Cited by 156Eating Disorders and BehaviorsGastrointestinal motility and disordersNutrition, Health and Food Behavior

Gastrointestinal symptoms and disorders in patients with eating disorders

Open access
Sato, Yasuhiro, Fukudo, Shin·2015·Clinical Journal of Gastroenterology

Abstract

The two most clinically serious eating disorders are anorexia nervosa and bulimia nervosa. A drive for thinness and fear of fatness lead patients with anorexia nervosa either to restrict their food intake or binge-eat then purge (through self-induced vomiting and/or laxative abuse) to reduce their body weight to much less than the normal range. A drive for thinness leads patients with bulimia nervosa to binge-eat then purge but fail to reduce their body weight. Patients with eating disorders present with various gastrointestinal disturbances such as postprandial fullness, abdominal distention, abdominal pain, gastric distension, and early satiety, with altered esophageal motility sometimes seen in patients with anorexia nervosa. Other common conditions noted in patients with eating disorders are postprandial distress syndrome, superior mesenteric artery syndrome, irritable bowel syndrome, and functional constipation. Binge eating may cause acute gastric dilatation and gastric perforation, while self-induced vomiting can lead to dental caries, salivary gland enlargement, gastroesophageal reflux disease, and electrolyte imbalance. Laxative abuse can cause dehydration and electrolyte imbalance. Vomiting and/or laxative abuse can cause hypokalemia, which carries a risk of fatal arrhythmia. Careful assessment and intensive treatment of patients with eating disorders is needed because gastrointestinal symptoms/disorders can progress to a critical condition.

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  • Differentiating a primary eating disorder from disordered eating patterns related to the aforementioned factors can be challenging in patients with HSD/hEDS.

    “Differentiating a primary eating disorder from disordered eating patterns related to the aforementioned factors can be challenging in patients with HSD/hEDS. 81”
  • The exact mechanisms by which purging behaviors affect gut microbes remain largely unclear, but are expected to be a consequence of structural and functional changes in the colon, such as damage to mucosal lining, electrolyte imbalance, and changes in transit time and intra-abdominal pressure, which collectively alter the gut environment for microbial colonization.

    “The exact mechanisms by which these behaviors affect the gut microbes remain largely unclear, but are expected to be a consequence of structural and functional changes in the colon, e.g., damage to mucosal lining, electrolyte imbalance, as well as changes in transit time and intra-abdominal pressure, which collectively alter the gut environment for microbial colonization [81,82].”

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1 retracted

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Research works printed but not linked: 2

  1. Szmukler GI, Young GP, Miller G, et al. A controlled trial of cisapride in anorexia nervosa. Int J Eat Disord. 1995;17(4):347-57.
  2. Crow SJ, Salisbury JJ, Crosby RD, Mitchell JE. Serum elec- trolytes as markers of vomiting in bulimia nervosa. Int J Eat Disord. 1997;21(1):95-8.

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Authors
Sato, Y., & Fukudo, S.
Affiliations
  • Tohoku University Hospital (JP)
  • Tohoku University (JP)
Corresponding author
Sato, Yasuhiro
Venue
Clinical Journal of Gastroenterology
Published
2015-10
Volume
8
Issue
5
Pages
255-263
ISSN
  • 1865-7257 (ISSN-L)
  • 1865-7265
OpenAlex
W1867730255
Cited by
156
References
121
Citations by year
2026: 5 · 2025: 29 · 2024: 15 · 2023: 15 · 2022: 16 · 2021: 29 · 2020: 14 · 2019: 15 · 2018: 5 · 2017: 6 · 2016: 7
FWCI
0.87
Type
journal article
Language
en
Open access
Locations
  • Clinical Journal of Gastroenterology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Social Sciences › Psychology › Clinical Psychology › Eating Disorders and Behaviors
  • Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
  • Health Sciences › Nursing › Nutrition and Dietetics › Nutrition, Health and Food Behavior
Keywords
eating disorders, anorexia nervosa, bulimia nervosa, gastrointestinal symptoms, postprandial fullness, abdominal pain, esophageal motility, postprandial distress syndrome, superior mesenteric artery syndrome, irritable bowel syndrome, functional constipation, gastric dilatation, gastric perforation, self-induced vomiting, laxative abuse, dental caries, gastroesophageal reflux disease, hypokalemia, electrolyte imbalance, cardiac arrhythmias
MeSH terms
Feeding and Eating Disorders, Constipation, Dyspepsia, Esophageal Diseases, Gastrointestinal Diseases, Gastrointestinal Motility, Humans, Liver Diseases, Rectal Prolapse, Superior Mesenteric Artery Syndrome, Irritable Bowel Syndrome

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