The DOI matches its Crossref record; 100 of the 100 references it cites were found in a registry or an index.
The role of BRCA1 in DNA damage response
Open accessAbstract
BRCA1 is a well-established tumor suppressor gene, which is frequently mutated in familial breast and ovarian cancers. The gene product of BRCA1 functions in a number of cellular pathways that maintain genomic stability, including DNA damage-induced cell cycle checkpoint activation, DNA damage repair, protein ubiquitination, chromatin remodeling, as well as transcriptional regulation and apoptosis. In this review, we discuss recent advances regarding our understanding of the role of BRCA1 in tumor suppression and DNA damage response, including DNA damage-induced cell cycle checkpoint activation and DNA damage repair.
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“Evidence suggests that BRCA1 could be one of the key players in DNA damage response [281].”
From Molecular Mechanisms of Ultraviolet Radiation‐Induced DNA Damage and Repair (2010) · cites this paper as [281]
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Cites
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A Strong Candidate for the Breast and Ovarian Cancer Susceptibility Gene BRCA1
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Linkage of Early-Onset Familial Breast Cancer to Chromosome 17q21
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Cited by
Sorted by citations
Molecular Mechanisms of Ultraviolet Radiation‐Induced DNA Damage and Repair
Rastogi, R. P., Richa, Kumar, A., Tyagi, M. B., & Sinha, R. P. (2010) · Journal of Nucleic Acids · doi:10.4061/2010/592980 · Cited by 1,329
Gadd45 in Stress Signaling, Cell Cycle Control, and Apoptosis
Salvador, J. M., Brown-Clay, J. D., & Fornace, A. J. (2013) · Advances in experimental medicine and biology · doi:10.1007/978-1-4614-8289-5_1 · Cited by 402
Mittal, S., Kaur, H., Gautam, N., & Mantha, A. K. (2016) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2016.08.028 · Cited by 295
Irianto, J., Xia, Y., Pfeifer, C. R., Athirasala, A., Ji, J., Alvey, C. M., Tewari, M., Bennett, R. R., Harding, S. M., Liu, A. J., et al. (2016) · Current Biology · doi:10.1016/j.cub.2016.11.049 · Cited by 289
Exploitation of EP300 and CREBBP Lysine Acetyltransferases by CancerPreprint
Attar, N., & Kurdistani, S. K. (2016) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a026534 · Cited by 237
Metadata
- Authors
- Wu, J., Lu, L.-Y., & Yu, X.
- Affiliations
- University of Michigan (US)
- Corresponding author
- Yu, Xiaochun
- Venue
- Protein & Cell
- Publisher
- Oxford University Press (OUP)
- Published
- 2010-02
- Volume
- 1
- Issue
- 2
- Pages
- 117-123
- ISSN
- 1674-800X (ISSN-L)
- 1674-8018
- PMC
- PMC3078634
- OpenAlex
- W2140930673
- Cited by
- 235
- References
- 100
- Citations by year
- 2026: 5 · 2025: 13 · 2024: 25 · 2023: 17 · 2022: 32 · 2021: 20 · 2020: 15 · 2019: 18 · 2018: 16 · 2017: 9 · 2016: 15 · 2015: 9 · 2014: 13 · 2013: 15 · 2012: 9
- FWCI
- 0.78
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Protein & Cell (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- University of Michigan
- National Institutes of Health
- National Cancer Institute (R01CA132755, R01CA130899, CA132755)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › BRCA gene mutations in cancer
- Health Sciences › Medicine › Oncology › PARP inhibition in cancer therapy
- Keywords
- BRCA1, DNA damage response, tumor suppression, DNA repair, genome stability, ubiquitination, chromatin remodeling, transcriptional regulation, apoptosis, breast cancer, ovarian cancer
- MeSH terms
- Breast Neoplasms, DNA Damage, DNA Repair, Female, Humans, Mutation, Ovarian Neoplasms, Signal Transduction, Genes, Tumor Suppressor, Apoptosis, Genes, cdc, BRCA1 Protein
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