Cited by 224Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatmentsCerebrospinal fluid and hydrocephalus

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Biomarkers for the Early Detection and Progression of Alzheimer's Disease

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Counts, Scott E., Ikonomovic, Milos D., Mercado, Natosha, Vega, Irving E., Mufson, Elliott J.·2017·Neurotherapeutics

DOI 10.1007/s13311-016-0481-zPMC PMC5233625

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Abstract

The recent failures of potential disease-modifying drugs for Alzheimer's disease (AD) may reflect the fact that the enrolled participants in clinical trials are already too advanced to derive a clinical benefit. Thus, well-validated biomarkers for the early detection and accurate diagnosis of the preclinical stages of AD will be crucial for therapeutic advancement. The combinatorial use of biomarkers derived from biological fluids, such as cerebrospinal fluid (CSF), with advanced molecular imaging and neuropsychological testing may eventually achieve the diagnostic sensitivity and specificity necessary to identify people in the earliest stages of the disease when drug modification is most likely possible. In this regard, positive amyloid or tau tracer retention on positron emission tomography imaging, low CSF concentrations of the amyloid-β 1-42 peptide, high CSF concentrations in total tau and phospho-tau, mesial temporal lobe atrophy on magnetic resonance imaging, and temporoparietal/precuneus hypometabolism or hypoperfusion on 18F-fluorodeoxyglucose positron emission tomography have all emerged as biomarkers for the progression to AD. However, the ultimate AD biomarker panel will likely involve the inclusion of novel CSF and blood biomarkers more precisely associated with confirmed pathophysiologic mechanisms to improve its reliability for detecting preclinical AD. This review highlights advancements in biological fluid and imaging biomarkers that are moving the field towards achieving the goal of a preclinical detection of AD.

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Authors: Counts, S. E., Ikonomovic, M. D., Mercado, N., Vega, I. E., & Mufson, E. J.
Affiliations: Trinity Health Grand Rapids (US)
Michigan State University (US)
Barrow Neurological Institute (US)
Corresponding author: Mufson, Elliott J.
ORCID: Counts, Scott E.
Vega, Irving E.
Mufson, Elliott J.
Venue: Neurotherapeutics
Publisher: Elsevier BV
Published: 2017-01
Volume: 14
Issue: 1
Pages: 35-53
ISSN: 1878-7479 (ISSN-L)
DOI: 10.1007/s13311-016-0481-z
PMC: PMC5233625
OpenAlex: W2529983878
Cited by: 224
References: 296
Citations by year: 2026: 23 · 2025: 25 · 2024: 35 · 2023: 27 · 2022: 24 · 2021: 33 · 2020: 22 · 2019: 18 · 2018: 11 · 2017: 3
FWCI: 1.62
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: other-oa
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 2423 d)
Locations: Neurotherapeutics (publishedVersion, other-oa)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute on Aging (AG043375, AG026032)
National Intitute on Aging (AG042146)
BNI Barrow and Beyond
Saint Mary’s Foundation
Miles for Memories of Battle Creek
National Insitute of Aging (PO1AG025204)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Health Sciences › Medicine › Clinical Neurology › Cerebrospinal fluid and hydrocephalus
Keywords: Alzheimer's disease, biomarkers, early detection, preclinical Alzheimer's disease, disease progression, cerebrospinal fluid biomarkers, amyloid-beta 42, total tau, phosphorylated tau, amyloid PET, tau PET, FDG-PET, blood biomarkers
MeSH terms: Alzheimer Disease, Autoantibodies, Humans, Sensitivity and Specificity, Biomarkers, Amyloid beta-Peptides, Disease Progression, Inflammation Mediators, Early Diagnosis, Positron-Emission Tomography

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Biomarkers for the Early Detection and Progression of Alzheimer's Disease

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