The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.
Transcriptional regulation of hemO encoding heme oxygenase in Clostridium perfringens
Abstract
A Gram-positive anaerobic pathogen, Clostridium perfringens, causes clostridial myonecrosis or gas gangrene in humans by producing numerous extracellular toxins and enzymes that act in concert to degrade host tissues. The ability of infectious bacteria to acquire sufficient iron during infection is essential for the pathogen to cause disease. In the C. perfringens strain 13 genome, a heme oxygenase gene homologue (CPE0214, hemO) was found and its role was examined. The purified recombinant HemO protein showed heme oxygenase activity that can convert heme to biliverdin. hemO transcription was induced in response to extracellular hemin in a dose-dependent manner. The global two-component VirR/VirS regulatory system and its secondary regulator VR-RNA had positive regulatory effects on the transcription of hemO. These data indicate that heme oxygenase may play important roles in iron acquisition and cellular metabolism, and that the VirR/VirS-VR-RNA system is also involved in the regulation of cellular iron homeostasis, which might be important for the survival of C. perfringens in a human host.
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Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“In the presence of heme, hemO is upregulated, but it is downregulated in the presence of iron (39).”
From Overcoming the Heme Paradox: Heme Toxicity and Tolerance in Bacterial Pathogens (2010) · cites this paper as [39]
In the citing paper
“In the presence of heme, hemO is upregulated, but it is downregulated in the presence of iron (39).”
From Overcoming the Heme Paradox: Heme Toxicity and Tolerance in Bacterial Pathogens (2010) · cites this paper as [39]
In the citing paper
“The VirSR TCS and the VirRregulated RNA (VR-RNA) contribute to the positive regulation of hemO and other C. perfringens virulence genes; however, the stimulus of VirSR is still unknown (39, 65).”
From Overcoming the Heme Paradox: Heme Toxicity and Tolerance in Bacterial Pathogens (2010) · cites this paper as [39]
In the citing paper
“Like hmuO , the hemO heme monooxygenase in Clostridium perfringens is regulated to maintain a certain level of iron and heme in the cell.”
From Overcoming the Heme Paradox: Heme Toxicity and Tolerance in Bacterial Pathogens (2010) · cites this paper as [39]
Citations
Cites
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Use of bacteriophage T7 RNA polymerase to direct selective high-level expression of cloned genes
Studier, F. W., & Moffatt, B. A. (1986) · Journal of Molecular Biology · doi:10.1016/0022-2836(86)90385-2 · Cited by 6,320
Evidence for two functional gal promoters in intact Escherichia coli cells.
Aiba, H., Adhya, S., & de Crombrugghe, B. (1981) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)68491-7 · Cited by 1,022
Complete genome sequence of Clostridium perfringens , an anaerobic flesh-eater
Shimizu, T., Ohtani, K., Hirakawa, H., Ohshima, K., Yamashita, A., Shiba, T., Ogasawara, N., Hattori, M., Kuhara, S., & Hayashi, H. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.022493799 · Cited by 725
Self-citationHatheway, C. L. (1990) · Clinical Microbiology Reviews · doi:10.1128/cmr.3.1.66 · Cited by 650
Clostridium perfringens: toxinotype and genotype
Petit, L., Gibert, M., & Popoff, M. R. (1999) · Trends in Microbiology · doi:10.1016/s0966-842x(98)01430-9 · Cited by 631
VIRULENCE GENES OF CLOSTRIDIUM PERFRINGENS
Rood, J. I. (1998) · Annual Review of Microbiology · doi:10.1146/annurev.micro.52.1.333 · Cited by 345
Clostridium perfringens toxins (type A, B, C, D, E)
McDonel, J. L. (1980) · Pharmacology & Therapeutics · doi:10.1016/0163-7258(80)90031-5 · Cited by 223
Cited by
Overcoming the Heme Paradox: Heme Toxicity and Tolerance in Bacterial Pathogens
Anzaldi, L. L., & Skaar, E. P. (2010) · Infection and Immunity · doi:10.1128/iai.00613-10 · Cited by 295
Metadata
- Authors
- Hassan, S., Ohtani, K., Wang, R., Yuan, Y., Wang, Y., Yamaguchi, Y., & Shimizu, T.
- Venue
- The Journal of Microbiology
- Publisher
- The Microbiological Society of Korea
- Published
- 2010-02
- Volume
- 48
- Issue
- 1
- Pages
- 96-101
- ISSN
- 1225-8873
- 1976-3794
- Cited by
- 17
- References
- 26
- Language
- en
- Licence
- www.springer.com/tdm (tdm)
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- CoChat. (2026). Citation check: Transcriptional regulation of hemO encoding heme oxygenase in Clostridium perfringens. https://app.cochat.ai/papers/10.1007/s12275-009-0384-3
- The paper
- Hassan, S., Ohtani, K., Wang, R., Yuan, Y., Wang, Y., Yamaguchi, Y., & Shimizu, T. (2010). Transcriptional regulation of hemO encoding heme oxygenase in Clostridium perfringens. The Journal of Microbiology. https://doi.org/10.1007/s12275-009-0384-3
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
