Expression of Membrane Progesterone Receptors (mPR/PAQR) in Ovarian Cancer Cells: Implications for Progesterone-Induced Signaling Events

Charles, Nathan J.; Thomas, Peter; Lange, Carol A.

doi:10.1007/s12672-010-0023-9

Cited by 86Estrogen and related hormone effectsOvarian cancer diagnosis and treatmentOvarian function and disorders

Expression of Membrane Progesterone Receptors (mPR/PAQR) in Ovarian Cancer Cells: Implications for Progesterone-Induced Signaling Events

Open access

Charles, Nathan J., Thomas, Peter, Lange, Carol A.·2010·Hormones and Cancer

DOI 10.1007/s12672-010-0023-9PMC PMC3926102

Open this paper in CoChat — free account Open PDF

Abstract

The high mortality rates associated with ovarian cancer are largely due to a lack of highly effective treatment options for advanced stage disease; a time when initial diagnosis most commonly occurs. Recent evidence suggests that the steroid hormone, progesterone, may possess anti-tumorigenic properties. With the discovery of a new class of membrane-bound progesterone receptors (mPRs) belonging to the progestin and adipoQ receptor (PAQR) gene family in the ovary, there are undefined mechanisms by which progesterone may inhibit tumor progression. Therefore, our goal was to define potential mPR-dependent signaling mechanisms operative in ovarian cancer cells. We detected abundant mPRα (PAQR7), mPRβ (PAQR8), and mPRγ (PAQR5), but not classical nuclear PR (A or B isoforms) mRNA expression and mPRα protein expression in a panel of commonly used ovarian cancer cell lines. In contrast to mPR action in breast cancer cells, progesterone alone failed to induce changes in cyclic adenosine monophosphate (cAMP) levels in ovarian cancer cells. However, progesterone enhanced cAMP production by β(1,2)-adrenergic receptors and increased isoproterenol-induced transcription from a cAMP response element (CRE)-driven reporter gene. Independently of β-adrenergic signaling, we additionally observed activation of both JNK1/2 and p38 MAPK in response to progesterone alone. This finding was supported by the results of a screen for potential mPR gene targets. Progesterone induced a significant increase in transcription of the pro-apoptotic marker BAX, whose activity and expression has been linked to JNK1/2 and p38 signaling. Inhibitors of JNK, but not p38, blocked progesterone-induced BAX expression. Taken together, these observations implicate at least two distinct signaling pathways that may be utilized by mPRs in ovarian cancer cells that exhibit regulatory genomic changes. These studies on mPR signaling in ovarian cancer lay the foundation for future work aimed at understanding how progesterone exerts its anti-tumorigenic effects in the ovary and suggest that pharmacologic activation of mPRs, abundantly expressed in ovarian cancers, may provide a new treatment option for patients with advanced stage disease.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1007/s12672-010-0023-9

Cites

55 of 55 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Most of progesterone's behavioral effects may result from its conversion to allopregnanolone rather than from classical nuclear progesterone receptor signaling.
“While P4 may exert behavioral effects through the classical nuclear P4 receptor (PR) mechanism64, most of P4’s effect may correspond to P4 conversion to ALLO63.”
From Emerging insights into hypothalamic‐pituitary‐gonadal axis regulation and interaction with stress signalling (2018) · cites this paper as [64]
The Results and Discussion (page unavailable) examine progesterone signaling through membrane receptors in ovarian cancer cells, not behavioral effects. Searches for allopregnanolone, progesterone conversion, and behavioral effects found no passage addressing whether conversion accounts for most of progesterone’s behavioral effects. (LLM, conf=0.76)
Experimental — accuracy not yet measured

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cancer statistics, 2009
Jemal, A., Siegel, R., Ward, E., Hao, Y., Xu, J., & Thun, M. J. (2009) · CA: A Cancer Journal for Clinicians · doi:10.3322/caac.20006 · Cited by 9,709 · see citing works
Ovarian Cancer
Rubin, M., & Stephen, C. D. (1993) · Cited by 3,149 · see citing works
Transcriptional regulation by the phosphorylation-dependent factor CREB
Mayr, B., & Montminy, M. (2001) · Nature Reviews Molecular Cell Biology · doi:10.1038/35085068 · Cited by 2,587 · see citing works
Ovarian cancer and oral contraceptives: collaborative reanalysis of data from 45 epidemiological studies including 23 257 women with ovarian cancer and 87 303 controls
Collaborative Group on Epidemiological Studies of Ovarian Cancer (2008) · The Lancet · doi:10.1016/s0140-6736(08)60167-1 · Cited by 819 · see citing works
Cloning, expression, and characterization of a membrane progestin receptor and evidence it is an intermediary in meiotic maturation of fish oocytes
Zhu, Y., Rice, C. D., Pang, Y., Pace, M. C., & Thomas, P. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0336132100 · Cited by 798 · see citing works
Self-citation
Identification, classification, and partial characterization of genes in humans and other vertebrates homologous to a fish membrane progestin receptor
Zhu, Y., Bond, J. E., & Thomas, P. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0436133100 · Cited by 710 · see citing works
Self-citation
Ovarian Cancer
Cho, K. R., & Shih, I. (2008) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev.pathol.4.110807.092246 · Cited by 694 · see citing works
JNK- and p38 kinase-mediated phosphorylation of Bax leads to its activation and mitochondrial translocation and to apoptosis of human hepatoma HepG2 cells
Kim, B.-J., Ryu, S.-W., & Song, B.-J. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m510644200 · Cited by 470 · see citing works
Association between cisplatin resistance and mutation of p53 gene and reduced bax expression in ovarian carcinoma cell systems.
Perego, P., Giarola, M., Righetti, S. C., Supino, R., Caserini, C., Delia, D., Pierotti, M. A., Miyashita, T., Reed, J. C., & Zunino, F. (1996) · PubMed · Cited by 386 · see citing works
Estradiol Activates Group I and II Metabotropic Glutamate Receptor Signaling, Leading to Opposing Influences on cAMP Response Element-Binding Protein
Boulware, M. I., Weick, J. P., Becklund, B. R., Kuo, S. P., Groth, R. D., & Mermelstein, P. G. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.1427-05.2005 · Cited by 379 · see citing works
Sustained Activation of JNK/p38 MAPK Pathways in Response to Cisplatin Leads to Fas Ligand Induction and Cell Death in Ovarian Carcinoma Cells
Mansouri, A., Ridgway, L. D., Korapati, A. L., Zhang, Q. C., Tian, L., Wang, Y., Siddik, Z. H., Mills, G. B., & Claret, F. X. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m208134200 · Cited by 377 · see citing works
Cancer Incidence in a Cohort of Infertile Woman
Modan, B., Ron, E., Lerner‐Geva, L., Blumstein, T., Menczer, J., Rabinovici, J., Oelsner, G., Freedman, L. S., Mashiach, S., & Lunenfeld, B. (1998) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a009397 · Cited by 360 · see citing works
Characteristics of membrane progestin receptor alpha (mPRα) and progesterone membrane receptor component 1 (PGMRC1) and their roles in mediating rapid progestin actions
Thomas, P. (2008) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2008.01.001 · Cited by 352 · see citing works
Self-citation
Parity, age at first childbirth, and risk of ovarian cancer
Adami, H., Lambe, M. P., Persson, I., Ekbom, A., Adami, H., Hsieh, C. C., Trichopoulos, D., Ekbom, A., Lambe, M. P., Leon, D. A., et al. (1994) · The Lancet · doi:10.1016/s0140-6736(94)90749-8 · Cited by 347 · see citing works
The ASK1-MAP Kinase Cascades in Mammalian Stress Response
Matsukawa, J. (2004) · Journal of Biochemistry · doi:10.1093/jb/mvh134 · Cited by 343 · see citing works
G protein‐coupled receptor hetero‐dimerization: contribution to pharmacology and function
Milligan, G. (2009) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2009.00169.x · Cited by 326 · see citing works
Expanding roles for β-arrestins as scaffolds and adapters in GPCR signaling and trafficking
Miller, W. E., & Lefkowitz, R. J. (2001) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(00)00190-3 · Cited by 322 · see citing works
Progesterone Signaling in Human Myometrium through Two Novel Membrane G Protein-Coupled Receptors: Potential Role in Functional Progesterone Withdrawal at Term
Karteris, E., Zervou, S., Pang, Y., Dong, J., Hillhouse, E. W., Randeva, H. S., & Thomas, P. (2006) · Molecular Endocrinology · doi:10.1210/me.2005-0243 · Cited by 315 · see citing works
Self-citation
Steroid and G Protein Binding Characteristics of the Seatrout and Human Progestin Membrane Receptor α Subtypes and Their Evolutionary Origins
Thomas, P., Pang, Y., Dong, J., Groenen, P. M. A., Kelder, J., de Vlieg, J., Zhu, Y., & Tubbs, C. W. (2006) · Endocrinology · doi:10.1210/en.2006-0974 · Cited by 312 · see citing works
Self-citation
The functional Interactions Between the MAPK and p53 Signaling Pathways
Wu, G. S. (2004) · Cancer Biology & Therapy · doi:10.4161/cbt.3.2.614 · Cited by 311 · see citing works
Expression of human estrogen receptor-α and -β, progesterone receptor, and androgen receptor mRNA in normal and malignant ovarian epithelial cells
Lau, K., Mok, S. C., & Ho, S. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.10.5722 · Cited by 281 · see citing works
Expression of gonadotropin receptor and growth responses to key reproductive hormones in normal and malignant human ovarian surface epithelial cells.
Syed, V., Ulinski, G., Mok, S. C., Yiu, G. K., & Ho, S. (2001) · PubMed · Cited by 245 · see citing works
Effect of progestin on the ovarian epithelium of macaques: cancer prevention through apoptosis? 1☆
Rodríguez, G., Walmer, D. K., CLINE, M., Krigman, H. R., Lessey, B. A., Whitaker, R. S., Dodge, R. K., & Hughes, C. L. (1998) · Journal of the Society for Gynecologic Investigation · doi:10.1016/s1071-5576(98)00017-3 · Cited by 213 · see citing works
Paclitaxel (Taxol)-induced Gene Expression and Cell Death Are Both Mediated by the Activation of c-Jun NH2-terminal Kinase (JNK/SAPK)
Lee, L., Li, G., Templeton, D. J., & Ting, J. P. ‐. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.43.28253 · Cited by 197 · see citing works
A Case-Control Study of Oral Contraceptive Use and Invasive Epithelial Ovarian Cancer
Rosenberg, L. A., Palmer, J. R., Zauber, A. G., Warshauer, M. E., Lewis, J. L., Strom, B. L., Harlap, S., & Shapiro, S. (1994) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a117055 · Cited by 195 · see citing works
Phosphorylation of Progesterone Receptor Serine 400 Mediates Ligand-Independent Transcriptional Activity in Response to Activation of Cyclin-Dependent Protein Kinase 2
Pierson-Mullany, L. K., & Lange, C. A. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.24.10542-10557.2004 · Cited by 135 · see citing works
Self-citation
WT1, Estrogen Receptor, and Progesterone Receptor as Markers for Breast or Ovarian Primary Sites in Metastatic Adenocarcinoma to Body Fluids
Lee, B. H., Hecht, J. L., Pinkus, J. L., & Pinkus, G. S. (2002) · American Journal of Clinical Pathology · doi:10.1309/qlv6-hh0h-uctf-wef6 · Cited by 120 · see citing works
Reproductive factors of ovarian and endometrial cancer risk in a high fertility population in Mexico.
Salazar-Martı́nez, E., Lazcano-Ponce, E. C., Gonzalez‐Lira, G., Ríos, P. E.-D. L., Salmerón, J., & Hernández-Ávila, M. (1999) · PubMed · Cited by 118 · see citing works
Identification of ATF-3, caveolin-1, DLC-1, and NM23-H2 as putative antitumorigenic, progesterone-regulated genes for ovarian cancer cells by gene profiling
Syed, V., Mukherjee, K., Lyons‐Weiler, J., Lau, K., Mashima, T., Tsuruo, T., & Ho, S. (2005) · Oncogene · doi:10.1038/sj.onc.1207991 · Cited by 118 · see citing works
Cloning and Characterization of an Ovine Intracellular Seven Transmembrane Receptor for Progesterone that Mediates Calcium Mobilization
Ashley, R. L., Clay, C. M., Farmerie, T. A., NISWENDER, G. D., & Nett, T. M. (2006) · Endocrinology · doi:10.1210/en.2006-0002 · Cited by 113 · see citing works
Expression and Regulation of Progestin Membrane Receptors in the Rat Corpus Luteum
Cai, Z., & Stocco, C. O. (2005) · Endocrinology · doi:10.1210/en.2005-0759 · Cited by 109 · see citing works
Progestin-Induced Apoptosis in the Macaque Ovarian Epithelium: Differential Regulation of Transforming Growth Factor-
Rodriguez, G. C. (2002) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/94.1.50 · Cited by 109 · see citing works
bcl-2, bax, bcl-XL, and bcl-XS expression in normal and neoplastic ovarian tissues.
Marone, M., Scambia, G., Mozzetti, S., Ferrandina, G., Iacovella, S., Pasqua, A., Benedetti-Panici, P., & Mancuso, S. (1998) · PubMed · Cited by 107 · see citing works
Identification of membrane progestin receptors in human breast cancer cell lines and biopsies and their potential involvement in breast cancer
Dressing, G. E., & Thomas, P. (2006) · Steroids · doi:10.1016/j.steroids.2006.10.006 · Cited by 87 · see citing works
Self-citation
Progesterone-induced apoptosis in immortalized normal and malignant human ovarian surface epithelial cells involves enhanced expression of FasL
Syed, V., & Ho, S. (2003) · Oncogene · doi:10.1038/sj.onc.1206828 · Cited by 85 · see citing works
Progestin Signaling through an Olfactory G Protein and Membrane Progestin Receptor-α in Atlantic Croaker Sperm: Potential Role in Induction of Sperm Hypermotility
Tubbs, C. W., & Thomas, P. (2008) · Endocrinology · doi:10.1210/en.2008-0512 · Cited by 80 · see citing works
Self-citation
Endocrine signaling in ovarian surface epithelium and cancer
Leung, P. C. K., & Choi, J. (2006) · Human Reproduction Update · doi:10.1093/humupd/dml002 · Cited by 78 · see citing works
Oral Contraceptives, Other Methods of Contraception, and Risk Reduction for Ovarian Cancer
Ness, R. B., Grisso, J. A., Vergona, R., Klapper, J., Morgan, M. A., & Wheeler, J. E. (2001) · Epidemiology · doi:10.1097/00001648-200105000-00010 · Cited by 73 · see citing works
Patterns and Clinical Outcomes Associated with Routine Intravenous Sodium and Fluid Administration after Colorectal Resection
Tambyraja, A. L., Sengupta, F., MacGregor, A. B., Bartolo, D. C. C., & Fearon, K. C. H. (2004) · World Journal of Surgery · doi:10.1007/s00268-004-7383-7 · Cited by 73 · see citing works
Differential Expression of Progesterone Receptor Isoforms A and B in the Normal Ovary, and in Benign, Borderline, and Malignant Ovarian Tumors
Akahira, J., Suzuki, T., Ito, K., Kaneko, C., Darnel, A. D., Moriya, T., Okamura, K., Yaegashi, N., & Sasano, H. (2002) · Japanese Journal of Cancer Research · doi:10.1111/j.1349-7006.2002.tb01323.x · Cited by 67 · see citing works
GnRH-II Antagonists Induce Apoptosis in Human Endometrial, Ovarian, and Breast Cancer Cells via Activation of Stress-Induced MAPKs p38 and JNK and Proapoptotic Protein Bax
Fister, S., Günthert, A. R., Aicher, B., Paulini, K., Emons, G., & Gründker, C. (2009) · Cancer Research · doi:10.1158/0008-5472.can-08-4657 · Cited by 62 · see citing works
Mitogen-activated protein kinases (MAPK) as predictors of clinical outcome in serous ovarian carcinoma in effusions
Givant-Horwitz, V., Davidson, B., Lazarovici, P., SCHAEFER, E. M., Nesland, J. M., Trope, C. G., & Reich, R. (2003) · Gynecologic Oncology · doi:10.1016/s0090-8258(03)00434-7 · Cited by 58 · see citing works
Binding characteristics of the ovine membrane progesterone receptor alpha and expression of the receptor during the estrous cycle
Ashley, R. L., Arreguin-Arevalo, J. A., & Nett, T. M. (2009) · Reproductive Biology and Endocrinology · doi:10.1186/1477-7827-7-42 · Cited by 56 · see citing works
An Adenovirus Encoding Proapoptotic Bax Induces Apoptosis and Enhances the Radiation Effect in Human Ovarian Cancer
Arafat, W. O., Gómez-Navarro, J., Xiang, J., Barnes, M. N., Mahasreshti, P. J., Alvarez, R. D., Siegal, G. P., Badib, A. O., Buchsbaum, D. J., Curiel, D. T., et al. (2000) · Molecular Therapy · doi:10.1006/mthe.2000.0071 · Cited by 55 · see citing works
Pregnancy and menstrual hormone levels in mothers of twins compared to mothers of singletons
Thomas, H., Murphy, M. F., Key, T. J., Fentiman, I. S., Allen, D., & Kinlen, L. J. (1998) · Annals of Human Biology · doi:10.1080/03014469800005432 · Cited by 54 · see citing works
The age peak in childhood acute lymphoblastic leukemia
Swensen, A. R., Ross, J. A., Severson, R. K., Pollock, B. H., & Robison, L. L. (1997) · Cancer · doi:10.1002/(sici)1097-0142(19970515)79:10 · Cited by 44 · see citing works
Progesterone induces Apoptosis in TRAIL‐resistant ovarian cancer cells by circumventing c‐FLIPL overexpression
Syed, V., Mukherjee, K., Godoy‐Tundidor, S., & Ho, S. (2007) · Journal of Cellular Biochemistry · doi:10.1002/jcb.21304 · Cited by 42 · see citing works
Cyclic AMP in Ovarian Cancer Cells Both Inhibits Proliferation and Increases c-KIT Expression
Shaw, T. J., Keszthelyi, E. J., Tonary, A. M., Cada, M., & Vanderhyden, B. C. (2002) · Experimental Cell Research · doi:10.1006/excr.2001.5426 · Cited by 41 · see citing works
Relationship between aromatase activity and steroid receptor levels in ovarian tumors from postmenopausal women
Noguchi, T., Kitawaki, J., Tamura, T., Kim, T., Kanno, H., Yamamoto, T., & Okada, H. (1993) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/0960-0760(93)90275-2 · Cited by 39 · see citing works
Randomized trial of megestrol acetate vs. megestrol acetate/tamoxifen for the management of progressive or recurrent epithelial ovarian carcinoma
Belinson, J. L., McClure, M., & Badger, G. J. (1987) · Gynecologic Oncology · doi:10.1016/0090-8258(87)90208-3 · Cited by 31 · see citing works
Expression profile of heptahelical putative membrane progesterone receptors in epithelial ovarian tumors
Romero, M., Peiper, S. C., Evans, B. J., Wang, Z., Catasús, L., Ribé, A., Prat, J., & Giri, J. G. (2008) · Human Pathology · doi:10.1016/j.humpath.2007.11.007 · Cited by 26 · see citing works
Short-Term Oral Contraceptive Use and the Risk of Epithelial Ovarian Cancer
Greer, J. B., Modugno, F., Allen, G. O., & Ness, R. B. (2005) · American Journal of Epidemiology · doi:10.1093/aje/kwi162 · Cited by 25 · see citing works
The Risk of Epithelial Ovarian Cancer in Short-Term Users of Oral Contraceptives
Gross, T. P., Schlesselman, J. J., Stadel, B. V., Yu, W., & Lee, N. C. (1992) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a116419 · Cited by 22 · see citing works
Effect of progesterone combined with chemotherapy on epithelial ovarian cancer.
Chen, X., & Feng, Y. (2003) · PubMed · Cited by 9 · see citing works
Role of Estrogen and Progesterone in the Survival of Ovarian Tumors — A Study of the Human Ovarian Adenocarcinoma Cell Line OC-117-VGH
Chao, K.-C., Wang, P., Yen, M., Chang, C., & Chi, C. (2005) · Journal of the Chinese Medical Association · doi:10.1016/s1726-4901(09)70176-5 · Cited by 6 · see citing works

Flagged first, then by citations

Sorted by citations

Progestogens Used in Postmenopausal Hormone Therapy: Differences in Their Pharmacological Properties, Intracellular Actions, and Clinical Effects
Stanczyk, F. Z., Hapgood, J. P., Winer, S., & Mishell, D. R. (2013) · Endocrine Reviews · doi:10.1210/er.2012-1008 · Cited by 429 · see citing works
Emerging insights into hypothalamic‐pituitary‐gonadal axis regulation and interaction with stress signalling
Acevedo‐Rodriguez, A., Kauffman, A. S., Cherrington, B. D., Borges, C. S., Roepke, T. A., & Laconi, M. (2018) · Journal of neuroendocrinology · doi:10.1111/jne.12590 · Cited by 298 · see citing works
Membrane progesterone receptor expression in mammalian tissues: A review of regulation and physiological implications
Dressing, G. E., Goldberg, J. E., Charles, N. J., Schwertfeger, K. L., & Lange, C. A. (2010) · Steroids · doi:10.1016/j.steroids.2010.09.006 · Cited by 178 · see citing works
Self-citation
Rapid steroid hormone actions initiated at the cell surface and the receptors that mediate them with an emphasis on recent progress in fish models
Thomas, P. (2011) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2011.11.032 · Cited by 164 · see citing works
Self-citation
Membrane Progesterone Receptors: Evidence for Neuroprotective, Neurosteroid Signaling and Neuroendocrine Functions in Neuronal Cells
Thomas, P., & Pang, Y. (2012) · Neuroendocrinology · doi:10.1159/000339822 · Cited by 160 · see citing works
Self-citation
Hormone response in ovarian cancer: time to reconsider as a clinical target?
Modugno, F., Laskey, R. A., Smith, A. L., Andersen, C. L., Haluska, P., & Oesterreich, S. (2012) · Endocrine Related Cancer · doi:10.1530/erc-12-0175 · Cited by 126 · see citing works
Membrane progesterone receptors in reproduction and cancer
Valadez-Cosmes, P., Vázquez-Martínez, E. R., Cerbón, M. A., & Camacho‐Arroyo, I. (2016) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2016.06.027 · Cited by 114 · see citing works
Membrane-Initiated Estrogen, Androgen, and Progesterone Receptor Signaling in Health and Disease
Mauvais‐Jarvis, F., Lange, C. A., & Levin, E. R. (2021) · Endocrine Reviews · doi:10.1210/endrev/bnab041 · Cited by 95 · see citing works
Self-citation
Progesterone receptors induce FOXO1-dependent senescence in ovarian cancer cells
Diep, C. H., Charles, N. J., Gilks, C. B., Kalloger, S. E., Argenta, P. A., & Lange, C. A. (2013) · Cell Cycle · doi:10.4161/cc.24550 · Cited by 94 · see citing works
Self-citation
Mitogen-Activated Protein Kinase Signal Transduction in Solid Tumors
Lei, Y., Wang, W., Mei, J.-H., & Wang, C. (2014) · Asian Pacific Journal of Cancer Prevention · doi:10.7314/apjcp.2014.15.20.8539 · Cited by 92 · see citing works
Membrane Progesterone Receptors (mPRs, PAQRs): Review of Structural and Signaling Characteristics
Thomas, P. (2022) · Cells · doi:10.3390/cells11111785 · Cited by 90 · see citing works
Self-citation
Antiprogestin mifepristone inhibits the growth of cancer cells of reproductive and non-reproductive origin regardless of progesterone receptor expression
Tieszen, C. R., Goyeneche, A. A., Brandhagen, B. N., Ortbahn, C. T., & Telleria, C. M. (2011) · BMC Cancer · doi:10.1186/1471-2407-11-207 · Cited by 80 · see citing works
Magnetic casein-CaFe2O4 nanohybrid carrier conjugated with progesterone for enhanced cytotoxicity of citrus peel derived hesperidin drug towards breast and ovarian cancer
Purushothaman, B. K., Uma Maheswari, P., & Begum, K. M. M. S. (2020) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2020.02.172 · Cited by 61 · see citing works
Cell division cycle associated 5 promotes colorectal cancer progression by activating the ERK signaling pathway
Shen, A., Liu, L., Chen, H., Qi, F., Huang, Y., Lin, J., Sferra, T. J., Sankararaman, S., Wei, L., Chu, J., et al. (2019) · Oncogenesis · doi:10.1038/s41389-019-0123-5 · Cited by 52 · see citing works
Molecular Characterization of Membrane Steroid Receptors in Hormone-Sensitive Cancers
Masi, M., Racchi, M., Travelli, C., Corsini, E., & Buoso, E. (2021) · Cells · doi:10.3390/cells10112999 · Cited by 49 · see citing works
Twenty years of transcriptomics, 17alpha-ethinylestradiol, and fish
Martyniuk, C. J., Feswick, A., Munkittrick, K. R., Dreier, D. A., & Denslow, N. D. (2019) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2019.113325 · Cited by 48 · see citing works
Progestin-mediated activation of MAPK and AKT in nuclear progesterone receptor negative breast epithelial cells: The role of membrane progesterone receptors
Salazar, M. G. S., Lerma-Ortiz, A., Hooks, G. M., Ashley, A. K., & Ashley, R. L. (2016) · Gene · doi:10.1016/j.gene.2016.06.044 · Cited by 45 · see citing works
Membrane progesterone receptors β and γ have potential as prognostic biomarkers of endometrial cancer
Sinreih, M., Knific, T., Thomas, P., Grazio, S. F., & Rižner, T. L. (2018) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2018.01.011 · Cited by 44 · see citing works
Self-citation
Activation of membrane progesterone receptor-alpha increases proliferation, migration, and invasion of human glioblastoma cells
González-Orozco, J. C., Hansberg-Pastor, V., Valadez-Cosmes, P., Nicolas-Ortega, W., Bastida-Beristain, Y., Fuente, M. D. L., González‐Arenas, A., & Camacho‐Arroyo, I. (2018) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2018.06.004 · Cited by 44 · see citing works
The regulation of ovary and conceptus on the uterine natural killer cells during early pregnancy
Gong, H., Chen, Y., Xu, J., Xie, X., Yu, D., Yang, B., & Kuang, H. (2017) · Reproductive Biology and Endocrinology · doi:10.1186/s12958-017-0290-1 · Cited by 41 · see citing works
Expression and hormonal regulation of membrane progesterone receptors in human astrocytoma cells
Valadez-Cosmes, P., German‐Castelan, L., González‐Arenas, A., Velasco-Velázquez, M. A., Hansberg-Pastor, V., & Camacho‐Arroyo, I. (2015) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2015.08.006 · Cited by 33 · see citing works
Emerging roles of CCM genes during tumorigenesis with potential application as novel biomarkers across major types of cancers
Abou‐Fadel, J., Qu, Y., Gonzalez, E. M., Smith, M., & Zhang, J. (2020) · Oncology Reports · doi:10.3892/or.2020.7550 · Cited by 33 · see citing works
Expression of Membrane Progesterone Receptors in Eutopic and Ectopic Endometrium of Women with Endometriosis
Vázquez-Martínez, E. R., Bello‐Alvarez, C., Hermenegildo-Molina, A. L., Solis‐Paredes, J. M., Parra-Hernández, S., Cruz-Orozco, O., Silvestri-Tomassoni, J. R., Escobar-Ponce, L. F., Hernández-López, L. A., Reyes-Mayoral, C., et al. (2020) · BioMed Research International · doi:10.1155/2020/2196024 · Cited by 31 · see citing works
PAQR3: a novel tumor suppressor gene.
Yu, X., Li, Z., Chan, M. T. V., & Wu, W. K. K. (2015) · Europe PMC (PubMed Central) · Cited by 31 · see citing works
Membrane progesterone receptor induces meiosis in Xenopus oocytes through endocytosis into signaling endosomes and interaction with APPL1 and Akt2
Nader, N., Dib, M., Hodeify, R. F., Courjaret, R. J., Elmi, A. A., Hammad, A. S., Dey, R., Huang, X., & Machaca, K. (2020) · PLoS Biology · doi:10.1371/journal.pbio.3000901 · Cited by 29 · see citing works
Selective ligands of membrane progesterone receptors as a key to studying their biological functions in vitro and in vivo
Levina, I. S., Kuznetsov, Y. V., Shchelkunova, T. A., & Zavarzin, I. V. (2021) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2021.105827 · Cited by 26 · see citing works
Establishment of procedures for studying mPR-interacting agents and physiological roles of mPR
Tokumoto, T., Hossain, M. B., & Wang, J. (2016) · Steroids · doi:10.1016/j.steroids.2016.02.015 · Cited by 25 · see citing works
Progesterone inhibits proliferation and modulates expression of proliferation—Related genes in classical progesterone receptor-negative human BxPC3 pancreatic adenocarcinoma cells
Goncharov, A. I., Maslakova, А. А., Polikarpova, A. V., Bulanova, E. A., Guseva, A. A., Morozov, I. A., Рубцов, П. М., Smirnova, О. V., & Shchelkunova, T. A. (2016) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2016.07.007 · Cited by 23 · see citing works
Participation of membrane progesterone receptor α in the inhibitory effect of progesterone on prolactin secretion
Camilletti, M. A., Ferraris, J., Abeledo-Machado, A., Converse, A., Faraoni, E. Y., Pisera, D. A., Gutiérrez, S., Thomas, P., & Dı́az-Torga, G. (2018) · Journal of Neuroendocrinology · doi:10.1111/jne.12614 · Cited by 22 · see citing works
Self-citation
Progesterone/Org inhibits lung adenocarcinoma cell growth via membrane progesterone receptor alpha
Xiao, J., Chen, X., Lu, X., Xie, M., He, B., He, S., You, S., & Chen, Q. (2020) · Thoracic Cancer · doi:10.1111/1759-7714.13528 · Cited by 22 · see citing works
PAQR6 Upregulation Is Associated with AR Signaling and Unfavorite Prognosis in Prostate Cancers
Yang, M., Li, J. C., Chang, T., Wu, S., Liu, B., Shu, Q., Li, B., & Zhu, R. (2021) · Biomolecules · doi:10.3390/biom11091383 · Cited by 20 · see citing works
Calm the raging hormone - a new therapeutic strategy involving progesterone-signaling for hemorrhagic CCMs
Zhang, J., & Abou‐Fadel, J. (2021) · Vessel Plus · doi:10.20517/2574-1209.2021.64 · Cited by 20 · see citing works
CmP signaling network unveils novel biomarkers for triple negative breast cancer in African American women
Abou‐Fadel, J., Grajeda, B. I., Jiang, X., Alyssa-Marie Cailing-De La, O., Flores, E., Padarti, A., Bhalli, M., Le, A., & Zhang, J. (2022) · Cancer Biomarkers · doi:10.3233/cbm-210351 · Cited by 20 · see citing works
PAQR8 promotes breast cancer recurrence and confers resistance to multiple therapies
Chen, S., Paul, M. R., Sterner, C. J., Belka, G. K., Wang, D., Xu, P. J., Sreekumar, A., Pan, T.-C., Pant, D. K., Makhlin, I., et al. (2023) · Breast Cancer Research · doi:10.1186/s13058-022-01559-3 · Cited by 20 · see citing works
Membrane progesterone receptor α (mPRα) enhances hypoxia-induced vascular endothelial growth factor secretion and angiogenesis in lung adenocarcinoma through STAT3 signaling
Xia, Z., Xiao, J., Dai, Z., & Chen, Q. (2022) · Journal of Translational Medicine · doi:10.1186/s12967-022-03270-5 · Cited by 18 · see citing works
The Role of mPRδ and mPRε in Human Glioblastoma Cells: Expression, Hormonal Regulation, and Possible Clinical Outcome
Moral‐Morales, A. D., González-Orozco, J. C., Capetillo-Velázquez, J. M., Piña-Medina, A. G., & Camacho‐Arroyo, I. (2020) · Hormones and Cancer · doi:10.1007/s12672-020-00381-7 · Cited by 18 · see citing works
Progesterone signaling in the regulation of luteal steroidogenesis
Yakın, K., Hela, F., & Öktem, Ö. (2023) · Molecular Human Reproduction · doi:10.1093/molehr/gaad022 · Cited by 17 · see citing works
CmP Signaling Network Leads to Identification of Prognostic Biomarkers for Triple-Negative Breast Cancer in Caucasian Women
Abou‐Fadel, J., Bhalli, M., Grajeda, B. I., & Zhang, J. (2022) · Genetic Testing and Molecular Biomarkers · doi:10.1089/gtmb.2021.0221 · Cited by 16 · see citing works
Reevaluating the Role of Progesterone in Ovarian Cancer: Is Progesterone Always Protective?
Mauro, L. J., Spartz, A. K., Austin, J. R., & Lange, C. A. (2023) · Endocrine Reviews · doi:10.1210/endrev/bnad018 · Cited by 16 · see citing works
Self-citation
Characterization of Golgi scaffold proteins and their roles in compartmentalizing cell signaling
Peng, W., Qiang, L., Jiang, Z., & Hu, Z. (2013) · Journal of Molecular Histology · doi:10.1007/s10735-013-9560-1 · Cited by 16 · see citing works
Progesterone decreases ovarian cancer cells migration and invasion
Lima, M. A., Silva, S. V., Jaeger, R. G., & Freitas, V. M. (2020) · Steroids · doi:10.1016/j.steroids.2020.108680 · Cited by 16 · see citing works
Requirement for LIM kinases in acute myeloid leukemia
Jensen, P., Carlet, M., Schlenk, R. F., Weber, A., Kress, J., Brunner, I., Slabicki, M. M., Grill, G., Weisemann, S., Cheng, Y., et al. (2020) · Leukemia · doi:10.1038/s41375-020-0943-5 · Cited by 15 · see citing works
Expression of Progesterone Receptor Membrane Component 1 (PGRMC1), Progestin and AdipoQ Receptor 7 (PAQPR7), and Plasminogen Activator Inhibitor 1 RNA-Binding Protein (PAIRBP1) in Glioma SpheroidsIn Vitro
Hlavatý, J., Ertl, R., Miller, I., & Gabriel, C. (2016) · BioMed Research International · doi:10.1155/2016/8065830 · Cited by 15 · see citing works
Non-genomic mechanisms mediate androgen-induced PSD95 expression
Zhang, Y., Li, S., Chen, H., Chen, M., Mi, S., Ma, J., Wang, C., Sun, H., Liu, X., & Cui, H. (2019) · Aging · doi:10.18632/aging.101913 · Cited by 15 · see citing works
Molecular basis and tissue specificity of the progestin effect
Shchelkunova, T. A., & Morozov, I. A. (2015) · Molecular Biology · doi:10.1134/s0026893315050155 · Cited by 14 · see citing works
Characterization of the Golgi scaffold protein PAQR3, and its role in tumor suppression and metabolic pathway compartmentalization
Lan, L., Ling, Z., Chen, X., Hong, L., & Ling, Z. (2020) · Cancer Management and Research · doi:10.2147/cmar.s210919 · Cited by 14 · see citing works
PAQR7: An intermediary mediating nongenomic progesterone action in female reproductive tissue
Wang, Y., Luo, T., Zheng, L., Huang, J., Zheng, Y., & Li, J. (2021) · Reproductive Biology · doi:10.1016/j.repbio.2021.100529 · Cited by 14 · see citing works
Mitogen-Activated Protein Kinase and Nuclear Hormone Receptor Crosstalk in Cancer Immunotherapy
Burgermeister, E. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241713661 · Cited by 13 · see citing works
Mechanism of Progesterone Action in the Brain
Camacho‐Arroyo, I., Hansberg-Pastor, V., Vázquez-Martínez, E. R., & Cerbón, M. A. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-803592-4.00053-5 · Cited by 14 · see citing works
Pigmentation-Independent Susceptibility Loci for Actinic Keratosis Highlighted by Compound Heterozygosity Analysis
Zhong, K., Verkouteren, J. A. C., Jacobs, L. C., Uitterlinden, A. G., Albert Hofman, D., Liu, F., Nijsten, T. E. C., & Kayser, M. (2016) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2016.09.007 · Cited by 12 · see citing works
Milk protein inspired multifunctional magnetic carrier targeting progesterone receptors: Improved anticancer potential of soybean-derived genistein against breast and ovarian cancers
Bindhya, K. P., Maheswari, P. U., & Begum, K. M. M. S. (2021) · Materials Chemistry and Physics · doi:10.1016/j.matchemphys.2021.125055 · Cited by 12 · see citing works
Correction: Membrane progesterone receptor induces meiosis in Xenopus oocytes through endocytosis into signaling endosomes and interaction with APPL1 and Akt2
Nader, N., Dib, M., Hodeify, R. F., Courjaret, R. J., Elmi, A. A., Hammad, A. S., Dey, R., Huang, X.-Y., & Machaca, K. (2021) · PLoS Biology · doi:10.1371/journal.pbio.3001117 · Cited by 12 · see citing works
Identification of 17 mRNAs and a miRNA as an integrated prognostic signature for lung squamous cell carcinoma
Zhang, J., Bing, Z., Yan, P., Tian, J., Shi, X., Wang, Y., & Yang, K. (2019) · The Journal of Gene Medicine · doi:10.1002/jgm.3105 · Cited by 11 · see citing works
Expression of nuclear progesterone receptors (nPRs), membrane progesterone receptors (mPRs) and progesterone receptor membrane components (PGRMCs) in the human endometrium after 6 months levonorgestrel low dose intrauterine therapy
Sletten, E. T., Smaglyukova, N., Ørbo, A., & Sager, G. (2020) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2020.105701 · Cited by 10 · see citing works
Progesterone receptor‐Src kinase signaling pathway mediates neuroprogesterone induction of the luteinizing hormone surge in female rats
Chuon, T., Feri, M., Carlson, C., Ondrejik, S., Micevych, P. E., & Sinchak, K. (2021) · Journal of Neuroendocrinology · doi:10.1111/jne.13071 · Cited by 10 · see citing works
Identifying Gene Signature for the Detection of Ovarian Cancer Based on the Achieved Related Genes
Wang, L., Wang, L., Ma, L., Liu, J., & Ma, S. (2016) · Gynecologic and Obstetric Investigation · doi:10.1159/000449160 · Cited by 9 · see citing works
PAQR5 inhibits the growth and metastasis of clear cell renal cell carcinoma by suppressing the JAK/STAT3 signaling pathway
Wang, L., Yue, Y., Zhang, L., Jing, M., Ma, M., Liu, C., Li, Y., Xu, S., Wang, K., Wang, X., et al. (2023) · Cellular Oncology · doi:10.1007/s13402-023-00813-w · Cited by 9 · see citing works
5alpha-dihydroprogesterone promotes proliferation and migration of human glioblastoma cells
Zamora-Sánchez, C. J., Hernández-Vega, A. M., Gaona-Domínguez, S., Rodríguez‐Dorantes, M., & Camacho‐Arroyo, I. (2020) · Steroids · doi:10.1016/j.steroids.2020.108708 · Cited by 9 · see citing works
Antiprogestins in Ovarian Cancer
Carlos, M., & Alicia, A. (2012) · InTech eBooks · doi:10.5772/25269 · Cited by 9 · see citing works
Cytotoxic Effects of the Selective Ligands of Membrane Progesterone Receptors in Human Pancreatic Adenocarcinoma Cells BxPC3
Goncharov, A. I., Levina, I. S., Shliapina, V. L., Morozov, I. A., Рубцов, П. М., Zavarzin, I. V., Smirnova, О. V., & Shchelkunova, T. A. (2021) · Biochemistry (Moscow) · doi:10.1134/s0006297921110080 · Cited by 8 · see citing works
Progestins and carcinogenesis
Shchelkunova, T. A., & Morozov, I. A. (2016) · Molecular Biology · doi:10.1134/s0026893316010179 · Cited by 7 · see citing works
PAQR5 drives the malignant progression and shapes the immunosuppressive microenvironment of hepatocellular carcinoma by activating the NF-κB signaling
Yang, R., Wang, H., Wu, C., Shi, Y. H., Li, H., Bao, X., Yang, Y., Han, S., Yang, X. C., Tao, J., et al. (2025) · Biomarker Research · doi:10.1186/s40364-025-00785-z · Cited by 6 · see citing works
Antitumor progestins activity: Cytostatic effect and immune response
Pavlík, T., Кончеков, Е. М., & Шимановский, Н. Л. (2024) · Steroids · doi:10.1016/j.steroids.2024.109474 · Cited by 6 · see citing works
Effect of Steroid Hormones, Prostaglandins (E2 and F2α), Oxytocin, and Tumor Necrosis Factor Alpha on Membrane Progesterone (P4) Receptors Gene Expression in Bovine Myometrial Cells
Kowalik, M. K., Dobrzyn, K., Młynarczuk, J., & Rękawiecki, R. (2022) · Animals · doi:10.3390/ani12040519 · Cited by 6 · see citing works
Progesterone limits the tumor-promoting effects of the beta-subunit of human chorionic gonadotropin via non-nuclear receptors
Sarkar, M., Sharma, H., Singh, P. P., Ranu, R., Sharma, R. D., Agrawal, U., & Pal, R. (2022) · iScience · doi:10.1016/j.isci.2022.104527 · Cited by 4 · see citing works
Inhibitory effects of progesterone on the human acute lymphoblastic leukemia cell line
Fallahi, N., Rafiee, M., Azaryan, E., Wilkinson, D. M., & Bagheri, V. (2024) · Gene Reports · doi:10.1016/j.genrep.2024.101991 · Cited by 4 · see citing works
Disrupting the CmP signaling network unveils novel biomarkers for triple negative breast cancer in Caucasian American womenPreprint
Abou‐Fadel, J., Bhalli, M., Grajeda, B. I., & Zhang, J. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.09.13.460145 · Cited by 4 · see citing works
PGRMC1 and PAQR4 are promising molecular targets for a rare subtype of ovarian cancer
Kozłowska-Tomczyk, K., Borski, N., Głód, P., Gogola-Mruk, J., & Ptak, A. (2024) · Open Life Sciences · doi:10.1515/biol-2022-0982 · Cited by 3 · see citing works
Expression and prognosis analysis of PAQR5 in kidney cancer
Lu, T., Xu, H., Dong, W., & Dong, H. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.955510 · Cited by 3 · see citing works
Molekularny mechanizm działania progesteronu w żeńskim układzie rozrodczym
Dobrzyn, K., & Kowalik, M. K. (2022) · Postępy Biochemii · doi:10.18388/pb.2021_458 · Cited by 2 · see citing works
Characterization of the Function of the Azospirillum brasilense Che1 Chemotaxis Pathway in the Regulation of Chemotaxis, Cell Length and Clumping
Bible, A. N. (2012) · Cited by 2 · see citing works
Hesperetin increases membrane progesterone receptor expression in human myeloid leukemia cells and reduces ROS
Hosseini, S. S., Esmailzadeh, E., Zangooei, M., & Bagheri, V. (2025) · Medical Oncology · doi:10.1007/s12032-025-02975-z · Cited by 1 · see citing works
Context-dependent effects of progesterone 4-pregnene metabolites on apoptosis and proliferation in ovarian cancer cell lines IGROV-1 and SK-OV-3
Sanhueza, M. D. L. Á., Pelegrina, L. T., Cáceres, A. R. R., Cardone, D. A., Cerdeño, M. R., Cannavó, J. I., Bruna, F., Cuello-Carrión, F. D., & Laconi, M. R. (2025) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2025.106900 · Cited by 1 · see citing works
Interactions Between Neurotrophins and Ovarian Steroids in Endometriosis and Their Implications for Neuroangiogenesis: A Narrative Review
Hernández-Hernández, O. T., Velázquez-Hernández, D. M., & Camacho‐Arroyo, I. (2026) · Current Issues in Molecular Biology · doi:10.3390/cimb48070649 · Cited by 1 · see citing works
Hypoxia-inducible factor inhibition affects luteal function with no effect on fertility in mice
Marinoni, R., Marco, M. J. E. D., Velázquez, C., Prost, K., Parborell, F., Tesone, M., & Abramovich, D. (2024) · Reproduction · doi:10.1530/rep-24-0313 · Cited by 1 · see citing works
Distribution of Progesterone Receptors and the Membrane Component of the Progesterone Receptor in Various Organs and Tissues of Male and Female Rats
Dmitrieva, A. D., Morozov, I. A., Karkhov, A. M., Рубцов, П. М., Smirnova, О. V., & Shchelkunova, T. A. (2024) · Biochemistry (Moscow) Supplement Series A Membrane and Cell Biology · doi:10.1134/s1990747825700047 · Cited by 1 · see citing works
Цитотоксические эффекты селективных лигандов мембранных рецепторов прогестерона в клетках ВхРС3 аденокарциномы поджелудочной железы человека
Goncharov, A. I., Levina, I. S., Shliapina, V. L., Морозов, И. А., Рубцов, П. М., Zavarzin, I. V., Smirnova, О. V., & Shchelkunova, T. A. (2021) · Biochemistry (Moscow) · doi:10.31857/s0320972521110087 · Cited by 1 · see citing works
Role of Progesterone Receptors in Neonatal Ovary Development
Dzyadyk, M. N. (2012) · Syracuse University Libraries (Syracuse University)
Improving the risk assessment of inherited breast and ovarian cancer : clinical significance of BRCA1/2 variants and risk modifiers
Brandão, R. D. (2012) · doi:10.26481/dis.20121031rb
Progesterone receptor modulators in breast cancer
Wiehle, R. D., & ** (2014) · TURKISH JOURNAL OF BIOLOGY · doi:10.3906/biy-1407-44
Influência dos hormônios esteroidais na migração, invasão e expressão das proteases ADAMTS 1 e 4 em células derivadas de tumores de ovários.
Lima, M. A. (2015) · doi:10.11606/d.42.2015.tde-05102015-190307
Expression of Mitochondrial Progesterone Receptor (PR-M) in Ovarian Cancer and Its Effect on Cell Metastasis Induced by ProgesteronePreprint
Yang, Q., Duan, C., Wang, H., Jiang, D., Wang, Y., Tian, Q., & Feng, Q. (2021) · Research Square · doi:10.21203/rs.3.rs-285751/v1
Função da progesterona e da protease ADAMTS-1 na migração de células derivadas de câncer de ovário.
Lima, M. A. (2020) · doi:10.11606/t.42.2020.tde-13082020-092104
LncRNA GUSBP11/miR-28-5p/PAQR7 axis regulates the phosphorylation of E-cadherin and N-cadherin on the migration of papillary thyroid carcinoma cellsPreprint
Shi, J., Xiang, Y., Liu, Y.-M., Guo, H., Li, H., & Liao, X. (2024) · Research Square · doi:10.21203/rs.3.rs-4952662/v1
Distribution of progesterone receptors and the membrane component of progesterone receptor in various organs and tissues of male and female rats
Dmitrieva, A. D., Morozov, I. A., Karkhov, A. M., Рубцов, П. М., Smirnova, О. V., & Shchelkunova, T. A. (2024) · Биологические мембраны Журнал мембранной и клеточной биологии · doi:10.31857/s0233475524040052
Identification of a novel natural compound that acts on the membrane progestin receptor α (paqr7) from the marine algae Padina
Amin, M. T., Kodani, S., Nakagawa, H., Furukawa, T., Ahamed, S., Naser, A. A., Yamaguchi, K., Omori, Y., Hossain, S., Hassan, M. M., et al. (2026) · Scientific Reports · doi:10.1038/s41598-026-36682-0

The role of non‐genomic actions of progesterone and its membrane receptor agonist in ovarian cancer cell death
Koyanagi, T., Saga, Y., Takahashi, Y., Tamura, K., Yoshiba, T., Takahashi, S., Taneichi, A., Takei, Y., Mizukami, H., & Fujiwara, H. (2023) · Cancer Reports · doi:10.1002/cnr2.1934 · Cited by 4 · see citing works
Ovarian cancer cell death induced by non-genomic action of progesterone and its receptor agonist via membrane receptorsPreprint
Koyanagi, T., Saga, Y., Takahashi, Y., Tamura, K., Yoshiba, T., Takahashi, S., Taneichi, A., Takei, Y., Mizukami, H., & Fujiwara, H. (2023) · doi:10.22541/au.168681067.74247928/v1
Expression profile of heptahelical putative membrane progesterone receptors in epithelial ovarian tumors
Romero, M., Peiper, S. C., Evans, B. J., Wang, Z., Catasús, L., Ribé, A., Prat, J., & Giri, J. G. (2008) · Human Pathology · doi:10.1016/j.humpath.2007.11.007 · Cited by 26 · see citing works
Membrane Progesterone Receptors (mPRs) Mediate Progestin Induced Antimorbidity in Breast Cancer Cells and Are Expressed in Human Breast Tumors
Dressing, G. E., Alyea, R. A., Pang, Y., & Thomas, P. (2012) · Hormones and Cancer · doi:10.1007/s12672-012-0106-x · Cited by 115 · see citing works
Self-citation
Abstract POSTER-BIOL-1311: Mechanisms of differential activities of progesterone receptor (PR) isoforms in ovarian cancer models
Diep, C. H., & Lange, C. A. (2015) · Clinical Cancer Research · doi:10.1158/1557-3265.ovcasymp14-poster-biol-1311
Self-citation

Authors: Charles, N. J., Thomas, P., & Lange, C. A.
Affiliations: Masonic Cancer Center (US)
University of Texas at Austin Marine Science Institute (US)
Corresponding author: Lange, Carol A.
ORCID: Thomas, Peter
Lange, Carol A.
Venue: Hormones and Cancer
Publisher: Springer Science and Business Media LLC
Published: 2010-08
Volume: 1
Issue: 4
Pages: 167-176
ISSN: 1868-8497 (ISSN-L)
1868-8500
DOI: 10.1007/s12672-010-0023-9
PMC: PMC3926102
OpenAlex: W1988676996
Cited by: 86
References: 55
Citations by year: 2026: 2 · 2025: 3 · 2024: 7 · 2023: 5 · 2022: 8 · 2021: 13 · 2020: 12 · 2019: 4 · 2018: 4 · 2017: 1 · 2016: 9 · 2015: 4 · 2014: 2 · 2013: 2 · 2012: 7
FWCI: 2.16
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Hormones and Cancer (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: Minnesota Ovarian Cancer Alliance
University of Minnesota
University of South Florida
National Cancer Institute (R01CA123763)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
Health Sciences › Medicine › Reproductive Medicine › Ovarian cancer diagnosis and treatment
Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
Keywords: membrane progesterone receptor, ovarian cancer, progesterone signaling, JNK1/2, p38 MAPK, apoptosis, cAMP response element, beta-adrenergic receptors, isoproterenol, JNK inhibitor
MeSH terms: Cyclic AMP, Dose-Response Relationship, Drug, Female, Humans, Membrane Proteins, Nerve Tissue Proteins, Ovarian Neoplasms, Phosphorylation, Progestins, Progesterone, Receptors, Progesterone, Time Factors, Blotting, Western, Signal Transduction, Gene Expression Regulation, Neoplastic, Reverse Transcriptase Polymerase Chain Reaction, Receptors, G-Protein-Coupled, Cell Line, Tumor, JNK Mitogen-Activated Protein Kinases, p38 Mitogen-Activated Protein Kinases, bcl-2-Associated X Protein

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Expression of Membrane Progesterone Receptors (mPR/PAQR) in Ovarian Cancer Cells: Implications for Progesterone-Induced Signaling Events

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Self-check

Cites

Cited by

Related

Record

About these checks