Osteoporosis among Italian women at risk: The OSTEOLAB study
Open accessAbstract
OBJECTIVE: The aim of the present study was to identify women at high risk of having osteoporosis according to the clinical judgment of their General Practitioners, but without a previous diagnosis of osteoporosis. DESIGN: Cross-sectional survey. PARTICIPANTS: The General Practitioners were asked to select a sample of women aged 65 years or more who could be affected by osteoporosis but had never been diagnosed nor treated: this sample included 8,268. Moreover, 8,956 women asked to be included in the study on a voluntary basis, and were analyzed separately. MEASUREMENTS: Participants were referred to a mobile unit equipped with GE Lunar Express Ultras (Achilles), where they were administered a questionnaire and underwent a QUS examination. They were classified at high, moderate or low risk of having osteoporosis according to the 2007 International Society for Clinical Densitometry official position. RESULTS: The prevalence rate of women at high risk of having osteoporosis was 12.5%; 53% were considered at moderate risk. Logistic regressions revealed that age, early age at menopause, history of fractures, dysthyroidism and smoking were associated with high and moderate risk. CONCLUSIONS: Results suggest that General Practitioners are able to identify women at risk of having osteoporosis, but often do not treat them, suggesting that osteoporosis in Italy is still a neglected condition. The strength of the association of risk factors is similar in women at high and medium risk: this may raise a debate on the validity of this classification in the Italian population.
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Post-menopausal women who smoke lose significantly more cortical bone than non-smokers.
“Similarly, an epidemiological study conducted by Noale et al. in 2012 on post-menopausal women showed that smokers lose significantly more cortical bone than non-smokers [20].”
From Skeletal System Biology and Smoke Damage: From Basic Science to Medical Clinic (2021) · cites this paper as [20]
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- Authors
- Noale, M., Maggi, S., & Crepaldi, G.
- Affiliations
- National Research Council (IT)
- Corresponding author
- Noale, Marianna
- Venue
- The Journal of nutrition, health and aging
- Publisher
- Elsevier BV
- Published
- 2012-06
- Volume
- 16
- Issue
- 6
- Pages
- 529-533
- ISSN
- 1279-7707 (ISSN-L)
- PMC
- PMC12878131
- OpenAlex
- W1988233509
- Cited by
- 13
- References
- 11
- Citations by year
- 2025: 1 · 2024: 1 · 2022: 2 · 2021: 1 · 2019: 2 · 2018: 1 · 2016: 1 · 2015: 2 · 2013: 2
- FWCI
- 0.68
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- The journal of nutrition health & aging (publishedVersion, cc-by-nc-nd)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- Funders
- Royal Osteoporosis Society
- Topics
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Menopause: Health Impacts and Treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
- Keywords
- osteoporosis, osteoporosis risk assessment, general practitioners, risk factor classification, bone mineral density, quantitative ultrasound, osteoporosis prevalence, age at menopause, fracture, smoking, hypothyroidism, underdiagnosis
- MeSH terms
- Aged, Aged, 80 and over, Cross-Sectional Studies, Female, Health Surveys, Humans, Italy, Professional Competence, Risk Factors, Osteoporosis, Postmenopausal, Prevalence, Logistic Models, General Practitioners
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