Cited by 176Diabetes, Cardiovascular Risks, and LipoproteinsDiabetes Treatment and ManagementDiabetes Management and Education

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The Look AHEAD Trial: A Review and Discussion of Its Outcomes

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Pi-Sunyer, Xavier·2014·Current Nutrition Reports

DOI 10.1007/s13668-014-0099-xPMC PMC4339027

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Abstract

The LookAhead trial was a randomized controlled trial comparing an Intensive Lifestyle Intervention (ILI) to a Diabetes Support and Education (DSE) in overweight and obese type 2 diabetes patients to track the development of cardiovascular disease over time. The triaI intervention was stopped for futility after a median follow-up of 9.6 years. While there was a differential effect on weight loss and fitness between the two groups, there was no effect on cardiovascular outcomes. Cardiovascular events were less than half the projected rate per year in the DSE group: thus there was a very low over-all rate of events in both groups. There were many other health benefits of ILI, including improved biomarkers of glucose and lipid control, less sleep apnea, lower liver fat, less depression, improved insulin sensitivity, less urinary incontinence, less kidney disease, reduced need of diabetes medications, maintenance of physical mobility, improved quality of life and lower costs.

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Authors: Pi-Sunyer, X.
Venue: Current Nutrition Reports
Publisher: Springer Science and Business Media LLC
Published: 2014-09-28
Volume: 3
Issue: 4
Pages: 387-391
ISSN: 2161-3311 (ISSN-L)
DOI: 10.1007/s13668-014-0099-x
PMC: PMC4339027
OpenAlex: W2077801798
Cited by: 176
References: 35
Citations by year: 2026: 14 · 2025: 13 · 2024: 19 · 2023: 21 · 2022: 21 · 2021: 13 · 2020: 23 · 2019: 16 · 2018: 14 · 2017: 12 · 2016: 4 · 2015: 6
FWCI: 5.90
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
Locations: Current Nutrition Reports (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of Diabetes and Digestive and Kidney Diseases (U01DK057178)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Education
Keywords: Look AHEAD trial, intensive lifestyle intervention, type 2 diabetes, obesity, overweight, diabetes support and education, cardiovascular disease, weight loss, physical fitness, sleep apnea, liver fat, insulin sensitivity, kidney disease, depression, urinary incontinence, quality of life, cost-effectiveness

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The Look AHEAD Trial: A Review and Discussion of Its Outcomes

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