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Cited by 247Neurogenesis and neuroplasticity mechanismsMesenchymal stem cell researchPluripotent Stem Cells Research

Neural Stem Cell Transplantation for Neurodegenerative Diseases

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De Gioia, Roberta, Biella, Fabio, Citterio, Gaia, Rizzo, Federica, Abati, Elena, Nizzardo, Monica, Bresolin, Nereo, Comi, Giacomo Pietro +1 more·2020·International Journal of Molecular Sciences
DOI 10.3390/ijms21093103PMC PMC7247151
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Abstract

Neurodegenerative diseases are disabling and fatal neurological disorders that currently lack effective treatment. Neural stem cell (NSC) transplantation has been studied as a potential therapeutic approach and appears to exert a beneficial effect against neurodegeneration via different mechanisms, such as the production of neurotrophic factors, decreased neuroinflammation, enhanced neuronal plasticity and cell replacement. Thus, NSC transplantation may represent an effective therapeutic strategy. To exploit NSCs’ potential, some of their essential biological characteristics must be thoroughly investigated, including the specific markers for NSC subpopulations, to allow profiling and selection. Another key feature is their secretome, which is responsible for the regulation of intercellular communication, neuroprotection, and immunomodulation. In addition, NSCs must properly migrate into the central nervous system (CNS) and integrate into host neuronal circuits, enhancing neuroplasticity. Understanding and modulating these aspects can allow us to further exploit the therapeutic potential of NSCs. Recent progress in gene editing and cellular engineering techniques has opened up the possibility of modifying NSCs to express select candidate molecules to further enhance their therapeutic effects. This review summarizes current knowledge regarding these aspects, promoting the development of stem cell therapies that could be applied safely and effectively in clinical settings.

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  • Since neurons are the main cell type lost during CNS injury, the foremost stem cell type initially thought appropriate for CNS disorder therapy is neural stem cells (NSCs).

    “Since neurons are the main cell type lost during CNS injury, the foremost stem cell type initially thought appropriate for CNS disorder therapy is neural stem cells (NSCs) [108].”

    From Extracellular vesicles as nanotheranostic platforms for targeted neurological disorder interventions (2024) · cites this paper as [108]

    The Introduction says that specific subsets of neurons degenerate in neurodegenerative diseases and describes NSCs as a physiological stem-cell source for treating them. It does not say that neurons are the main cell type lost across CNS injuries or that NSCs were historically the first choice for CNS disorder therapy. Section 3 discusses a stroke-injury model but does not establish those broader claims; page numbers are unavailable in our copy. (LLM, conf=0.86)

    Experimental — accuracy not yet measured

  • NSCs persist in the subventricular zone (SVZ) of the brain into adulthood and possess minimal regenerative abilities, giving rise to the main CNS cell types: neurons, astrocytes, and oligodendrocytes.

    “NSCs persist in the subventricular zone (SVZ) of the brain into adulthood and possess minimal regenerative abilities, giving rise to the main CNS cell types: neurons, astrocytes, and oligodendrocytes [108].”

    From Extracellular vesicles as nanotheranostic platforms for targeted neurological disorder interventions (2024) · cites this paper as [108]

  • NSCs transplanted into the brain often cluster near the injection site, showing a limited ability to efficiently migrate toward injury or disease-affected regions.

    “NSCs transplanted into the brain often cluster near the injection site, showing a limited ability to efficiently migrate toward injury or disease-affected regions.”

    From Extracellular vesicles as nanotheranostic platforms for targeted neurological disorder interventions (2024) · cites this paper as [108]

  • The effectiveness of NSCs depends on their capacity to reach and repopulate the damaged areas within the CNS.

    “Their effectiveness depends on their capacity to reach and repopulate the damaged areas within the CNS [108].”

    From Extracellular vesicles as nanotheranostic platforms for targeted neurological disorder interventions (2024) · cites this paper as [108]

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Cited by

Sorted by citations

Authors
De Gioia, R., Biella, F., Citterio, G., Rizzo, F., Abati, E., Nizzardo, M., Bresolin, N., Comi, G. P., & Corti, S.
Affiliations
  • Foundation IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Neurology Unit, Via Francesco Sforza 35, 20122 Milan, Italy
  • University of Milan (IT)
Corresponding author
Corti, Stefania
ORCID
Venue
International Journal of Molecular Sciences
Publisher
MDPI AG
Published
2020-04-28
Volume
21
Issue
9
Pages
3103
ISSN
1422-0067 (ISSN-L)
DOI
10.3390/ijms21093103
PMC
PMC7247151
OpenAlex
W3023327298
Cited by
247
References
9
Citations by year
2026: 33 · 2025: 56 · 2024: 55 · 2023: 47 · 2022: 33 · 2021: 21 · 2020: 1 · 2019: 1
FWCI
3.98
Type
journal article
Language
en
Open access
Licence
Locations
  • International Journal of Molecular Sciences (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Archivio Istituzionale della Ricerca (Universita Degli Studi Di Milano) (submittedVersion, cc-by)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • Italian Ministry of Health (RF-2016-02362317)
  • Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (Ricerca Corrente 2019)
Topics
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
  • Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Pluripotent Stem Cells Research
Keywords
neural stem cell transplantation, neurodegenerative diseases, neurotrophic factors, neuroinflammation, neuroplasticity, cell replacement, secretome, neuroprotection, immunomodulation, cell migration, genome editing, cell engineering, stem cell therapy
MeSH terms
Animals, Humans, Nerve Growth Factors, Neurodegenerative Diseases, Stem Cell Transplantation, Immunomodulation, Neural Stem Cells

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