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Glucagon-Like Peptide-1 Receptor Agonist-Experienced Adults with Type 2 Diabetes Switching to Once-Weekly Semaglutide in a Real-World Setting: SURE Program Post Hoc Analysis
Open accessAbstract
To investigate outcomes in adults with type 2 diabetes who switched to once-weekly (OW) semaglutide from another glucagon-like peptide-1 receptor agonist (GLP-1RA) in clinical practice. This post hoc analysis used data from the SemaglUtide Real-world Evidence (SURE) program, which included nine observational studies investigating the initiation of OW semaglutide in people with type 2 diabetes in routine clinical practice. Using a random coefficient-adjusted mixed model for repeated measurements, changes in glycosylated hemoglobin (HbA1c), body weight, and body mass index were analyzed for GLP-1RA-experienced patients who had at least one documented HbA1c value within the 12 weeks before switching to OW semaglutide. In addition, descriptive statistics were used for HbA1c, body weight target achievement, and safety data. Of the 3,505 patients included in the nine SURE studies, 651 switched to OW semaglutide from another GLP-1RA. GLP-1RA-experienced patients who switched to OW semaglutide demonstrated a 0.67%-point [95% confidence interval (CI) − 0.74; − 0.60, p < 0.0001] reduction in HbA1c, and a 3.69-kg [95% CI − 3.98; − 3.41, p < 0.0001] reduction in body weight over 30 weeks. A body weight reduction of ≥ 5% was achieved by 27.6% of patients, and 33.3% of patients with baseline HbA1c ≥ 7% achieved HbA1c < 7% at end of study. No new safety concerns were identified. Data from this post hoc analysis suggest that, for those not adequately responding to treatment with other GLP-1RAs, switching to OW semaglutide could provide additional glycemic and weight benefits with the convenience of an OW dosing regimen. A graphical abstract is available with this article.
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Studies reporting results in an 'as-started' approach found considerably lower weight-loss effectiveness.
“Importantly, the weight‐loss effectiveness of GLP‐1RA was similar to what has been observed in trials when focusing on the subgroup of adherent patients who consistently took their prescribed GLP‐1RA, for example, at 12 months follow‐up, 50 , 53 , 55 , 56 , 57 , 58 , 61 whereas studies reporting results in an ‘as‐started’ approach found considerably lower effectiveness. 52 , 59 , 63 , 66”
From Real‐world evidence on the utilization, clinical and comparative effectiveness, and adverse effects of newer GLP ‐ 1RA ‐based weight‐loss therapies (2025) · cites this paper as [63]
The Methods (Statistical Analyses; page unavailable) include patients who paused or discontinued semaglutide, consistent with an ‘as-started’ approach. The Results (Clinical Outcomes; page unavailable) report 3.69 kg of weight loss over 30 weeks, but do not compare that result with adherent patients or trials. The source therefore does not establish that as-started effectiveness was considerably lower. (LLM, conf=0.83)
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Semaglutide added to basal insulin in type 2 diabetes (SUSTAIN 5): a randomized, controlled trial.
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Cited by
Sorted by citations
Thomsen, R. W., Mailhac, A., Løhde, J. B., & Pottegård, A. (2025) · Diabetes Obesity and Metabolism · doi:10.1111/dom.16364 · Cited by 207
Metadata
- Authors
- Rudofsky, G., Menzen, M., Potier, L., Catarig, A.-M., Clark, A., Priyadarshini, P., & Abreu, C.
- Affiliations
- Centre National de la Recherche Scientifique (FR)
- Novo Nordisk (Denmark) (DK)
- Novo Nordisk (India) (IN)
- Hospital General De Segovia (ES)
- Corresponding author
- Rudofsky, Gottfried
- Venue
- Advances in Therapy
- Published
- 2024-12-05
- Volume
- 42
- Issue
- 2
- Pages
- 788-800
- ISSN
- 0741-238X (ISSN-L)
- 1865-8652
- PMC
- PMC11787244
- OpenAlex
- W4405079383
- Cited by
- 3
- References
- 7
- Citations by year
- 2026: 2 · 2025: 1
- FWCI
- 1.32
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Advances in Therapy (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Funders
- Novo Nordisk
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Health Sciences › Medicine › Pharmacology (medical) › Pharmacology and Obesity Treatment
- Keywords
- semaglutide, type 2 diabetes, GLP-1 receptor agonists, treatment switching, weekly dosing, glycemic control, HbA1c, weight loss, body mass index, real-world evidence, treatment non-responders
- MeSH terms
- Glucagon-Like Peptide-1 Receptor, Glucagon-Like Peptide-1 Receptor Agonists, Semaglutide, Adult, Aged, Blood Glucose, Body Weight, Diabetes Mellitus, Type 2, Drug Administration Schedule, Glucagon-Like Peptides, Female, Glycated Hemoglobin, Humans, Hypoglycemic Agents, Male, Middle Aged, Body Mass Index, Treatment Outcome, Glucagon-Like Peptide 1, Drug Substitution
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