The DOI matches its Crossref record; 378 of the 378 references it cites were found in a registry or an index.
The Multifaceted Roles Neutrophils Play in the Tumor Microenvironment
Open accessAbstract
Neutrophils are myeloid cells that constitute 50-70 % of all white blood cells in the human circulation. Traditionally, neutrophils are viewed as the first line of defense against infections and as a major component of the inflammatory process. In addition, accumulating evidence suggest that neutrophils may also play a key role in multiple aspects of cancer biology. The possible involvement of neutrophils in cancer prevention and promotion was already suggested more than half a century ago, however, despite being the major component of the immune system, their contribution has often been overshadowed by other immune components such as lymphocytes and macrophages. Neutrophils seem to have conflicting functions in cancer and can be classified into anti-tumor (N1) and pro-tumor (N2) sub-populations. The aim of this review is to discuss the varying nature of neutrophil function in the cancer microenvironment with a specific emphasis on the mechanisms that regulate neutrophil mobilization, recruitment and activation.
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Cited by
Neutrophil: A Cell with Many Roles in Inflammation or Several Cell Types?
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Multidimensional communication in the microenvirons of glioblastoma
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Neutrophils in Cancer: Two Sides of the Same Coin
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Metadata
- Authors
- Sionov, R. V., Fridlender, Z. G., & Granot, Z.
- Venue
- Cancer Microenvironment
- Published
- 2014-06-04
- Volume
- 8
- Issue
- 3
- Pages
- 125-158
- ISSN
- 1875-2284 (ISSN-L)
- 1875-2292
- OpenAlex
- W1999482469
- Cited by
- 416
- References
- 378
- FWCI
- 10.11
- Type
- journal article
- Language
- en
- Open access
- hybrid
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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