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Semaglutide, delayed gastric emptying, and intraoperative pulmonary aspiration: a case report

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Klein, Sandra R., Hobai, Ion A.·2023·Canadian Journal of Anesthesia/Journal canadien d'anesthésie

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Purpose We report a case in which the use of semaglutide for weight loss was associated with delayed gastric emptying and intraoperative pulmonary aspiration of gastric contents. Clinical features A 42-yr-old patient with Barrett's esophagus underwent repeat upper gastrointestinal endoscopy and ablation of dysplastic mucosa. Two months earlier, the patient had started weekly injections of semaglutide for weight loss. Despite having fasted for 18 hr, and differing from the findings of prior procedures, endoscopy revealed substantial gastric content, which was suctioned before endotracheal intubation. Food remains were removed from the trachea and bronchi using bronchoscopy. The patient was extubated four hours later and remained asymptomatic. Conclusion Patients using semaglutide and other glucagon-like peptide 1 agonists for weight management may require specific precautions during induction of anesthesia to prevent pulmonary aspiration of gastric contents.

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Self-citation
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Authors: Klein, S. R., & Hobai, I. A.
Affiliations: Massachusetts General Hospital (US)
Harvard University (US)
Corresponding author: Hobai, Ion A.
ORCID: Hobai, Ion A.
Venue: Canadian Journal of Anesthesia/Journal canadien d'anesthésie
Publisher: Springer Science and Business Media LLC
Published: 2023-03-28
Volume: 70
Issue: 8
Pages: 1394-1396
ISSN: 0832-610X (ISSN-L)
1496-8975
DOI: 10.1007/s12630-023-02440-3
OpenAlex: W4361212412
Cited by: 207
References: 12
Citations by year: 2026: 55 · 2025: 58 · 2024: 70 · 2023: 24
FWCI: 68.56
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.springernature.com/gp/researchers/text-and-data-mining (tdm)
www.springernature.com/gp/researchers/text-and-data-mining (vor)
Locations: Canadian Journal of Anesthesia/Journal canadien d anesthésie (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Anesthesiology and Pain Medicine › Airway Management and Intubation Techniques
Health Sciences › Medicine › Anesthesiology and Pain Medicine › Anesthesia and Sedative Agents
Health Sciences › Medicine › Surgery › Enhanced Recovery After Surgery
Keywords: semaglutide, delayed gastric emptying, GLP-1 receptor agonists, weight loss, Barrett's esophagus, upper gastrointestinal endoscopy, anesthesia induction, endotracheal intubation, bronchial aspiration, bronchoscopy
MeSH terms: Semaglutide, Diabetes Mellitus, Type 2, Glucagon-Like Peptides, Humans, Weight Loss, Endoscopy, Gastrointestinal, Gastroparesis

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Semaglutide, delayed gastric emptying, and intraoperative pulmonary aspiration: a case report

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