Tolerability of Topical Retinoids: Are There Clinically Meaningful Differences Among Topical Retinoids?

Culp, Leonora; Moradi Tuchayi, Sara; Alinia, Hossein; Feldman, Steven R.

doi:10.1177/1203475415591117

Cited by 40Acne and Rosacea Treatments and EffectsDermatology and Skin DiseasesSkin Protection and Aging

Tolerability of Topical Retinoids: Are There Clinically Meaningful Differences Among Topical Retinoids?

Culp, Leonora, Moradi Tuchayi, Sara, Alinia, Hossein, Feldman, Steven R.·2015·Journal of Cutaneous Medicine and Surgery

DOI 10.1177/1203475415591117

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Abstract

Background: Topical retinoids are first-line treatment options for acne vulgaris. These drugs, however, produce varying degree of cutaneous irritation within the first few weeks of treatment. Objective: Our purpose was to examine differences in tolerability of topical retinoids and assess whether these differences would be clinically meaningful. Methods: A PubMed search was performed for sources on topical retinoids in acne vulgaris treatment. Thirty-four clinical studies were analyzed. Results: Thirteen studies had statistically significant results on tolerability of retinoid based on retinoid, vehicle, concentration, or skin type. All studies classified most of skin reactions as mild-moderate. Large differences in the number of dropouts due to irritation were not identified. Conclusion: Irritation studies did not show a high frequency of clinically significant irritation with topical retinoids. We anticipate that the large variation in patient use of topical retinoids would likely account for more variation in response than differences between drug formulations.

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Authors: Culp, L., Moradi Tuchayi, S., Alinia, H., & Feldman, S. R.
Affiliations: Wake Forest University Health Sciences (US)
Center for Dermatology Research, Departments of Dermatology, Wake Forest School of Medicine, Winston-Salem, NC, USA
ORCID: Alinia, Hossein
Feldman, Steven R.
Venue: Journal of Cutaneous Medicine and Surgery
Publisher: SAGE Publications
Published: 2015-06-18
Volume: 19
Issue: 6
Pages: 530-538
ISSN: 1203-4754 (ISSN-L)
1615-7109
DOI: 10.1177/1203475415591117
OpenAlex: W1828582648
Cited by: 40
References: 34
Citations by year: 2025: 8 · 2024: 5 · 2023: 7 · 2022: 1 · 2021: 4 · 2020: 3 · 2019: 5 · 2018: 1 · 2017: 2 · 2016: 3 · 2015: 1
FWCI: 0.37
Type: journal article
Language: en
Open access: closed
Licence: journals.sagepub.com/page/policies/text-and-data-mining-license (tdm)
Locations: Journal of Cutaneous Medicine and Surgery (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Dermatology › Acne and Rosacea Treatments and Effects
Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
Health Sciences › Medicine › Dermatology › Skin Protection and Aging
Keywords: topical retinoids, acne, drug tolerability, skin irritation, adverse skin reactions, treatment discontinuation, skin type
MeSH terms: Acne Vulgaris, Administration, Cutaneous, Dermatologic Agents, Humans, Retinoids

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Tolerability of Topical Retinoids: Are There Clinically Meaningful Differences Among Topical Retinoids?

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