Cited by 235DNA Repair MechanismsBRCA gene mutations in cancerPARP inhibition in cancer therapy

The DOI matches its Crossref record; 100 of the 100 references it cites were found in a registry or an index.

The role of BRCA1 in DNA damage response

Open access

Wu, Jiaxue, Lu, Lin-Yu, Yu, Xiaochun·2010·Protein & Cell

DOI 10.1007/s13238-010-0010-5PMC PMC3078634

Open this paper in CoChat — free account Open PDF

Abstract

BRCA1 is a well-established tumor suppressor gene, which is frequently mutated in familial breast and ovarian cancers. The gene product of BRCA1 functions in a number of cellular pathways that maintain genomic stability, including DNA damage-induced cell cycle checkpoint activation, DNA damage repair, protein ubiquitination, chromatin remodeling, as well as transcriptional regulation and apoptosis. In this review, we discuss recent advances regarding our understanding of the role of BRCA1 in tumor suppression and DNA damage response, including DNA damage-induced cell cycle checkpoint activation and DNA damage repair.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1007/s13238-010-0010-5

Cites

100 of 100 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy
Farmer, H., McCabe, N., Lord, C. J., Tutt, A. N. J., Johnson, D. A., Richardson, T. B., Santarosa, M., Dillon, K. J., Hickson, I., Knights, C., et al. (2005) · Nature · doi:10.1038/nature03445 · Cited by 6,683
A Strong Candidate for the Breast and Ovarian Cancer Susceptibility Gene BRCA1
Miki, Y., Swensen, J. J., Shattuck-Eidens, D. M., Futreal, P. A., Harshman, K., Tavtigian, S. V., Liu, Q., Cochran, C., Bennett, L. M., Ding, W., et al. (1994) · Science · doi:10.1126/science.7545954 · Cited by 6,069
Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase
Bryant, H. E., Schultz, N., Thomas, H. D., Parker, K. M., Flower, D., Lopez, E., Kyle, S., Meuth, M., Curtin, N. J., & Helleday, T. (2005) · Nature · doi:10.1038/nature03443 · Cited by 5,198
Inhibition of Poly(ADP-Ribose) Polymerase in Tumors from BRCA Mutation Carriers
Fong, P. C., Boss, D. S., Yap, T. A., Tutt, A., Wu, P., Mergui-Roelvink, M., Mortimer, P., Swaisland, H., Lau, A., O'Connor, M. J., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0900212 · Cited by 3,634
Checkpoints: Controls That Ensure the Order of Cell Cycle Events
Hartwell, L. H., & Weinert, T. A. (1989) · Science · doi:10.1126/science.2683079 · Cited by 3,053
Linkage of Early-Onset Familial Breast Cancer to Chromosome 17q21
Hall, J., Lee, M. K., Newman, B. M., Morrow, J. E., Anderson, L. A., Huey, B., & King, M. (1990) · Science · doi:10.1126/science.2270482 · Cited by 2,544
Cell Cycle Control and Cancer
Hartwell, L. H., & Kastan, M. B. (1994) · Science · doi:10.1126/science.7997877 · Cited by 2,539
ATM Phosphorylates Histone H2AX in Response to DNA Double-strand Breaks
Burma, S., Chen, B. P., Murphy, M., Kurimasa, A., & Chen, D. J. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.c100466200 · Cited by 1,954
Wild-type p53 is a cell cycle checkpoint determinant following irradiation.
Kuerbitz, S. J., Plunkett, B., Walsh, W., & Kastan, M. B. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.16.7491 · Cited by 1,837
Cancer Susceptibility and the Functions of BRCA1 and BRCA2
Venkitaraman, A. R. (2002) · Cell · doi:10.1016/s0092-8674(02)00615-3 · Cited by 1,713

Show all 100 references

Sorted by citations

Molecular Mechanisms of Ultraviolet Radiation‐Induced DNA Damage and Repair
Rastogi, R. P., Richa, Kumar, A., Tyagi, M. B., & Sinha, R. P. (2010) · Journal of Nucleic Acids · doi:10.4061/2010/592980 · Cited by 1,329
Gadd45 in Stress Signaling, Cell Cycle Control, and Apoptosis
Salvador, J. M., Brown-Clay, J. D., & Fornace, A. J. (2013) · Advances in experimental medicine and biology · doi:10.1007/978-1-4614-8289-5_1 · Cited by 402
Biosensors for breast cancer diagnosis: A review of bioreceptors, biotransducers and signal amplification strategies
Mittal, S., Kaur, H., Gautam, N., & Mantha, A. K. (2016) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2016.08.028 · Cited by 295
DNA Damage Follows Repair Factor Depletion and Portends Genome Variation in Cancer Cells after Pore Migration
Irianto, J., Xia, Y., Pfeifer, C. R., Athirasala, A., Ji, J., Alvey, C. M., Tewari, M., Bennett, R. R., Harding, S. M., Liu, A. J., et al. (2016) · Current Biology · doi:10.1016/j.cub.2016.11.049 · Cited by 289
Exploitation of EP300 and CREBBP Lysine Acetyltransferases by CancerPreprint
Attar, N., & Kurdistani, S. K. (2016) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a026534 · Cited by 237
Breast cancer in low-middle income countries: abnormality in splicing and lack of targeted treatment options.
Francies, F. Z., Hull, R., Khanyile, R., & Dlamini, Z. (2020) · PubMed Central · Cited by 228
Comprehensive molecular biomarker identification in breast cancer brain metastases
Schulten, H.-J., Bangash, M., Karim, S., Dallol, A., Hussein, D. M., Merdad, A. A., Althoubaity, F., Al-Maghrabi, J. A., Jamal, A., Alghamdi, F. A., et al. (2017) · Journal of Translational Medicine · doi:10.1186/s12967-017-1370-x · Cited by 217
DNA Double-Strand Break Resection Occurs during Non-homologous End Joining in G1 but Is Distinct from Resection during Homologous Recombination
Diemer-Biehs, R., Steinlage, M., Barton, O., Juhász, S., Künzel, J., Spies, J., Shibata, A., Jeggo, P. A., & Löbrich, M. (2017) · Molecular Cell · doi:10.1016/j.molcel.2016.12.016 · Cited by 224
BAP1: Not just a BRCA1-associated protein
Louie, B. H., & Kurzrock, R. (2020) · Cancer Treatment Reviews · doi:10.1016/j.ctrv.2020.102091 · Cited by 198
FOXM1 (Forkhead box M1) in Tumorigenesis
Wierstra, I. (2013) · Advances in cancer research · doi:10.1016/b978-0-12-407190-2.00016-2 · Cited by 190
The Transcription Factor FOXM1 (Forkhead box M1)
Wierstra, I. (2013) · Advances in cancer research · doi:10.1016/b978-0-12-407173-5.00004-2 · Cited by 180
BRCA-related ATM-mediated DNA double-strand break repair and ovarian aging
Turan, V., & Oktay, K. (2019) · Human Reproduction Update · doi:10.1093/humupd/dmz043 · Cited by 181
Hereditary breast cancer; Genetic penetrance and current status with BRCA
Mahdavi, M., Nassiri, M., Kooshyar, M. M., Azghandi, M. V., Avan, A., Sandry, R., Pillai, S., Lam, A. K.-Y., & Gopalan, V. (2018) · Journal of Cellular Physiology · doi:10.1002/jcp.27464 · Cited by 181
Structural basis of homologous recombination
Sun, Y., McCorvie, T. J., Yates, L. A., & Zhang, X. (2019) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-019-03365-1 · Cited by 175
β-Hydroxybutyrate Prevents Vascular Senescence through hnRNP A1-Mediated Upregulation of Oct4
Han, Y., Bédarida, T., Ding, Y., Somba, B. K., Lu, Q., Wang, Q., Song, P., & Zou, M. (2018) · Molecular Cell · doi:10.1016/j.molcel.2018.07.036 · Cited by 148
Zika virus infection leads to mitochondrial failure, oxidative stress and DNA damage in human iPSC-derived astrocytes
Ledur, P. F., Karmirian, K., Pedrosa, C. D. S. G., Souza, L. R. Q., Assis-de-Lemos, G., Martins, T. M., Ferreira, J. D. C. C. G., de Azevedo Reis, G. F., Silva, E. S., Silva, D., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-57914-x · Cited by 145
Comparison of seven diagnostic tests to detect Trypanosoma cruzi infection in patients in chronic phase of Chagas disease.
Díaz, E., García, L., Hernández, M., Palacio, L., Ruiz, D., Velandia, N., Villavicencio, J., & Moreno, F. (2012) · Europe PMC (PubMed Central) · Cited by 126
CRISPR/Cas9 gene editing: a new approach for overcoming drug resistance in cancer
Vaghari‐Tabari, M., Hassanpour, P., Sadeghsoltani, F., Malakoti, F., Alemi, F., Qujeq, D., Asemi, Z., & Yousefi, B. (2022) · Cellular & Molecular Biology Letters · doi:10.1186/s11658-022-00348-2 · Cited by 137
BRCA1 Promotes Unloading of the CMG Helicase from a Stalled DNA Replication Fork
Long, D. T., Joukov, V., Budzowska, M., & Walter, J. C. (2014) · Molecular Cell · doi:10.1016/j.molcel.2014.08.012 · Cited by 124
Regulatory mechanisms and clinical perspectives of miRNA in tumor radiosensitivity
Zhao, L., Bode, A. M., Cao, Y., & Dong, Z. (2012) · Carcinogenesis · doi:10.1093/carcin/bgs235 · Cited by 114
Prevention of Treacher Collins syndrome craniofacial anomalies in mouse models via maternal antioxidant supplementation
Sakai, D., Dixon, J., Achilleos, A., Dixon, M. J., & Trainor, P. A. (2016) · Nature Communications · doi:10.1038/ncomms10328 · Cited by 117
Neuron-specific methylome analysis reveals epigenetic regulation and tau-related dysfunction of BRCA1 in Alzheimer’s disease
Mano, T., Nagata, K., Nonaka, T., Tarutani, A., Imamura, T., Hashimoto, T., Bannai, T., Mano, K. K., Tsuchida, T., Ohtomo, R., et al. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1707151114 · Cited by 105
Homologous recombination proficiency in ovarian and breast cancer patients
Creeden, J. F., Nanavaty, N. S., Einloth, K. R., Gillman, C. E., Stanbery, L., Hamouda, D., Dworkin, L. D., & Nemunaitis, J. J. (2021) · BMC Cancer · doi:10.1186/s12885-021-08863-9 · Cited by 96
Inhibition of PTEN activates bovine non-growing follicles in vitro but increases DNA damage and reduces DNA repair response
Maidarti, M., Clarkson, Y. L., Mclaughlin, M., Anderson, R. A., & Telfer, E. E. (2018) · Human Reproduction · doi:10.1093/humrep/dey354 · Cited by 87
Enhanced efficacy of combined HDAC and PARP targeting in glioblastoma
Rasmussen, R. D., Gajjar, M. K., Jensen, K. E., & Hamerlik, P. (2016) · Molecular Oncology · doi:10.1016/j.molonc.2015.12.014 · Cited by 79
Targeted agents in the third-/fourth-line treatment of patients with advanced (stage III/IV) non-small cell lung cancer (NSCLC)
Langer, C. J., Mok, T. S. K., & Postmus, P. E. (2012) · Cancer Treatment Reviews · doi:10.1016/j.ctrv.2012.05.003 · Cited by 75
GADD45 in Stress Signaling, Cell Cycle Control, and Apoptosis
Humayun, A., & Fornace, A. J. (2022) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-94804-7_1 · Cited by 75
Oxidative Stress Diverts tRNA Synthetase to Nucleus for Protection against DNA Damage
Wei, N., Shi, Y., Truong, L. N., Fisch, K. M., Xu, T., Gardiner, E. M. M., Fu, G., Hsu, Y.-S. O., Kishi, S., Su, A. I., et al. (2014) · Molecular Cell · doi:10.1016/j.molcel.2014.09.006 · Cited by 78
Splicing alterations in healthy aging and disease
Angarola, B. L., & Anczuków, O. (2021) · Wiley Interdisciplinary Reviews - RNA · doi:10.1002/wrna.1643 · Cited by 73
HMGA2 and high-grade serous ovarian carcinoma
Wu, J., & Wei, J. (2013) · Journal of Molecular Medicine · doi:10.1007/s00109-013-1055-8 · Cited by 65
Self-citation
Single-Cell RNA Sequencing of the Nucleus Pulposus Reveals Chondrocyte Differentiation and Regulation in Intervertebral Disc Degeneration
Han, S., Zhang, Y., Zhang, X., Zhang, H., Meng, S., Kong, M., Liu, X., & Ma, X. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.824771 · Cited by 63
Downregulation of BRCA1 protein in BCR-ABL1 leukemia cells depends on stress-triggered TIAR-mediated suppression of translation
Podszywalow‐Bartnicka, P., Wołczyk, M., Kusio-Kobiałka, M., Wolanin, K., Skowronek, K. J., Nieborowska-Skorska, M., Dasgupta, Y., Skórski, T., & Piwocka, K. (2014) · Cell Cycle · doi:10.4161/15384101.2014.965013 · Cited by 62
The significance of ovarian fibrosis
Landry, D. A., Vaishnav, H. T., & Vanderhyden, B. C. (2020) · Oncotarget · doi:10.18632/oncotarget.27822 · Cited by 61
DNA damage response and repair in ovarian cancer: Potential targets for therapeutic strategies
Mirza‐Aghazadeh‐Attari, M., Ostadian, C., Saei, A. A., Mihanfar, A., Darband, S. G., Sadighparvar, S., Kaviani, M., Kafil, H. S., Yousefi, B., & Majidinia, M. (2019) · DNA repair · doi:10.1016/j.dnarep.2019.06.005 · Cited by 56
Effects of the Community-Based Wellspring Cancer Exercise Program on Functional and Psychosocial Outcomes in Cancer Survivors
Mina, D. S., Au, D., Brunet, J., Jones, J. M., TOMLINSON, G. A., Taback, N., Field, D., Berlingeri, A., Bradley, H., & Howell, D. (2017) · Current Oncology · doi:10.3747/co.23.3585 · Cited by 55
Human Adipose Stromal Cells (ASC) for the Regeneration of Injured Cartilage Display Genetic Stability after In Vitro Culture Expansion
Neri, S., Bourin, P., Peyrafitte, J.-A., Cattini, L., Facchini, A., & Mariani, E. (2013) · PLoS ONE · doi:10.1371/journal.pone.0077895 · Cited by 53
Targeting GPX4-mediated ferroptosis protection sensitizes BRCA1-deficient cancer cells to PARP inhibitors
Xie, X., Chen, C., Wang, C., Guo, Y., Sun, B., Tian, J., Yan, J., Li, D., & Chen, G. (2024) · Redox Biology · doi:10.1016/j.redox.2024.103350 · Cited by 50
Circulating Tumor DNA Alterations in Advanced Urothelial Carcinoma and Association with Clinical Outcomes: A Pilot Study
Grivas, P. D., Lalani, A. A., Pond, G. R., Nagy, R. J., Faltas, B. M., Agarwal, N., Gupta, S. V., Drakaki, A., Vaishampayan, U. N., Wang, J., et al. (2019) · European Urology Oncology · doi:10.1016/j.euo.2019.02.004 · Cited by 50
Overactive BRCA1 Affects Presenilin 1 in Induced Pluripotent Stem Cell-Derived Neurons in Alzheimer’s Disease
Wężyk, M., Szybińska, A., Wojsiat, J., Szczerba, M., Day, K., Rönnholm, H., Kele, M., Berdyński, M., Pepłońska, B., Fichna, J. P., et al. (2018) · Journal of Alzheimer s Disease · doi:10.3233/jad-170830 · Cited by 51
Efficient prediction of human protein-protein interactions at a global scale
Schoenrock, A., Samanfar, B., Pitre, S., Hooshyar, M., Jin, K., Phillips, C., Wang, H., Phanse, S., Omidi, K., Gui, Y., et al. (2014) · BMC Bioinformatics · doi:10.1186/s12859-014-0383-1 · Cited by 49
Theoretical Investigation of 5-Fluorouracil and Tamoxifen Complex – Structural, Spectrum, DFT, ADMET and Docking Simulation
Sukumaran, S., Zochedh, A., Viswanathan, T. M., Bahadur, S. A., & Kathiresan, T. (2023) · Polycyclic aromatic compounds · doi:10.1080/10406638.2022.2164018 · Cited by 47
Exploring the co‐activity of FDA approved drug gemcitabine and docetaxel for enhanced anti‐breast cancer activity: DFT , docking, molecular dynamics simulation and pharmacophore studies
Sukumaran, S., Zochedh, A., Chandran, K., Bahadur, S. A., & Kathiresan, T. (2024) · International Journal of Quantum Chemistry · doi:10.1002/qua.27359 · Cited by 46
Polymorphisms in DNA repair and apoptosis-related genes and clinical outcomes of patients with non-small cell lung cancer treated with first-line paclitaxel-cisplatin chemotherapy
Lee, S. Y., Kang, H., Yoo, S. S., Kang, Y. E., Choi, Y. Y., Lee, W. K., Choi, J. E., Jeon, H., Shin, K. M., Oh, I., et al. (2013) · Lung Cancer · doi:10.1016/j.lungcan.2013.07.024 · Cited by 46
Role of miR-182 in response to oxidative stress in the cell fate of human fallopian tube epithelial cells
Liu, Y., Qiang, W., Xu, X., Dong, R., Karst, A. M., Liu, Z., Kong, B., Drapkin, R., & Wei, J. (2015) · Oncotarget · doi:10.18632/oncotarget.5493 · Cited by 45
ANRIL Genetic Variants in Iranian Breast Cancer Patients.
Khorshidi, H. R., Taheri, M. N., Noroozi, R., Sarrafzadeh, S., Sayad, A., & Ghafouri‐Fard, S. (2017) · Europe PMC (PubMed Central) · doi:10.22074/cellj.2017.4496 · Cited by 44
Aldehyde dehydrogenase 3A1 confers oxidative stress resistance accompanied by altered DNA damage response in human corneal epithelial cells
Voulgaridou, G.-P., Tsochantaridis, I., Tolkas, C., Franco, R., Giatromanolaki, A. N., Panayiotidis, M. I., & Pappa, A. (2020) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2020.01.183 · Cited by 44
Role of tyrosyl-DNA phosphodiesterase 1 and inter-players in regulation of tumor cell sensitivity to topoisomerase I inhibition
Perego, P., Cossa, G., Tinelli, S., Corna, E., Carenini, N., Gatti, L., Cesare, M. D., Ciusani, E., Zunino, F., Luison, E., et al. (2011) · Biochemical Pharmacology · doi:10.1016/j.bcp.2011.09.021 · Cited by 44
Identification of direct target genes of miR-7, miR-9, miR-96, and miR-182 in the human breast cancer cell lines MCF-7 and MDA-MB-231
Moazzeni, H., Najafi, A., & Khani, M. (2017) · Molecular and Cellular Probes · doi:10.1016/j.mcp.2017.05.005 · Cited by 42
Proteomic Analysis of the Downstream Signaling Network of PARP1
Zhen, Y., & Yu, Y. (2018) · Biochemistry · doi:10.1021/acs.biochem.7b01022 · Cited by 40
BRCA1 deficiency in ovarian cancer is associated with alteration in expression of several key regulators of cell motility – A proteomics study
Gau, D. M., Lesnock, J. L., Hood, B. L., Bhargava, R., Sun, M., Darcy, K. M., Luthra, S., Chandran, U. R., Conrads, T. P., Edwards, R. P., et al. (2015) · Cell Cycle · doi:10.1080/15384101.2015.1036203 · Cited by 40
Molecular mechanisms involved in DNA repair in human cancers: An overview of PI3k/Akt signaling and PIKKs crosstalk
Alemi, F., Sadigh, A. R., Malakoti, F., Elhaei, Y., Ghaffari, S. H., Maleki, M., Asemi, Z., Yousefi, B., Targhazeh, N., & Majidinia, M. (2021) · Journal of Cellular Physiology · doi:10.1002/jcp.30573 · Cited by 42
The HDAC6-RNF168 axis regulates H2A/H2A.X ubiquitination to enable double-strand break repair
Qiu, L., Xu, W., Lu, X., Chen, F., Chen, Y., Tian, Y., Zhu, Q., Liu, X., Wang, Y., Pei, X., et al. (2023) · Nucleic Acids Research · doi:10.1093/nar/gkad631 · Cited by 38
Mre11-Rad50 oligomerization promotes DNA double-strand break repair
Kissling, V. M., Reginato, G., Bianco, E., Kasaciunaite, K., Tilma, J., Cereghetti, G., Schindler, N., Lee, S. S., Guérois, R., Luke, B., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-29841-0 · Cited by 39
MicroRNAs as a clue to overcome breast cancer treatment resistance
Garrido‐Cano, I., Pattanayak, B., Adam‐Artigues, A., Lameirinhas, A., Torres‐Ruiz, S., Tormo, E., Cervera, R., & Eroles, P. (2021) · Cancer and Metastasis Reviews · doi:10.1007/s10555-021-09992-0 · Cited by 37
MXene supported biomimetic bilayer lipid membrane biosensor for zeptomole detection of BRCA1 gene
Divya, K. P., Keerthana, S., Viswanathan, C., & Ponpandian, N. (2023) · Microchimica Acta · doi:10.1007/s00604-023-05694-2 · Cited by 35
The C-terminal Proteolytic Fragment of the Breast Cancer Susceptibility Type 1 Protein (BRCA1) Is Degraded by the N-end Rule Pathway
Xu, Z., Payoe, R., & Fahlman, R. P. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.301002 · Cited by 35
Atypical ubiquitin ligase RNF31: the nuclear factor modulator in breast cancer progression
Zhu, J., Zhuang, T., Yang, H., Li, X., Liu, H., & Wang, H. (2016) · BMC Cancer · doi:10.1186/s12885-016-2575-8 · Cited by 35
Overcoming the Impact of Hypoxia in Driving Radiotherapy Resistance in Head and Neck Squamous Cell Carcinoma
Hill, R. M., Rocha, S., & Parsons, J. L. (2022) · Cancers · doi:10.3390/cancers14174130 · Cited by 33
Multipronged activity of combinatorial miR-143 and miR-506 inhibits Lung Cancer cell cycle progression and angiogenesis in vitro
Hossian, A. K. M. N., Sajib, M. S., Tullar, P., Mikelis, C. M., & Mattheolabakis, G. (2018) · Scientific Reports · doi:10.1038/s41598-018-28872-2 · Cited by 33
CRISPR/Cas9-Mediated BRCA1 Knockdown Adipose Stem Cells Promote Breast Cancer Progression
Zhao, R., Kaakati, R. N., Liu, X., Xu, L., Lee, A. K., Bachelder, R. E., Li, C., & Hollenbeck, S. T. (2019) · Plastic & Reconstructive Surgery · doi:10.1097/prs.0000000000005316 · Cited by 35
Crosstalk between P53 and DNA damage response in ageing
Mohammadzadeh, A., Mirza‐Aghazadeh‐Attari, M., Hallaj, S., Saei, A. A., Alivand, M. R., Valizadeh, A., Yousefi, B., & Majidinia, M. (2019) · DNA repair · doi:10.1016/j.dnarep.2019.05.004 · Cited by 34
Selective mode of action of plumbagin through BRCA1 deficient breast cancer stem cells
Somasundaram, V., Hemalatha, S. K., Pal, K., Sinha, S., Nair, S. A., Mukhopadhyay, D., & Srinivas, P. (2016) · BMC Cancer · doi:10.1186/s12885-016-2372-4 · Cited by 32
BET-Inhibitor I-BET762 and PARP-Inhibitor Talazoparib Synergy in Small Cell Lung Cancer Cells
Fiorentino, F. P., Marchesi, I., Schröder, C., Schmidt, R., Yokota, J., & Bagella, L. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21249595 · Cited by 31
Potential Impact of Human Cytomegalovirus Infection on Immunity to Ovarian Tumours and Cancer Progression
Cox, M., Kartikasari, A. E. R., Gorry, P. R., Flanagan, K. L., & Plebanski, M. (2021) · Biomedicines · doi:10.3390/biomedicines9040351 · Cited by 30
DNA repair pathway activation features in follicular and papillary thyroid tumors, interrogated using 95 experimental RNA sequencing profiles
Vladimirova, U., Rumyantsev, P. O., Zolotovskaia, M., Albert, E. A., Abrosimov, A., Slashchuk, K. Y., Алексеевич, Н. П., Chukhacheva, O. S., Гайфуллин, Н., Suntsova, M., et al. (2021) · Heliyon · doi:10.1016/j.heliyon.2021.e06408 · Cited by 34
BRCA1 deficiency in triple-negative breast cancer: Protein stability as a basis for therapy
Choi, E. A., Mun, G., Lee, J., Lee, H., Cho, J., & Lee, Y. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.114090 · Cited by 34
Analysis of DNA Damage Responses After Boric Acid-mediated Boron Neutron Capture Therapy in Hepatocellular Carcinoma
Chen, K., Lai, Z., LI, D.-Y., Lin, Y.-C., Chou, F., & Chuang, Y. (2019) · Anticancer Research · doi:10.21873/anticanres.13881 · Cited by 29
The Role of E3, E4 Ubiquitin Ligase (UBE4B) in Human Pathologies
Antoniou, N. G., Lаgopati, N., Balourdas, D.-I., Nikolaou, M., Papalampros, A., Vasileiou, P. V. S., Myrianthopoulos, V., Kotsinas, A., Shiloh, Y., Liontos, M., et al. (2019) · Cancers · doi:10.3390/cancers12010062 · Cited by 28
ID4 controls luminal lineage commitment in normal mammary epithelium and inhibits BRCA1 function in basal-like breast cancer
Baker, L. A., Holliday, H., & Swarbrick, A. (2016) · Endocrine Related Cancer · doi:10.1530/erc-16-0196 · Cited by 28
BRCA1 regulates the cancer stem cell fate of breast cancer cells in the context of hypoxia and histone deacetylase inhibitors
Kim, H., Lin, Q., & Yun, Z. (2019) · Scientific Reports · doi:10.1038/s41598-019-46210-y · Cited by 29
Mitochondria and Familial Predisposition to Breast Cancer
Weigl, S., Paradiso, A., & Tommasi, S. (2013) · Current Genomics · doi:10.2174/1389202911314030005 · Cited by 28
Establishing gene regulatory networks from Parkinson’s disease risk loci
Farrow, S. L., Schierding, W. S., Gokuladhas, S., Golovina, E., Fadason, T., Cooper, A. A., & O'Sullivan, J. M. (2022) · Brain · doi:10.1093/brain/awac022 · Cited by 27
Breast cancer susceptibility gene 1 (BRCA1) predict clinical outcome in platinum- and toxal-based chemotherapy in non-small-cell lung cancer (NSCLC) patients: a system review and meta-analysis
Yang, Y., Xie, Y., & Xian, L. (2013) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/1756-9966-32-15 · Cited by 27
BRCA1 promoter hypermethylation in sporadic epithelial ovarian carcinoma: Association with low expression of BRCA1, improved survival and co-expression of DNA methyltransferases
Bai, X., Fu, Y., XUE, H., Guo, K., Song, Z. J., Yu, Z., Jia, T., Yan, Y., Zhao, L., Mi, X., et al. (2014) · Oncology Letters · doi:10.3892/ol.2014.1878 · Cited by 27
Molecular simulations of IDPs: From ensemble generation to IDP interactions leading to disorder-to-order transitions
Fatafta, H., Samantray, S., Sayyed–Ahmad, A., Coskuner‐Weber, O., & Strodel, B. (2021) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2021.06.003 · Cited by 26
Transcription Factors in Breast Cancer—Lessons From Recent Genomic Analyses and Therapeutic Implications
Zacksenhaus, E., Liu, J.-K., Jiang, Z., Yao, Y., Xia, L., Shrestha, M., & Ben‐David, Y. (2016) · Advances in protein chemistry and structural biology · doi:10.1016/bs.apcsb.2016.10.003 · Cited by 28
Pyrrolizidine alkaloids cause cell cycle and DNA damage repair defects as analyzed by transcriptomics in cytochrome P450 3A4-overexpressing HepG2 clone 9 cells
Abdelfatah, S., Naß, J., Knorz, C., Klauck, S. M., Küpper, J., & Efferth, T. (2021) · Cell Biology and Toxicology · doi:10.1007/s10565-021-09599-9 · Cited by 27
Disentangling the aging gene expression network of termite queens
Kuhn, J. M. M., Meusemann, K., & Korb, J. (2021) · BMC Genomics · doi:10.1186/s12864-021-07649-4 · Cited by 27
Extracellular Vesicles as Mediators of Cancer Disease and as Nanosystems in Theranostic Applications
Burgos-Ravanal, R., Campos, A. V., Díaz‐Vesga, M. C., González, M. F., León, D., Lobos‐González, L., Leyton, L., Kogan, M. J., & Quest, A. F. G. (2021) · Cancers · doi:10.3390/cancers13133324 · Cited by 26
SPT6-driven error-free DNA repair safeguards genomic stability of glioblastoma cancer stem-like cells
Obara, E. A. A., Morante, D. A., Rasmussen, R. D., Frías, A., Vitting‐Seerup, K., Lim, Y. C., Elbæk, K. J., Pedersen, H., Vardouli, L., Jensen, K. E., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-18549-8 · Cited by 26
BRCA1 levels and DNA-damage response are controlled by the competitive binding of circHIPK3 or FMRP to the BRCA1 mRNA
Grelloni, C., Garraffo, R., Setti, A., Rossi, F., Peruzzi, G., Cinquanta, M., Rosa, M. C. D., Pierotti, M. A., Beltran-Nebot, M., & Bozzoni, I. (2024) · Molecular Cell · doi:10.1016/j.molcel.2024.09.016 · Cited by 24
Downregulation of c-Myc and p21 expression and induction of S phase arrest by naphthalene diimide derivative in gastric adenocarcinoma cells
Gurung, S. K., Dana, S., Mandal, K., Mukhopadhyay, P., & Mondal, N. (2019) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2019.02.010 · Cited by 26
T helper cell-mediated epitranscriptomic regulation via m6A RNA methylation bridges link between coronary artery disease and invasive ductal carcinoma
Rakshit, S., Sunny, J. S., George, M., Hanna, L. E., Leela, K. V., & Sarkar, K. (2022) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-022-04130-x · Cited by 23
Vorinostat enhances the anticancer effect of oxaliplatin on hepatocellular carcinoma cells
Liao, B., Zhang, Y., Sun, Q., & Jiang, P. (2017) · Cancer Medicine · doi:10.1002/cam4.1278 · Cited by 23
An immunotherapy response prediction model derived from proliferative CD4+ T cells and antigen-presenting monocytes in ccRCC
Zheng, K. C., Gao, L., Hao, J., Zou, X., & Hu, X. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.972227 · Cited by 23
DNA repair prognostic index modelling reveals an essential role for base excision repair in influencing clinical outcomes in ER negative and triple negative breast cancers
Abdel-Fatah, T. M. A., Arora, A., Moseley, P. M., Perry, C., Rakha, E. A., Green, A. R., Chan, S. Y. T., Ellis, I. O., & Madhusudan, S. (2015) · Oncotarget · doi:10.18632/oncotarget.4157 · Cited by 22
Strong preference of BRCA1 protein to topologically constrained non-B DNA structures
Brázda, V., Hároníková, L., Liao, J. C. C., Fridrichová, H., & Jagelská, E. B. (2016) · BMC Molecular Biology · doi:10.1186/s12867-016-0068-6 · Cited by 22
Low concentrations of antimony impair DNA damage signaling and the repair of radiation-induced DSB in HeLa S3 cells
Koch, B., Maser, E., & Hartwig, A. (2017) · Archives of Toxicology · doi:10.1007/s00204-017-2004-z · Cited by 23
Transcriptomic profiling and genomic mutational analysis of Human coronavirus (HCoV)-229E -infected human cells
Friedman, N., Jacob‐Hirsch, J., Drori, Y., Eyal, E., Kol, N., Nayshool, O., Mendelson, E., Rechavi, G., & Mandelboim, M. (2021) · PLoS ONE · doi:10.1371/journal.pone.0247128 · Cited by 25
Impact of DNA damage response defects in cancer cells on response to immunotherapy and radiotherapy
Czajkowski, D., Szmyd, R., & Gee, H. E. (2022) · Journal of Medical Imaging and Radiation Oncology · doi:10.1111/1754-9485.13413 · Cited by 24
Plasma, cancer, immunity
Bekeschus, S., & Clemen, R. (2022) · Journal of Physics D Applied Physics · doi:10.1088/1361-6463/ac9398 · Cited by 22
The small GTPase RhoU lays downstream of JAK/STAT signaling and mediates cell migration in multiple myeloma
Nunes, S. C., Manzoni, M., Pizzi, M., Mandato, E., Carrino, M., Tubi, L. Q., Zambello, R., Adami, F., Visentin, A., Barilà, G., et al. (2018) · Blood Cancer Journal · doi:10.1038/s41408-018-0053-z · Cited by 21
Impacts of Cancer-associated Mutations on the Structure–Activity Relationship of BAP1
Puri, S., Chen, S.-N., Chiu, Y.-H., Drączkowski, P., Ko, K.-T., Yang, T., Wang, Y., Uchiyama, S., & Hsu, S. D. (2022) · Journal of Molecular Biology · doi:10.1016/j.jmb.2022.167553 · Cited by 22
Evaluation of antitumoral effect of Hibiscus sabdariffa extract on human breast cancer cells
Malacrida, A., Erriquez, J., Hashemi, M., Rodriguez‐Menendez, V., Cassetti, A., Cavaletti, G., & Miloso, M. (2022) · Biochemistry and Biophysics Reports · doi:10.1016/j.bbrep.2022.101353 · Cited by 28
Characterisation of the spectrum and genetic dependence of collateral mutations induced by translesion DNA synthesis
Póti, Á., Szikriszt, B., Gervai, J. Z., Chen, D., & Szüts, D. (2022) · PLoS Genetics · doi:10.1371/journal.pgen.1010051 · Cited by 20
Polθ Inhibition: An Anticancer Therapy for HR-Deficient Tumours
Barszczewska-Pietraszek, G., Drzewiecka, M., Czarny, P. L., Skórski, T., & Śliwiński, T. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms24010319 · Cited by 19
Evaluation of microRNA expression profiles and their associations with risk alleles in lymphoblastoid cell lines of familial ovarian cancer
Shen, J., Wang, D., Gregory, S. R., Medico, L., Hu, Q., Yan, L., Odunsi, K. O., Lele, S., Ambrosone, C. B., Liu, S., et al. (2012) · Carcinogenesis · doi:10.1093/carcin/bgs008 · Cited by 18
Pharmacometabolomics Applied to Personalized Medicine in Urological Cancers
Amaro, F., Carvalho, M. C., Bastos, M. D. L., de Pinho, P. G., & Pinto, J. (2022) · Pharmaceuticals · doi:10.3390/ph15030295 · Cited by 20
The Interactome of Protein Kinase CK2
Montenarh, M., & Götz, C. (2013) · Wiley eBooks · doi:10.1002/9781118482490.ch2 · Cited by 18
Combinatory Effect of Gemcitabine and 5‐Fluorouracil Investigated Through Chemoinformatics and Molecular Dynamics Simulation Against Breast Cancer
Sukumaran, S., Zochedh, A., Chandran, K., Bahadur, S. A., & Kathiresan, T. (2024) · International Journal of Quantum Chemistry · doi:10.1002/qua.27498 · Cited by 17

Authors: Wu, J., Lu, L.-Y., & Yu, X.
Affiliations: University of Michigan (US)
Corresponding author: Yu, Xiaochun
ORCID: Wu, Jiaxue
Lu, Lin-Yu
Yu, Xiaochun
Venue: Protein & Cell
Publisher: Oxford University Press (OUP)
Published: 2010-02
Volume: 1
Issue: 2
Pages: 117-123
ISSN: 1674-800X (ISSN-L)
1674-8018
DOI: 10.1007/s13238-010-0010-5
PMC: PMC3078634
OpenAlex: W2140930673
Cited by: 235
References: 100
Citations by year: 2026: 5 · 2025: 13 · 2024: 25 · 2023: 17 · 2022: 32 · 2021: 20 · 2020: 15 · 2019: 18 · 2018: 16 · 2017: 9 · 2016: 15 · 2015: 9 · 2014: 13 · 2013: 15 · 2012: 9
FWCI: 0.78
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.springer.com/tdm (tdm)
Locations: Protein & Cell (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: University of Michigan
National Institutes of Health
National Cancer Institute (R01CA132755, R01CA130899, CA132755)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › BRCA gene mutations in cancer
Health Sciences › Medicine › Oncology › PARP inhibition in cancer therapy
Keywords: BRCA1, DNA damage response, tumor suppression, DNA repair, genome stability, ubiquitination, chromatin remodeling, transcriptional regulation, apoptosis, breast cancer, ovarian cancer
MeSH terms: Breast Neoplasms, DNA Damage, DNA Repair, Female, Humans, Mutation, Ovarian Neoplasms, Signal Transduction, Genes, Tumor Suppressor, Apoptosis, Genes, cdc, BRCA1 Protein

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

The role of BRCA1 in DNA damage response

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks