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Cited by 19Peripheral Neuropathies and DisordersPain Mechanisms and TreatmentsDiabetic Foot Ulcer Assessment and Management

The Peripheral Neuropathy Prevalence and Characteristics Are Comparable in People with Obesity and Long-Duration Type 1 Diabetes

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Lim, J. Z. M., Burgess, J., Ooi, C. G., Ponirakis, G., Malik, R. A., Wilding, J. P. H., Alam, Uazman·2022·Advances in Therapy
DOI 10.1007/s12325-022-02208-zPMC PMC9402741
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Abstract

Peripheral neuropathy is reported in obesity even in the absence of hyperglycaemia. To compare the prevalence and characterise the phenotype of peripheral neuropathy in people living with obesity (OB) and long-duration type 1 diabetes (T1D). We performed a prospective cross-sectional study of 130 participants including healthy volunteers (HV) ( n = 28), people with T1D ( n = 51), and OB (BMI 30–50 kg/m 2 ) ( n = 51). Participants underwent assessment of neuropathic symptoms (Neuropathy Symptom Profile, NSP), neurological deficits (Neuropathy Disability Score, NDS), vibration perception threshold (VPT) and evaluation of sural nerve conduction velocity and amplitude. Peripheral neuropathy was present in 43.1% of people with T1D (age 49.9 ± 12.9 years; duration of diabetes 23.4 ± 13.5 years) and 33.3% of OB (age 48.2 ± 10.8 years). VPT for high risk of neuropathic foot ulceration (VPT ≥ 25 V) was present in 31.4% of T1D and 19.6% of OB. Participants living with OB were heavier (BMI 42.9 ± 3.5 kg/m 2 ) and had greater centripetal adiposity with an increased body fat percentage (FM%) ( P < 0.001) and waist circumference (WC) ( P < 0.001) compared to T1D. The OB group had a higher NDS ( P < 0.001), VAS for pain ( P < 0.001), NSP ( P < 0.001), VPT ( P < 0.001) and reduced sural nerve conduction velocity ( P < 0.001) and amplitude ( P < 0.001) compared to HV, but these parameters were comparable in T1D. VPT was positively associated with increased WC ( P = 0.011), FM% ( P = 0.001) and HbA1c ( P < 0.001) after adjusting for age ( R 2 = 0.547). Subgroup analysis of respiratory quotient (RQ) measured in the OB group did not correlate with VPT ( P = 0.788), nerve conduction velocity ( P = 0.743) or amplitude ( P = 0.677). The characteristics of peripheral neuropathy were comparable between normoglycaemic people living with obesity and people with long-duration T1D, suggesting that metabolic factors linked to obesity play a pivotal role in the development of peripheral neuropathy. Further studies are needed to investigate the mechanistic link between visceral adiposity and neuropathy.

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  • Obesity can also contribute to the development of peripheral neuropathy, independent of glycaemic status.

    “Obesity can also contribute to the development of peripheral neuropathy, independent of glycaemic status.129,130”

    From Definition and diagnostic criteria of clinical obesity (2025) · cites this paper as [130]

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Cited by

Sorted by citations

Authors
Lim, J. Z. M., Burgess, J., Ooi, C. G., Ponirakis, G., Malik, R. A., Wilding, J. P. H., & Alam, U.
Affiliations
  • University of Liverpool (GB)
  • Aintree University Hospitals NHS Foundation Trust (GB)
  • Weill Cornell Medical College in Qatar (QA)
Corresponding author
Alam, Uazman
ORCID
Venue
Advances in Therapy
Publisher
Springer Science and Business Media LLC
Published
2022-07-22
Volume
39
Issue
9
Pages
4218-4229
ISSN
  • 0741-238X (ISSN-L)
  • 1865-8652
DOI
10.1007/s12325-022-02208-z
PMC
PMC9402741
OpenAlex
W4286698528
Cited by
19
References
6
Citations by year
2026: 5 · 2025: 6 · 2024: 4 · 2023: 4
FWCI
1.84
Type
journal article
Language
en
Open access
Licence
Locations
  • Advances in Therapy (publishedVersion, cc-by-nc)
  • PubMed Central (publishedVersion, cc-by-nc)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Neurology › Peripheral Neuropathies and Disorders
  • Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetic Foot Ulcer Assessment and Management
Keywords
peripheral neuropathy, obesity, type 1 diabetes, long-standing diabetes, vibration perception threshold, neuropathic foot ulcer, adiposity, waist circumference, body fat percentage, HbA1c, respiratory quotient, neuropathy disability score, neuropathy prevalence
MeSH terms
Cross-Sectional Studies, Diabetes Mellitus, Type 1, Diabetic Neuropathies, Humans, Obesity, Prospective Studies, Prevalence

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