The DOI matches its Crossref record; 54 of the 54 references it cites were found in a registry or an index.
Human Neural Stem Cell Extracellular Vesicles Improve Tissue and Functional Recovery in the Murine Thromboembolic Stroke Model
Open accessAbstract
Over 700 drugs have failed in stroke clinical trials, an unprecedented rate thought to be attributed in part to limited and isolated testing often solely in "young" rodent models and focusing on a single secondary injury mechanism. Here, extracellular vesicles (EVs), nanometer-sized cell signaling particles, were tested in a mouse thromboembolic (TE) stroke model. Neural stem cell (NSC) and mesenchymal stem cell (MSC) EVs derived from the same pluripotent stem cell (PSC) line were evaluated for changes in infarct volume as well as sensorimotor function. NSC EVs improved cellular, tissue, and functional outcomes in middle-aged rodents, whereas MSC EVs were less effective. Acute differences in lesion volume following NSC EV treatment were corroborated by MRI in 18-month-old aged rodents. NSC EV treatment has a positive effect on motor function in the aged rodent as indicated by beam walk, instances of foot faults, and strength evaluated by hanging wire test. Increased time with a novel object also indicated that NSC EVs improved episodic memory formation in the rodent. The therapeutic effect of NSC EVs appears to be mediated by altering the systemic immune response. These data strongly support further preclinical development of a NSC EV-based stroke therapy and warrant their testing in combination with FDA-approved stroke therapies.
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1 retracted
Otero‐Ortega, L., Frutos, M. C. G.-D., Laso-García, F., Rodríguez‐Frutos, B., Medina-Gutiérrez, E., López, J. A., Vázquez, J., Díez‐Tejedor, E., & Gutiérrez‐Fernández, M. (2017) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x17708917 · Cited by 149
RetractedExtracellular vesicles: Exosomes, microvesicles, and friends
Raposo, G., & Stoorvogel, W. (2013) · Journal of Cell Biology · doi:10.1083/jcb.201211138 · Cited by 8,099
Exosomes: composition, biogenesis and function
Théry, C., Zitvogel, L., & Amigorena, S. (2002) · Nature Reviews Immunology · doi:10.1038/nri855 · Cited by 5,346
The organization of recent and remote memories
Frankland, P. W., & Bontempi, B. (2005) · Nature Reviews Neuroscience · doi:10.1038/nrn1607 · Cited by 2,138
Wiklander, O. P. B., Nordin, J. Z., O'Loughlin, A., Gustafsson, Y., Corso, G., Mäger, I., Vader, P., Lee, Y., Sork, H., Seow, Y., et al. (2015) · Journal of Extracellular Vesicles · doi:10.3402/jev.v4.26316 · Cited by 1,730
Applying extracellular vesicles based therapeutics in clinical trials – an ISEV position paper
Lener, T., Gimona, M., Aigner, L., Börger, V., Buzas, E., Camussi, G., Chaput, N., Chatterjee, D., Court, F. A., del Portillo, H. A., et al. (2015) · Journal of Extracellular Vesicles · doi:10.3402/jev.v4.30087 · Cited by 1,491
Episodic and declarative memory: Role of the hippocampus
Tulving, E., & Markowitsch, H. J. (1998) · Hippocampus · doi:10.1002/(sici)1098-1063(1998)8:3<198::aid-hipo2>3.0.co;2-g · Cited by 1,277
MSC-derived exosomes: a novel tool to treat therapy-refractory graft-versus-host disease
Kordelas, L., Rebmann, V, Ludwig, A.-K., Radtke, S., Ruesing, J., Doeppner, T. R., Epple, M., Horn, P. A., Beelen, D. W., & Giebel, B. (2014) · Leukemia · doi:10.1038/leu.2014.41 · Cited by 1,084
Management of Adult Stroke Rehabilitation Care: A Clinical Practice Guideline
Duncan, P. W., Zorowitz, R., Bates, B., Choi, J. Y., Glasberg, J. J., Graham, G. D., Katz, R. C., Lamberty, K., & Reker, D. (2005) · Stroke · doi:10.1161/01.str.0000180861.54180.ff · Cited by 1,046
Xin, H., Li, Y., Cui, Y., Yang, J. J., Zhang, Z. G., & Chopp, M. (2013) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2013.152 · Cited by 984
Cited by
Exosomes — beyond stem cells for restorative therapy in stroke and neurological injury
Zhang, Z. G., Buller, B., & Chopp, M. (2019) · Nature Reviews Neurology · doi:10.1038/s41582-018-0126-4 · Cited by 503
Rong, Y., Liu, W., Wang, J., Fan, J., Luo, Y., Li, L., Kong, F., Chen, J., Tang, P., & Cai, W. (2019) · Cell Death & Disease · doi:10.1038/s41419-019-1571-8 · Cited by 333
Neural stem cells traffic functional mitochondria via extracellular vesicles
Peruzzotti-Jametti, L., Bernstock, J. D., Willis, C. M., Manferrari, G., Rogall, R., Fernandez-Vizarra, E., Williamson, J. C., Braga, A., van den Bosch, A., Leonardi, T., et al. (2021) · PLOS Biology · doi:10.1371/journal.pbio.3001166 · Cited by 263
Neural Stem Cell Transplantation for Neurodegenerative Diseases
De Gioia, R., Biella, F., Citterio, G., Rizzo, F., Abati, E., Nizzardo, M., Bresolin, N., Comi, G. P., & Corti, S. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21093103 · Cited by 247
Xu, M., Feng, T., Liu, B., Qiu, F., Xu, Y., Zhao, Y., & Zheng, Y. (2021) · Theranostics · doi:10.7150/thno.62330 · Cited by 229
Metadata
- Authors
- Webb, R. L., Kaiser, E. E., Scoville, S. L., Thompson, T. A., Fatima, S., Pandya, C., Sriram, K., Swetenburg, R. L., Vaibhav, K., Arbab, A. S., Baban, B., Dhandapani, K. M., Hess, D. C., Hoda, M. N., & Stice, S. L.
- Venue
- Translational Stroke Research
- Published
- 2017-12-28
- Volume
- 9
- Issue
- 5
- Pages
- 530-539
- ISSN
- 1868-4483 (ISSN-L)
- 1868-601X
- OpenAlex
- W2777343869
- Cited by
- 282
- References
- 54
- FWCI
- 6.21
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- CoChat. (2026). Citation check: Human Neural Stem Cell Extracellular Vesicles Improve Tissue and Functional Recovery in the Murine Thromboembolic Stroke Model. https://app.cochat.ai/papers/10.1007/s12975-017-0599-2
- The paper
- Webb, R. L., Kaiser, E. E., Scoville, S. L., Thompson, T. A., Fatima, S., Pandya, C., Sriram, K., Swetenburg, R. L., Vaibhav, K., Arbab, A. S., Baban, B., Dhandapani, K. M., Hess, D. C., Hoda, M. N., & Stice, S. L. (2018). Human Neural Stem Cell Extracellular Vesicles Improve Tissue and Functional Recovery in the Murine Thromboembolic Stroke Model. Translational Stroke Research. https://doi.org/10.1007/s12975-017-0599-2
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
