The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
Semaglutide, delayed gastric emptying, and intraoperative pulmonary aspiration: a case report
Open accessAbstract
Purpose We report a case in which the use of semaglutide for weight loss was associated with delayed gastric emptying and intraoperative pulmonary aspiration of gastric contents. Clinical features A 42-yr-old patient with Barrett's esophagus underwent repeat upper gastrointestinal endoscopy and ablation of dysplastic mucosa. Two months earlier, the patient had started weekly injections of semaglutide for weight loss. Despite having fasted for 18 hr, and differing from the findings of prior procedures, endoscopy revealed substantial gastric content, which was suctioned before endotracheal intubation. Food remains were removed from the trachea and bronchi using bronchoscopy. The patient was extubated four hours later and remained asymptomatic. Conclusion Patients using semaglutide and other glucagon-like peptide 1 agonists for weight management may require specific precautions during induction of anesthesia to prevent pulmonary aspiration of gastric contents.
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“These drugs may be associated with risks of peri‐operative pulmonary aspiration or euglycaemic ketoacidosis.”
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“For instance, Klein et al. [43] described a 42-year-old male patient receiving once-weekly semaglutide for weight loss who aspirated a substantial amount of solid and liquid gastric contents during anesthesia induction despite an 18-hour fasting period.”
From Delayed gastric emptying induced by glucagon-like peptide-1 receptor agonists and its implications for perioperative risk during anesthesia (2026) · cites this paper as [43]
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“These medications may be associated with nausea, vomiting, and delayed gastric emptying, and there have been case reports of pulmonary aspiration during general anesthesia and deep sedation (154).”
From 16. Diabetes Care in the Hospital: Standards of Care in Diabetes—2026 (2026) · cites this paper as [154]
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In the citing paper
“The correlation between delayed gastric emptying and GLP-1 RAs raises concerns about the possible negative effects in the periprocedural setting, as evidenced by case reports of aspiration events occurring during procedural anesthesia in patients administered GLP-1 RAs [14,15].”
From Exploring the Side Effects of GLP-1 Receptor Agonist: To Ensure Its Optimal Positioning (2025) · cites this paper as [15]
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Cites
Semaglutide and Cardiovascular Outcomes in Patients with Type 2 Diabetes
Marso, S. P., Bain, S. C., Consoli, A., Eliaschewitz, F. G., Jódar, E., Leiter, L. A., Lingvay, I., Rosenstock, J., Seufert, J., Warren, M. L., et al. (2016) · New England Journal of Medicine · doi:10.1056/nejmoa1607141 · Cited by 6,900
Once-Weekly Semaglutide in Adults with Overweight or Obesity
Wilding, J. P. H., Batterham, R. L., Calanna, S., Davies, M., Van Gaal, L. F., Lingvay, I., McGowan, B. M., Rosenstock, J., Tran, M. T. D., Wadden, T. A., et al. (2021) · New England Journal of Medicine · doi:10.1056/nejmoa2032183 · Cited by 5,205
Friedrichsen, M., Breitschaft, A., Tadayon, S., Wizert, A., & Skovgaard, D. (2021) · Diabetes, Obesity and Metabolism · doi:10.1111/dom.14280 · Cited by 427
Gastric emptying and release of incretin hormones after glucose ingestion in humans.
Schirra, J., Katschinski, M., Weidmann, C., Schäfer, T., Wank, U., Arnold, R., & Göke, B. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118411 · Cited by 426
Meier, J. J., Rosenstock, J., Hincelin-Méry, A., Roy-Duval, C., Delfolie, A., Coester, H.-V., Menge, B. A., Forst, T., & Kapitza, C. (2015) · Diabetes Care · doi:10.2337/dc14-1984 · Cited by 262
Hjerpsted, J. B., Flint, A., Brooks, A., Axelsen, M. B., Kvist, T., & Blundell, J. (2018) · Diabetes, Obesity and Metabolism · doi:10.1111/dom.13120 · Cited by 245
How Useful Is Paracetamol Absorption as a Marker of Gastric Emptying? A Systematic Literature Study
Willems, M., Quartero, A. O., & Numans, M. E. (2001) · Digestive Diseases and Sciences · doi:10.1023/a:1011935603893 · Cited by 211
Hall, S. F., Isaacs, D. M., & Clements, J. N. (2018) · Clinical Pharmacokinetics · doi:10.1007/s40262-018-0668-z · Cited by 136
Pulmonary Aspiration of Gastric Contents: A Closed Claims Analysis
Warner, M. A. A., Meyerhoff, K. L., Warner, M. E., Posner, K. L., Stephens, L. S., & Domino, K. B. (2021) · Anesthesiology · doi:10.1097/aln.0000000000003831 · Cited by 115
Dahl, K., Brooks, A., Almazedi, F., Hoff, S. T., Boschini, C., & Bækdal, T. A. (2021) · Diabetes, Obesity and Metabolism · doi:10.1111/dom.14373 · Cited by 87
Cited by
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Glucagon-Like Peptide-1 Receptor Agonist Use and Residual Gastric Content Before Anesthesia
Sen, S., Potnuru, P. P., Hernandez, N., Goehl, C., Praestholm, C., Sridhar, S., & Nwokolo, O. O. (2024) · JAMA Surgery · doi:10.1001/jamasurg.2024.0111 · Cited by 202
Preoperative assessment of adults undergoing elective noncardiac surgery
Lamperti, M., Romero, C. S., Guarracino, F., Cammarota, G., Vetrugno, L., Tufegdzic, B., Chacón-Lozsán, F., Frias, J. J. M., Duma, A., Böck, M., et al. (2024) · European Journal of Anaesthesiology · doi:10.1097/eja.0000000000002069 · Cited by 187
Kindel, T. L., Wang, A. Y., Wadhwa, A. N., Schulman, A. R., Sharaiha, R. Z., Kroh, M., Ghanem, O. M., Levy, S. M., Joshi, G. P., & LaMasters, T. L. (2024) · Surgery for Obesity and Related Diseases · doi:10.1016/j.soard.2024.08.033 · Cited by 152
El‐Boghdadly, K., Dhesi, J., Fabb, P., Levy, N., Lobo, D. N., McKechnie, A., Mustafa, O., Newland‐Jones, P., Patel, A., Pournaras, D. J., et al. (2025) · Anaesthesia · doi:10.1111/anae.16541 · Cited by 147
Ushakumari, D. S., & Sladen, R. N. (2024) · Anesthesiology · doi:10.1097/aln.0000000000004776 · Cited by 139
Metadata
- Authors
- Klein, S. R., & Hobai, I. A.
- Affiliations
- Massachusetts General Hospital (US)
- Harvard University (US)
- Corresponding author
- Hobai, Ion A.
- ORCID
- Hobai, Ion A.
- Venue
- Canadian Journal of Anesthesia/Journal canadien d'anesthésie
- Published
- 2023-03-28
- Volume
- 70
- Issue
- 8
- Pages
- 1394-1396
- ISSN
- 0832-610X (ISSN-L)
- 1496-8975
- OpenAlex
- W4361212412
- Cited by
- 207
- References
- 12
- Citations by year
- 2026: 55 · 2025: 58 · 2024: 70 · 2023: 24
- FWCI
- 68.56
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Canadian Journal of Anesthesia/Journal canadien d anesthésie (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Anesthesiology and Pain Medicine › Airway Management and Intubation Techniques
- Health Sciences › Medicine › Anesthesiology and Pain Medicine › Anesthesia and Sedative Agents
- Health Sciences › Medicine › Surgery › Enhanced Recovery After Surgery
- Keywords
- semaglutide, delayed gastric emptying, GLP-1 receptor agonists, weight loss, Barrett's esophagus, upper gastrointestinal endoscopy, anesthesia induction, endotracheal intubation, bronchial aspiration, bronchoscopy
- MeSH terms
- Semaglutide, Diabetes Mellitus, Type 2, Glucagon-Like Peptides, Humans, Weight Loss, Endoscopy, Gastrointestinal, Gastroparesis
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