Central Obesity is Associated With Neuropathy in the Severely Obese
Open accessAbstract
Objective To determine the prevalence of neuropathy stratified by glycemic status and the association between extensive anthropometric measurements and neuropathy. Patients and methods We performed a cross-sectional, observational study in obese individuals, before surgery, with body mass index (BMI) greater than 35 kg/m 2. Lean controls were recruited from a research website. Neuropathy was defined by the Toronto consensus definition of probable neuropathy. We compared nine anthropometric measurements between obese participants with and without neuropathy. We used multivariable logistic regression to explore associations between these measures, and other metabolic risk factors, and neuropathy. Results We recruited 138 obese individuals and 46 lean controls. The mean age (SD) was 45.1 (11.3) years in the obese population (76.1% female, n=105) and 43.8 (12.1) years in the lean controls (82.2% female, n=37). The prevalence of neuropathy was 2.2% (n=1) in lean controls, 12.1% (n=4) in obese participants with normoglycemia, 7.1% (n=4) in obese participants with pre-diabetes, and 40.8% (n=20) in obese participants with diabetes (p≤.01). Waist circumference was the only anthropometric measure that was larger in those with neuropathy (139.3 cm vs 129.1 cm, p=.01). Hip-thigh (71.1 cm vs 76.6 cm, p<.01) and mid-thigh (62.2 cm vs 66.3 cm, p=.03) circumferences were smaller in those with neuropathy. The body mass index was comparable between patients who were obese with and without neuropathy (p=.86). Waist circumference (odds ratio [OR], 1.39; 95% CI, 1.10 to 1.75), systolic blood pressure (OR, 2.89; 95% CI, 1.49 to 5.61), and triglycerides (OR, 1.31; 95% CI, 1.00 to 1.70) were significantly associated with neuropathy. Conclusion Normoglycemic obese patients have a high prevalence of neuropathy indicating that obesity alone may be sufficient to cause neuropathy. Waist circumference, but not general obesity, is significantly associated with neuropathy.
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Obesity can also contribute to the development of peripheral neuropathy, independent of glycaemic status.
“Obesity can also contribute to the development of peripheral neuropathy, independent of glycaemic status.129,130”
From Definition and diagnostic criteria of clinical obesity (2025) · cites this paper as [129]
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- Authors
- Callaghan, B. C., Reynolds, E., Banerjee, M., Chant, E., Villegas-Umana, E., & Feldman, E. L.
- Affiliations
- University of Michigan (US)
- Corresponding author
- Callaghan, Brian C.
- Venue
- Mayo Clinic Proceedings
- Publisher
- Elsevier BV
- Published
- 2020-07
- Volume
- 95
- Issue
- 7
- Pages
- 1342-1353
- ISSN
- 0025-6196 (ISSN-L)
- PMC
- PMC7340115
- OpenAlex
- W3038664189
- Cited by
- 115
- References
- 34
- Citations by year
- 2026: 22 · 2025: 24 · 2024: 17 · 2023: 20 · 2022: 16 · 2021: 13 · 2020: 3
- FWCI
- 5.54
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Mayo Clinic Proceedings (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (NS079417)
- National Institute of Diabetes and Digestive and Kidney Diseases (DK094292, DK115687, R21 NS102924, R24082841)
- A. Alfred Taubman Medical Research Institute
- Michigan Diabetes Research Center, University of Michigan
- Novo Nordisk Foundation Center for Basic Metabolic Research (NNF14°C0011633)
- Topics
- Health Sciences › Medicine › Neurology › Peripheral Neuropathies and Disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
- Keywords
- abdominal obesity, diabetic neuropathy, morbid obesity, waist circumference, anthropometry, prediabetes, diabetes mellitus, systolic blood pressure, triglycerides, body mass index
- MeSH terms
- Adult, Cross-Sectional Studies, Female, Humans, Male, Middle Aged, Obesity, Polyneuropathies, Causality, Case-Control Studies, Risk Assessment, Waist Circumference
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