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Cited by 159Skin Protection and AgingPhytochemicals and Antioxidant ActivitiesFood Science and Nutritional Studies

Nutraceuticals: A Review

Open access
Souyoul, Skylar A., Saussy, Katharine P., Lupo, Mary P.·2018·Dermatology and Therapy
DOI 10.1007/s13555-018-0221-xPMC PMC5825326
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Abstract

Skin aging is continuously influenced by various internal and external factors such as the biologic progression of cells, ultraviolet (UV) radiation, tobacco, nutritional deficiencies, and hormonal imbalances that lead to the degradation of skin cells. Through the degradation of skin cells, free radicals and inflammation weaken repair mechanisms and result in collagen and elastic fiber breakdown. The appearance of aging skin is highlighted by skin roughness, wrinkling, pigmentation change, telangiectasias, loss of elasticity, and decreased firmness, all of which are accelerated by these internal and external factors. Throughout the years, nutraceuticals have been studied to delay and fight against these internal and external factors, many of which are found in foods and byproducts consumed naturally. The aim of this review is to aid dermatologists in understanding the mechanism of action of popular nutraceuticals and their possible efficacy in antiaging and skin health.

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  • Omega-3 and omega-6 fatty acids can lessen UV-induced inflammation.

    “These components, which can lessen UV-induced inflammation, are mostly found in oils, such as canola oil, cold-water fish, nuts, and seeds [10, 42].”

    From AN OVERVIEW OF NEW TRENDS IN THE COSMETICS INDUSTRY (2025) · cites this paper as [42]

    The Fatty Acids section reports reduced UV-induced inflammation with fatty-acid supplements, and the Conclusions table lists that benefit for ALA, EPA, and DHA—all omega-3 fatty acids. Our copy describes omega-6 linoleic acid as a structural component of the epidermis but does not establish that it lessens UV-induced inflammation. (LLM, conf=0.85)

    Experimental — accuracy not yet measured

  • Vitamin C is a powerful hydrophilic antioxidant that can scavenge and quench free radicals.

    “This is a powerful hydrophilic antioxidant that can scavenge and quench free radicals [42].”

    From AN OVERVIEW OF NEW TRENDS IN THE COSMETICS INDUSTRY (2025) · cites this paper as [42]

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Cited by

Sorted by citations

Authors
Souyoul, S. A., Saussy, K. P., & Lupo, M. P.
Affiliations
Tulane University (US)
Corresponding author
Souyoul, Skylar A.
ORCID
Lupo, Mary P.
Venue
Dermatology and Therapy
Publisher
Springer Science and Business Media LLC
Published
2018-02-06
Volume
8
Issue
1
Pages
5-16
ISSN
  • 2190-9172 (ISSN-L)
  • 2193-8210
DOI
10.1007/s13555-018-0221-x
PMC
PMC5825326
OpenAlex
W2787620706
Cited by
159
References
6
Citations by year
2026: 12 · 2025: 14 · 2024: 21 · 2023: 23 · 2022: 30 · 2021: 18 · 2020: 19 · 2019: 9 · 2018: 12 · 2016: 1
FWCI
2.35
Type
journal article
Language
en
Open access
Licence
Locations
  • Dermatology and Therapy (publishedVersion, cc-by-nc)
  • PubMed Central (publishedVersion, cc-by-nc)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Dermatology › Skin Protection and Aging
  • Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
  • Health Sciences › Nursing › Nutrition and Dietetics › Food Science and Nutritional Studies
Keywords
nutraceuticals, skin aging, anti-aging, free radicals, inflammation, collagen degradation, elastic fibers, ultraviolet radiation, nutritional deficiency, skin health, mechanism of action

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