diagnostic insights in chronic liver disease
Dinçer, S., Ülger, Y., & Delik, A. (2025) · BMC Gastroenterology · doi:10.1186/s12876-025-04204-3 · Cited by 1 · see citing works
(2021) · Middle East Journal of Applied Sciences · doi:10.36632/mejas/2021.11.4.72
Rozo, L., & Rozo, G. J. L. (2013)
Probiotics: Role in the Prevention of Chronic Viral Diseases
Kassaa, I. A., & Zaylaa, M. (2016) · Springer eBooks · doi:10.1007/978-3-319-49688-7_3
EFFECT BY INTESTINAL MICROBIOM ON THE PROGRESSION OF VIRAL HEPATITIS
Поліщук, Н. М., & Kamyshny, A. М. (2017) · Russian Journal of Infection and Immunity · doi:10.15789/2220-7619-2016-4-325-334
Immunity, microbiome and probiotics in viral infections
Rosenson, R. I. (2021) · Terapevt (General Physician) · doi:10.33920/med-12-2108-07
Properties of Bifidobacteria and Their Use for Scientific and Practical Purposes
Николаева, Л. И. (2021) · Biotekhnologiya · doi:10.21519/0234-2758-2021-37-3-3-10
Mei, L., Wang, T., Chen, Y., Wei, D., Zhang, Y., Cui, T., Meng, J., Zhang, X., Liu, Y., Ding, L., et al. (2022) · Figshare · doi:10.6084/m9.figshare.17799918
ESMAIL, E. A., Fathy, H. M., Badr, D. A., Mohamed, A. F., & Fazary, A. E. (2026) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-026-11161-0
- Authors
- Lee, D. K., Kang, J. Y., Shin, H. S., Park, I. H., & Ha, N. J.
- Affiliations
- Sahmyook University (KR)
- Duksung Women's University (KR)
- Corresponding author
- Ha, Nam Joo
- Venue
- Archives of Pharmacal Research
- Published
- 2013-05-09
- Volume
- 36
- Issue
- 12
- Pages
- 1525-1532
- ISSN
- 0253-6269 (ISSN-L)
- 1976-3786
- OpenAlex
- W2073127005
- Cited by
- 59
- References
- 45
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 3 · 2023: 6 · 2022: 4 · 2021: 14 · 2020: 7 · 2019: 4 · 2018: 1 · 2017: 5 · 2016: 2 · 2015: 3 · 2014: 2 · 2013: 1
- FWCI
- 1.94
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Archives of Pharmacal Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Sahmyook University
- Small and Medium Business Administration
- Topics
- Health Sciences › Medicine › Epidemiology › Hepatitis B Virus Studies
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Life Sciences › Immunology and Microbiology › Immunology › interferon and immune responses
- Keywords
- Bifidobacterium adolescentis, hepatitis B virus, antiviral activity, probiotics, hepatitis B surface antigen, interferon signaling, MX1, HepG2.2.15 cells, cell extracts
- MeSH terms
- Adult, Animals, Antiviral Agents, Bifidobacterium, DNA, Viral, Dose-Response Relationship, Drug, Female, Hepatitis B virus, Humans, Male, Sheep, Probiotics, Young Adult, Hep G2 Cells
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