Clinicopathological and prognostic significance of hypoxia-inducible factor-1α in esophageal squamous cell carcinoma: a meta-analysis
Abstract
Published literatures on the prognostic value of hypoxia-inducible factor-1α (HIF-1α) overexpression in esophageal squamous cell carcinoma (ESCC) are conflicting and heterogeneous. We performed a meta-analysis to more precisely evaluate the clinicopathological and prognostic value of HIF-1α in patients with ESCC. Searches were applied to MEDLINE, Pubmed, Embase, Cochrane Library, Web of Science, and Chinese BioMedical Literature Databases until September 10, 2013, without language restrictions. The pooled hazard ratios (HRs) and odds ratios (ORs) with corresponding 95 % confidence intervals (CIs) were used to estimate the effects. Twelve studies with 942 ESCC patients were selected to evaluate the correlation between HIF-1α and overall survival (OS), disease-free survival (DFS), response to chemoradiation (RC), and clinicopathological features. HIF-1α overexpression was significantly associated with poor OS (HR 1.78, 95% CI 1.41-2.24), DFS (HR 1.91, 95% CI 1.15-3.18), and RC (HR 3.56, 95% CI 1.68-7.53). Besides, HIF-1α overexpression was significantly associated with stage (OR 2.90, 95% CI 1.97-4.27), lymph node metastasis (OR 1.86, 95% CI 1.39-2.49), depth of invasion (OR 2.45, 95% CI 1.24-4.86), lymphatic invasion (OR 2.28, 95% CI 1.46-3.56), distant metastasis (OR 2.04, 95% CI 1.19-3.50), and vascular endothelial growth factor (OR 3.67, 95% CI 1.81-7.46). Our results indicate that HIF-1α overexpression can potently predict the poor prognosis and chemoradiation resistance for ESCC. Large prospective studies with multivariable survival analyses are now needed to confirm the clinical utility of HIF-1α as an independent prognostic marker.
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High HIF-1 expression is associated with metastasis in patients with gynecological, pancreatic, esophageal, lung, and prostate cancers.
“Immunohistochemical analysis of human primary tumor samples has revealed an association between high HIF-1 expression and metastasis in patients with gynecological, pancreatic, esophageal, lung, and prostate cancers”
From Hypoxic control of metastasis (2016) · cites this paper as [38]
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- Authors
- Ping, W., Sun, W., Zu, Y., Chen, W., & Fu, X.
- Affiliations
- Tongji Hospital (CN)
- Corresponding author
- Fu, Xiangning
- Venue
- Tumor Biology
- Published
- 2014-01-15
- Volume
- 35
- Issue
- 5
- Pages
- 4401-4409
- ISSN
- 1010-4283 (ISSN-L)
- 1423-0380
- OpenAlex
- W2009485201
- Cited by
- 36
- References
- 54
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 1 · 2023: 1 · 2022: 3 · 2021: 4 · 2020: 2 · 2019: 2 · 2018: 2 · 2017: 7 · 2016: 6 · 2015: 2 · 2014: 1
- FWCI
- 1.01
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Tumor Biology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Hubei Province
- Topics
- Health Sciences › Medicine › Surgery › Esophageal Cancer Research and Treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
- Health Sciences › Medicine › Otorhinolaryngology › Head and Neck Cancer Studies
- Keywords
- hypoxia-inducible factor-1α, esophageal squamous cell carcinoma, prognostic factors, overall survival, disease-free survival, chemoradiotherapy resistance, clinicopathological features, lymph node metastasis, vascular endothelial growth factor, tumor hypoxia, gene overexpression, distant metastasis, lymphatic invasion, depth of invasion, tumor stage
- MeSH terms
- Esophageal Squamous Cell Carcinoma, Carcinoma, Squamous Cell, Esophageal Neoplasms, Humans, Prognosis, Publication Bias, Vascular Endothelial Growth Factor A, Hypoxia-Inducible Factor 1, alpha Subunit
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