The ASK1-MAP Kinase Cascades in Mammalian Stress Response

Mammalian Mitogen-Activated Protein Kinase Signal Transduction Pathways Activated by Stress and Inflammation

Kyriakis, J. M., & Avruch, J. (2001) · Physiological Reviews · doi:10.1152/physrev.2001.81.2.807 · Cited by 3,369 · see citing works

Coupling of Stress in the ER to Activation of JNK Protein Kinases by Transmembrane Protein Kinase IRE1

Urano, F., Wang, X.-Z., Bertolotti, A., Zhang, Y., Chung, P., Harding, H. P., & Ron, D. (2000) · Science · doi:10.1126/science.287.5453.664 · Cited by 2,997 · see citing works

Mammalian thioredoxin is a direct inhibitor of apoptosis signal‐regulating kinase (ASK) 1

Saitoh, M., Nishitoh, H., Fujii, M., Takeda, K., Tobiume, K., Sawada, Y., Kawabata, M., Miyazono, K., & Ichijo, H. (1998) · The EMBO Journal · doi:10.1093/emboj/17.9.2596 · Cited by 2,377 · see citing works

Induction of Apoptosis by ASK1, a Mammalian MAPKKK That Activates SAPK/JNK and p38 Signaling Pathways

Ichijo, H., Nishida, E., Irie, K., ten Dijke, P., Saitoh, M., Moriguchi, T., Takagi, M., Matsumoto, K., Miyazono, K., & Gotoh, Y. (1997) · Science · doi:10.1126/science.275.5296.90 · Cited by 2,310 · see citing works

MAPK cascade signalling and synaptic plasticity

Thomas, G. M., & Huganir, R. L. (2004) · Nature Reviews Neuroscience · doi:10.1038/nrn1346 · Cited by 1,454 · see citing works

ASK1 is essential for endoplasmic reticulum stress-induced neuronal cell death triggered by expanded polyglutamine repeatsPreprint

Nishitoh, H., Matsuzawa, A., Tobiume, K., Saegusa, K., Takeda, K., Inoue, K., Hori, S., Kakizuka, A., & Ichijo, H. (2002) · Genes & Development · doi:10.1101/gad.992302 · Cited by 1,331 · see citing works

ASK1 is required for sustained activations of JNK/p38 MAP kinases and apoptosis

Tobiume, K., Matsuzawa, A., Takahashi, T., Nishitoh, H., Morita, K., Takeda, K., Minowa, O., Miyazono, K., Noda, T., & Ichijo, H. (2001) · EMBO Reports · doi:10.1093/embo-reports/kve046 · Cited by 1,213 · see citing works

BCL-2 Is Phosphorylated and Inactivated by an ASK1/Jun N-Terminal Protein Kinase Pathway Normally Activated at G2/M

Yamamoto, K., Ichijo, H., & Korsmeyer, S. J. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.12.8469 · Cited by 1,003 · see citing works

Cellular Defenses against Unfolded Proteins

Sherman, M. Y., & Goldberg, A. L. (2001) · Neuron · doi:10.1016/s0896-6273(01)00177-5 · Cited by 984 · see citing works

The Role of c-Jun N-terminal Kinase (JNK) in Apoptosis Induced by Ultraviolet C and γ Radiation

Chen, Y.-R., Wang, X., Templeton, D., Davis, R. J., & Tan, T.-H. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.50.31929 · Cited by 867 · see citing works

β-Arrestin 2: A Receptor-Regulated MAPK Scaffold for the Activation of JNK3

McDonald, P. H., Chow, C.-W., Miller, W. E., Laporte, S. A., Field, M. E., Lin, F., Davis, R. J., & Lefkowitz, R. J. (2000) · Science · doi:10.1126/science.290.5496.1574 · Cited by 818 · see citing works

Fas Ligand-Induced Apoptosis

Nagata, S. (1999) · Annual Review of Genetics · doi:10.1146/annurev.genet.33.1.29 · Cited by 772 · see citing works

Inhibition of JNK activation through NF-κB target genes

Tang, G., Minemoto, Y., Dibling, B., Purcell, N. H., Li, Z., Karin, M., & Lin, A. (2001) · Nature · doi:10.1038/35104568 · Cited by 721 · see citing works

ASK1 Is Essential for JNK/SAPK Activation by TRAF2

Nishitoh, H., Saitoh, M., Mochida, Y., Takeda, K., Nakano, H., Rothe, M., Miyazono, K., & Ichijo, H. (1998) · Molecular Cell · doi:10.1016/s1097-2765(00)80283-x · Cited by 647 · see citing works

Accumulation of Mutant Huntingtin Fragments in Aggresome-like Inclusion Bodies as a Result of Insufficient Protein Degradation

Waelter, S., Boeddrich, A., Lurz, R., Scherzinger, E., Lüder, G., Lehrach, H. R., & Wanker, E. E. (2001) · Molecular Biology of the Cell · doi:10.1091/mbc.12.5.1393 · Cited by 632 · see citing works

Direct evidence for tumor necrosis factor-induced mitochondrial reactive oxygen intermediates and their involvement in cytotoxicity.

Goossens, V., Grooten, J., Vos, K. J. D., & Fiers, W. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.18.8115 · Cited by 595 · see citing works

Activation of Apoptosis Signal-Regulating Kinase 1 (ASK1) by the Adapter Protein Daxx

Chang, H. Y., Nishitoh, H., Yang, X., Ichijo, H., & Baltimore, D. (1998) · Science · doi:10.1126/science.281.5384.1860 · Cited by 594 · see citing works

Activation of Apoptosis Signal-Regulating Kinase 1 (ASK1) by Tumor Necrosis Factor Receptor-Associated Factor 2 Requires Prior Dissociation of the ASK1 Inhibitor Thioredoxin

Liu, H., Nishitoh, H., Ichijo, H., & Kyriakis, J. M. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.6.2198-2208.2000 · Cited by 545 · see citing works

From receptors to stress-activated MAP kinases

Ichijo, H. (1999) · Oncogene · doi:10.1038/sj.onc.1203129 · Cited by 519 · see citing works

Activation of apoptosis signal‐regulating kinase 1 by the stress‐induced activating phosphorylation of pre‐formed oligomer

Tobiume, K., Saitoh, M., & Ichijo, H. (2002) · Journal of Cellular Physiology · doi:10.1002/jcp.10080 · Cited by 362 · see citing works

Reactive Oxygen Species- and Dimerization-induced Activation of Apoptosis Signal-regulating Kinase 1 in Tumor Necrosis Factor-α Signal Transduction

Gotoh, Y., & Cooper, J. A. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.28.17477 · Cited by 355 · see citing works

Suppression of apoptosis signal-regulating kinase 1-induced cell death by 14-3-3 proteins

Zhang, L., Chen, J., & Fu, H. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.15.8511 · Cited by 347 · see citing works

Execution of Apoptosis Signal-regulating Kinase 1 (ASK1)-induced Apoptosis by the Mitochondria-dependent Caspase Activation

Hatai, T., Matsuzawa, A., Inoshita, S., Mochida, Y., Kuroda, T., Sakamaki, K., Kuida, K., Yonehara, S., Ichijo, H., & Takeda, K. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m003412200 · Cited by 332 · see citing works

Gadd45β mediates the NF-κB suppression of JNK signalling by targeting MKK7/JNKK2

Papa, S., Zazzeroni, F., Bubici, C., Jayawardena, S., Alvarez, K., Matsuda, S., Nguyen, D. U., Pham, C. G., Nelsbach, A. H., Melis, T., et al. (2004) · Nature Cell Biology · doi:10.1038/ncb1093 · Cited by 321 · see citing works

Negative feedback regulation of ASK1 by protein phosphatase 5 (PP5) in response to oxidative stress

Morita, K., Saitoh, M., Tobiume, K., Matsuura, H., Enomoto, S., Nishitoh, H., & Ichijo, H. (2001) · The EMBO Journal · doi:10.1093/emboj/20.21.6028 · Cited by 293 · see citing works

Integration of endoplasmic reticulum signaling in health and disease

Aridor, M., & Balch, W. E. (1999) · Nature Medicine · doi:10.1038/10466 · Cited by 281 · see citing works

Apoptosis induced in neuronal cells by oxidative stress: role played by caspases and intracellular calcium ions

Annunziato, L. (2003) · Toxicology Letters · doi:10.1016/s0378-4274(02)00427-7 · Cited by 272 · see citing works

Role of Glutaredoxin in Metabolic Oxidative Stress

Song, J. J., Rhee, J. G., Suntharalingam, M., Walsh, S. A., Spitz, D. R., & Lee, Y. J. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m206826200 · Cited by 260 · see citing works

Apoptosis and oxidants in the heart

Kumar, D., & Jugdutt, B. I. (2003) · Journal of Laboratory and Clinical Medicine · doi:10.1016/s0022-2143(03)00148-3 · Cited by 234 · see citing works

Apoptosis Signal-Regulating Kinase 1 Plays a Pivotal Role in Angiotensin II–Induced Cardiac Hypertrophy and Remodeling

Izumiya, Y., Kim, S., Izumi, Y., Yoshida, K., Yoshiyama, M., Matsuzawa, A., Ichijo, H., & Iwao, H. (2003) · Circulation Research · doi:10.1161/01.res.0000100665.67510.f5 · Cited by 230 · see citing works

Activation of Apoptosis Signal-regulating Kinase 1 by Reactive Oxygen Species through Dephosphorylation at Serine 967 and 14-3-3 Dissociation

Goldman, E. H., Chen, L., & Fu, H. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m311129200 · Cited by 221 · see citing works

The CaMKII UNC-43 Activates the MAPKKK NSY-1 to Execute a Lateral Signaling Decision Required for Asymmetric Olfactory Neuron Fates

Sagasti, A., Hisamoto, N., Hyodo, J., et al. (2001) · Cell · doi:10.1016/s0092-8674(01)00313-0 · Cited by 209 · see citing works

ASK1 mediates apoptotic cell death induced by genotoxic stress

Chen, Z., Seimiya, H., Naito, M., Mashima, T., Kizaki, A., Dan, S., Imaizumi, M., Ichijo, H., Miyazono, K., & Tsuruo, T. (1999) · Oncogene · doi:10.1038/sj.onc.1202276 · Cited by 177 · see citing works

Role of Apoptosis Signal-Regulating Kinase in Regulation of the c-Jun N-Terminal Kinase Pathway and Apoptosis in Sympathetic Neurons

Kanamoto, T., Mota, M. A., Takeda, K., Rubin, L. L., Miyazono, K., Ichijo, H., & Bazenet, C. E. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.1.196-204.2000 · Cited by 164 · see citing works

Apoptosis Signal-regulating Kinase 1 (ASK1) Induces Neuronal Differentiation and Survival of PC12 Cells

Takeda, K., Hatai, T., Hamazaki, T. S., et al. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.13.9805 · Cited by 161 · see citing works

Huntingtin forms toxic NH2-terminal fragment complexes that are promoted by the age-dependent decrease in proteasome activity

Zhou, H., Cao, F., Wang, Z., Yu, Z.-X., Nguyen, H. P., Evans, J., Li, S.-H., & Li, X. (2003) · The Journal of Cell Biology · doi:10.1083/jcb.200306038 · Cited by 158 · see citing works

Molecular Cloning and Characterization of a Novel Protein Kinase with a Catalytic Domain Homologous to Mitogen-activated Protein Kinase Kinase Kinase

Xuhong, S. W., Diener, K., Jannuzzi, D., Trollinger, D. B., Tse-Hua, T., Lichenstein, H. S., Zukowski, M. M., & Yao, Z. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.49.31607 · Cited by 148 · see citing works

Apoptosis Signal-regulating Kinase 1 (ASK1) Is an Intracellular Inducer of Keratinocyte Differentiation

Sayama, K., Hanakawa, Y., Shirakata, Y., Yamasaki, K., Sawada, Y., Sun, L., Yamanishi, K., Ichijo, H., & Hashimoto, K. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m003425200 · Cited by 131 · see citing works

Redox Control of Signal Transduction, Gene Expression and Cellular Senescence

Esposito, F., Ammendola, R., Faraonio, R., Russo, T., & Cimino, F. (2004) · Neurochemical Research · doi:10.1023/b:nere.0000014832.78725.1a · Cited by 113 · see citing works

Dissecting Fas signaling with an altered-specificity death-domain mutant: Requirement of FADD binding for apoptosis but not Jun N-terminal kinase activation

Chang, H. Y., Yang, X., & Baltimore, D. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.4.1252 · Cited by 88 · see citing works

Ebselen inhibits NO‐induced apoptosis of differentiated PC12 cells via inhibition of ASK1‐p38 MAPK‐p53 and JNK signaling and activation of p44/42 MAPK and Bcl‐2

Sarker, K. P., Biswas, K. K., Rosales, J. L., et al. (2003) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.02096.x · Cited by 61 · see citing works

Huntingtin phosphorylation and signaling pathways that regulate toxicity in Huntington's disease

Humbert, S., & Saudou, F. (2003) · Clinical Neuroscience Research · doi:10.1016/s1566-2772(03)00057-4 · Cited by 15 · see citing works

Reactive Oxygen Species, Toxicity, Oxidative Stress, and Antioxidants: Chronic Diseases and Aging

Jomova, K., Raptova, R., Alomar, S. Y., Alwasel, S. H., Nepovimova, E., Kuca, K., & Valko, M. (2023) · Archives of Toxicology · doi:10.1007/s00204-023-03562-9 · Cited by 2,638 · see citing works

Ros and ros-mediated cellular signaling

Zhang, J., Wang, X., Vikash, V., Ye, Q., Wu, D., Liu, Y., & Dong, W. (2016) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/4350965 · Cited by 1,980 · see citing works

The genome of the choanoflagellate Monosiga brevicollis and the origin of metazoans

King, N., Westbrook, M. J., Young, S. L., Kuo, A., Abedin, M., Chapman, J., Fairclough, S., Hellsten, U., Isogai, Y., Letunic, I., et al. (2008) · Nature · doi:10.1038/nature06617 · Cited by 1,139 · see citing works

Environmental toxicity, oxidative stress and apoptosis: Ménage à Trois

Franco, R., Sánchez-Olea, R., Reyes-Reyes, E. M., & Panayiotidis, M. I. (2009) · Mutation Research/Genetic Toxicology and Environmental Mutagenesis · doi:10.1016/j.mrgentox.2008.11.012 · Cited by 541 · see citing works

High Levels of SIRT1 Expression as a Protective Mechanism Against Disease-Related Conditions

Elibol, B., & Kilic, U. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00614 · Cited by 171 · see citing works

Physical inactivity, insulin resistance, and the oxidative-inflammatory loop

Gratas-Delamarche, A., Derbré, F., Vincent, S., & Cillard, J. (2014) · Free Radical Research · doi:10.3109/10715762.2013.847528 · Cited by 99 · see citing works

Expression of Membrane Progesterone Receptors (mPR/PAQR) in Ovarian Cancer Cells: Implications for Progesterone-Induced Signaling Events

Charles, N. J., Thomas, P., & Lange, C. A. (2010) · Hormones and Cancer · doi:10.1007/s12672-010-0023-9 · Cited by 86 · see citing works

UVB-Induced Activation of NF-κb Is Regulated by the IGF-1R and Dependent on P38 MAPK

Lewis, D. A., & Spandau, D. F. (2008) · Journal of Investigative Dermatology · doi:10.1038/sj.jid.5701127 · Cited by 41 · see citing works

MEKK1 Binds Raf-1 and the ERK2 Cascade Components

Karandikar, M. S., Xu, S., & Cobb, M. H. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m005926200 · Cited by 117 · see citing works

Regulation of a Mitogen-Activated Protein Kinase Kinase Kinase, MLTK by PKN

Takahashi, M. (2003) · The Journal of Biochemistry · doi:10.1093/jb/mvg022 · Cited by 34 · see citing works

Scaffold Role of a Mitogen-activated Protein Kinase Phosphatase, SKRP1, for the JNK Signaling Pathway

Zama, T., Aoki, R., Kamimoto, T., Inoue, K., Ikeda, Y., & Hagiwara, M. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m200838200 · Cited by 53 · see citing works

Characterization of a Protein Kinase that Phosphorylates Serine 189 of the Mitogen-activated Protein Kinase Homolog ERK3

Cheng, M. M., Zhen, E., Robinson, M. J., Ebert, D. J., Goldsmith, E. J., & Cobb, M. H. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.20.12057 · Cited by 42 · see citing works

Reconstitution of Mitogen-activated Protein Kinase Phosphorylation Cascades in Bacteria

Khokhlatchev, A. V., Xu, S., English, J. M., Wu, P., SCHAEFER, E. M., & Cobb, M. H. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.17.11057 · Cited by 200 · see citing works