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Cited by 686Pain Mechanisms and TreatmentsVagus Nerve Stimulation ResearchIon Channels and Receptors

Neurogenic inflammation and the peripheral nervous system in host defense and immunopathology

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Chiu, Isaac M, von Hehn, Christian A, Woolf, Clifford J·2012·Nature Neuroscience
DOI 10.1038/nn.3144PMC PMC3520068
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Abstract

The peripheral nervous and immune systems are traditionally thought of as serving separate functions. The line between them is, however, becoming increasingly blurred by new insights into neurogenic inflammation. Nociceptor neurons possess many of the same molecular recognition pathways for danger as immune cells, and, in response to danger, the peripheral nervous system directly communicates with the immune system, forming an integrated protective mechanism. The dense innervation network of sensory and autonomic fibers in peripheral tissues and high speed of neural transduction allows rapid local and systemic neurogenic modulation of immunity. Peripheral neurons also seem to contribute to immune dysfunction in autoimmune and allergic diseases. Therefore, understanding the coordinated interaction of peripheral neurons with immune cells may advance therapeutic approaches to increase host defense and suppress immunopathology.

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  • The central nervous system can influence peripheral inflammation via efferent vagus nerve activity, which down-regulates inflammation by strongly suppressing TNF gene transcription.

    “The central nervous system can also influence peripheral inflammation via efferent vagus nerve activity, which down-regulates inflammation by strongly suppressing TNF gene transcription”

    From From stress to inflammation and major depressive disorder: A social signal transduction theory of depression. (2014) · cites this paper as Chiu, von Hehn, & Woolf, 2012

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Sorted by citations

Authors
Chiu, I. M., von Hehn, C. A., & Woolf, C. J.
Affiliations
Boston Children's Hospital (US)
Corresponding author
Woolf, Clifford J
ORCID
Venue
Nature Neuroscience
Publisher
Springer Science and Business Media LLC
Published
2012-07-26
Volume
15
Issue
8
Pages
1063-1067
ISSN
  • 1097-6256 (ISSN-L)
  • 1546-1726
DOI
10.1038/nn.3144
PMC
PMC3520068
OpenAlex
W2010841889
Cited by
686
References
3
Citations by year
2026: 45 · 2025: 62 · 2024: 79 · 2023: 51 · 2022: 68 · 2021: 55 · 2020: 57 · 2019: 49 · 2018: 56 · 2017: 47 · 2016: 30 · 2015: 27 · 2014: 39 · 2013: 20 · 2012: 1
FWCI
18.65
Type
journal article
Language
en
Open access
Licence
www.springer.com/tdm (tdm)
Locations
  • Nature Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institutes of Health
  • National Institute of Neurological Disorders and Stroke (R37NS039518, F32NS076297)
Topics
  • Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
  • Life Sciences › Neuroscience › Neurology › Vagus Nerve Stimulation Research
  • Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
Keywords
neurogenic inflammation, peripheral nervous system, host defense, immunopathology, nociceptors, threat detection, neuroimmune interactions, autoimmune disease, allergic diseases
MeSH terms
Autonomic Nervous System, Humans, Immune System, Nociceptors, Sensory Receptor Cells, Peripheral Nervous System, Neurogenic Inflammation

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