Cited by 20Virus-based gene therapy researchCoronary Interventions and DiagnosticsRNA Interference and Gene Delivery

Delivery of viral vectors for gene therapy in intimal hyperplasia and restenosis in atherosclerotic swine

Hall, Sannette, Agrawal, Devendra K.·2018·Drug Delivery and Translational Research

Abstract

Cardiovascular diseases including atherosclerosis are a major financial and health burden globally. Inflammation associated with atherosclerosis results in the development of plaques that can rupture causing thrombosis, stroke, or death. The most widely used treatment for the removal of atherosclerotic plaques is percutaneous transluminal coronary angioplasty (PTCA) with or without stenting. Although this is a safer and minimally invasive method, restenosis and intimal hyperplasia after interventional procedure remains a major hurdle and more refined approaches are needed. Studies in large animal models such as pigs have facilitated a greater understanding of the underlying mechanisms of the disease and provided novel targets for therapeutic intervention. In pre-clinical studies, viral vector gene therapy has emerged as a promising option for the reduction and/or prevention of restenosis and intimal hyperplasia. Although studies in animal models have generated promising results, clinical trials have yet to prove the clinical efficacy of gene therapy in coronary artery diseases. In this review, we examined and critically reviewed the most recent advances in viral vector gene therapy obtained from studies using porcine model of atherosclerosis.

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Crossref · 10.1007/s13346-017-0409-0

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65 of 65 references verified0 citation errors · 0 not checkable

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Authors
Hall, S., & Agrawal, D. K.
Affiliations
Creighton University (US)
Corresponding author
Agrawal, Devendra K.
Venue
Drug Delivery and Translational Research
Published
2017-07-13
Volume
8
Issue
4
Pages
918-927
ISSN
  • 2190-393X (ISSN-L)
  • 2190-3948
OpenAlex
W2736009019
Cited by
20
References
65
Citations by year
2026: 1 · 2025: 2 · 2024: 2 · 2022: 4 · 2021: 2 · 2020: 6 · 2019: 1 · 2018: 2
FWCI
0.32
Type
journal article
Language
en
Open access
closed
Locations
  • Drug Delivery and Translational Research (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (R01HL112597)
  • National Heart, Lung, and Blood Institute (R01 HL116042, R01 HL120659)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Virus-based gene therapy research
  • Health Sciences › Medicine › Surgery › Coronary Interventions and Diagnostics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Interference and Gene Delivery
Keywords
viral vector gene therapy, intimal hyperplasia, restenosis, atherosclerosis, percutaneous transluminal coronary angioplasty, coronary stenting, porcine model, inflammation, large animal model, coronary artery disease
MeSH terms
Dependovirus, Adenoviridae, Animals, Genetic Vectors, Humans, Hyperplasia, Swine, Genetic Therapy, Tunica Intima, Coronary Restenosis, Atherosclerosis

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