The DOI matches its Crossref record; 80 of the 80 references it cites were found in a registry or an index.
Recent advances and comparisons of conventional and alternative extraction techniques of phenolic compounds
Open accessAbstract
Phenolic compounds are a group of secondary metabolites produced by plants under stressful conditions. Phenolic compounds play an important role in the prevention and treatment of certain illnesses and are exploited by the food and pharmaceutical industries. Conventional methods are commonly used as models to compare the efficiencies of alternative extraction methods. Among alternative extraction processes, microwave-assisted extraction (MAE), pressurized liquid extraction (PLE), supercritical fluid extraction (SFE) and ultrasonic-assisted extraction (UAE) are the most studied. These methods produce extracts rich in phenolic compounds using moderate temperatures, short extraction times, and solvents generally recognized as safe. The combination of extraction time and temperature plays a critical role in the stability of the compounds. Solvents of higher polarity enhance the extraction of phenolic compounds. The use of the ethanol-water mixture for MAE, PLE, and UAE is recommended. MAE and UAE involve shorter extraction times than do PLE and SFE. SFE requires a low average temperature (40 °C). MAE produces the highest total phenolic content [227.63 mg GAE/g dry basis (d.b.)], followed by PLE (173.65 mg GAE/g d.b.), UAE (92.99 mg GAE/g d.b.) and SFE (37 mg GAE/g d.b.). Extraction yields and recovery rates of the phenolic compounds can be enhanced by combining and integrating extraction methods.
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In the citing paper
“prolonged or harsh conditions often compromise the antioxidant and antimicrobial efficacy of phenolic-rich extracts”
From Influence of Extraction Parameters on Bioactive Compounds and Antimicrobial Activity of Banana Peel Using Ethanol-Water Solvent (2026) · cites this paper as Osorio-Tobón, 2020
In the citing paper
“The usual temperature range for conventional extraction methods to produce the greatest recovery of polyphenols is typically between 40 and 80 • C [50,51].”
From Bioactive Compound Extraction of Hemp ( Cannabis sativa L.) Leaves through Response Surface Methodology Optimization (2024) · cites this paper as [51]
Citations
Cites
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Ultrasound: A clean, green extraction technology
Tiwari, B. K. (2015) · TrAC Trends in Analytical Chemistry · doi:10.1016/j.trac.2015.04.013 · Cited by 1,042
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Plant derived and dietary phenolic antioxidants: Anticancer properties
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Green extraction methods of food polyphenols from vegetable materials
Panja, P. (2017) · Current Opinion in Food Science · doi:10.1016/j.cofs.2017.11.012 · Cited by 273
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Gil‐Martín, E., Forbes-Hernández, T. Y., Romero, A., Cianciosi, D., Giampieri, F., & Battino, M. A. (2021) · Food Chemistry · doi:10.1016/j.foodchem.2021.131918 · Cited by 715
Jha, A. K., & Sit, N. (2021) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2021.11.019 · Cited by 631
Techniques and modeling of polyphenol extraction from food: A review
Sridhar, A., Ponnuchamy, M., Kumar, P. S., Kapoor, A., Vo, D.-V. N., & Prabhakar, S. (2021) · Environmental Chemistry Letters · doi:10.1007/s10311-021-01217-8 · Cited by 348
Exploring phenolic compounds as natural stress alleviators in plants- a comprehensive review
Saini, N., Anmol, A., Kumar, S., Wani, A. W., Bakshi, M., & Zarina, D. (2024) · Physiological and Molecular Plant Pathology · doi:10.1016/j.pmpp.2024.102383 · Cited by 216
Traditional and innovative approaches for the extraction of bioactive compounds
Usman, I., Hussain, M., Imran, A., Afzaal, M., Saeed, F., Javed, M., Afzal, A., Ashfaq, I., Al Jbawi, E., & A. Saewan, S. (2022) · International Journal of Food Properties · doi:10.1080/10942912.2022.2074030 · Cited by 209
“Extraction of Phenolic compounds by utilizing conventional methods, such as maceration, infusion, digestion, and Soxhlet, has been done for many years.([41]) Most important among these methods are maceration as well as Soxhlet.”
Method
Metadata
- Authors
- Osorio-Tobón, J. F.
- Affiliations
- Institución Universitaria Colegio Mayor de Antioquia (CO)
- Corresponding author
- Osorio-Tobón, J. Felipe
- Venue
- Journal of Food Science and Technology
- Published
- 2020-05-28
- Volume
- 57
- Issue
- 12
- Pages
- 4299-4315
- ISSN
- 0022-1155 (ISSN-L)
- 0975-8402
- PMC
- PMC7550548
- OpenAlex
- W3029959204
- Cited by
- 407
- References
- 80
- Citations by year
- 2026: 96 · 2025: 113 · 2024: 76 · 2023: 53 · 2022: 37 · 2021: 30 · 2020: 2
- FWCI
- 2.65
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Food Science and Technology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
- Life Sciences › Agricultural and Biological Sciences › Food Science › Agricultural and Biological Research
- Physical Sciences › Chemistry › Organic Chemistry › Edible Oils Quality and Analysis
- Keywords
- phenolic compounds, extraction methods, microwave-assisted extraction, accelerated solvent extraction, supercritical fluid extraction, ultrasound-assisted extraction, ethanol-water solvent, extraction temperature and time, total phenolic content, extraction yield, plant secondary metabolites
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