Minocycline development for acute ischemic stroke
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Minocycline, a tetracycline antibiotic, has shown anti-inflammatory, anti-apoptotic, and neuroprotective effects in many models of cerebral ischemia and neurodegenerative disease. Its high penetration of the blood-brain barrier, good safety profile, and delayed therapeutic window make it an ideal candidate for use in stroke. In animal models, minocycline reduced infarct size and improved neurologic outcome when administered acutely, with similar neuroprotective benefits seen following delayed administration. To date, two early phase clinical trials have shown minocycline to be safe and potentially effective in acute ischemic stroke, alone or in combination with tissue plasminogen activator. A large efficacy clinical trial is now needed to confirm previous studies, allow for subgroup analysis, and pinpoint the potential place for minocycline in acute stroke therapy.
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Minocycline has been incorporated into two clinical trials involving ischemic stroke patients, demonstrating that minocycline administration (both alone and in combination with fibrinolysis) improved neurological functional outcome following stroke.
“So far, minocycline has been incorporated into two clinical trials involving ischemic stroke patients, demonstrating that minocycline administration (both alone and in combination with Fibrinolysis) improved neurological functional outcome following stroke (Fagan et al., 2011).”
From The impact of microglial activation on blood-brain barrier in brain diseases (2014) · cites this paper as Fagan et al., 2011
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Wu, D. C., Jackson-Lewis, V., Vila, M., Tieu, K., Teismann, P., Vadseth, C., Choi, D.-K., Ischiropoulos, H., & Przedborski, S. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-05-01763.2002 · Cited by 1,183 · see citing works
Zhu, S., Stavrovskaya, I. G., Drozda, M., Kim, B. Y. S., Ona, V. O., Li, M., Sarang, S. S., Liu, A. S., Hartley, D. M., Wu, D. C., et al. (2002) · Nature · doi:10.1038/417074a · Cited by 1,071 · see citing works
Chen, M., Ona, V. O., Li, M., Ferrante, R. J., Fink, K., Zhu, S., Bian, J., Guo, L., Farrell, L. A., Hersch, S. M., et al. (2000) · Nature Medicine · doi:10.1038/77528 · Cited by 1,056 · see citing works
Yrjänheikki, J., Kauppinen, T. M., Keinänen, R., Goldsteins, G., Chan, P. H., & Koıstınaho, J. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.23.13496 · Cited by 1,040 · see citing works
Tetracyclines inhibit microglial activation and are neuroprotective in global brain ischemia
Yrjänheikki, J., Keinänen, R., Pellikka, M., Hökfelt, T., & Koistinaho, J. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.26.15769 · Cited by 1,006 · see citing works
Tikka, T., Fiebich, B. L., Goldsteins, G., Keinänen, R., & Koistinaho, J. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-08-02580.2001 · Cited by 958 · see citing works
Clinical interpretation and use of stroke scales
Kasner, S. E. (2006) · The Lancet Neurology · doi:10.1016/s1474-4422(06)70495-1 · Cited by 947 · see citing works
Du, Y., Ma, Z., Lin, S., Dodel, R. C., Gao, F., Bales, K. R., Triarhou, L. C., Chernet, E., Perry, K. W., Nelson, D. L. G., et al. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.251341998 · Cited by 789 · see citing works
Matrix Metalloproteinases Increase Very Early during Experimental Focal Cerebral Ischemia
Heo, J. H., Lucero, J. D., Abumiya, T., Koziol, J. A., Copeland, B. R., & del Zoppo, G. J. (1999) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-199906000-00005 · Cited by 547 · see citing works
Minocycline and Neurodegenerative Diseases
Kim, H.-S., & Suh, Y.-H. (2009) · Behavioural Brain Research · doi:10.1016/j.bbr.2008.09.040 · Cited by 447 · see citing works
Minocycline treatment in acute stroke
Lampl, Y., Boaz, M., Gilad, R., Lorberboym, M., Dabby, R., Rapoport, A. M., Anca-Hershkowitz, M., & Sadeh, M. (2007) · Neurology · doi:10.1212/01.wnl.0000277487.04281.db · Cited by 443 · see citing works
Neuroprotection by minocycline facilitates significant recovery from spinal cord injury in mice.
Wells, J., Hurlbert, R., Fehlings, M., & Yong, W. V. (2003) · Brain : a journal of neurology · doi:10.1093/brain/awg178 · Cited by 437 · see citing works
Proteolytic Cascade Enzymes Increase in Focal Cerebral Ischemia in Rat
Rosenberg, G. A., Navratil, M., Barone, F. C., & Feuerstein, G. (1996) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-199605000-00002 · Cited by 403 · see citing works
Gasche, Y. G., Fujimura, M., Morita‐Fujimura, Y., Copin, J., 川瀬, 誠., Massengale, J. L., & Chan, P. H. (1999) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-199909000-00010 · Cited by 400 · see citing works
Sanchez-Mejia, R., Ona, V., Li, M.-W., & Friedlander, R. (2001) · Neurosurgery · doi:10.1097/00006123-200106000-00051 · Cited by 373 · see citing works
Intracerebral hemorrhage induces macrophage activation and matrix metalloproteinases
Power, C., Henry, S. D., Bigio, M. R. D., Larsen, P. H., Corbett, D., Imai, Y., Yong, V. W., & Peeling, J. (2003) · Annals of Neurology · doi:10.1002/ana.10553 · Cited by 363 · see citing works
He, Y., Appel, S. H., & Le, W. (2001) · Brain Research · doi:10.1016/s0006-8993(01)02681-6 · Cited by 350 · see citing works
Clinical Pharmacokinetics of Doxycycline and Minocycline
Saivin, S., & Houin, G. (1988) · Clinical Pharmacokinetics · doi:10.2165/00003088-198815060-00001 · Cited by 350 · see citing works
Fujimura, M., Gasche, Y., Morita‐Fujimura, Y., Massengale, J. L., 川瀬, 誠., & Chan, P. H. (1999) · Brain Research · doi:10.1016/s0006-8993(99)01843-0 · Cited by 339 · see citing works
Minocycline in Rheumatoid Arthritis: A 48-Week, Double-Blind, Placebo-Controlled Trial
Tilley, B. C., Alarcon, G. S., Heyse, S. P., Trentham, D. E., Neuner, R., Kaplan†, D. A., Clegg, D. O., Leisen, J. C. C., Buckley, L., Cooper, S. M., et al. (1995) · Annals of Internal Medicine · doi:10.7326/0003-4819-122-2-199501150-00001 · Cited by 339 · see citing works
Minocycline markedly protects the neonatal brain against hypoxic‐ischemic injury
Arvin, K. L., Han, B., Du, Y.-S., Lin, S.-Z., Paul, S. M., & Holtzman, D. (2002) · Annals of Neurology · doi:10.1002/ana.10242 · Cited by 323 · see citing works
Liu, Z., Yang, F., Won, S. J., Neumann, M., Hu, D., Zhou, L., Weinstein, P. R., & Liu, J. (2006) · Stroke · doi:10.1161/01.str.0000251791.64910.cd · Cited by 291 · see citing works
Focal Cerebral Ischemia Induces Active Proteases That Degrade Microvascular Matrix
Fukuda, S., Fini, C. A., Mabuchi, T., Koziol, J. A., Eggleston, L. L., & del Zoppo, G. J. (2004) · Stroke · doi:10.1161/01.str.0000119383.76447.05 · Cited by 277 · see citing works
Neuroprotective agents for clinical trials in Parkinson’s disease
Ravina, B. M., Fagan, S. C., Hart, R. G., Hovinga, C. A., Murphy, D. D., Dawson, T. M., & Marler, J. R. (2003) · Neurology · doi:10.1212/01.wnl.0000058760.13152.1a · Cited by 261 · see citing works
Self-citationMinocycline to Improve Neurologic Outcome in Stroke (MINOS)
Fagan, S. C., Waller, J. L., Nichols, F. T., Edwards, D. J., Pettigrew, L. C., Clark, W. M., Hall, C. E., Switzer, J. A., Ergul, A., & Hess, D. C. (2010) · Stroke · doi:10.1161/strokeaha.110.582601 · Cited by 244 · see citing works
Self-citationMinocycline Up-regulates Bcl-2 and Protects against Cell Death in Mitochondria
Wang, J., Wei, Q., Wang, C., Hill, W., Hess, D. C., & Dong, Z. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m313629200 · Cited by 242 · see citing works
Self-citationMinocycline inhibits poly(ADP-ribose) polymerase-1 at nanomolar concentrations
Alano, C. C., Kauppinen, T. M., Valls, A. V., & Swanson, R. A. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0600554103 · Cited by 229 · see citing works
Tilley, B. C., Marler, J. R., Geller, N. L., Lü, M., Legler, J. M., Brott, T. G., Lyden, P. D., & Grotta, J. C. (1996) · Stroke · doi:10.1161/01.str.27.11.2136 · Cited by 227 · see citing works
Extension of the Thrombolytic Time Window With Minocycline in Experimental Stroke
Murata, Y., Rosell, A., Scannevin, R. H., Rhodes, K. J., Wang, X., & Lo, E. H. (2008) · Stroke · doi:10.1161/strokeaha.108.514026 · Cited by 225 · see citing works
Minocycline for Short‐Term Neuroprotection
Elewa, H. F., Hilali, H., Hess, D. C., Machado, L. S., & Fagan, S. C. (2006) · Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy · doi:10.1592/phco.26.4.515 · Cited by 198 · see citing works
Self-citationMachado, L. S., Kozak, A., Ergul, A., Hess, D. C., Borlongan, C. V., & Fagan, S. C. (2006) · BMC Neuroscience · doi:10.1186/1471-2202-7-56 · Cited by 193 · see citing works
Self-citationAdditive neuroprotective effects of minocycline with creatine in a mouse model of ALS
Zhang, W., Narayanan, M. V., & Friedlander, R. M. (2003) · Annals of Neurology · doi:10.1002/ana.10476 · Cited by 185 · see citing works
Xu, L., Fagan, S. C., Waller, J. L., Edwards, D. J., Borlongan, C. V., Zheng, J., Hill, W., Feuerstein, G., & Hess, D. C. (2004) · BMC Neurology · doi:10.1186/1471-2377-4-7 · Cited by 172 · see citing works
Self-citationMejia, R. O. S., Ona, V. O., Li, M., et al. (2001) · Neurosurgery · doi:10.1227/00006123-200106000-00051 · Cited by 171 · see citing works
Hayakawa, K., Mishima, K., Nozako, M., Hazekawa, M., Mishima, S., Fujioka, M., Orito, K., Egashira, N., Iwasaki, K., & Fujiwara, M. (2008) · Stroke · doi:10.1161/strokeaha.107.495820 · Cited by 151 · see citing works
US Geographic Distribution of rt-PA Utilization by Hospital for Acute Ischemic Stroke
Kleindorfer, D., Xu, Y. Y., Moomaw, C. J., Khatri, P., Adeoye, O. M., & Hornung, R. (2009) · Stroke · doi:10.1161/strokeaha.109.554626 · Cited by 149 · see citing works
Therapeutic targets and limits of minocycline neuroprotection in experimental ischemic stroke
Matsukawa, N., Yasuhara, T., Hara, K., Xu, L., Maki, M., Yu, G., Kaneko, Y., Ojika, K., Hess, D. C., & Borlongan, C. V. (2009) · BMC Neuroscience · doi:10.1186/1471-2202-10-126 · Cited by 146 · see citing works
Self-citationPlacebo-controlled phase I/II studies of minocycline in amyotrophic lateral sclerosis
Gordon, P. H., Moore, D. H., Gelinas, D. F., Qualls, C., Meister, M. E., Werner, J., Mendoza, M., Mass, J., Kushner, G., & Miller, R. G. (2004) · Neurology · doi:10.1212/01.wnl.0000125321.92112.7e · Cited by 139 · see citing works
Čolović, M., & Caccia, S. (2003) · Journal of Chromatography B · doi:10.1016/s1570-0232(03)00247-2 · Cited by 134 · see citing works
Nagel, S., Su, Y., Horstmann, S., Heiland, S., Gardner, H., Koziol, J., Martinez-Torres, F. J., & Wagner, S. (2007) · Brain Research · doi:10.1016/j.brainres.2007.10.052 · Cited by 130 · see citing works
Lin, S., Zhang, Y., Dodel, R. C., Farlow, M. R., Paul, S. M., & Du, Y. (2001) · Neuroscience Letters · doi:10.1016/s0304-3940(01)02324-2 · Cited by 126 · see citing works
Sex Differences in Minocycline-Induced Neuroprotection after Experimental Stroke
Li, J., & McCullough, L. D. (2009) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2009.3 · Cited by 116 · see citing works
Minocycline and Tissue-Type Plasminogen Activator for Stroke
Machado, L. S., Sazonova, I. Y., Kozak, A., Wiley, D. C., El‐Remessy, A. B., Ergul, A., Hess, D. C., Waller, J. L., & Fagan, S. C. (2009) · Stroke · doi:10.1161/strokeaha.109.556852 · Cited by 103 · see citing works
Self-citationEffects of minocycline alone and in combination with mild hypothermia in embolic stroke
Wang, C. X., Yang, T., & Shuaib, A. M. (2003) · Brain Research · doi:10.1016/s0006-8993(02)04045-3 · Cited by 84 · see citing works
Weng, Y. C., & Križ, J. (2007) · Experimental Neurology · doi:10.1016/j.expneurol.2006.12.003 · Cited by 75 · see citing works
Hewlett, K. A., & Corbett, D. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2006.03.071 · Cited by 74 · see citing works
Delayed minocycline but not delayed mild hypothermia protects against embolic stroke
Wang, C. X., Yang, T., Noor, R., & Shuaib, A. M. (2002) · BMC Neurology · doi:10.1186/1471-2377-2-2 · Cited by 59 · see citing works
Drew, T. M., Altman, R., Black, K. L., & Goldfield, M. (1976) · The Journal of Infectious Diseases · doi:10.1093/infdis/133.2.194 · Cited by 40 · see citing works
Sathasivam, S., Grierson, A. J., & Shaw, P. J. (2005) · Neuropathology and Applied Neurobiology · doi:10.1111/j.1365-2990.2005.00658.x · Cited by 38 · see citing works
Determinants of the Timing of Symptomatic Treatment in Early Parkinson Disease
Parashos, S. A. (2009) · Archives of Neurology · doi:10.1001/archneurol.2009.159 · Cited by 28 · see citing works
Minocycline administered intravenously: pharmacological activity and clinical experience.
Clark, B., Hodgson, C. R., Dornbush, A. C., & Hutchinson, J. (1974) · PubMed · Cited by 14 · see citing works
Acne: treatment with minocycline.
Coskey, R. J. (1976) · PubMed · Cited by 12 · see citing works
Minocycline treatment in acute stroke.
Goldstein, L. B. (2008) · PubMed · Cited by 11 · see citing works
Dupuis, L. L., Taylor, T. L., & Saunders, E. F. (2006) · Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy · doi:10.1592/phco.2006.26.1.15 · Cited by 9 · see citing works
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Amantea, D., Micieli, G., Tassorelli, C., Cuartero, M. I., Ballesteros, I., Certo, M., Moro, M. Á., Lizasoaín, I., & Bagetta, G. (2015) · Frontiers in Neuroscience · doi:10.3389/fnins.2015.00147 · Cited by 215 · see citing works
Sex differences in the brain: Implications for behavioral and biomedical research
Choleris, E., Galea, L. A. M., Sohrabji, F., & Frick, K. M. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.07.005 · Cited by 214 · see citing works
The role of microglia activation in the development of sepsis-induced long-term cognitive impairment
Michels, M., Vieira, A. S., Vuolo, F. S., Zapelini, H. G., Mendonça, B. D. S., Mina, F., Dominguini, D., Steckert, A. V., Schuck, P. F., Quevedo, J., et al. (2014) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2014.07.002 · Cited by 205 · see citing works
An, C., Shi, Y., Li, P., Hu, X., Gan, Y., Stetler, R. A., Leak, R. K., Gao, Y., Sun, B., Zheng, P., et al. (2014) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2013.12.002 · Cited by 204 · see citing works
Ronaldson, P. T., & Davis, T. P. (2012) · Current Pharmaceutical Design · doi:10.2174/138161212802002625 · Cited by 157 · see citing works
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Neumann, J. T., Cohan, C. H., Dave, K. R., Wright, C. B., & Pérez‐Pinzón, M. A. (2012) · Current Drug Targets · doi:10.2174/138945013804806514 · Cited by 135 · see citing works
Yang, Q., Huang, Q., Hu, Z., & Tang, X. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.01036 · Cited by 134 · see citing works
Association between periodontal disease and stroke
Sfyroeras, G. S., Roussas, N., Saleptsis, V., Argyriou, C., & Giannoukas, A. D. (2012) · Journal of Vascular Surgery · doi:10.1016/j.jvs.2011.10.008 · Cited by 127 · see citing works
Chen, Y., Nguyen, H. M., Maezawa, I., Grössinger, E. M., Garing, A. L. A., Köhler, R., Jin, L., & Wulff, H. (2015) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x15611434 · Cited by 104 · see citing works
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Yang, Y. R., Kimura‐Ohba, S., Thompson, J. F., Salayandia, V. M., Cossé, M., Raz, L., Jalal, F. Y., & Rosenberg, G. A. (2018) · Neurobiology of Disease · doi:10.1016/j.nbd.2018.02.012 · Cited by 97 · see citing works
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Miao, H., Li, R., Han, C., Lu, X., & Zhang, H. (2018) · Journal of Neurophysiology · doi:10.1152/jn.00234.2018 · Cited by 91 · see citing works
Turner, R. C., Dodson, S. C., Rosen, C. L., & Huber, J. D. (2013) · Journal of neurosurgery · doi:10.3171/2012.11.jns12408 · Cited by 87 · see citing works
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Althammer, F., Ferreira‐Neto, H. C., Rubaharan, M., Roy, R. K., Patel, A. A., Murphy, A. Z., Cox, D. N., & Stern, J. E. (2020) · Journal of Neuroinflammation · doi:10.1186/s12974-020-01892-4 · Cited by 85 · see citing works
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Lodise, T. P., Wart, S. V., Sund, Z. M., Bressler, A. M., Khan, A., Makley, A. T., Hamad, Y., Salata, R. A., Silveira, F. P., Sims, M. D., et al. (2020) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01809-20 · Cited by 49 · see citing works
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Minocycline promotes axonal regeneration through suppression of RGMa in rat MCAO/reperfusion model
Tao, T., Xu, G., Chen, C. S., Feng, J., Kong, Y., & Qin, X. (2012) · Synapse · doi:10.1002/syn.21629 · Cited by 33 · see citing works
Li, R., Yin, X., Jin, Y., Chen, X., Zhao, B., Wang, W., Zhong, S., & Han, D. (2021) · The Journal of Chemical Thermodynamics · doi:10.1016/j.jct.2021.106399 · Cited by 32 · see citing works
Stroke and immunotherapy: Potential mechanisms and its implications as immune‐therapeutics
Chavda, V. K., Madhwani, K., & Chaurasia, B. K. (2021) · European Journal of Neuroscience · doi:10.1111/ejn.15224 · Cited by 30 · see citing works
Cho, D.-Y., & Jeun, S. (2018) · Stem Cell Research & Therapy · doi:10.1186/s13287-018-1011-1 · Cited by 30 · see citing works
Quan, Y., Tan, F.-H., Tan, J.-A., Chen, X., Xiao, Q., Liu, Y., Zhang, G., & Luo, J. (2019) · Acta Pharmacologica Sinica · doi:10.1038/s41401-019-0214-z · Cited by 29 · see citing works
Zhu, X., Yao, Y., Yang, J., Ge, Q., Niu, D., Liu, X., Zhang, C., Gan, G., Zhang, A., & Yao, H. (2020) · Neuropharmacology · doi:10.1016/j.neuropharm.2020.108044 · Cited by 29 · see citing works
Emerging Targets for Modulation of Immune Response and Inflammation in Stroke
Thapa, K., Shivam, K., Khan, H., Kaur, A., Dua, K., Singh, S. K., & Singh, T. G. (2023) · Neurochemical Research · doi:10.1007/s11064-023-03875-2 · Cited by 29 · see citing works
Luzzi, S., Bektaşoğlu, P. K., Doğruel, Y., & Güngör, A. (2024) · Neurosurgical Review · doi:10.1007/s10143-024-02543-5 · Cited by 27 · see citing works
Delivering Minocycline into Brain Endothelial Cells with Liposome-Based Technology
Xing, C., Levchenko, T. S., Guo, S., Stins, M. F., Torchilin, V. P., & Lo, E. H. (2012) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2012.48 · Cited by 26 · see citing works
Vascular Protection to Increase the Safety of Tissue Plasminogen Activator for Stroke
Ishrat, T., Soliman, S. M., Guan, W., Saler, M., & Fagan, S. C. (2012) · Current Pharmaceutical Design · doi:10.2174/138161212802002779 · Cited by 24 · see citing works
Self-citationSen, S., Curtis, J. W., Hicklin, D., Nichols, C., Glover, S. H., Merchant, A. T., Hardin, J. W., Logue, M., Meyer, J., Mason, E., et al. (2023) · Stroke · doi:10.1161/strokeaha.122.042047 · Cited by 22 · see citing works
Giri, P. K., Lu, Y., Lei, S., Li, W., Zheng, J., Lü, H., Chen, X., Liu, Y., & Zhang, P. (2017) · Neuroreport · doi:10.1097/wnr.0000000000000937 · Cited by 21 · see citing works
McIver, S. R., Muccigrosso, M. M., & Haydon, P. G. (2012) · Experimental Biology and Medicine · doi:10.1258/ebm.2012.012029 · Cited by 21 · see citing works
Fan, X., Jiang, Y., Yu, Z., Yuan, J., Sun, X., Xiang, S., Lo, E. H., & Wang, X. (2014) · Advances in pharmacology · doi:10.1016/bs.apha.2014.06.007 · Cited by 21 · see citing works
Self-Assembly of DNA–Minocycline Complexes by Metal Ions with Controlled Drug Release
Zhang, T., Nong, J., Alzahrani, N. M., Wang, Z., Oh, S. W., Meier, T., Yang, D. G., Ke, Y., Zhong, Y., & Fu, J. (2019) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.9b08126 · Cited by 21 · see citing works
Guest, J. D., Harrop, J. S., Aarabi, B., Grossman, R. G., Fawcett, J. W., Fehlings, M. G., & Tator, C. H. (2012) · Journal of Neurosurgery Spine · doi:10.3171/2012.5.aospine1289 · Cited by 20 · see citing works
Obesity after neonatal overfeeding is independent of hypothalamic microgliosis
Soch, A., Sominsky, L., Luca, S. N. D., & Spencer, S. J. (2019) · Journal of Neuroendocrinology · doi:10.1111/jne.12757 · Cited by 20 · see citing works
Prophylactic Antibiotic Therapy for Preventing Poststroke Infection
Schwarz, S. T. (2016) · Neurotherapeutics · doi:10.1007/s13311-016-0466-y · Cited by 19 · see citing works
Tao, T., Feng, J., Xu, G., Fu, J., Li, X., & Qin, X. (2016) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-016-0374-z · Cited by 17 · see citing works
Young, J. E., Matyska, M. T., Azad, A. K., Yoc, S. E., & Pesek, J. J. (2013) · Journal of Liquid Chromatography & Related Technologies · doi:10.1080/10826076.2012.678457 · Cited by 17 · see citing works
Structure–Function Correlation in Cobalt-Induced Brain Toxicity
Obied, B., Richard, S., Zahavi, A., Fixler, D., Girshevitz, O., & Goldenberg‐Cohen, N. (2024) · Cells · doi:10.3390/cells13211765 · Cited by 16 · see citing works
Yu, I.-C. I., Kuo, P., Yen, J.-H. J., Paraiso, H. C., Curfman, E. T., Hong-Goka, B. C., Sweazey, R. D., & Chang, F. (2017) · Translational Stroke Research · doi:10.1007/s12975-017-0543-5 · Cited by 16 · see citing works
Multiparametric magnetic resonance imaging of acute experimental brain ischaemia
Kauppinen, R. A. (2014) · Progress in Nuclear Magnetic Resonance Spectroscopy · doi:10.1016/j.pnmrs.2014.05.002 · Cited by 16 · see citing works
Intranasal Fluorescent Nanocrystals for Longitudinal In Vivo Evaluation of Cerebral Microlesions
Choi, A. O., & Maysinger, D. (2013) · Pharmaceutical Nanotechnology · doi:10.2174/2211738511301020005 · Cited by 16 · see citing works
Constantakis, J., Reed-McBain, C. A., & Famakin, B. M. (2022) · Neurochemistry International · doi:10.1016/j.neuint.2022.105456 · Cited by 15 · see citing works
Recycled Translation: Repurposing Drugs for Stroke
Spellicy, S. E., & Hess, D. C. (2022) · Translational Stroke Research · doi:10.1007/s12975-022-01000-z · Cited by 15 · see citing works
Self-citationFast Neuroprotection (Fast-NPRX) for Acute Ischemic Stroke Victims: the Time for Treatment Is Now
Lapchak, P. A. (2013) · Translational Stroke Research · doi:10.1007/s12975-013-0303-0 · Cited by 14 · see citing works
Kondo, M., Okazaki, H., Nakayama, K., Hohjoh, H., Nakagawa, K., Segi‐Nishida, E., & Hasegawa, H. (2022) · Neurochemical Research · doi:10.1007/s11064-022-03703-z · Cited by 13 · see citing works
Pawletko, K., Jędrzejowska–Szypułka, H., Bogus, K., Pascale, A., Fahmideh, F., Marchesi, N., Grajoszek, A., de Carrillo, D. G., & Barski, J. J. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24119446 · Cited by 13 · see citing works
Does Minocycline Improve Recovery After Acute Ischemic Stroke?
Singh, R., Agustin, S. J. U., Jane, M., Cheong, J. M. Y., Lee, S. H., & Choo, T. B. (2019) · Journal of Stroke Medicine · doi:10.1177/2516608519856263 · Cited by 10 · see citing works
Li, R., Zhang, S., Song, M., Yu, W., & Fan, X. (2024) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.4c06985 · Cited by 10 · see citing works
Wang, S., Wang, C., Wang, L., & Cai, Z. (2020) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527319999200831153748 · Cited by 10 · see citing works
Lipid engineered nanomaterials: A novel paradigm shift for combating stroke
Amulya, E., Bahuguna, D., Negi, M., Phatale, V., Sikder, A., Vambhurkar, G. B., Katta, C. B., Dandekar, M. P., Madan, J., & Srivastava, S. K. (2024) · Applied Materials Today · doi:10.1016/j.apmt.2024.102194 · Cited by 9 · see citing works
Shamsaei, G., & Mohammadi, P. (2017) · Jundishapur Journal of Natural Pharmaceutical Products · doi:10.5812/jjnpp.63792 · Cited by 8 · see citing works
Liu, W., Wan, M., Shi, Y., & Yang, X. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.1008752 · Cited by 8 · see citing works
Jiang, Z., Alamuri, T. T., Muir, E. R., Choi, D. W., & Duong, T. Q. (2020) · Brain Research · doi:10.1016/j.brainres.2020.147122 · Cited by 8 · see citing works
Zebrafish as a potential model for stroke: A comparative study with standardized models
Borges, H. D. M., Dagostin, C. S., Córneo, E. D. S., Dondossola, E. R., Bernardo, H. T., Pickler, K. D. P., Pereira, B. D. C., de Oliveira, M. A., Scussel, R., Michels, M., et al. (2022) · Life Sciences · doi:10.1016/j.lfs.2022.121200 · Cited by 7 · see citing works
Shahrivar, A. A., Khakpourian, Z., Majdi, F., Sobhani, S., Coleman‐Fuller, N., Gholami, M., & Motaghinejad, M. (2022) · Biologia · doi:10.1007/s11756-022-01162-z · Cited by 7 · see citing works
An Ultrastructural Perspective on Cell Death
Najdawi, Z. R., & Abu-Asab, M. S. (2022) · Jordan Medical Journal · doi:10.35516/jmj.v56i1.232 · Cited by 6 · see citing works
Offenbacher, S., Beck, J. D., Sen, S., Susin, C., Merchant, A., Giamberardino, L., McMillian, B., Glover, S., Hardin, J., Phillips, S. T., et al. (2019) · International Journal of Cerebrovascular Disease and Stroke · doi:10.29011/2688-8734.100021 · Cited by 6 · see citing works
Effects of 9-t-butyl doxycycline on the innate immune response to CNS ischemia-reperfusion injury
Mai, N., Knowlden, S. A., Miller‐Rhodes, K., Prifti, V., Sims, M. H., Grier, M. C., Nelson, M. L., & Halterman, M. W. (2020) · Experimental and Molecular Pathology · doi:10.1016/j.yexmp.2020.104601 · Cited by 5 · see citing works
Minocycline: A Novel Stroke Therapy
Møller, A. R. (2015) · Journal of Neurology & Stroke · doi:10.15406/jnsk.2015.02.00073 · Cited by 4 · see citing works
Brain white matter damage biomarkers
Nabizadeh, F. (2024) · Advances in clinical chemistry · doi:10.1016/bs.acc.2024.11.005 · Cited by 3 · see citing works
Park, J.-E., Freeman, B. H., Park, H., Kim, S., Bafor, A. E., Myint, O., Gao, S., Xu, Z., Körbelin, J., Aronowski, J. A., et al. (2026) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x261421424 · Cited by 3 · see citing works
Sustained Release of Minocycline Hydrochloride from Biomaterials
Zhang, Z., & Zhong, Y. (2016) · Journal of Nanomedicine & Biotherapeutic Discovery · doi:10.4172/2155-983x.1000e142 · Cited by 3 · see citing works
Therapeutics Targeting Matrix Metalloproteinases
Cathcart, J. M., Pulkoski‐Gross, A., Zucker, S., & Cao, J. P. (2015) · Wiley eBooks · doi:10.1002/9781118772287.ch5 · Cited by 3 · see citing works
Minocycline: The search for a community hospital acute stroke therapy
Hess, D., Howard, V. J., & Howard, G. (2012) · Neurology India · doi:10.4103/0028-3886.93580 · Cited by 3 · see citing works
Self-citationNeuroprotection Following Stroke
Amantea, D., & Greco, R. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-820472-6.00032-3 · Cited by 3 · see citing works
Minocycline, A Tetracycline Derivative, as a Potential Protective Agent for Acute Stroke
Koıstınaho, J., & Koistinaho, M. (2013) · Springer eBooks · doi:10.1007/978-1-4614-8915-3_15 · Cited by 2 · see citing works
Park, S., Pin-Barre, C., Luzel, B., Cousinie, S., Garrigue, P., Pellegrino, C., Gigmès, D., Laurin, J., & Trimaille, T. (2026) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2026.127030 · Cited by 1 · see citing works
Ronaldson, P. T., & Davis, T. P. (2016) · Springer series in translational stroke research · doi:10.1007/978-3-319-32337-4_3 · Cited by 1 · see citing works
Cipriani, R., Domercq, M., & Matute, C. (2014) · Springer eBooks · doi:10.1007/978-1-4939-1429-6_17 · Cited by 1 · see citing works
Valdes, C., Martínez, J. L., & Laurido, C. (2015) · Pakistan Veterinary Journal · Cited by 1 · see citing works
Gelatinase-Mediated Impairment of Microvascular Beds in Cerebral Ischemia and Reperfusion Injury
Chen, S., Song, H., Cui, J., Shenker, J. I., Chen, Y., Sun, G. Y., Feng, H., & Gu, Z. (2018) · Springer series in translational stroke research · doi:10.1007/978-3-319-90194-7_1 · Cited by 1 · see citing works
The Role of Matrix Metalloproteinases in Neurovascular Injury
Seo, J. H., Guo, S., Lok, J. M., Navaratna, D., Xing, C., & Lo, E. H. (2013) · Springer eBooks · doi:10.1007/978-1-4614-9099-9_5
Polarization of Microglia/Macrophages in Brain Ischaemia: Relevance for Stroke Therapy
Amantea, D., Greco, R., Tassorelli, C., & Bagetta, G. (2017) · Springer series in translational stroke research · doi:10.1007/978-3-319-45345-3_12
Matrix metalloproteinases in stroke
Paltsyn, A. A. (2017) · Zhurnal «Patologicheskaia fiziologiia i eksperimental`naia terapiia» · doi:10.25557/0031-2991.2017.03.110-115
Araújo, S. C. (2014) · Americanae (AECID Library)
Castañeda, M. S. L., Duarte, N., Solorio, Y., Aguilera, M. F. G., Hjeala‐Varas, A., Ulloa, M. A. R., Desai, S. M., & Singhal, N. S. (2026) · medRxiv · doi:10.64898/2026.06.24.26356506
- Authors
- Fagan, S. C., Cronic, L. E., & Hess, D. C.
- Affiliations
- University of Georgia (US)
- Corresponding author
- Fagan, Susan C.
- ORCID
- Hess, David C.
- Venue
- Translational Stroke Research
- Published
- 2011-04-13
- Volume
- 2
- Issue
- 2
- Pages
- 202-208
- ISSN
- 1868-4483 (ISSN-L)
- 1868-601X
- PMC
- PMC3169090
- OpenAlex
- W2019475666
- Cited by
- 100
- References
- 53
- Citations by year
- 2026: 2 · 2024: 5 · 2023: 6 · 2022: 7 · 2021: 3 · 2020: 9 · 2019: 5 · 2018: 8 · 2017: 6 · 2016: 7 · 2015: 8 · 2014: 7 · 2013: 15 · 2012: 10
- FWCI
- 8.19
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Translational Stroke Research (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Neurological Disorders and Stroke (R01NS063965, R01NS055728)
- Topics
- Health Sciences › Medicine › Epidemiology › Acute Ischemic Stroke Management
- Life Sciences › Neuroscience › Neurology › Neurological Disorders and Treatments
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- minocycline, acute ischemic stroke, neuroprotection, anti-inflammatory activity, anti-apoptotic effects, blood-brain barrier penetration, infarct size, tissue plasminogen activator, clinical trials, drug development
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