Vascular endothelial growth factor enhances atherosclerotic plaque progression

Celletti, Francesca L.; Waugh, Jacob M.; Amabile, Philippe G.; Brendolan, Andrea; Hilfiker, Paul R.; Dake, Michael D.

doi:10.1038/86490

Cited by 708Atherosclerosis and Cardiovascular DiseasesAngiogenesis and VEGF in CancerCholesterol and Lipid Metabolism

Vascular endothelial growth factor enhances atherosclerotic plaque progression

Celletti, Francesca L., Waugh, Jacob M., Amabile, Philippe G., Brendolan, Andrea, Hilfiker, Paul R., Dake, Michael D.·2001·Nature Medicine

DOI 10.1038/86490

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Abstract

Vascular endothelial growth factor (VEGF) can promote angiogenesis but may also exert certain effects to alter the rate of atherosclerotic plaque development. To evaluate this potential impact on plaque progression, we treated cholesterol-fed mice doubly deficient in apolipoprotein E/apolipoprotein B100 with low doses of VEGF (2 microg/kg) or albumin. VEGF significantly increased macrophage levels in bone marrow and peripheral blood and increased plaque area 5-, 14- and 4-fold compared with controls at weeks 1, 2 and 3, respectively. Plaque macrophage and endothelial cell content also increased disproportionately over controls. In order to confirm that the VEGF-mediated plaque progression was not species-specific, the experiment was repeated in cholesterol-fed rabbits at the three-week timepoint, which showed comparable increases in plaque progression.

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“A major disadvantage of this approach, as can be deduced from the build-up of atherosclerotic plaques, might be that these nanoparticles accumulate in the plaques, thus contributing to neovascularization and thereby advancing plaque accumulation112.”
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Authors: Celletti, F. L., Waugh, J. M., Amabile, P. G., Brendolan, A., Hilfiker, P. R., & Dake, M. D.
Affiliations: Stanford Medicine (US)
Corresponding author: Dake, Michael D.
ORCID: Brendolan, Andrea
Dake, Michael D.
Venue: Nature Medicine
Publisher: Springer Science and Business Media LLC
Published: 2001-04
Volume: 7
Issue: 4
Pages: 425-429
ISSN: 1078-8956 (ISSN-L)
1546-170X
DOI: 10.1038/86490
OpenAlex: W1561059299
Cited by: 708
References: 33
Citations by year: 2026: 7 · 2025: 5 · 2024: 5 · 2023: 14 · 2022: 6 · 2021: 13 · 2020: 6 · 2019: 15 · 2018: 16 · 2017: 24 · 2016: 23 · 2015: 25 · 2014: 31 · 2013: 34 · 2012: 21
FWCI: 19.72
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (unspecified)
Locations: Nature Medicine (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
Keywords: vascular endothelial growth factor, atherosclerosis, atherosclerotic plaque progression, macrophage accumulation, apolipoprotein E deficiency, cholesterol-fed rabbits, angiogenesis, endothelial cells, plaque composition
MeSH terms: Animals, Apolipoproteins B, Apolipoproteins E, Arteriosclerosis, Diet, Atherogenic, Disease Models, Animal, Endothelium, Vascular, Hematopoietic Stem Cells, Humans, Lymphokines, Macrophages, Monocytes, Rabbits, Recombinant Proteins, Endothelial Growth Factors, Vascular Endothelial Growth Factors, Vascular Endothelial Growth Factor A, Mice, Apolipoprotein B-100

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Vascular endothelial growth factor enhances atherosclerotic plaque progression

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