Cited by 116Reproductive Biology and FertilityReproductive biology and impacts on aquatic speciesOvarian function and disorders

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Oocyte aging underlies female reproductive aging: biological mechanisms and therapeutic strategies

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Igarashi, Hideki, Takahashi, Toshifumi, Nagase, Satoru·2015·Reproductive Medicine and Biology

DOI 10.1007/s12522-015-0209-5PMC PMC5715832

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Abstract

In recent years, postponement of marriage and childbearing in women of reproductive age has led to an increase in the incidence of age‐related infertility. The reproductive aging process in women is assumed to occur due to a decrease in both the quantity and quality of the oocytes, with the ultimate result being a decline in fecundity. This age‐related decline in fecundity is strongly dependent on oocyte quality, which is critical for fertilization and subsequent embryo development. Aged oocytes display increased chromosomal abnormality and dysfunction of cellular organelles, both of which factor into oocyte quality. In particular, mitochondrial dysfunction has been suggested as a major contributor to the reduction in oocyte quality as well as to chromosomal abnormalities in aged oocytes and embryos. Participation of oxidative stress in the oocyte aging process has been proposed because oxidative stress has the capacity to induce mitochondrial dysfunction and directly damage many intracellular components of the oocytes such as lipids, protein, and DNA. In an attempt to improve mitochondrial function in aged oocytes, several therapeutic strategies have been investigated using both animal models and assisted reproductive technology. Here, we review the biological mechanisms and present status of therapeutic strategies in the female reproductive aging field and indicate possible future therapeutic strategies.

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Authors: Igarashi, H., Takahashi, T., & Nagase, S.
Affiliations: Yamagata University (JP)
Corresponding author: Igarashi, Hideki
ORCID: Igarashi, Hideki
Takahashi, Toshifumi
Nagase, Satoru
Venue: Reproductive Medicine and Biology
Publisher: Wiley
Published: 2015-05-09
Volume: 14
Issue: 4
Pages: 159-169
ISSN: 1445-5781 (ISSN-L)
1447-0578
DOI: 10.1007/s12522-015-0209-5
PMC: PMC5715832
OpenAlex: W636461026
Cited by: 116
References: 97
Citations by year: 2026: 9 · 2025: 18 · 2024: 12 · 2023: 10 · 2022: 18 · 2021: 18 · 2020: 18 · 2019: 11 · 2018: 1
FWCI: 0.05
Type: journal article
Language: en
Open access: gold
doi.org
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
doi.wiley.com/10.1002/tdm_license_1.1 (tdm, 115 d)
Locations: Reproductive Medicine and Biology (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: Japan Society for the Promotion of Science (26462474)
Topics: Health Sciences › Medicine › Reproductive Medicine › Reproductive Biology and Fertility
Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Reproductive biology and impacts on aquatic species
Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
Keywords: oocyte aging, female reproductive aging, age-related infertility, oocyte quality, mitochondrial dysfunction, oxidative stress, chromosomal abnormalities, fecundity decline, assisted reproduction, treatment options

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Oocyte aging underlies female reproductive aging: biological mechanisms and therapeutic strategies

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