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Artificial Intelligence and Patient-Centered Decision-Making
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Advanced AI systems are rapidly making their way into medical research and practice, and, arguably, it is only a matter of time before they will surpass human practitioners in terms of accuracy, reliability, and knowledge. If this is true, practitioners will have a prima facie epistemic and professional obligation to align their medical verdicts with those of advanced AI systems. However, in light of their complexity, these AI systems will often function as black boxes: the details of their contents, calculations, and procedures cannot be meaningfully understood by human practitioners. When AI systems reach this level of complexity, we can also speak of black-box medicine. In this paper, we want to argue that black-box medicine conflicts with core ideals of patient-centered medicine. In particular, we claim, black-box medicine is not conducive for supporting informed decision-making based on shared information, shared deliberation, and shared mind between practitioner and patient.
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“studies show that many AI systems used in medicine are highly reliable, and sometimes have greater precision than human doctors.”
From The Epistemic Cost of Opacity: How the Use of Artificial Intelligence Undermines the Knowledge of Medical Doctors in High-Stakes Contexts (2025) · cites this paper as Bjerring and Busch (2021, 350)
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“For specific medical treatments, the studies establishing their effec -tiveness are available in journals, or online. So, as Bjerring and Busch ( 2021 , 364) point out, there is indeed some information made available that can be used by medi -cal doctors to justify their belief that a certain treatment is effective.”
From The Epistemic Cost of Opacity: How the Use of Artificial Intelligence Undermines the Knowledge of Medical Doctors in High-Stakes Contexts (2025) · cites this paper as Bjerring and Busch, 2021
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“Similarly, AI can help patients with diabetes to manage their blood glucose levels, diet, and exercise using a chatbot that provides education and coaching based on natural language processing and machine learning. 66”
From Artificial Intelligence and Decision-Making in Healthcare: A Thematic Analysis of a Systematic Review of Reviews (2024) · cites this paper as [66]
Experimental — accuracy not yet measuredIn the citing paper
“Since clinicians are no longer able to fully comprehend the inner workings and calculations of the decision aid they are not able to explain to the patient how certain outcomes or recommendations were derived [33].”
From Explainability for artificial intelligence in healthcare: a multidisciplinary perspective (2020) · cites this paper as [33]
In the citing paper
“Seeking to address these questions, it was recently argued that so-called ‘black-box medicine’ conflicts with core ideals of patient-centered medicine [33].”
From Explainability for artificial intelligence in healthcare: a multidisciplinary perspective (2020) · cites this paper as [33]
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“…systems takes its point of departure in various functionalities and characteristics of these systems – such as, notably, their opacity (e.g. Bjerring and Busch, 2021; Symons and Alvarado, 2022; Pozzi, 2023; Burrell, 2016) – we focus on the practices and activities of data scientists and…”
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Maximizing impact of explainable artificial intelligence in radiotherapy: a critical review
Heising, L. M., Wolfs, C. J. A., Ou, C. X. J., Hoebers, F. J. P., van Limbergen, E. J., Verhaegen, F., & Jacobs, M. J. G. (2026) · Physics in Medicine & Biology · doi:10.1088/1361-6560/ae25b2 · Cited by 2
“Bjerring and Busch (2021) argue that using black-box AI in clinical practice conflicts with core elements of patient-centered care since the black-box AI decisions leave no room for exchange of information, explanation, and understanding.”
PatientSafeBench: Evaluating the Safety of Medical LLMs for Patient Use
Kim, M., Park, H., Kim, W., Choi, S. H., Kim, H. E., Sohn, H., Park, J., Kim, S., Yu, S.-C., & Oh, Y. (2025) · IEEE-EMBS International Conference on Biomedical and Health Informatics (BHI ...) · doi:10.1109/bhi67747.2025.11269553 · Cited by 3
“While legal compliance, transparency, and fairness are essential for trust-worthy medical LLMs [11], practical evaluations are lacking, risking disparities and undermining autonomy [12], [13].”
Reflexivity and positionality statements: a way to tackle “second-level arbitrariness” bias in AI?
Conti, L. G., & Seele, P. (2025) · Humanities and Social Sciences Communications · doi:10.1057/s41599-025-06208-6 · Cited by 3
“…becoming increasingly ubiquitous, revolutio-nising entire sectors (Binns, 2018; Crawford & Calo, 2016; de Laat, 2018; Peters, 2022), from healthcare (Bjerring & Busch, 2021; Gichoya et al., 2023) to education (Bellas et al., 2024; X. Wang et al., 2024; Zhao et al., 2024), from HR management…”
Enhancing dental clinical education through AI: insights into post-clinical summaries
Luo, F., Li, J., Zhang, T., Huang, B., Jiang, L., Hua, C., & Hu, P. (2026) · BMC Medical Education · doi:10.1186/s12909-026-08774-y · Cited by 2
“A promising approach to further enhance this capability would be to refine AI algorithms to simulate more diverse, dynamic clinical scenarios that closely resemble real-world complexities [15].”
Milota, M., Drogt, J., & Jongsma, K. R. (2023) · Digital Society · doi:10.1007/s44206-023-00072-0 · Cited by 2
“It is still unclear to what extent these systems will impact clinicians’ autonomy (Bjerring & Busch, 2021; Sambasivan et al., 2012; Strohm et al., 2020), under what circumstances these systems should be trusted (Asan et al., 2020; Durán & Jongsma 2021; Hatherley, 2020), and how their use will…”
BackgroundSchneider, D., & Weber, K. (2024) · TATuP - Zeitschrift für Technikfolgenabschätzung in Theorie und Praxis · doi:10.14512/tatup.33.1.08 · Cited by 3
“Otherwise, the system becomes a threat towards the ideal of human-centered reproducible and understandable science as well as patient-centered care (Bjerring and Busch 2021).”
BackgroundInfluentialGerdes, A., Fasterholdt, I., & Rasmussen, B. S. (2024) · Ugeskrift for Læger · doi:10.61409/v09230600 · Cited by 2
Neurosurgery, Explainable AI, and Legal Liability
Matulionytė, R., Molina, E. S., & Ieva, A. D. (2024) · Advances in experimental medicine and biology · doi:10.1007/978-3-031-64892-2_34 · Cited by 2
Marr, C., & Tsang, Y. M. (2025) · Technical Innovations & Patient Support in Radiation Oncology · doi:10.1016/j.tipsro.2025.100300 · Cited by 3
Dale, R., Cheng, M., Pines, K. C., & Currie, M. E. (2025) · medRxiv · doi:10.1101/2025.05.20.25328009 · Cited by 2
Increasing the Patient-Centeredness of Predictive Analytics Tools
Crossnohere, N. L., Childerhose, J. E., & Bose‐Brill, S. (2022) · Patient · doi:10.1007/s40271-022-00595-7 · Cited by 1
“For most patient and clinician shareholders, predictive analytics powered by AI/ML remains a black box [5].”
BackgroundArtificial Intelligence in the System of “Physician-Patient”: Anthropocentrism vs Technocentrism
Izutkin, D. A. (2024) · Humanitarian Vector · doi:10.21209/1996-7853-2024-19-1-149-157 · Cited by 1
Intelligent Medicine Box Monitoring System Based on ZigBee Technology
Diao, J., Sun, P., Chen, J. B., Zhang, Z., & Chen, Z. (2024) · International Conference on Power Electronics and Artificial Intelligence (PEAI) · doi:10.1145/3674225.3674391 · Cited by 1
The role of humans in the future of medicine: Completing the cycle
Kenig, N., & Vives, A. M. (2025) · Metaverse · doi:10.54517/m3129 · Cited by 2
AI-Driven Predictive Analytics for Early Detection of High-Functioning Anxiety Symptoms
Alqaidoom, M. M., Ateeq, A. A., & Aljazrawi, Z. (2025) · Studies in big data · doi:10.1007/978-3-031-83915-3_60 · Cited by 1
Wee, A. K. J., Lin, M., Jenkins, M. A., & Lee, S. E. (2025) · Advances in computational intelligence and robotics book series · doi:10.4018/979-8-3693-5837-5.ch004 · Cited by 2
Mahmood, T., Wang, Y., Khan, A. R., & Ayesha, N. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-23979-3.00013-0 · Cited by 1
Managing High-Risk Surgery Using Artificial Intelligence
Kumar, A., & Singh, D. (2025) · Transactions on computer systems and networks · doi:10.1007/978-981-96-6703-1_10 · Cited by 1
Dedivitis, R. A., de Castro, M. A. F., Matos, L. L., Ribeiro, D. A., Duarte, B. P., & Kowalski, L. P. (2025) · Laryngoscope Investigative Otolaryngology · doi:10.1002/lio2.70296 · Cited by 1
Behdadi, D., Vanfleteren, L. E. G. W., & Sundemo, D. S. (2025) · AI & Society · doi:10.1007/s00146-025-02806-9 · Cited by 1
“This shift may reinforce reductive understandings of COPD by sidelining factors like patient testimony and lived experience, patient values and preferences, and psychosocial and environmental conditions (Bjerring and Busch 2021; Kenis 2025).”
Artificial Intelligence in Clinical Trials: From Protocol Design to Pharmacovigilance
Schulman, A., Fernández‐Torras, A., Gadiya, Y., Saeed, K., Mestres, J., & Tanoli, Z. (2026) · Springer eBooks · doi:10.1007/978-3-031-98022-0_24 · Cited by 1
Beyond (Relational) Autonomy: AI Healthcare Through the Lens of Care Ethics
Boldrini, M. (2026) · Integrated science · doi:10.1007/978-3-032-14537-6_9 · Cited by 1
Ameliorative medical AI: feminist hermeneutics and algorithmic normativity in healthcare
Kenis, D. (2026) · AI & Society · doi:10.1007/s00146-026-02890-5 · Cited by 1
“The implication of such accounts is normative: given their characterization as expert systems, physicians might have an epistemic obligation to follow CDSS recommendations (Bjerring and Busch 2021).”
Forecasting AI-induced technostress in healthcare: identifying techno-paralysis in decision-making
Jabbouri, R., Issa, H., & Jaber, J. (2026) · DECISION · doi:10.1007/s40622-025-00455-x · Cited by 1
Jecker, N. S., Ozeki-Hayashi, R., Nakazawa, E., & Fujita, T. (2026) · Philosophy & Technology · doi:10.1007/s13347-026-01073-w · Cited by 1
“Bjerring and Busch ( 2021, p. 359) claim that “in patient centered medicine… the ultimate goal of treatment is not necessarily identified with the eradication of a disease but rather with the creation of an informed decision space in which a patient’s specific values and preferences are represented…”
An actor-network-theory informed normative framework for the governance of AI-systems in medicine
Hahn, M., Samhammer, D., Tretter, M., & Dabrock, P. (2026) · Humanities and Social Sciences Communications · doi:10.1057/s41599-026-07957-8 · Cited by 2
“This opaque character then leads to outcomes that remain only partially comprehensible, which contradicts the principle of informed decision-making (Bjerring and Busch, 2021).”
Metadata
- Authors
- Bjerring, J. C., & Busch, J.
- Affiliations
- Aarhus University (DK)
- Corresponding author
- Bjerring, Jens Christian
- Busch, Jacob
- Venue
- Philosophy & Technology
- Published
- 2020-01-08
- Volume
- 34
- Issue
- 2
- Pages
- 349-371
- ISSN
- 2210-5433 (ISSN-L)
- 2210-5441
- OpenAlex
- W2999885075
- Cited by
- 274
- References
- 77
- Citations by year
- 2026: 47 · 2025: 66 · 2024: 65 · 2023: 34 · 2022: 36 · 2021: 22 · 2020: 4
- FWCI
- 7.04
- Type
- journal article
- Language
- en
- Open access
- green
- pure.au.dk
- Licence
- Locations
- Philosophy & Technology (publishedVersion)
- PhilPapers (PhilPapers Foundation) (submittedVersion)
- Topics
- Health Sciences › Medicine › Health Informatics › Artificial Intelligence in Healthcare and Education
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Ethics and bioethics in healthcare
- Physical Sciences › Computer Science › Artificial Intelligence › Ethics and Social Impacts of AI
- Keywords
- artificial intelligence in healthcare, patient-centered medicine, shared decision-making, informed consent, clinical judgment
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