The DOI matches its Crossref record; 49 of the 49 references it cites were found in a registry or an index.
Current Perspectives on Gut Microbiome Dysbiosis and Depression
Open accessAbstract
The human gut microbiome partakes in a bidirectional communication pathway with the central nervous system (CNS), named the microbiota-gut-brain axis. The microbiota-gut-brain axis is believed to modulate various central processes through the vagus nerve as well as production of microbial metabolites and immune mediators which trigger changes in neurotransmission, neuroinflammation, and behavior. Little is understood about the utilization of microbiome manipulation to treat disease. Though studies exploring the role of the microbiome in various disease processes have shown promise, mechanisms remain unclear and evidence-based treatments for most illnesses have not yet been developed. The animal studies reviewed here offer an excellent array of basic science research that continues to clarify mechanisms by which the microbiome may affect mental health. More evidence is needed, particularly as it relates to translating this work to human subjects. The studies presented in this paper largely demonstrate encouraging results in the treatment of depression. Limitations include small sample sizes and heterogeneous methodology. The exact mechanism by which the gut microbiota causes or alters neuropsychiatric disease states is not fully understood. In this review, we focus on recent studies investigating the relationship between gut microbiome dysbiosis and the pathogenesis of depression. This article is based on previously conducted studies and does not contain any studies with human participants or animals performed by any of the authors.
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“The participation of gut microbiome in bidirectional communication pathway with the central nervous system (CNS) was named the microbiota-gut-brain axis, which is believed to regulate various central processes through microbial metabolites [98].”
From Circular RNAs in depression: Biogenesis, function, expression, and therapeutic potential (2021) · cites this paper as [98]
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Citations
Cites
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“Depression is one of the most prevalent mental health disorders in the USA and the second leading cause of disability worldwide [10].”
BackgroundThe Effect of Diet on the Human Gut Microbiome: A Metagenomic Analysis in Humanized Gnotobiotic Mice
Turnbaugh, P. J., Ridaura, V. K., Faith, J. J., Rey, F. E., Knight, R., & Gordon, J. I. (2009) · Science Translational Medicine · doi:10.1126/scitranslmed.3000322 · Cited by 3,058
Dysfunction of the intestinal microbiome in inflammatory bowel disease and treatment
Morgan, X. C., Tickle, T. L., Sokol, H., Gevers, D., Devaney, K. L., Ward, D. V., Reyes, J. A., Shah, S. A., LeLeiko, N., Snapper, S. B., et al. (2012) · Genome Biology · doi:10.1186/gb-2012-13-9-r79 · Cited by 2,713
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The Economic Burden of Adults With Major Depressive Disorder in the United States (2005 and 2010)
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Cited by
Sorted by citations
Yang, D., Huang, W.-C., Wu, C. W., Huang, C., Yang, Y. S. H., & Tung, Y. (2022) · Microbiological Research · doi:10.1016/j.micres.2022.127292 · Cited by 235
Zhang, J., Ma, L., Chang, L., Pu, Y., Qu, Y., & Hashimoto, K. (2020) · Translational Psychiatry · doi:10.1038/s41398-020-00878-3 · Cited by 217
Alli, S. R., Gorbovskaya, I., Liu, J. C. W., Kolla, N. J., Brown, L., & Müller, D. J. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23094494 · Cited by 202
“Our observations are consistent with findings in patients with MDD [47], and psychiatric disorders more generally where changes in beta diversity have been noted [92], and aligns with the hypothesis that MDD involves a dysbiotic state [96].”
ResultThe Role of Gut Dysbiosis in the Pathophysiology of Neuropsychiatric Disorders
Anand, N., Gorantla, V. R., & Chidambaram, S. B. (2022) · Cells · doi:10.3390/cells12010054 · Cited by 194
“In addition, BD patients showed lower abundance of family Clostridiaceae [244] and butyrate producers such as genera Roseburia and Coprococcus [242], while showing increased abundance of genera Clostridium, Bifidobacterium, Oscillibacter, Streptococcus, Escherichia, Klebsiella, as well as Atopobium Cluster, Enterobact…”
BackgroundInfluentialBacterial Metabolites of Human Gut Microbiota Correlating with Depression
Averina, O. V., Zorkina, Y., Yunes, R. А., Kovtun, A. S., Ushakova, V. M., Morozova, A. Y., Kostyuk, G. P., Даниленко, В. Н., & Chekhonin, V. P. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21239234 · Cited by 171
Metadata
- Authors
- Capuco, A., Urits, I., Hasoon, J., Chun, R., Gerald, B., Wang, J. K., Kassem, H., Ngo, A. L., Abd-Elsayed, A., Simopoulos, T., Kaye, A. D., & Viswanath, O.
- Affiliations
- Georgetown University (US)
- Beth Israel Deaconess Medical Center (US)
- University of Arizona College of Medicine- Phoenix (US)
- Harvard University (US)
- Mount Sinai Medical Center (US)
- University of Wisconsin–Madison (US)
- Louisiana State University Health Sciences Center Shreveport (US)
- Creighton University (US)
- Corresponding author
- Urits, Ivan
- ORCID
- Venue
- Advances in Therapy
- Published
- 2020-03-04
- Volume
- 37
- Issue
- 4
- Pages
- 1328-1346
- ISSN
- 0741-238X (ISSN-L)
- 1865-8652
- PMC
- PMC7140737
- OpenAlex
- W3010636850
- Cited by
- 216
- References
- 49
- Citations by year
- 2026: 18 · 2025: 29 · 2024: 33 · 2023: 59 · 2022: 41 · 2021: 27 · 2020: 7
- FWCI
- 3.21
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Advances in Therapy (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Keywords
- gut dysbiosis, depression, microbiota-gut-brain axis, vagus nerve, microbial metabolites, neuroinflammation, neurotransmission, neuropsychiatric disorders, animal models of depression, microbiota-based therapy
- MeSH terms
- Gastrointestinal Microbiome, Animals, Brain, Central Nervous System, Depression, Humans, Dysbiosis
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