The variability of female reproductive ageing

te Velde, E. R.

doi:10.1093/humupd/8.2.141

Cited by 1,214Reproductive Biology and FertilityOvarian function and disordersMenopause: Health Impacts and Treatments

The variability of female reproductive ageing

te Velde, E. R.·2002·Human Reproduction Update

DOI 10.1093/humupd/8.2.141

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Abstract

The delay in childbearing is an important societal change contributing to an increasing incidence of subfertility. The prevailing concept of female reproductive ageing assumes that the decline of both quantity and quality of the oocyte/follicle pool determines an age-dependent loss of female fertility. There is an apparent discrepancy between the ability to maintain a regular ovulatory cycle pattern and the several years earlier cessation of female fertility. This latter is largely explained by an age-related increase of meiotic non-disjunction leading to chromosomal aneuploidy and early pregnancy loss, such that most embryos from women > or =40 years old are chromosomally abnormal and rarely develop further. The final stage of reproductive ageing-the occurrence of menopause-shows a huge variation between women. Age at last birth in natural fertility populations, which marks the end of female fertility, shows an identically wide variation as age at menopause, but occurs on average 10 years earlier. Given the high heritability for age at menopause, the variation in both age of menopause and last birth are probably under genetic control by the same set of genes. Some of those genes must carry heritable variants which modulate the rate of ovarian ageing and give rise to the wide age variations for the various phases of reproductive ageing.

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The mean follicle density in TS ovarian tissue is considerably lower than the density of age-matched controls.
“The mean follicle density in TS ovarian tissue is considerably lower than the density of age-matched controls.610,619”
From Clinical practice guidelines for the care of girls and women with Turner syndrome. (2024) · cites this paper as [619]

Incidence of early loss of pregnancy
Wilcox, A. J., Weinberg, C. R., O'Connor, J. F., Baird, D. D., Schlatterer, J. P., Canfield, R. E., Armstrong, E. G., & Nisula, B. C. (1988) · New England Journal of Medicine · doi:10.1056/nejm198807283190401 · Cited by 2,354 · see citing works
Europe's second demographic transition.
van de Kaa, D. J. (1987) · PubMed · Cited by 1,935 · see citing works
Growth differentiation factor-9 is required during early ovarian folliculogenesis
Dong, J., Albertini, D. F., Nishimori, K., Kumar, T. R., Lu, N., & Matzuk, M. M. (1996) · Nature · doi:10.1038/383531a0 · Cited by 1,650 · see citing works
Regulation of ovarian follicular development in primates: facts and hypotheses
GOUGEON, A. (1996) · Endocrine Reviews · doi:10.1210/edrv-17-2-121 · Cited by 1,497 · see citing works
Accelerated disappearance of ovarian follicles in mid-life: implications for forecasting menopause
Faddy, M. J., Gosden, R. G., Gougeon, A., Richardson, S. J., & Nelson, J. F. (1992) · Human Reproduction · doi:10.1093/oxfordjournals.humrep.a137570 · Cited by 1,361 · see citing works
Evolution of senescence: late survival sacrificed for reproduction
Kirkwood, T. B. L., & Rose, M. R. (1991) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.1991.0028 · Cited by 1,118 · see citing works
A quantitative and cytological study of germ cells in human ovaries
Baker, T. G. (1963) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.1963.0055 · Cited by 1,094 · see citing works
Incidence of Premature Ovarian Failure
Coulam, C. B., Adamson, S. C., & Annegers, J. F. (1987) · Obstetrical & Gynecological Survey · doi:10.1097/00006254-198703000-00020 · Cited by 1,024 · see citing works
VARIATION OF THE HUMAN MENSTRUAL CYCLE THROUGH REPRODUCTIVE LIFE
TRELOAR, A. E., BOYNTON, R. E., BEHN, B. G., & BROWN, B. W. (1968) · Obstetrical & Gynecological Survey · doi:10.1097/00006254-196801000-00019 · Cited by 1,018 · see citing works
Control of Primordial Follicle Recruitment by Anti-Mullerian Hormone in the Mouse Ovary1
Durlinger, A. L. L., Kramer, P., Karels, B., de Jong, F. H., Uilenbroek, J. T. J., Grootegoed, J. A., & Themmen, A. P. N. (1999) · Endocrinology · doi:10.1210/endo.140.12.7204 · Cited by 1,011 · see citing works
The putative forkhead transcription factor FOXL2 is mutated in blepharophimosis/ptosis/epicanthus inversus syndrome
Crisponi, L., Deiana, M., Loi, A., Chiappe, F., Uda, M., Amati‐Bonneau, P., Bisceglia, L., Zelante, L., Nagaraja, R., Porcu, S., et al. (2001) · Nature Genetics · doi:10.1038/84781 · Cited by 982 · see citing works
Measurement of dimeric inhibin B throughout the human menstrual cycle
Groome, N. P., Illingworth, P. J., O'Brien, M., Pai, R., Rodger, F. E., Mather, J. P., & McNeilly, A. S. (1996) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.81.4.8636341 · Cited by 949 · see citing works
Factors Associated with Age at Natural Menopause in a Multiethnic Sample of Midlife Women
Gold, E. B. (2001) · American Journal of Epidemiology · doi:10.1093/aje/153.9.865 · Cited by 862 · see citing works
Extension of Drosophila lifespan by overexpression of human SOD1 in motorneurons
Parkes, T. L., Elia, A., Dickinson, D., Hilliker, A. J., Phillips, J. P., & Boulianne, G. L. (1998) · Nature Genetics · doi:10.1038/534 · Cited by 862 · see citing works
Ovarian Follicle Atresia: A Hormonally Controlled Apoptotic Process*
Hsueh, A. J. W., Billig, H., & TSAFRIRI, A. (1994) · Endocrine Reviews · doi:10.1210/edrv-15-6-707 · Cited by 790 · see citing works
Untitled work
(1997) · PubMed · Cited by 784 · see citing works
Follicular Depletion During the Menopausal Transition: Evidence for Accelerated Loss and Ultimate Exhaustion*
Richardson, S. J., Senikas, V., & Nelson, J. F. (1987) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-65-6-1231 · Cited by 714 · see citing works
Factors that affect outcome of in-vitro fertilisation treatment
Templeton, A. A., Morris, J. K., & Parslow, W. (1996) · The Lancet · doi:10.1016/s0140-6736(96)05291-9 · Cited by 709 · see citing works
Age and Infertility
MENKEN, J. A., Trussell, J., & Larsen, U. (1986) · Science · doi:10.1126/science.3755843 · Cited by 705 · see citing works
Paracrine Actions Of Growth Differentiation Factor-9 in the Mammalian Ovary
Elvin, J. A., Clark, A. T., Wang, P., Wolfman, N. M., & Matzuk, M. M. (1999) · Molecular Endocrinology · doi:10.1210/mend.13.6.0310 · Cited by 650 · see citing works
Fertilization and early embryology: Influence of maternal age on meiotic spindle assembly oocytes from naturally cycling women
Battaglia, D. E., Goodwin, P., Klein, N. A., & Soules, M. R. (1996) · Human Reproduction · doi:10.1093/oxfordjournals.humrep.a019080 · Cited by 645 · see citing works
Female Fecundity as a Function of Age
Fédération, C., Schwartz, D., & Mayaux, M. J. (1982) · New England Journal of Medicine · doi:10.1056/nejm198202183060706 · Cited by 641 · see citing works
Human longevity at the cost of reproductive success
Westendorp, R. G. J., & Kirkwood, T. B. L. (1998) · Nature · doi:10.1038/25519 · Cited by 607 · see citing works
Estimating a woman's risk of having a pregnancy associated with Down's syndrome using her age and serum alpha‐fetoprotein level
Cuckle, H., Wald, N., & THOMPSON, S. G. (1987) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.1987.tb03115.x · Cited by 607 · see citing works
The Menopausal Transition: Analysis of LH, FSH, Estradiol, and Progesterone Concentrations During Menstrual Cycles of Older Women
Sherman, B. M., West, J. H., & Korenman, S. G. (1976) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-42-4-629 · Cited by 583 · see citing works
Cohesin Rec8 is required for reductional chromosome segregation at meiosis
Watanabe, Y., & Nurse, P. (1999) · Nature · doi:10.1038/22774 · Cited by 572 · see citing works
Women with polycystic ovary syndrome wedge resected in 1956 to 1965: A long-term follow-up focusing on natural history and circulating hormones
Dahlgren, E., Johansson, S., Lindstedt, G., Knutsson, F., Odén, A., Janson, P. O., Mattson, L.-A., Crona, N., & Lundberg, P.-A. (1992) · International Journal of Gynecology & Obstetrics · doi:10.1016/0020-7292(92)90704-m · Cited by 527 · see citing works
The developmental potential of the human oocyte is related to the dissolved oxygen content of follicular fluid: association with vascular endothelial growth factor levels and perifollicular blood flow characteristics
Blerkom, J. V., Antczak, M., & Schrader, R. M. (1997) · Human Reproduction · doi:10.1093/humrep/12.5.1047 · Cited by 527 · see citing works
QUANTITATIVE MORPHOLOGICAL INVESTIGATIONS OF THE FOLLICULAR SYSTEM IN WOMEN
Block, E. (2008) · Acta Anatomica · doi:10.1159/000140595 · Cited by 518 · see citing works
Early embryonic mortality in women
Edmonds, D. K., Lindsay, K. S., Miller, J. F., Williamson, E., & Wood, P. J. (1982) · Fertility and Sterility · doi:10.1016/s0015-0282(16)46579-9 · Cited by 512 · see citing works
Manipulation of Human Ovarian Function: Physiological Concepts and Clinical Consequences*
Fauser, B. C. J. M., & van Heusden, A. M. (1997) · Endocrine Reviews · doi:10.1210/edrv.18.1.0290 · Cited by 509 · see citing works
Comprehensive chromosomal analysis of human preimplantation embryos using whole genome amplification and single cell comparative genomic hybridization
Wells, D. (2000) · Molecular Human Reproduction · doi:10.1093/molehr/6.11.1055 · Cited by 503 · see citing works
FETAL LOSS AFTER IMPLANTATION
Miller, J. F., Williamson, E., Glue, J., Gordon, Y. B., Grudzinskas, J. G., & Sykes, A. (1980) · The Lancet · doi:10.1016/s0140-6736(80)91991-1 · Cited by 494 · see citing works
Differentiation of mammalian embryonic gonad
Byskov, A. G. (1986) · Physiological Reviews · doi:10.1152/physrev.1986.66.1.71 · Cited by 476 · see citing works
Aromatic hydrocarbon receptor-driven Bax gene expression is required for premature ovarian failure caused by biohazardous environmental chemicals
Matikainen, T., Perez, G. I., Jurisicova, A., Pru, J. K., Schlezinger, J. J., Ryu, H., Laine, J. T., Sakai, T., Korsmeyer, S. J., Casper, R. F., et al. (2001) · Nature Genetics · doi:10.1038/ng575 · Cited by 465 · see citing works
Women with polycystic ovary syndrome wedge resected in 1956 to 1965: a long-term follow-up focusing on natural history and circulating hormones
Dahlgren, E., Johansson, S., Lindstedt, G., Knutsson, F., Odén, A., Janson, P. O., Mattson, L.-Å., Crona, N., & Lundberg, P. (1992) · Fertility and Sterility · doi:10.1016/s0015-0282(16)54892-4 · Cited by 463 · see citing works
Age-Related Changes of the Population of Human Ovarian Follicles: Increase in the Disappearance Rate of Non-Growing and Early-Growing Follicles in Aging Women
Gougeon, A., Écochard, R., & Thalabard, J. (1994) · Biology of Reproduction · doi:10.1095/biolreprod50.3.653 · Cited by 456 · see citing works
Preimplantation diagnosis for aneuploidies in patients undergoing in vitro fertilization with a poor prognosis: identification of the categories for which it should be proposed
Gianaroli, L., Magli, M. C., Ferraretti, A. P., & Munné, S. (1999) · Fertility and Sterility · doi:10.1016/s0015-0282(99)00377-5 · Cited by 453 · see citing works
Chiasma Frequency and Maternal Age in Mammals
Henderson, S. A., & Edwards, R. (1968) · Nature · doi:10.1038/218022a0 · Cited by 446 · see citing works
Delaying childbearing: effect of age on fecundity and outcome of pregnancy.
van Noord‐Zaadstra, B. M., Looman, C. W. N., Alsbach, H., Habbema, J. D. F., Velde, E. R. T., & Karbaat, J. (1991) · BMJ · doi:10.1136/bmj.302.6789.1361 · Cited by 446 · see citing works
Disjunction of Homologous Chromosomes in Meiosis I Depends on Proteolytic Cleavage of the Meiotic Cohesin Rec8 by Separin
Buonomo, S. B. C., Clyne, R. K., Fuchs, J., Loidl, J., Uhlmann, F., & Nasmyth, K. (2000) · Cell · doi:10.1016/s0092-8674(00)00131-8 · Cited by 427 · see citing works
Ovarian Response to Follicle-Stimulating Hormone (FSH) Stimulation Depends on the FSH Receptor Genotype
Pérez-Mayorga, M., Gromoll, J., Behre, H. M., Gassner, C., Nieschlag, E., & Simoni, M. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.85.9.6789 · Cited by 425 · see citing works
Prospective Study of the Determinants of Age at Menopause
Bromberger, J. T., Matthews, K. A., Kuller, L. H., Wing, R. R., Meilahn, E. N., & Plantinga, P. (1997) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a009083 · Cited by 425 · see citing works
Antral follicle counts by transvaginal ultrasonography are related to age in women with proven natural fertility
Scheffer, G. J., Broekmans, F. J., Dorland, M., Habbema, J. D. F., Looman, C. W. N., & Velde, E. R. T. (1999) · Fertility and Sterility · doi:10.1016/s0015-0282(99)00396-9 · Cited by 386 · see citing works
Decreased inhibin B secretion is associated with the monotropic FSH rise in older, ovulatory women: a study of serum and follicular fluid levels of dimeric inhibin A and B in spontaneous menstrual cycles
Klein, N. A., Illingworth, P. J., Groome, N. P., McNeilly, A. S., Battaglia, D. E., & Soules, M. R. (1996) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.81.7.8675606 · Cited by 372 · see citing works
Prolongation of ovarian lifespan into advanced chronological age by Bax-deficiency
Perez, G. I., Robles, R., Knudson, C. M., Flaws, J. A., Korsmeyer, S. J., & Tilly, J. L. (1999) · Nature Genetics · doi:10.1038/5985 · Cited by 366 · see citing works
Menstrual cyclicity and the pre-menopause
Treloar, A. E. (1981) · Maturitas · doi:10.1016/0378-5122(81)90032-3 · Cited by 365 · see citing works
Hormonal regulation of apoptosis in early antral follicles: follicle- stimulating hormone as a major survival factor
Chun, S. Y., Eisenhauer, K. M., Minami, S., Billig, H., Perlas, E., & Hsueh, A. J. W. (1996) · Endocrinology · doi:10.1210/endo.137.4.8625923 · Cited by 360 · see citing works
Genes Control the Cessation of a Woman’s Reproductive Life: A Twin Study of Hysterectomy and Age at Menopause1
Snieder, H., MacGregor, A. J., & Spector, T. D. (1998) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.83.6.4890 · Cited by 359 · see citing works
RELATION BETWEEN SMOKING AND AGE OF NATURAL MENOPAUSE
Jick, H., Porter, J., & Morrison, A. (1977) · The Lancet · doi:10.1016/s0140-6736(77)92562-4 · Cited by 351 · see citing works
Age at natural menopause in a population-based screening cohort: the role of menarche, fecundity, and lifestyle factors
van Noord, P. A. H., Dubas, J. S., Dorland, M., Boersma, H., & Velde, E. R. T. (1997) · Fertility and Sterility · doi:10.1016/s0015-0282(97)81482-3 · Cited by 345 · see citing works
Is early natural menopause a biologic marker of health and aging?
Snowdon, D. A., Kane, R. L., Beeson, W. L., Burke, G. L., Sprafka, J. M., Potter, J. D., Iso, H., Jacobs, D. R., & Phillips, R. L. (1989) · American Journal of Public Health · doi:10.2105/ajph.79.6.709 · Cited by 342 · see citing works
Female Reproductive Aging Is Marked by Decreased Secretion of Dimeric Inhibin1
Welt, C. K., McNicholl, D. J., Taylor, A. E., & Hall, J. E. (1999) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.84.1.5381 · Cited by 333 · see citing works
Human Fertility: The Basic Components.
B., J., Léridon, H., & Helzner, J. F. (1978) · Population and Development Review · doi:10.2307/1972295 · Cited by 330 · see citing works
Impact of climacteric on well-being
Oldenhave, A., Jaszmann, L., Haspels, A. A., & Everaerd, W. T. A. M. (1993) · American Journal of Obstetrics and Gynecology · doi:10.1016/s0002-9378(12)90817-0 · Cited by 329 · see citing works
Pituitary control of ovarian function–concepts derived from gonadotrophin therapy
Brown, J. B. (1978) · Australian and New Zealand Journal of Obstetrics and Gynaecology · doi:10.1111/j.1479-828x.1978.tb00011.x · Cited by 320 · see citing works
Inhibin-B: a likely candidate for the physiologically important form of inhibin in men.
Illingworth, P. J., Groome, N. P., Byrd, W. E., et al. (1996) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.81.4.8636325 · Cited by 320 · see citing works
A Caenorhabditis elegans cohesion protein with functions in meiotic chromosome pairing and disjunctionPreprint
Pasierbek, P., Jantsch, M. F., Melcher, M., Schleiffer, A., Schweizer, D., & Loidl, J. (2001) · Genes & Development · doi:10.1101/gad.192701 · Cited by 315 · see citing works
Recent Demographic Developments in Europe: 1994.
McNicoll, G. (1995) · Population and Development Review · doi:10.2307/2137508 · Cited by 313 · see citing works
Morphometric studies of small follicles in ovaries of women at different ages
Gougeon, A., & Chainy, G. B. N. (1987) · Reproduction · doi:10.1530/jrf.0.0810433 · Cited by 305 · see citing works
First-Meiotic-Division Nondisjunction in Human Oocytes
Angell, R. R. (1997) · The American Journal of Human Genetics · doi:10.1086/513890 · Cited by 304 · see citing works
The role of genetic factors in age at natural menopause
de Bruin, J. P., Bovenhuis, H., van Noord, P. A. H., Pearson, P. L., van Arendonk, J. A. M., Velde, E. R. T., Kuurman, W. W., & Dorland, M. (2001) · Human Reproduction · doi:10.1093/humrep/16.9.2014 · Cited by 302 · see citing works
Age at Natural Menopause and Mortality
Cooper, G. S., & Sandler, D. P. (1998) · Annals of Epidemiology · doi:10.1016/s1047-2797(97)00207-x · Cited by 278 · see citing works
Genes Control the Cessation of a Woman's Reproductive Life: A Twin Study of Hysterectomy and Age at Menopause
Snieder, H. (1998) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.83.6.1875 · Cited by 276 · see citing works
Clinical features of primary ovarian failure caused by a point mutation in the follicle-stimulating hormone receptor gene
Aittomäki, K. (1996) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.81.10.3722 · Cited by 274 · see citing works
Factors influencing age at natural menopause
Arınkan, S. A., & Gunacti, M. (2020) · Journal of obstetrics and gynaecology research · doi:10.1111/jog.14614 · Cited by 268 · see citing works
Menopausal flushes: a neuroendocrine link with pulsatile luteinizing hormone secretion
Casper, R. F., Yen, S. S. C., & Wilkes, M. M. (1979) · Science · doi:10.1126/science.462193 · Cited by 267 · see citing works
Effects of age, cigarette smoking, and other factors on fertility: findings in a large prospective study.
Howe, G. R., Westhoff, C. L., Vessey, M. P., & Yeates, D. (1985) · BMJ · doi:10.1136/bmj.290.6483.1697 · Cited by 266 · see citing works
Reproductive outcome in patients with diminished ovarian reserve
Levi, A. J., Raynault, M. F., Bergh, P. A., Drews, M. R., Miller, B. T., & Scott, R. T. W. (2001) · Fertility and Sterility · doi:10.1016/s0015-0282(01)02017-9 · Cited by 261 · see citing works
A prospective study of factors affecting age at menopause
Brambilla, D. J., & McKinlay, S. M. (1989) · Journal of Clinical Epidemiology · doi:10.1016/0895-4356(89)90044-9 · Cited by 257 · see citing works
A cytogenetic study of human spontaneous abortions using banding techniques
Creasy, M. R., Crolla, J. A., & Alberman, E. D. (1976) · Human Genetics · doi:10.1007/bf00296145 · Cited by 254 · see citing works
Female Reproductive Aging Is Marked by Decreased Secretion of Dimeric Inhibin
Welt, C. K. (1999) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.84.1.105 · Cited by 253 · see citing works
REDUCED FECUNDABILITY IN WOMEN WITH PRENATAL EXPOSURE TO CIGARETTE SMOKING
Weinberg, C. R., Wilcox, A. J., & Baird, D. D. (1989) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a115211 · Cited by 250 · see citing works
The molecular basis of oocyte growth and development
Picton, H. M., Briggs, D., & Gosden, R. G. (1998) · Molecular and Cellular Endocrinology · doi:10.1016/s0303-7207(98)00166-x · Cited by 248 · see citing works
Boston Collaborative Drug Surveillance Program
Jick, H. (1978) · BMJ · doi:10.1136/bmj.1.6109.365-a · Cited by 248 · see citing works
Effects of Cigarette Smoking, Caffeine Consumption, and Alcohol Intake on Fecundability
Curtis, K. M., Savitz, D. A., & Arbuckle, T. E. (1997) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a009189 · Cited by 245 · see citing works
Family history as a predictor of early menopause
Cramer, D. W., Xu, H., & Harlow, B. L. (1995) · Fertility and Sterility · doi:10.1016/s0015-0282(16)57849-2 · Cited by 244 · see citing works
The meiotic competence of in-vitro matured human oocytes is influenced by donor age: evidence that folliculogenesis is compromised in the reproductively aged ovary
Volarcik, K., Sheean, L. A., Goldfarb, J. M., Woods, L., Abdul‐Karim, F. W., & Hunt, P. A. (1998) · Human Reproduction · doi:10.1093/humrep/13.1.154 · Cited by 243 · see citing works
Maternal age effect: The enigma of Down syndrome and other trisomic conditions
Gaulden, M. E. (1992) · Mutation Research/Reviews in Genetic Toxicology · doi:10.1016/0165-1110(92)90033-6 · Cited by 241 · see citing works
Middle-aged mothers live longer
Perls, T. T., Alpert, L., & Fretts, R. C. (1997) · Nature · doi:10.1038/38148 · Cited by 240 · see citing works
Physiology: A mathematical model of follicle dynamics in the human ovary
Faddy, M. J., & Gosden, R. G. (1995) · Human Reproduction · doi:10.1093/oxfordjournals.humrep.a136036 · Cited by 240 · see citing works
The New Role Of Women
Blossfeld, H., & KIERNAN, K. E. (2019) · Routledge eBooks · doi:10.4324/9780429313141 · Cited by 239 · see citing works
Pituitary-ovarian relationships preceding the menopause
Reyes, F. I., Winter, J. S. D., & Faiman, C. (1977) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(77)90097-7 · Cited by 239 · see citing works
Delayed conception and active and passive smoking
Hull, M. G. R., Northstone, K., Taylor, H., Farrow, A., & Ford, W. C. L. (2000) · Fertility and Sterility · doi:10.1016/s0015-0282(00)01501-6 · Cited by 238 · see citing works
Rec8p, a Meiotic Recombination and Sister Chromatid Cohesion Phosphoprotein of the Rad21p Family Conserved from Fission Yeast to Humans
Parisi, S., McKay, M. J., Molnar, M., et al. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.5.3515 · Cited by 234 · see citing works
The effect of age on the cyclical patterns of plasma LH, FSH, oestradiol and progesterone in women with regular menstrual cycles
Lee, S. J., Lenton, E. A., SEXTON, L., & Cooke, I. D. (1988) · Human Reproduction · doi:10.1093/oxfordjournals.humrep.a136796 · Cited by 232 · see citing works
In Vivo Treatment with GDF-9 Stimulates Primordial and Primary Follicle Progression and Theca Cell Marker CYP17 in Ovaries of Immature Rats 1
Vitt, U. A., McGee, E. A., Hayashi, M., & Hsueh, A. J. W. (2000) · Endocrinology · doi:10.1210/endo.141.10.7732 · Cited by 231 · see citing works
Estrogen Receptor Polymorphism Predicts the Onset of Natural and Surgical Menopause1
Weel, A. E. A. M., Uitterlinden, A. G., Westendorp, I. C. D., Burger, H., Schuit, S. C. E., Albert Hofman, D., Helmerhorst, T. J. M., van Leeuwen, J. P. T. M., & Pols, H. A. P. (1999) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.84.9.5981 · Cited by 229 · see citing works
Ovarian follicle atresia: a hormonally controlled apoptotic process
Hsueh, A. J. W. (1994) · Endocrine Reviews · doi:10.1210/er.15.6.707 · Cited by 228 · see citing works
MENSTRUAL AND REPRODUCTWE CHARACTERISTICS AND AGE AT NATURAL MENOPAUSE
Whelan, E. A., Sandler, D. P., McConnaughey, D. R., et al. (1990) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a115546 · Cited by 222 · see citing works
Survival probability of human conceptions from fertilization to term.
Boklage, C. E. (1990) · PubMed · Cited by 220 · see citing works
Characterization of susceptible chiasma configurations that increase the risk for maternal nondisjunction of chromosome 21
Lamb, N. E. (1997) · Human Molecular Genetics · doi:10.1093/hmg/6.9.1391 · Cited by 217 · see citing works
Post-ovulatory ageing of the human oocyte and embryo failure
Wilcox, A. J., Weinberg, C. R., & Baird, D. D. (1998) · Human Reproduction · doi:10.1093/humrep/13.2.394 · Cited by 215 · see citing works
Menopause: The Aging of Multiple Pacemakers
Wise, P. M., Krajnak, K., & Kashon, M. L. (1996) · Science · doi:10.1126/science.273.5271.67 · Cited by 215 · see citing works
Developmental and endocrine aspects of normal ovarian aging
Velde, E. R. T., Scheffer, G. J., Dorland, M., Broekmans, F. J., & Fauser, B. C. J. M. (1998) · Molecular and Cellular Endocrinology · doi:10.1016/s0303-7207(98)00171-3 · Cited by 210 · see citing works
Cytogenetics of Pregnancy Wastage
Boué, A., Boué, J., & Gropp, A. (1985) · Springer eBooks · doi:10.1007/978-1-4615-9400-0_1 · Cited by 206 · see citing works
Semen characteristics as a function of age in 833 fertile men
Schwartz, D., Mayaux, M. J., Spira, A., et al. (1983) · Fertility and Sterility · doi:10.1016/s0015-0282(16)46946-3 · Cited by 203 · see citing works
Relationship between age, percentage body fat, fitness, and 24-hour growth hormone release in healthy young adults: effects of gender
WELTMAN, A. L., Weltman, J. Y., Hartman, M. L., Abbott, R. D., Rogol, A. D., Evans, W. S., & Veldhuis, J. D. (1994) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.78.3.8126124 · Cited by 199 · see citing works
Female Fecundity as a Function of Age
Schwartz, D., & Mayaux, M. J. (1982) · Obstetrical & Gynecological Survey · doi:10.1097/00006254-198208000-00019 · Cited by 194 · see citing works
Factors associated with onset of menopause in women aged 45–49
Torgerson, D. J., Avenell, A., Russell, I. T., & Reid, D. M. (1994) · Maturitas · doi:10.1016/0378-5122(94)90057-4 · Cited by 184 · see citing works
Manipulation of Human Ovarian Function: Physiological Concepts and Clinical Consequences
Fauser, B. C. J. M. (1997) · Endocrine Reviews · doi:10.1210/er.18.1.71 · Cited by 178 · see citing works
Spermatogenesis and Aging in the Human
Johnson, L. W. (1986) · Journal of Andrology · doi:10.1002/j.1939-4640.1986.tb00943.x · Cited by 177 · see citing works
Fecundity and natural fertility in humans.
Wood, J. W. (1989) · PubMed · Cited by 177 · see citing works
A QUANTITATIVE MORPHOLOGICAL INVESTIGATION OF THE FOLLICULAR SYSTEM IN NEWBORN FEMALE INFANTS
Block, E. (2008) · Acta Anatomica · doi:10.1159/000140805 · Cited by 176 · see citing works
Serum Inhibins A and B fall differentially as FSH rises in perimenopausal women
Burger, H., Cahir, Robertson, Groome, J. R., Dudley, Green, & Dennerstein (1998) · Clinical Endocrinology · doi:10.1046/j.1365-2265.1998.00482.x · Cited by 174 · see citing works
Estrogen Receptor Polymorphism Predicts the Onset of Natural and Surgical Menopause
Weel, A. E. A. M. (1999) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.84.9.3146 · Cited by 171 · see citing works
Survival of Human Ovarian Follicles from Fetal to Adult Life: Apoptosis, Apoptosis-Related Proteins, and Transcription Factor GATA-41
Vaskivuo, T. E., Anttonen, M., Herva, R., Billig, H., Dorland, M., Velde, E. R. T., Stenbäck, F., Heikinheimo, M., & Tapanainen, J. S. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.7.7679 · Cited by 167 · see citing works
The New Role of Women: Family Formation in Modern Societies.
Rogers, S. J., & Blossfeld, H. (1996) · Social Forces · doi:10.2307/2580805 · Cited by 167 · see citing works
Risk factors for trisomy 21: Maternal cigarette smoking and oral contraceptive use in a spopulation-based case-control study
Yang, Q., Sherman, S. L., Hassold, T. J., et al. (1999) · Genetics in Medicine · doi:10.1097/00125817-199903000-00004 · Cited by 166 · see citing works
Pregnancy after age 50: application of oocyte donation to women after natural menopause
Sauer, M. V., Paulson, R. J., & Lobo, R. A. (1993) · The Lancet · doi:10.1016/0140-6736(93)90132-z · Cited by 164 · see citing works
Maternal ageing and aneuploid embryos?Evidence from the mouse that biological and not chronological age is the important influence
Brook, J. D., Gosden, R. G., & Chandley, A. C. (1984) · Human Genetics · doi:10.1007/bf00275184 · Cited by 158 · see citing works
Age-dependent decrease in embryo implantation rate after in vitro fertilization
van Kooij, R. J., Looman, C. W. N., Habbema, J. D. F., et al. (1996) · Fertility and Sterility · doi:10.1016/s0015-0282(16)58634-8 · Cited by 151 · see citing works
UNSUSPECTED PREGNANCY LOSS IN HEALTHY WOMEN
Whittaker, P. G., Taylor, A., & LIND, T. (1983) · The Lancet · doi:10.1016/s0140-6736(83)92865-9 · Cited by 151 · see citing works
Effect of smoking on ovarian reserve and ovarian stimulation in in- vitro fertilization and embryo transfer
El-Nemr, A., Al‐Shawaf, T., Sabatini, L., Wilson, C., Lower, A. M., & Grudzinskas, J. G. (1998) · Human Reproduction · doi:10.1093/humrep/13.8.2192 · Cited by 150 · see citing works
Defining menopausal status: The impact of longitudinal data
Kaufert, P. A., Gilbert, P., & TATE, R. B. (1987) · Maturitas · doi:10.1016/0378-5122(87)90004-1 · Cited by 146 · see citing works
Women with a Reduced Ovarian Complement May Have an Increased Risk for a Child with Down Syndrome
Freeman, S. B., Yang, Q., Allran, K., Taft, L. F., & Sherman, S. L. (2000) · The American Journal of Human Genetics · doi:10.1086/302907 · Cited by 144 · see citing works
A population study of apoE genotype at the age of 85: relation to dementia, cerebrovascular disease, and mortality
Skoog, I. G., Hesse, C., Aevarsson, Ó., Landahl, S., Wahlström, J., Fredman, P., & Blennow, K. (1998) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.64.1.37 · Cited by 143 · see citing works
Association between idiopathic premature ovarian failure and fragile X premutation
Marozzi, A., Vegetti, W., Manfredini, E., Tibiletti, M. G., Testa, G., Crosignani, P. G., Ginelli, E., Meneveri, R., & Dalprà, L. (2000) · Human Reproduction · doi:10.1093/humrep/15.1.197 · Cited by 141 · see citing works
Dimeric inhibin: a direct marker of ovarian aging
Danforth, D. R., Arbogast, L. K., Mroueh, J., et al. (1998) · Fertility and Sterility · doi:10.1016/s0015-0282(98)00127-7 · Cited by 141 · see citing works
The effects of smoking on ovarian function and fertility during assisted reproduction cycles
Voorhis, B. J. V., Dawson, J. D., Stovall, D. W., Sparks, A. E., & Syrop, C. H. (1996) · Obstetrics and Gynecology · doi:10.1016/0029-7844(96)00286-4 · Cited by 139 · see citing works
Inhibin-B: a likely candidate for the physiologically important form of inhibin in men
Illingworth, P. J. (1996) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.81.4.1321 · Cited by 139 · see citing works
Elevated day 3 serum follicle stimulating hormone and/or estradiol may predict fetal aneuploidy
Nasseri, A., Mukherjee, T., GRIFO, J. A., et al. (1999) · Fertility and Sterility · doi:10.1016/s0015-0282(98)00525-1 · Cited by 138 · see citing works
Cytogenetic analyses of culture failures by comparative genomic hybridisation (CGH)–Re-evaluation of chromosome aberration rates in early spontaneous abortions
Fritz, B., Hallermann, C., Olert, J., Fuchs, B., Bruns, M., Aslan, M., Schmidt, S., Coerdt, W., Müntefering, H., & Rehder, H. (2001) · European Journal of Human Genetics · doi:10.1038/sj.ejhg.5200669 · Cited by 138 · see citing works
Does “incessant” ovulation increase risk for early menopause?
Cramer, D. W., Xu, H., & Harlow, B. L. (1995) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(95)90574-x · Cited by 137 · see citing works
Cell cycle: Aetiology of age-associated aneuploidy: a mechanism based on the 'free radical theory of ageing'
Tarín, J. J. (1995) · Human Reproduction · doi:10.1093/humrep/10.6.1563 · Cited by 134 · see citing works
Regulation of ovarian follicular development in primates: facts and hypotheses
Gougeon, A. (1996) · Endocrine Reviews · doi:10.1210/er.17.2.121 · Cited by 134 · see citing works
Hypothalamic‐pituitary ageing: progressive increase in FSH and LH concentrations throughout the reproductive life in regularly menstruating women*
Ebbiary, N. A. A., Lenton, E. A., & Cooke, I. D. (1994) · Clinical Endocrinology · doi:10.1111/j.1365-2265.1994.tb02530.x · Cited by 131 · see citing works
Net Increase in Stimulatory Input Resulting from a Decrease in Inhibin B and an Increase in Activin A May Contribute in Part to the Rise in Follicular Phase Follicle-Stimulating Hormone of Aging Cycling Women1
Reame, N. E., Wyman, T. L., Phillips, D. J., de Kretser, D., & Padmanabhan, V. (1998) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.83.9.5130 · Cited by 124 · see citing works
Relationship between the Supply of Primordial Follicles and the Onset of Follicular Growth in Rats1
Hirshfield, A. N. (1994) · Biology of Reproduction · doi:10.1095/biolreprod50.2.421 · Cited by 123 · see citing works
Programmed Cell Death in Human Ovary Is a Function of Follicle and Corpus Luteum Status*
Yuan, W., & Giudice, L. C. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.82.9.4191 · Cited by 119 · see citing works
Cross-sectional and case-controlled analyses of the association between smoking and early menopause
Cramer, D. W., Harlow, B. L., Xu, H., Fraer, C., & Barbieri, R. L. (1995) · Maturitas · doi:10.1016/0378-5122(95)00928-e · Cited by 117 · see citing works
PATERNAL CONTRIBUTION TO EMBRYONIC DEATH
BISHOP, M. W. H. (1964) · Reproduction · doi:10.1530/jrf.0.0070383 · Cited by 113 · see citing works
Genetic influences on the age at menopause
Treloar, S. A., Do, K.-A., & Martin, N. G. (1998) · The Lancet · doi:10.1016/s0140-6736(05)79753-1 · Cited by 111 · see citing works
Infertility and early pregnancy loss
Hakim, R. B., Gray, R. H., & Zacur, H. A. (1995) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(95)90489-1 · Cited by 111 · see citing works
Spontaneous Abortion and Aging of Human Ova and Spermatozoa
Rodrigo, G. V., & Rojas, O. I. (1975) · New England Journal of Medicine · doi:10.1056/nejm197509182931202 · Cited by 111 · see citing works
Follicle-stimulating hormone concentrations in relation to active and passive smoking
Cooper, G., Baird, D. D., Hulka, B. S., Weinberg, C. R., Savitz, D. A., & Hughes, C. L. (1995) · Obstetrics and Gynecology · doi:10.1016/0029-7844(94)00381-m · Cited by 109 · see citing works
CYTOGENETIC ABNORMALITIES IN SPONTANEOUS ABORTIONS OF RECOGNIZED CONCEPTIONS
Warburton, D., Kline, J. K., STEIN, Z. A., & Strobino, B. A. (1986) · Elsevier eBooks · doi:10.1016/b978-0-12-562855-6.50007-8 · Cited by 108 · see citing works
Reproductive Characteristics and the Age at Inception of the Perimenopause in a British National Cohort
Hardy, R., & Kuh, D. J. (1999) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a009861 · Cited by 106 · see citing works
Ovarian follicular development and the follicular fluid hormones and growth factors in normal women of advanced reproductive age.
Klein, N. A., Battaglia, D. E., Miller, P. B. W., et al. (1996) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.81.5.8626862 · Cited by 105 · see citing works
Biomedical and Demographic Determinants of Reproduction
(1993) · doi:10.1093/oso/9780198283713.001.0001 · Cited by 102 · see citing works
Lack of correlation between maximum early follicular phase serum follicle stimulating hormone concentrations and menstrual cycle characteristics in women under the age of 35 years
Schipper, I., de Jong, F. H., & Fauser, B. C. J. M. (1998) · Human Reproduction · doi:10.1093/humrep/13.6.1442 · Cited by 100 · see citing works
The effect of cigarette smoking on ovarian function and early pregnancy outcome of in vitro fertilization treatment
Pattinson, H. A., Taylor, P. J., & Pattinson, M. H. (1991) · Fertility and Sterility · doi:10.1016/s0015-0282(16)54248-4 · Cited by 98 · see citing works
Premature ovarian failure
Vegetti, W., Marozzi, A., Manfredini, E., et al. (2000) · Molecular and Cellular Endocrinology · doi:10.1016/s0303-7207(99)00224-5 · Cited by 95 · see citing works
The effect of maternal age on the frequency of trisomy: change in meiosis or in utero selection?
Warburton, D. (1989) · PubMed · Cited by 90 · see citing works
Sterility in a Population with Natural Fertility
Trussell, J., & Wilson, C. (1985) · Population Studies · doi:10.1080/0032472031000141486 · Cited by 88 · see citing works
Ultrastructure of the Resting Ovarian Follicle Pool in Healthy Young Women1
de Bruin, J. P., Dorland, M., Spek, E. R., Posthuma, G., van Haaften, M., Looman, C. W. N., & Velde, E. R. T. (2002) · Biology of Reproduction · doi:10.1095/biolreprod66.4.1151 · Cited by 87 · see citing works
Regulation of Oocyte Growth in the Mouse Ovary
Krarup, T., PEDERSEN, T., & Faber, M. (1969) · Nature · doi:10.1038/224187a0 · Cited by 86 · see citing works
French national IVF registry: analysis of 1986 to 1990 data
National), F. (. I. V. (1993) · Fertility and Sterility · doi:10.1016/s0015-0282(16)55805-1 · Cited by 86 · see citing works
The CBA mouse as a model for age-related aneuploidy in man: studies of oocyte maturation, spindle formation and chromosome alignment during meiosis
Eichenlaub-Ritter, U., Chandley, A. C., & Gosden, R. G. (1988) · Chromosoma · doi:10.1007/bf00302361 · Cited by 85 · see citing works
Neuroendocrine Influences and Repercussions of the Menopause
Wise, P. M., Smith, M. J., Dubal, D. B., et al. (1999) · Endocrine Reviews · doi:10.1210/edrv.20.3.0364 · Cited by 84 · see citing works
Ovarian Follicular Concentrations of Activin, Follistatin, Inhibin, Insulin-Like Growth Factor I (IGF-I), IGF-II, IGF-Binding Protein-2 (IGFBP-2), IGFBP-3, and Vascular Endothelial Growth Factor in Spontaneous Menstrual Cycles of Normal Women of Advanced Reproductive Age1
Klein, N. A., Battaglia, D. E., Woodruff, T. K., et al. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.85.12.7056 · Cited by 84 · see citing works
Survival of Human Ovarian Follicles from Fetal to Adult Life: Apoptosis, Apoptosis-Related Proteins, and Transcription Factor GATA-4
Vaskivuo, T. E. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.86.7.3421 · Cited by 84 · see citing works
Increased serum FSH in female fragile X premutation carriers with either regular menstrual cycles or on oral contraceptives
Hundscheid, R. D. L., Braat, D. D. M., Kiemeney, L. A. L. M., Smits, A. P. T., & Thomas, C. M. G. (2001) · Human Reproduction · doi:10.1093/humrep/16.3.457 · Cited by 82 · see citing works
Menstrual cycle length preceding menopause in relation to age at menopause
den Tonkelaar, I., Velde, E. R. T., & Looman, C. W. N. (1998) · Maturitas · doi:10.1016/s0378-5122(98)00013-9 · Cited by 82 · see citing works
Increased concentrations of folliclestimulating hormone in mothers of children with Down's syndrome
van Montfrans, J., Dorland, M., Oosterhuis, G., et al. (1999) · The Lancet · doi:10.1016/s0140-6736(99)00936-8 · Cited by 81 · see citing works
Female Fecundity and Age
DeCherney, A. H., & Berkowitz, G. S. (1982) · New England Journal of Medicine · doi:10.1056/nejm198202183060712 · Cited by 80 · see citing works
Oral contraceptive use in relation to age at menopause in the DOM cohort
de Vries, E. (2001) · Human Reproduction · doi:10.1093/humrep/16.8.1657 · Cited by 77 · see citing works
Age related changes in the female reproductive cycle
Fitzgerald, C. T., Seif, M. W., Killick, S. R., & Bennett, D. A. (1994) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.1994.tb13115.x · Cited by 77 · see citing works
Female sex preponderance for idiopathic familial premature ovarian failure suggests an X chromosome defect: Opinion
Davis, C. (2000) · Human Reproduction · doi:10.1093/humrep/15.11.2418 · Cited by 76 · see citing works
Donor age is paramount to success in oocyte donation *
Cohen, M. A., Lindheim, S. R., & Sauer, M. V. (1999) · Human Reproduction · doi:10.1093/humrep/14.11.2755 · Cited by 76 · see citing works
Natural fertility in pre-industrial Germany
Knodel, J. E. (1978) · Population Studies · doi:10.1080/00324728.1978.10412810 · Cited by 75 · see citing works
Follicular fluid concentrations of adrenomedullin, vascular endothelial growth factor and nitric oxide in IVF cycles: relationship to ovarian response
Manau, D., Balasch, J., Jiménez, W., Fábregues, F., Cı́vico, S., Casamitjana, R., Creus, M. T., & Vanrell, J. A. (2000) · Human Reproduction · doi:10.1093/humrep/15.6.1295 · Cited by 75 · see citing works
Factors affecting the age at menopause
van Keep, P. A., Brand, P., & Lehert, P. (1979) · Journal of Biosocial Science · doi:10.1017/s0021932000024299 · Cited by 74 · see citing works
The idiopathic forms of premature menopause and early menopause show the same genetic pattern
Tibiletti, M. G., Testa, G., Vegetti, W., et al. (1999) · Human Reproduction · doi:10.1093/humrep/14.11.2731 · Cited by 73 · see citing works
THE EFFECT OF MATERNAL AGE ON OVULATION, CORPORA LUTEA OF PREGNANCY, AND IMPLANTATION FAILURE IN MICE
Harman, S. M., & Talbert, G. B. (1970) · Reproduction · doi:10.1530/jrf.0.0230033 · Cited by 72 · see citing works
Numbers or words? A randomized controlled trial of presenting screen negative results to pregnant women
Marteau, T. M., Saidi, G., Goodburn, S. F., Lawton, J., Michie, S., & Bobrow, M. (2000) · Prenatal Diagnosis · doi:10.1002/1097-0223(200009)20:9 · Cited by 70 · see citing works
In Vivo Treatment with GDF-9 Stimulates Primordial and Primary Follicle Progression and Theca Cell Marker CYP17 in Ovaries of Immature Rats
Vitt, U. A. (2000) · Endocrinology · doi:10.1210/en.141.10.3814 · Cited by 70 · see citing works
Net Increase in Stimulatory Input Resulting from a Decrease in Inhibin B and an Increase in Activin A May Contribute in Part to the Rise in Follicular Phase Follicle-Stimulating Hormone of Aging Cycling Women
Reame, N. E. (1998) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.83.9.3302 · Cited by 70 · see citing works
Predictors of ovarian follicle number
Westhoff, C. L., Murphy, P. A., & Heller, D. S. (2000) · Fertility and Sterility · doi:10.1016/s0015-0282(00)01527-2 · Cited by 67 · see citing works
Characteristics of luteinizing hormone secretion in younger versus older premenopausal women
Matt, D. W., Kauma, S. W., Pincus, S. M., Veldhuis, J. D., & Evans, W. S. (1998) · American Journal of Obstetrics and Gynecology · doi:10.1016/s0002-9378(98)70429-6 · Cited by 66 · see citing works
A Two-Site Chemiluminescent Assay for Activin-Free Follistatin Reveals That Most Follistatin Circulating in Men and Normal Cycling Women Is in an Activin-Bound State1
McConnell, D. S., Wang, Q., Sluss, P. M., Bolf, N., Khoury, R. H., Schneyer, A. L., MIDGLEY, A. R., Reame, N. E., Crowley, W. F., & Padmanabhan, V. (1998) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.83.3.4651 · Cited by 65 · see citing works
Significance of basal follicle-stimulating hormone levels in women with one ovary in a program of in vitro fertilization
Khalifa, E., Toner, J. P., Muasher, S. J., et al. (1992) · Fertility and Sterility · doi:10.1016/s0015-0282(16)54967-x · Cited by 63 · see citing works
Age-related changes in the female hormonal environment during reproductive life
Musey, V. C., Collins, D. C., Musey, P. I., Martino-Saltzman, D., & Preedy, J. R. K. (1987) · American Journal of Obstetrics and Gynecology · doi:10.1016/s0002-9378(87)80159-x · Cited by 60 · see citing works
Male Age and Fertility Results From Ireland Prior to 1911
Anderson, B. A. (1975) · Population Index · doi:10.2307/2734844 · Cited by 60 · see citing works
Age at Menopause and Childbearing Patterns in Relation to Mortality
Cooper, G. S., Baird, D. D., Weinberg, C. R., et al. (2000) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a010250 · Cited by 59 · see citing works
Relation of parity to age at menopause
Soberón, J., Calderón, J. J. A., & Goldzieher, J. W. (1966) · American Journal of Obstetrics and Gynecology · doi:10.1016/s0002-9378(16)34647-6 · Cited by 58 · see citing works
X-chromosome abnormalities in women with premature ovarian failure.
Devi, A. S., & Benn, P. A. (1999) · PubMed · Cited by 54 · see citing works
Maternal Age: A Major Factor Affecting the Prospects and Outcome of Pregnancya
Gosden, R. G. (1985) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1985.tb37504.x · Cited by 54 · see citing works
Programmed Cell Death in Human Ovary Is a Function of Follicle and Corpus Luteum Status
Yuan, W. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.82.9.3148 · Cited by 54 · see citing works
The early lethality of autosomal monosomy in the mouse
Magnuson, T., Debrot, S., Dimpfl, J., et al. (1985) · Journal of Experimental Zoology · doi:10.1002/jez.1402360313 · Cited by 53 · see citing works
Effects of age, gravidity and male infertility status on cumulative conception rates following artificial insemination with cryopreserved donor semen: analysis of 2998 cycles of treatment in one centre over 10 years
Shenfield, F., Doyle, P., Valentine, A., et al. (1993) · Human Reproduction · doi:10.1093/oxfordjournals.humrep.a137875 · Cited by 53 · see citing works
Effects of Aging on Ovarian Fecundity in Terms of the Incidence of Apoptotic Granulosa Cells
Sadraie, S. H., Saito, H., Kaneko-Tarui, T., Saito, T., & Hiroi, M. (2000) · Journal of Assisted Reproduction and Genetics · doi:10.1023/a:1009422323306 · Cited by 49 · see citing works
Elevation of follicular phase inhibin and luteinizing hormone levels in mothers of dizygotic twins suggests nonovarian control of human multiple ovulation
Martin, N. G., Robertson, D. M., Chenevix‐Trench, G., et al. (1991) · Fertility and Sterility · doi:10.1016/s0015-0282(16)54542-7 · Cited by 48 · see citing works
The decline of fecundity with age
Spira, A. (1988) · Maturitas · doi:10.1016/0378-5122(88)90004-7 · Cited by 47 · see citing works
Human recombinant activin-A alters pituitary luteinizing hormone and follicle-stimulating hormone secretion, follicular development, and steroidogenesis, during the menstrual cycle in rhesus monkeys.
Stouffer, R. L., Woodruff, T. K., Dahl, K. D., et al. (1993) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.77.1.8325947 · Cited by 46 · see citing works
A Two-Site Chemiluminescent Assay for Activin-Free Follistatin Reveals That Most Follistatin Circulating in Men and Normal Cycling Women Is in an Activin-Bound State
McConnell, D. S. (1998) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.83.3.851 · Cited by 46 · see citing works
Growth and development of mammalian oocytes in vitro.
Eppig, J. J. (1992) · PubMed · Cited by 45 · see citing works
Pregnancy and lifestyle study: the long-term use of the contraceptive pill and the risk of age-related miscarriage
Ford, J. H., & MacCormac, L. (1995) · Human Reproduction · doi:10.1093/humrep/10.6.1397 · Cited by 45 · see citing works
Factors that affect outcome of in-vitro fertilisation treatment
(1997) · International Journal of Gynecology & Obstetrics · doi:10.1016/s0020-7292(97)83415-7 · Cited by 43 · see citing works
Cytogenetics of Spontaneous Abortion
Pflueger, S. (2005) · Humana Press eBooks · doi:10.1385/1-59259-833-1:323 · Cited by 42 · see citing works
Restricted Expression of WT1 Messenger Ribonucleic Acid in Immature Ovarian Follicles: Uniformity in Mammalian and Avian Species and Maintenance during Reproductive Senescence1
Chun, S., McGee, E. A., Hsu, S. Y., et al. (1999) · Biology of Reproduction · doi:10.1095/biolreprod60.2.365 · Cited by 42 · see citing works
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Klein, N. A. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.85.12.4520 · Cited by 42 · see citing works
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Hs, C., Wald, N., & Thompson, S. E. (1988) · International Journal of Gynecology & Obstetrics · doi:10.1016/0020-7292(88)90310-4 · Cited by 36 · see citing works
Spontaneous heteroploidy in one-cell mouse embryos
Martin‐DeLeon, P. A., & Boice, M. L. (2008) · Cytogenetics and Cell Genetics · doi:10.1159/000131837 · Cited by 31 · see citing works
Selective elimination of chromosomally unbalanced zygotes at the two-cell stage in the Chinese hamster
Sonta, S., Fukui, K., & Yamamura, H. (2008) · Cytogenetics and Cell Genetics · doi:10.1159/000132022 · Cited by 30 · see citing works
REPRODUCTIVE MEDICINE
Velde, E. R. T. (1993) · The Lancet · doi:10.1016/0140-6736(93)93133-l · Cited by 30 · see citing works
Pregnancy in women with Kallmann’s syndrome
Sungurtekin, Ü., Fraser, I. S., & Shearman, R. P. (1995) · Fertility and Sterility · doi:10.1016/s0015-0282(16)57415-9 · Cited by 29 · see citing works
Infertile or childless by choice? A multipractice survey of women aged 35 and 50.
Johnson, G. H., Roberts, D., Brown, R., et al. (1987) · BMJ · doi:10.1136/bmj.294.6575.804 · Cited by 29 · see citing works
The Aging of Gametes, Heteroploidy, and Embryonic Death
Bomsel‐Helmreich, O. (1976) · International Journal of Gynecology & Obstetrics · doi:10.1002/j.1879-3479.1976.tb00576.x · Cited by 29 · see citing works
90137575 Menstrual and reproductive characteristics and age at natural menopause
Whelan, E., Sandler, D. P., McConnaughey, D. R., et al. (1990) · Maturitas · doi:10.1016/0378-5122(90)90051-7 · Cited by 28 · see citing works

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Muka, T., Oliver-Williams, C., Kunutsor, S., Laven, J. S. E., Fauser, B. C. J. M., Chowdhury, R., Kavousi, M., & Franco, O. H. (2016) · JAMA Cardiology · doi:10.1001/jamacardio.2016.2415 · Cited by 826 · see citing works
Definition and prevalence of subfertility and infertility
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Ceresara, S., & Giarda, A. (1974) · Philosophical magazine · doi:10.1080/14786437408226183 · Cited by 6 · see citing works

Authors: te Velde, E. R.
Venue: Human Reproduction Update
Publisher: Oxford University Press (OUP)
Published: 2002-03-01
Volume: 8
Issue: 2
Pages: 141-154
ISSN: 1355-4786 (ISSN-L)
1460-2369
DOI: 10.1093/humupd/8.2.141
OpenAlex: W2098124125
Cited by: 1,214
References: 223
Citations by year: 2026: 48 · 2025: 58 · 2024: 45 · 2023: 48 · 2022: 57 · 2021: 74 · 2020: 67 · 2019: 50 · 2018: 55 · 2017: 62 · 2016: 64 · 2015: 68 · 2014: 60 · 2013: 75 · 2012: 58
FWCI: 4.87
Type: journal article
Language: en
Open access: closed
Locations: Human Reproduction Update (publishedVersion)
PubMed (publishedVersion)
Funders: Georgetown University
Nederlands Interdisciplinair Demografisch Instituut
Erasmus Universitair Medisch Centrum Rotterdam
Topics: Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Reproductive Biology and Fertility
Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Menopause: Health Impacts and Treatments
Keywords: age at menopause, age at last birth, oocyte quality, meiotic nondisjunction, aneuploidy, subfertility, delayed childbearing, heritability, ovarian aging
MeSH terms: Adult, Aging, Chromosome Aberrations, Embryo, Mammalian, Female, Ovarian Follicle, Humans, Infertility, Female, Menopause, Middle Aged, Oocytes, Ovary, Reproduction

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The variability of female reproductive ageing

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