Cited by 164Acne and Rosacea Treatments and EffectsDermatology and Skin DiseasesDermatologic Treatments and Research

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Why Topical Retinoids Are Mainstay of Therapy for Acne

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Leyden, James, Stein-Gold, Linda, Weiss, Jonathan·2017·Dermatology and Therapy

DOI 10.1007/s13555-017-0185-2PMC PMC5574737

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Abstract

Acne-focused dermatology expert groups have consistently recommended that most patients with acne be treated with a combination of topical retinoid and antimicrobial therapy. This is based on clinical data as well as evidence that these drug classes have different and complementary mechanisms of action that target multiple aspects of acne's complex pathophysiology. Recent evidence-based guidelines for acne, including those from the American Academy of Dermatology (AAD) and the European Dermatology Forum (EDF), have agreed that retinoids have an essential role in this widespread disease. The AAD states "retinoids are the core of topical therapy for acne because they are comedolytic, resolve the precursor microcomedone lesion, and are anti-inflammatory;" further, they "allow for maintenance of clearance." Despite uniform recommendation for use of topical retinoids, a recent study of prescribing practices from 2012 to 2014 indicated that dermatologists prescribed retinoids just 58.8% of the time while non-dermatologists prescribed them for only 32.4% of cases. In this article, we review the reasons supporting retinoids as the mainstay of acne therapy and discuss some of the perceived barriers that may be limiting use of this important drug class. Further, we discuss how and when titrating retinoid concentrations may be utilized in clinical practice. FUNDING: Galderma International.

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Fig. 1 Dose-dependent actions of adapalene at the molecular level. From Tenaud et al. [21]CC BY-NC · PubMed Central

Fig. 2 Dose-dependent clinical success rate (IGA) of 0.3 A/BPO, A/BPO, and vehicle in patients with severe acne at baseline. From Weiss et al. [68]CC BY-NC · PubMed Central

Fig. 3 Clinical efficacy of topical retinoid monotherapy on inflammatory lesions after 12 or 15 weeks therapy. From Leyden et al. [37]CC BY-NC · PubMed Central

Fig. 4 Changes over time in the skin with retinoid therapy, differentiating transient irritation versus inflammation. MoA mechanism of action, IL interleukin, TNF tumor necrosis factorCC BY-NC · PubMed Central

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Guidelines of care for the management of acne vulgaris
Zaenglein, A. L., Pathy, A. L., Schlosser, B. J., Alikhan, A., Baldwin, H. E., Berson, D. S., Bowe, W. P., Graber, E. M., Harper, J. C., Kang, S., et al. (2016) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2015.12.037 · Cited by 1,597
Self-citation
New insights into the management of acne: An update from the Global Alliance to Improve Outcomes in Acne Group
Thiboutot, D. M., Gollnick, H. P. M., Bettoli, V., Dréno, B., Kang, S., Leyden, J. J., Shalita, A. R., Lozada, V. T., Berson, D. S., Finlay, A. Y., et al. (2009) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2009.01.019 · Cited by 863
Self-citation
Management of Acne
Gollnick, H. P. M., Cunliffe, W. J., Berson, D. S., Dréno, B., Finlay, A. Y., Leyden, J. J., Shalita, A. R., & Thiboutot, D. M. (2003) · Journal of the American Academy of Dermatology · doi:10.1067/mjd.2003.618 · Cited by 818
Self-citation
Retinoids in the treatment of skin aging: an overview of clinical efficacy and safety
Mukherjee, S., Date, A., Patravale, V., Korting, H. C., Roeder, A., & Weindl, G. (2006) · Clinical Interventions in Aging · doi:10.2147/ciia.2006.1.4.327 · Cited by 580
Guidelines of care for acne vulgaris management
Strauss, J. S., Krowchuk, D. P., Leyden, J. J., Lucky, A. W., Shalita, A. R., Siegfried, E. C., Thiboutot, D. M., Voorhees, A. S. V., Beutner, K. A., Sieck, C. K., et al. (2007) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2006.08.048 · Cited by 552
Self-citation
Inflammatory Events Are Involved in Acne Lesion Initiation
Jeremy, A. H. T., Holland, D. B., Roberts, S. G., Thomson, K. F., & Cunliffe, W. J. (2003) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.2003.12321.x · Cited by 541
Acne Scars: Pathogenesis, Classification and Treatment
Fabbrocini, G., Annunziata, M. C., D′Arco, V., Vita, V. D., Lodi, G., Mauriello, M. C., Pastore, F., & Monfrecola, G. (2010) · Dermatology Research and Practice · doi:10.1155/2010/893080 · Cited by 442
European Evidence‐based (S3) Guidelines for the Treatment of Acne
Nast, A., Dréno, B., Bettoli, V., Degitz, K., ERDMANN, R., Finlay, A. Y., Gancevičienė, R., Hædersdal, M., Layton, A., López-Estebaranz, J. L., et al. (2012) · Journal of the European Academy of Dermatology and Venereology · doi:10.1111/j.1468-3083.2011.04374.x · Cited by 425
Induction of proinflammatory cytokines by a soluble factor of Propionibacterium acnes: implications for chronic inflammatory acne
Vowels, B. R., Yang, S., & Leyden, J. J. (1995) · Infection and Immunity · doi:10.1128/iai.63.8.3158-3165.1995 · Cited by 331
Self-citation
Evidence-Based Recommendations for the Diagnosis and Treatment of Pediatric Acne
Eichenfield, L. F., Krakowski, A. C., Piggott, C. D. S., Rosso, J. Q. D., Baldwin, H. E., Friedlander, S. F., Levy, M. L., Lucky, A. W., Mancini, A. J., Orlow, S. J., et al. (2013) · PEDIATRICS · doi:10.1542/peds.2013-0490b · Cited by 256
DISORDERS OF HYPERPIGMENTATION
Pandya, A. G., & Guevara, I. L. (2000) · Dermatologic Clinics · doi:10.1016/s0733-8635(05)70150-9 · Cited by 248
Topical tretinoin (retinoic acid) improves melasma. A vehicle-controlled, clinical trial
Griffiths, C. E. M., Finkel, L. J., Ditre, C. M., HAMILTON, T. A., Ellis, C. N., & Voorhees, J. J. (1993) · British Journal of Dermatology · doi:10.1111/j.1365-2133.1993.tb03169.x · Cited by 247
Topical Tretinoin (Retinoic Acid) Therapy for Hyperpigmented Lesions Caused by Inflammation of the Skin in Black Patients
Bulengo-Ransby, S. M., Griffiths, C. E. M., Kimbrough-Green, C. K., Finkel, L. J., Hamilton, T. A., Ellis, C. N., & Voorhees, J. J. (1993) · New England Journal of Medicine · doi:10.1056/nejm199305203282002 · Cited by 211
Understanding innate immunity and inflammation in acne: implications for management
Dréno, B., Gollnick, H. P. M., Kang, S., Thiboutot, D. M., Bettoli, V., Torres, V., Leyden, J., & the Global Alliance to Improve Outcomes in Acne (2015) · Journal of the European Academy of Dermatology and Venereology · doi:10.1111/jdv.13190 · Cited by 191
Self-citation
A comparison of the efficacy and safety of adapalene gel 0.1% and tretinoin gel 0.025% in the treatment of acne vulgaris: A multicenter trial
Shalita, A. R., Weiss, J., Chalker, D. K., Ellis, C. N., Greenspan, A., Katz, H. I., Kantor, I., Millikan, L. E., Swinehart, T., Swinyer, L. J., et al. (1996) · Journal of the American Academy of Dermatology · doi:10.1016/s0190-9622(96)90443-0 · Cited by 184
Self-citation
Beliefs and perceptions of patients with acne
Tan, J. K. L., Vasey, K., & Fung, K. Y. (2001) · Journal of the American Academy of Dermatology · doi:10.1067/mjd.2001.111340 · Cited by 184
Acne and rosacea
Plewig, G., & Kligman, A. M. (1992) · Medical Entomology and Zoology · Cited by 175
Can We Define Acne as a Chronic Disease?
Gollnick, H. P. M., Finlay, A. Y., & Shear, N. H. (2008) · American Journal of Clinical Dermatology · doi:10.2165/00128071-200809050-00001 · Cited by 155
ACNE and ROSACEA
Plewig, G., & Kligman, A. M. (2000) · Springer eBooks · doi:10.1007/978-3-642-59715-2 · Cited by 153
Topical Retinoids in Acne Vulgaris
Thielitz, A., & Gollnick, H. P. M. (2008) · American Journal of Clinical Dermatology · doi:10.2165/0128071-200809060-00003 · Cited by 145
A consensus‐based practical and daily guide for the treatment of acne patients
Gollnick, H. P. M., Bettoli, V., Lambert, J., Araviiskaia, E., Binić, I., Dessinioti, C., Galadari, I. H., Gancevičienė, R., İlter, N., Kaegi, M., et al. (2016) · Journal of the European Academy of Dermatology and Venereology · doi:10.1111/jdv.13675 · Cited by 123
Antibiotic stewardship in dermatology: limiting antibiotic use in acne
Dréno, B., Thiboutot, D. M., Gollnick, H. P. M., Bettoli, V., Kang, S., Leyden, J. J., Shalita, A. R., & Torres, V. (2014) · European Journal of Dermatology · doi:10.1684/ejd.2014.2309 · Cited by 118
Self-citation
Prevalence and Risk Factors of Acne Scarring Among Patients Consulting Dermatologists in the USA
Tan, J. K. L., Kang, S., & Leyden, J. (2017) · PubMed · Cited by 115
Self-citation
In vitro modulation of TLR‐2, CD1d and IL‐10 by adapalene on normal human skin and acne inflammatory lesions
Tenaud, I., Khammari, A., & Dréno, B. (2007) · Experimental Dermatology · doi:10.1111/j.1600-0625.2007.00552.x · Cited by 111
Pharmacology of adapalene
MichelL, Jomard, & Démarchez (1998) · British Journal of Dermatology · doi:10.1046/j.1365-2133.1998.1390s2003.x · Cited by 106
RESEARCH REPORT Perceptions of acne vulgaris in final year medical student written examination answers
Green, J., & Sinclair, R. D. (2001) · Australasian Journal of Dermatology · doi:10.1046/j.1440-0960.2001.00489.x · Cited by 103
Topical retinoids in acne – an evidence‐based overview
Thielitz, A., Abdel‐Naser, M. B., Fluhr, J. W., Zouboulis, C. C., & Gollnick, H. P. M. (2008) · JDDG Journal der Deutschen Dermatologischen Gesellschaft · doi:10.1111/j.1610-0387.2008.06741.x · Cited by 102
The mechanism of retinol-induced irritation and its application to anti-irritant development
Kim, B. (2003) · Toxicology Letters · doi:10.1016/j.toxlet.2003.09.001 · Cited by 97
Update in retinoid therapy of acne
Thielitz, A., Krautheim, A., & Gollnick, H. P. M. (2006) · Dermatologic Therapy · doi:10.1111/j.1529-8019.2006.00084.x · Cited by 96
The short-term treatment of acne vulgaris with benzoyl peroxide: effects on the surface and follicular cutaneous microflora
Bojar, R. A., Cunliffe, W. J., & Holland, K. T. (2006) · British Journal of Dermatology · doi:10.1111/j.1365-2133.1995.tb05014.x · Cited by 95
Lipid analysis of follicular casts from cyanoacrylate strips as a new method for studying therapeutic effects of antiacne agents
Thielitz, A., Helmdach, M., Röpke, E.-M., & Gollnick, H. P. M. (2001) · British Journal of Dermatology · doi:10.1046/j.1365-2133.2001.04276.x · Cited by 91
Tazarotene cream for postinflammatory hyperpigmentation and acne vulgaris in darker skin: a double-blind, randomized, vehicle-controlled study.
Grimes, P. E., & Callender, V. D. (2006) · PubMed · Cited by 89
Adapalene biochemistry and the evolution of a new topical retinoid for treatment of acne
Czernielewski, J., Michel, S., Bouclier, M., Baker, M., & Hensby, C. N. (2001) · Journal of the European Academy of Dermatology and Venereology · doi:10.1046/j.0926-9959.2001.00006.x · Cited by 83
Successful Treatment of Acne Vulgaris Using a New Method
Bershad, S. V., Singer, G., Parente, J. E., Tan, M., Sherer, D. W., Persaud, A. N., & Lebwohl, M. (2002) · Archives of Dermatology · doi:10.1001/archderm.138.4.481 · Cited by 82
An in vivo experimental model for effects of topical retinoic acid in human skin
Griffiths, C. E. M., Finkel, L. J., TKANFAGLIA, M. G., HAMILTON, T. A., & Voorhees, J. J. (1993) · British Journal of Dermatology · doi:10.1111/j.1365-2133.1993.tb03163.x · Cited by 73
Computer-assisted alignment and tracking of acne lesions indicate that most inflammatory lesions arise from comedones and de novo
Thy, T., Zarkhin, S., Orringer, J. S., Nemeth, S. A., Hamilton, T. A., Sachs, D. L., Voorhees, J. J., & Kang, S. (2008) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2007.12.024 · Cited by 70
Topical retinoids in inflammatory acne: A retrospective, investigator-blinded, vehicle-controlled, photographic assessment
Leyden, J. J., Shalita, A. R., Thiboutot, D. M., Washenik, K., & WEBSTER, G. F. (2005) · Clinical Therapeutics · doi:10.1016/j.clinthera.2005.02.009 · Cited by 67
Self-citation
Adapalene gel 0.3% for the treatment of acne vulgaris: a multicenter, randomized, double-blind, controlled, phase III trial
Thiboutot, D., Pariser, D. M., Egan, N., Flores, J., Herndon, J. H., Kanof, N. B., Kempers, S. E., Maddin, S., Poulin, Y. P., Wilson, D. C., et al. (2006) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2004.10.879 · Cited by 67 · cited 1×
“1% across all efficacy measures, with good tolerability at both dosages [26, 27].”
Moderate and Severe Inflammatory Acne Vulgaris Effectively Treated with Single-Agent Therapy by a New Fixed-Dose Combination Adapalene 0.3 %/Benzoyl Peroxide 2.5 % Gel: A Randomized, Double-Blind, Parallel-Group, Controlled Study
Stein Gold, L., Weiss, J., Rueda, M. J., Liu, H., & Tanghetti, E. (2016) · American Journal of Clinical Dermatology · doi:10.1007/s40257-016-0178-4 · Cited by 61
Self-citation
Anti-inflammatory actions of benzoyl peroxide: effects on the generation of reactive oxygen species by leucocytes and the activity of protein kinase C and calmodulin
Hegemann, L., Toso, S. M., KITAY, K., & WEBSTER, C. F. (1994) · British Journal of Dermatology · doi:10.1111/j.1365-2133.1994.tb13101.x · Cited by 59
Mechanism of anti-inflammatory action of retinoids on keratinocytes
Bécherel, P., Mossalayi, M. D., Goff, L., Francès, C., Chosidow, O., Debré, P., & Arock, M. (1994) · The Lancet · doi:10.1016/s0140-6736(94)90377-8 · Cited by 55
An ultrastructural study of the effects of topical tretinoin on microcomedones.
Lavker, R. M., Leyden, J. J., & Thorne, E. G. (1993) · PubMed · Cited by 49
Self-citation
A multicenter, double-blind, randomized comparison study of the efficacy and tolerability of once-daily tazarotene 0.1% gel and adapalene 0.1% gel for the treatment of facial acne vulgaris.
WEBSTER, G. F., Guenther, L., Poulin, Y. P., Solomon, B. A., Loven, K. H., & Lee, J. (2002) · PubMed · Cited by 48
Efficacy and tolerability of once-daily tazarotene 0.1% gel versus once-daily tretinoin 0.025% gel in the treatment of facial acne vulgaris: a randomized trial.
WEBSTER, G. F., Berson, D., Stein, L. F., Fivenson, D. P., Tanghetti, E. A., & LING, M. R. (2001) · PubMed · Cited by 47
Synergistic efficacy of adapalene 0.1%-benzoyl peroxide 2.5% in the treatment of 3855 acne vulgaris patients
Tan, J. K. L., Gollnick, H. P. M., Loesche, C., Ma, Y. M., & Gold, L. S. (2010) · Journal of Dermatological Treatment · doi:10.3109/09546631003681094 · Cited by 47
The Epidermal Skin Barrier: Implications for the Wound Care Practitioner, Part I
Fore-Pfliger, J. (2004) · Advances in Skin & Wound Care · doi:10.1097/00129334-200410000-00011 · Cited by 45
Serial sections of atrophic acne scars help in the interpretation of microscopic findings and the selection of good therapeutic modalities
Lee, W. J., Jung, H.-A., Lim, H.-J., Jang, Y. H., Lee, S. ‐., & Kim, D. W. (2011) · Journal of the European Academy of Dermatology and Venereology · doi:10.1111/j.1468-3083.2011.04330.x · Cited by 43
Adapalene gel 0.1% for topical treatment of acne vulgaris in African patients.
Jacyk, W. K., & Mpofu, P. (2001) · PubMed · Cited by 41
Tolerability of Topical Retinoids: Are There Clinically Meaningful Differences Among Topical Retinoids?
Culp, L., Moradi Tuchayi, S., Alinia, H., & Feldman, S. R. (2015) · Journal of Cutaneous Medicine and Surgery · doi:10.1177/1203475415591117 · Cited by 40
Acne counseling to improve adherence.
Thiboutot, D. M., Dréno, B., & Layton, A. (2008) · PubMed · Cited by 37
Randomized comparison of the safety and efficacy of tazarotene 0.1% cream and adapalene 0.3% gel in the treatment of patients with at least moderate facial acne vulgaris.
Tanghetti, E. A., Dhawan, S., Green, L., Rosso, J. Q. D., Draelos, Z. D., Leyden, J., Shalita, A. R., Glaser, D. A., Grimes, P. E., WEBSTER, G. F., et al. (2010) · PubMed · Cited by 37
Self-citation
A call to limit antibiotic use in acne.
Thiboutot, D. M., Dréno, B., Gollnick, H. P. M., Bettoli, V., Kang, S., Leyden, J., Shalita, A. R., & Torres, V. (2013) · PubMed · Cited by 33
Self-citation
Ex vivo demonstration of a synergistic effect of Adapalene and benzoyl peroxide on inflammatory acne lesions
Zuliani, T., Khammari, A., Chaussy, H., Knol, A., & Dréno, B. (2011) · Experimental Dermatology · doi:10.1111/j.1600-0625.2011.01339.x · Cited by 30
Facial tolerability of topical retinoid therapy.
Leyden, J., Grove, G. L., & Zerweck, C. R. (2005) · PubMed · Cited by 29
Self-citation
The efficacy and safety of adapalene gel 0.3% in the treatment of acne vulgaris: A randomized, multicenter, investigator-blinded, controlled comparison study versus adapalene gel 0.1% and vehicle.
Pariser, D. M., Thiboutot, D. M., Clark, S. D., Jones, T. M., Liu, Y., & Graeber, M. (2005) · PubMed · Cited by 28
Systematic review on the rapidity of the onset of action of topical treatments in the therapy of mild-to-moderate acne vulgaris
Jacobs, A., Starke, G., Rosumeck, S., & Nast, A. (2013) · British Journal of Dermatology · doi:10.1111/bjd.12706 · Cited by 24
Use of topical retinoids by dermatologists and non-dermatologists in the management of acne vulgaris
da Pena, S. R. T., Hill, D., & Feldman, S. R. (2016) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2016.01.011 · Cited by 24
Adapalene 0·1% gel has low skin irritation potential even when applied immediately after washing
Dunlap, Baker, Plott, & Verschoore (1998) · British Journal of Dermatology · doi:10.1046/j.1365-2133.1998.1390s2023.x · Cited by 22
Physicians underutilize topical retinoids in the management of acne vulgaris: analysis of U.S. National Practice Data
Balkrishnan, R., Fleischer, A. B., Paruthi, S., & Feldman, S. R. (2003) · Journal of Dermatological Treatment · doi:10.1080/09546630310012037 · Cited by 17
The Relationship of Proper Skin Cleansing to Pathophysiology, Clinical Benefits, and the Concomitant Use of Prescription Topical Therapies in Patients with Acne Vulgaris
Levin, J. (2016) · Dermatologic Clinics · doi:10.1016/j.det.2015.11.001 · Cited by 16
Customized Single-agent Therapy Management of Severe Inflammatory Acne: A Randomized, Double-blind, Parallel-group, Controlled Study of a New Treatment--Adapalene 0.3%-Benzoyl Peroxide 2.5% Gel.
Weiss, J., Gold, L. S., Leoni, M. J., Rueda, M. J., Liu, H., & Tanghetti, E. A. (2015) · PubMed · Cited by 15
Self-citation
Topical retinoids for acne
Yeh, L. C., Bonati, L. M., & Silverberg, N. B. (2016) · Seminars in Cutaneous Medicine and Surgery · doi:10.12788/j.sder.2016.024 · Cited by 15
A Meta-analysis to Investigate the Relation Between Fitzpatrick Skin Types and Tolerability of Adapalene-Benzoyl Peroxide Topical Gel in Subjects with Mild or Moderate Acne.
Callender, V. D., Preston, N. J., Osborn, C. D., Johnson, L. A., & Gottschalk, R. W. (2010) · PubMed Central · Cited by 13
Synergy and its clinical reievance in topical acne therapy.
Kircik, L. (2011) · PubMed Central · Cited by 12
Prescribing patterns for topical retinoids: Analyses of 15 years of data from the National Ambulatory Medical Care Survey
Balkrishnan, R., Bhosle, M. J., CAMACHO, F. T., Fleischer, A. B., & Feldman, S. R. (2009) · Journal of Dermatological Treatment · doi:10.3109/09546630903341960 · Cited by 9
Fixed-Combination Gels of Adapalene and Benzoyl Peroxide Provide Optimal Percutaneous Absorption Compared to Monad Formulations of These Compounds: Results from Two In Vitro Studies
Osman‐Ponchet, H., Sevin, K., Gaborit, A., Wagner, N., & Poncet, M. (2016) · Dermatology and Therapy · doi:10.1007/s13555-016-0159-9 · Cited by 9
Exfoliative cytology of stratum corneum and the effects of topical retinoids on the physical properties of corneocytes
Haidl, G., & Plewig, G. (1988) · Journal of the Society of Cosmetic Chemists · Cited by 6
Predictors of local adverse effects caused by topical tretinoin cream 0·1% in the Veterans Affairs Topical Tretinoin Chemoprevention trial
Pomerantz, H., Weinstock, M. A., & the Veterans Affairs Topical Tretinoin Chemoprevention (VATTC) Group (2014) · British Journal of Dermatology · doi:10.1111/bjd.12987 · Cited by 4

Research works printed but not linked: 1

Ikoma ATJ, Bissonnette R, Gratton D, Kerrouche N. Enhancing tolerability to adapalene 0.1%/benzoyl peroxide 2.5% gel in acne patients: a randomized controlled trial of 4 different application regimens. Presented at 4th Eastern Asia Conference, Nov 16-18, 2016 Tokyo, Japan. 2016.

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Authors: Leyden, J., Stein-Gold, L., & Weiss, J.
Affiliations: University of Pennsylvania (US)
Gwinnett Dermatology (US)
Corresponding author: Leyden, James
Venue: Dermatology and Therapy
Publisher: Springer Science and Business Media LLC
Published: 2017-06-05
Volume: 7
Issue: 3
Pages: 293-304
ISSN: 2190-9172 (ISSN-L)
2193-8210
DOI: 10.1007/s13555-017-0185-2
PMC: PMC5574737
OpenAlex: W2621447419
Cited by: 164
References: 68
Citations by year: 2026: 14 · 2025: 20 · 2024: 22 · 2023: 21 · 2022: 20 · 2021: 20 · 2020: 23 · 2019: 15 · 2018: 6 · 2017: 2
FWCI: 2.25
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by-nc
Locations: Dermatology and Therapy (publishedVersion, cc-by-nc)
PubMed Central (publishedVersion, cc-by-nc)
PubMed (publishedVersion)
Funders: Galderma International
Topics: Health Sciences › Medicine › Dermatology › Acne and Rosacea Treatments and Effects
Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
Health Sciences › Medicine › Dermatology › Dermatologic Treatments and Research
Keywords: topical retinoids, acne, combination therapy, antimicrobial therapy, anti-inflammatory activity, acne pathophysiology, prescribing patterns

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Why Topical Retinoids Are Mainstay of Therapy for Acne

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