Cited by 235DNA Repair MechanismsBRCA gene mutations in cancerPARP inhibition in cancer therapy

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The role of BRCA1 in DNA damage response

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Wu, Jiaxue, Lu, Lin-Yu, Yu, Xiaochun·2010·Protein & Cell

DOI 10.1007/s13238-010-0010-5PMC PMC3078634

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Abstract

BRCA1 is a well-established tumor suppressor gene, which is frequently mutated in familial breast and ovarian cancers. The gene product of BRCA1 functions in a number of cellular pathways that maintain genomic stability, including DNA damage-induced cell cycle checkpoint activation, DNA damage repair, protein ubiquitination, chromatin remodeling, as well as transcriptional regulation and apoptosis. In this review, we discuss recent advances regarding our understanding of the role of BRCA1 in tumor suppression and DNA damage response, including DNA damage-induced cell cycle checkpoint activation and DNA damage repair.

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Molecular Mechanisms of Ultraviolet Radiation‐Induced DNA Damage and Repair
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DNA Damage Follows Repair Factor Depletion and Portends Genome Variation in Cancer Cells after Pore Migration
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Authors: Wu, J., Lu, L.-Y., & Yu, X.
Affiliations: University of Michigan (US)
Corresponding author: Yu, Xiaochun
ORCID: Wu, Jiaxue
Lu, Lin-Yu
Yu, Xiaochun
Venue: Protein & Cell
Publisher: Oxford University Press (OUP)
Published: 2010-02
Volume: 1
Issue: 2
Pages: 117-123
ISSN: 1674-800X (ISSN-L)
1674-8018
DOI: 10.1007/s13238-010-0010-5
PMC: PMC3078634
OpenAlex: W2140930673
Cited by: 235
References: 100
Citations by year: 2026: 5 · 2025: 13 · 2024: 25 · 2023: 17 · 2022: 32 · 2021: 20 · 2020: 15 · 2019: 18 · 2018: 16 · 2017: 9 · 2016: 15 · 2015: 9 · 2014: 13 · 2013: 15 · 2012: 9
FWCI: 0.78
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.springer.com/tdm (tdm)
Locations: Protein & Cell (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: University of Michigan
National Institutes of Health
National Cancer Institute (R01CA132755, R01CA130899, CA132755)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › BRCA gene mutations in cancer
Health Sciences › Medicine › Oncology › PARP inhibition in cancer therapy
Keywords: BRCA1, DNA damage response, tumor suppression, DNA repair, genome stability, ubiquitination, chromatin remodeling, transcriptional regulation, apoptosis, breast cancer, ovarian cancer
MeSH terms: Breast Neoplasms, DNA Damage, DNA Repair, Female, Humans, Mutation, Ovarian Neoplasms, Signal Transduction, Genes, Tumor Suppressor, Apoptosis, Genes, cdc, BRCA1 Protein

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The role of BRCA1 in DNA damage response

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