The DOI matches its Crossref record; 97 of the 97 references it cites were found in a registry or an index.
Oocyte aging underlies female reproductive aging: biological mechanisms and therapeutic strategies
Open accessAbstract
In recent years, postponement of marriage and childbearing in women of reproductive age has led to an increase in the incidence of age‐related infertility. The reproductive aging process in women is assumed to occur due to a decrease in both the quantity and quality of the oocytes, with the ultimate result being a decline in fecundity. This age‐related decline in fecundity is strongly dependent on oocyte quality, which is critical for fertilization and subsequent embryo development. Aged oocytes display increased chromosomal abnormality and dysfunction of cellular organelles, both of which factor into oocyte quality. In particular, mitochondrial dysfunction has been suggested as a major contributor to the reduction in oocyte quality as well as to chromosomal abnormalities in aged oocytes and embryos. Participation of oxidative stress in the oocyte aging process has been proposed because oxidative stress has the capacity to induce mitochondrial dysfunction and directly damage many intracellular components of the oocytes such as lipids, protein, and DNA. In an attempt to improve mitochondrial function in aged oocytes, several therapeutic strategies have been investigated using both animal models and assisted reproductive technology. Here, we review the biological mechanisms and present status of therapeutic strategies in the female reproductive aging field and indicate possible future therapeutic strategies.
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“Aging progresses throughout the lifespan can be accentuated at etiologic sites of multiple acute and chronic diseases, including in children6,8–12.”
From Cellular senescence and senolytics: the path to the clinic (2022) · cites this paper as [12]
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“fundamental aging processes can operate even before conception, for example, in the context of aged oocytes linked to Down syndrome12,13.”
From Cellular senescence and senolytics: the path to the clinic (2022) · cites this paper as [12]
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1 retracted
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Cited by
Sorted by citations
Cellular senescence and senolytics: the path to the clinic
Chaib, S., Tchkonia, T., & Kirkland, J. L. (2022) · Nature Medicine · doi:10.1038/s41591-022-01923-y · Cited by 1,134
Impact of Oxidative Stress on Age-Associated Decline in Oocyte Developmental Competence
Sasaki, H., Hamatani, T., Kamijo, S., Iwai, M., Kobanawa, M., Ogawa, S., Miyado, K., & Tanaka, M. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00811 · Cited by 344
Oocytes maintain ROS-free mitochondrial metabolism by suppressing complex I
Rodríguez‐Nuevo, A., Torres-Sanchez, A., Duran, J. M., de Guirior, C., Martínez‐Zamora, M. Á., & Böke, E. (2022) · Nature · doi:10.1038/s41586-022-04979-5 · Cited by 254
Babayev, E., & Duncan, F. E. (2022) · Biology of Reproduction · doi:10.1093/biolre/ioab241 · Cited by 122
Cecchino, G. N., Seli, E. U., Motta, E. L. A., & García-Velasco, J. A. (2018) · Reproductive BioMedicine Online · doi:10.1016/j.rbmo.2018.02.007 · Cited by 110
Metadata
- Authors
- Igarashi, H., Takahashi, T., & Nagase, S.
- Affiliations
- Yamagata University (JP)
- Corresponding author
- Igarashi, Hideki
- Venue
- Reproductive Medicine and Biology
- Publisher
- Wiley
- Published
- 2015-05-09
- Volume
- 14
- Issue
- 4
- Pages
- 159-169
- ISSN
- 1445-5781 (ISSN-L)
- 1447-0578
- PMC
- PMC5715832
- OpenAlex
- W636461026
- Cited by
- 116
- References
- 97
- Citations by year
- 2026: 9 · 2025: 18 · 2024: 12 · 2023: 10 · 2022: 18 · 2021: 18 · 2020: 18 · 2019: 11 · 2018: 1
- FWCI
- 0.05
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Reproductive Medicine and Biology (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Japan Society for the Promotion of Science (26462474)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Reproductive Biology and Fertility
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Reproductive biology and impacts on aquatic species
- Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
- Keywords
- oocyte aging, female reproductive aging, age-related infertility, oocyte quality, mitochondrial dysfunction, oxidative stress, chromosomal abnormalities, fecundity decline, assisted reproduction, treatment options
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