Cited by 176Diabetes, Cardiovascular Risks, and LipoproteinsDiabetes Treatment and ManagementDiabetes Management and Education

The DOI matches its Crossref record; 34 of the 35 references it cites were found in a registry or an index.

The Look AHEAD Trial: A Review and Discussion of Its Outcomes

Open access

Pi-Sunyer, Xavier·2014·Current Nutrition Reports

DOI 10.1007/s13668-014-0099-xPMC PMC4339027

Open this paper in CoChat — free account

Abstract

The LookAhead trial was a randomized controlled trial comparing an Intensive Lifestyle Intervention (ILI) to a Diabetes Support and Education (DSE) in overweight and obese type 2 diabetes patients to track the development of cardiovascular disease over time. The triaI intervention was stopped for futility after a median follow-up of 9.6 years. While there was a differential effect on weight loss and fitness between the two groups, there was no effect on cardiovascular outcomes. Cardiovascular events were less than half the projected rate per year in the DSE group: thus there was a very low over-all rate of events in both groups. There were many other health benefits of ILI, including improved biomarkers of glucose and lipid control, less sleep apnea, lower liver fat, less depression, improved insulin sensitivity, less urinary incontinence, less kidney disease, reduced need of diabetes medications, maintenance of physical mobility, improved quality of life and lower costs.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1007/s13668-014-0099-x

Cites

34 of 34 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin
(2002) · New England Journal of Medicine · doi:10.1056/nejmoa012512 · Cited by 19,011
International Diabetes Federation 2017
Carracher, A. M., Marathe, P. H., & Close, K. L. (2018) · Journal of Diabetes · doi:10.1111/1753-0407.12644 · Cited by 13,379
Prevalence of obesity and trends in the distribution of body mass index among US adults, 1999-2010.
Flegal, K., Carroll, M., Kit, B., & Ogden, C. (2012) · Journal of the American Medical Association (JAMA) · doi:10.1001/jama.2012.39 · Cited by 5,523
Diabetes mellitus, fasting blood glucose concentration, and risk of vascular disease: a collaborative meta-analysis of 102 prospective studies
The Emerging Risk Factors Collaboration (2010) · The Lancet · doi:10.1016/s0140-6736(10)60484-9 · Cited by 5,125
The incidence of co-morbidities related to obesity and overweight: A systematic review and meta-analysis
Guh, D. P., Zhang, W., Bansback, N., Amarsi, Z., Birmingham, C. L., & Anis, A. H. (2009) · BMC Public Health · doi:10.1186/1471-2458-9-88 · Cited by 3,855
Cardiovascular effects of intensive lifestyle intervention in type 2 diabetes
The Look AHEAD Research Group (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1212914 · Cited by 2,908
Reduction in Weight and Cardiovascular Disease Risk Factors in Individuals With Type 2 Diabetes
The Look AHEAD Research Group (2007) · Diabetes Care · doi:10.2337/dc07-0048 · Cited by 1,522
Long-term Effects of a Lifestyle Intervention on Weight and Cardiovascular Risk Factors in Individuals With Type 2 Diabetes Mellitus: Four-Year Results of the Look AHEAD Trial
(2010) · Archives of Internal Medicine · doi:10.1001/archinternmed.2010.334 · Cited by 1,162
Review of article: Prevalence of obesity and trends in the distribution of body mass index among US adults, 1999-2010 by Katherine M. Flegal, PhD; Margaret D. Carroll, MSPH; Brian K. Kit, MD; Cynthia L. Ogden, PhD (JAMA 2012;307:491-7)
Fitzgerald, K. R. (2013) · Journal of Vascular Nursing · doi:10.1016/j.jvn.2013.06.004 · Cited by 875
The Look AHEAD Study: A Description of the Lifestyle Intervention and the Evidence Supporting It
The Look AHEAD Research Group (2006) · Obesity · doi:10.1038/oby.2006.84 · Cited by 873

Show all 35 references

Research works printed but not linked: 3

International Diabetes Federation. IDF Diabetes Atlas. 6th ed. Brussels: International Diabetes Federation; 2013. http://www.idf.org/diabetesatlas.
NIH press release Oct 19,2012.
Look AHEAD Research Group, Wadden TA, West DS. The Look AHEAD study: a description of the lifestyle intervention and the evidence supporting it. Obesity (Silver Spring). 2006;14:737–52 [Erratum, Obesity (Silver Spring) 2007; 15: 1339.]. · DOI · Paper page

Sorted by citations

Physical activity/exercise and diabetes: A position statement of the American Diabetes Association
Colberg, S. R., Sigal, R. J., Yardley, J. E., Riddell, M. C., Dunstan, D. W., Dempsey, P. C., Horton, E. S., Castorino, K., & Tate, D. F. (2016) · Diabetes Care · doi:10.2337/dc16-1728 · Cited by 2,991
Management of Hyperglycemia in Type 2 Diabetes, 2022. A Consensus Report by the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD)
Davies, M. J., Aroda, V. R., Collins, B. S., Gabbay, R. A., Green, J., Maruthur, N. M., Rosas, S. E., Del Prato, S., Mathieu, C., Mingrone, G., et al. (2022) · Diabetes Care · doi:10.2337/dci22-0034 · Cited by 2,104
Type 2 diabetes
Ahmad, E., Lim, S., Lamptey, R., Webb, D. R., & Davies, M. J. (2022) · The Lancet · doi:10.1016/s0140-6736(22)01655-5 · Cited by 1,120
Management of hyperglycaemia in type 2 diabetes, 2022. A consensus report by the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD)
Davies, M. J., Aroda, V. R., Collins, B. S., Gabbay, R. A., Green, J., Maruthur, N. M., Rosas, S. E., Del Prato, S., Mathieu, C., Mingrone, G., et al. (2022) · Diabetologia · doi:10.1007/s00125-022-05787-2 · Cited by 1,048
Obesity in adults
Lingvay, I., Cohen, R. V., Roux, C. W. L., & Sumithran, P. (2024) · The Lancet · doi:10.1016/s0140-6736(24)01210-8 · Cited by 433
Sarcopenic obesity in older adults: a clinical overview
Prado, C. M., Batsis, J. A., Donini, L. M., Gonzalez, M. C., & Siervo, M. (2024) · Nature Reviews Endocrinology · doi:10.1038/s41574-023-00943-z · Cited by 355
Non-alcoholic fatty liver disease, insulin resistance, metabolic syndrome and their association with vascular risk
Muzurović, E. M., Mikhailidis, D. P., & Mantzoros, C. S. (2021) · Metabolism · doi:10.1016/j.metabol.2021.154770 · Cited by 363
Diet, weight loss, and liver health in nonalcoholic fatty liver disease: Pathophysiology, evidence, and practice
Marchesini, G., Petta, S., & Grave, R. D. (2015) · Hepatology · doi:10.1002/hep.28392 · Cited by 306
5. Facilitating Positive Health Behaviors and Well-being to Improve Health Outcomes: Standards of Care in Diabetes—2024
ElSayed, N. A., Aleppo, G., Bannuru, R. R., Beverly, E. A., Bruemmer, D., Collins, B. S., Darville, A. K., Ekhlaspour, L., Hassanein, M. M., Hilliard, M. E., et al. (2023) · Diabetes Care · doi:10.2337/dc24-s005 · Cited by 366
Impact of glucose-lowering drugs on cardiovascular disease in type 2 diabetes
Ferrannini, E., & DeFronzo, R. A. (2015) · European Heart Journal · doi:10.1093/eurheartj/ehv239 · Cited by 265
Physical Activity and Diabetes
Sigal, R. J., Armstrong, M. J., Bacon, S., Boulé, N. G., Dasgupta, K., Kenny, G. P., & Riddell, M. C. (2018) · Canadian Journal of Diabetes · doi:10.1016/j.jcjd.2017.10.008 · Cited by 287
Prevalence and recognition of obesity and its associated comorbidities: cross-sectional analysis of electronic health record data from a large US integrated health system
Pantalone, K. M., Hobbs, T. M., Chagin, K. M., Kong, S. X., Wells, B. J., Kattan, M. W., Bouchard, J. R., Sakurada, B., Milinovich, A., Weng, W., et al. (2017) · BMJ Open · doi:10.1136/bmjopen-2017-017583 · Cited by 231
Comparison of Surgical and Medical Therapy for Type 2 Diabetes in Severely Obese Adolescents
Inge, T. H., Laffel, L. M., Jenkins, T. M., Marcus, M. D., Leibel, N. I., Brandt, M. L., Haymond, M., Urbina, E. M., Dolan, L. M., Zeitler, P. S., et al. (2018) · JAMA Pediatrics · doi:10.1001/jamapediatrics.2017.5763 · Cited by 189
RSSDI-ESI clinical practice recommendations for the management of type 2 diabetes mellitus 2020
Madhu, S., Chawla, R., Makkar, B. M., Ghosh, S. K., Saboo, B., & Kalra, S. (2020) · Indian Journal of Endocrinology and Metabolism · doi:10.4103/ijem.ijem_225_20 · Cited by 182
Body composition changes in diabetes and aging
Al‐Sofiani, M. E., Ganji, S. S., & Kalyani, R. R. (2019) · Journal of Diabetes and its Complications · doi:10.1016/j.jdiacomp.2019.03.007 · Cited by 172
The importance of exercise for glycemic control in type 2 diabetes
Syeda, U. S. A., Battillo, D. J., Visaria, A., & Malin, S. K. (2023) · American Journal of Medicine Open · doi:10.1016/j.ajmo.2023.100031 · Cited by 198
Olive oil and prevention of chronic diseases: Summary of an International conference
Visioli, F., Franco, M., Toledo, E., Luchsinger, J. A., Willett, W. C., Hu, F. B., & Martínez‐González, M. Á. (2018) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2018.04.004 · Cited by 158
Impact of Lifestyle Modifications on Cardiovascular Health: A Narrative Review
Ghodeshwar, G. K., Dube, A., & Khobragade, D. (2023) · Cureus · doi:10.7759/cureus.42616 · Cited by 178
Targeting weight loss interventions to reduce cardiovascular complications of type 2 diabetes: a machine learning-based post-hoc analysis of heterogeneous treatment effects in the Look AHEAD trial
Baum, A., Scarpa, J. R., Bruzelius, E., Tamler, R., Basu, S., & Faghmous, J. H. (2017) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(17)30176-6 · Cited by 125
Physical activity, cardiorespiratory fitness, and cardiovascular health: A clinical practice statement of the American Society for Preventive Cardiology Part II: Physical activity, cardiorespiratory fitness, minimum and goal intensities for exercise training, prescriptive methods, and special patient populations
Franklin, B. A., Eijsvogels, T. M. H., Pandey, A., Quindry, J., & Toth, P. P. (2022) · American Journal of Preventive Cardiology · doi:10.1016/j.ajpc.2022.100425 · Cited by 121
“The intensive lifestyle intervention group, which included dietary modification and unsupervised exercise, achieved significantly greater improvements in CRF, blood glucose control, weight loss, blood pressure, and quality of life (QOL) [108].”
The consequences of a weight‐centric approach to healthcare: A case for a paradigm shift in how clinicians address body weight
Mauldin, K., May, M. S., & Clifford, D. E. (2022) · Nutrition in Clinical Practice · doi:10.1002/ncp.10885 · Cited by 114
Physical Activity and Risk of Major Diabetes-Related Complications in Individuals With Diabetes: A Systematic Review and Meta-Analysis of Observational Studies
Rietz, M., Lehr, A., Mino, E., Lang, A., Szczerba, E., Schiemann, T., Herder, C., Saatmann, N., Geidl, W., Barbaresko, J., et al. (2022) · Diabetes Care · doi:10.2337/dc22-0886 · Cited by 115
Treatment of Obesity in Patients With Diabetes
Bramante, C. T., Lee, C. J., & Gudzune, K. A. (2017) · Diabetes Spectrum · doi:10.2337/ds17-0030 · Cited by 103
Best Practices in the Management of Overweight and Obesity
Tchang, B. G., Saunders, K. H., & Igel, L. I. (2020) · Medical Clinics of North America · doi:10.1016/j.mcna.2020.08.018 · Cited by 97
Advances in the management of type 2 diabetes in adults
Galindo, R. J., Trujillo, J. M., Wang, C. C. L., & McCoy, R. G. (2023) · BMJ Medicine · doi:10.1136/bmjmed-2022-000372 · Cited by 90
Effect of the Holiday Season on Weight Gain: A Narrative Review
Díaz-Zavala, R. G., Castro-Cantú, M. F., Valencia, M. E., Álvarez-Hernández, G., Haby, M. M., & Esparza-Romero, J. (2017) · Journal of Obesity · doi:10.1155/2017/2085136 · Cited by 74
Dietary interventions to treat type 2 diabetes in adults with a goal of remission: an expert consensus statement from the American College of Lifestyle Medicine
Rosenfeld, R. M., Kelly, J. H., Agarwal, M., Aspry, K., Barnett, T., Davis, B. C., Fields, D., Gaillard, T., Gulati, M., Guthrie, G. E., et al. (2022) · American Journal of Lifestyle Medicine · doi:10.1177/15598276221087624 · Cited by 71
Binge Eating Disorder in Patients with Type 2 Diabetes: Diagnostic and Management Challenges
Chevinsky, J. D., Wadden, T. A., & Chao, A. M. (2020) · Diabetes Metabolic Syndrome and Obesity · doi:10.2147/dmso.s213379 · Cited by 66
Fifty Years of Behavioral/Lifestyle Interventions for Overweight and Obesity: Where Have We Been and Where Are We Going?
Williamson, D. A. (2017) · Obesity · doi:10.1002/oby.21914 · Cited by 59
Cagrilintide: A Long-Acting Amylin Analog for the Treatment of Obesity
D’Ascanio, A. M., Mullally, J. A., & Frishman, W. H. (2024) · Cardiology in Review · doi:10.1097/crd.0000000000000513 · Cited by 46
Position statement on nutrition therapy for overweight and obesity: nutrition department of the Brazilian association for the study of obesity and metabolic syndrome (ABESO—2022)
Pepe, R. B., Lottenberg, A. M., Fujiwara, C. T. H., Beyruti, M., Cintra, D. E., Machado, R. M., Rodrigues, A., Jensen, N. S. O., Caldas, A. P. S., Fernandes, A. E., et al. (2023) · Diabetology & Metabolic Syndrome · doi:10.1186/s13098-023-01037-6 · Cited by 59
Insights on medical nutrition therapy for type 2 diabetes mellitus: an Indian perspective
Viswanathan, V., Krishnan, D., Kalra, S., Chawla, R., Tiwaskar, M., Saboo, B., Baruah, M., Chowdhury, S., Makkar, B. M., & Jaggi, S. (2019) · Advances in Therapy · doi:10.1007/s12325-019-0872-8 · Cited by 45
Efficacy of a mobile hypertension prevention delivery platform with human coaching
Toro-Ramos, T., Kim, Y., Wood, M., Rajda, J., Niejadlik, K., Honcz, J., Marrero, D., Fawer, A., & Michaelides, A. (2017) · Journal of Human Hypertension · doi:10.1038/jhh.2017.69 · Cited by 44
Mechanisms of aerobic exercise impairment in diabetes: a narrative review
Wahl, M. P., Scalzo, R. L., Regensteiner, J. G., & Reusch, J. E. B. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00181 · Cited by 44
RSSDI-ESI Clinical Practice Recommendations for the Management of Type 2 Diabetes Mellitus 2020
Chawla, R., Madhu, S. V., Makkar, B. M., Ghosh, S. K., Saboo, B., Kalra, S., & On behalf of RSSDI-ESI Consensus Group (2020) · International Journal of Diabetes in Developing Countries · doi:10.1007/s13410-020-00819-2 · Cited by 44
Drug Discovery and Development of Novel Therapeutics for Inhibiting TMAO in Models of Atherosclerosis and Diabetes
Steinke, I., Ghanei, N., Govindarajulu, M., Yoo, S., Zhong, J., & Amin, R. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.567899 · Cited by 44
Changes in physical activity and adiposity with all-cause, cardiovascular disease, and cancer mortality
Ahmadi, M. N., Lee, I.-M. M., Hamer, M., Cruz, B. D. P., Chen, L. J., Eroglu, E. I., Lai, Y., Ku, P., & Stamatakis, E. (2022) · International Journal of Obesity · doi:10.1038/s41366-022-01195-z · Cited by 44
Effect of a physical activity intervention and frailty on frailty trajectory and major mobility disability
Quach, J., Theou, O., Pérez‐Zepeda, M. U., Godin, J., Rockwood, K. J., & Kehler, D. S. (2022) · Journal of the American Geriatrics Society · doi:10.1111/jgs.17941 · Cited by 37
Educational weight loss interventions in obese and overweight adults with type 2 diabetes: a systematic review and meta‐analysis of randomized controlled trials
Maula, A., Kai, J., Woolley, A. K., Weng, S. F., Dhalwani, N. N., Griffiths, F. E., Khunti, K. K., & Kendrick, D. (2019) · Diabetic Medicine · doi:10.1111/dme.14193 · Cited by 37
Aerobic exercise can modulate the underlying mechanisms involved in the development of diabetic complications
Yaribeygi, H., Butler, A. E., & Sahebkar, A. (2019) · Journal of Cellular Physiology · doi:10.1002/jcp.28110 · Cited by 34
Aerobic exercise training may improve nerve function in type 2 diabetes and pre‐diabetes: A systematic review
Gu, Y., Dennis, S. M., Kiernan, M. C., & Harmer, A. R. (2018) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.3099 · Cited by 35
The cardiovascular effects of novel weight loss therapies
Usman, M., Davies, M. J., Hall, M. E., Verma, S., Anker, S. D., Rosenstock, J., & Butler, J. (2023) · European Heart Journal · doi:10.1093/eurheartj/ehad664 · Cited by 31
Mindful eating for weight loss in women with obesity: a randomised controlled trial
Pepe, R. B., Coelho, G. S. D. M. A., Miguel, F. D. S., Gualassi, A. C., Sarvas, M. M., Cercato, C., Mancini, M. C., & de Melo, M. E. (2022) · British Journal Of Nutrition · doi:10.1017/s0007114522003932 · Cited by 30
Exploring Therapeutic Targets to Reverse or Prevent the Transition from Metabolically Healthy to Unhealthy Obesity
Dagpo, T., Nolan, C. J., & Delghingaro‐Augusto, V. (2020) · Cells · doi:10.3390/cells9071596 · Cited by 32
Does comorbid obesity impact quality of life outcomes in patients undergoing endoscopic sinus surgery?
Steele, T. O., Mace, J. C., DeConde, A. S., Xiao, C. C., Storck, K. A., Gudis, D. A., Schlosser, R. J., Soler, Z. M., & Smith, T. L. (2015) · International Forum of Allergy & Rhinology · doi:10.1002/alr.21599 · Cited by 28
The Role of the Kidney and SGLT2 Inhibitors in Type 2 Diabetes
Katz, P. M., & Leiter, L. A. (2015) · Canadian Journal of Diabetes · doi:10.1016/j.jcjd.2015.09.001 · Cited by 24
Emerging incretin- and multi-agonist-based treatments – the continued refinement and continuous expansion of a potent therapeutic armamentarium for cardio-kidney-liver-metabolic diseases and beyond
Muzurović, E. M., Katsiki, N., Volčanšek, Š., Plescia, F., Rizzo, M., & Mantzoros, C. S. (2026) · Metabolism · doi:10.1016/j.metabol.2026.156494 · Cited by 24
Skeletal muscle microvascular insulin resistance in type 2 diabetes is not improved by eight weeks of regular walking
Park, L. K., Parks, E. J., Pettit‐Mee, R. J., Woodford, M. L., Ghiarone, T., Smith, J. A. H., Sales, A. R. K., Martinez‐Lemus, L. A., Manrique‐Acevedo, C., & Padilla, J. (2020) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00174.2020 · Cited by 23
Mobility and Vitality Lifestyle Program (MOVE UP): A Community Health Worker Intervention for Older Adults With Obesity to Improve Weight, Health, and Physical Function
Venditti, E. M., Zgibor, J. C., Bilt, J. V., Kieffer, L. A., Boudreau, R. M., Burke, L. E., Glynn, N. W., Jakicic, J. M., Smith, K. J., Semler, L., et al. (2018) · Innovation in Aging · doi:10.1093/geroni/igy012 · Cited by 23
Demographic and Social-Cognitive Factors Associated with Weight Loss in Overweight, Pre-diabetic Participants of the PREVIEW Study
Hansen, S., Huttunen‐Lenz, M., Sluik, D., Brand-Miller, J. C., Drummen, M., Fogelholm, M., Handjieva‐Darlenska, T., Macdonald, I. A., Martínez, J. A., Larsen, T. M., et al. (2018) · International Journal of Behavioral Medicine · doi:10.1007/s12529-018-9744-x · Cited by 27
Within-Trial Cost-Effectiveness of a Structured Lifestyle Intervention in Adults With Overweight/Obesity and Type 2 Diabetes: Results From the Action for Health in Diabetes (Look AHEAD) Study
Zhang, P., Atkinson, K. M., Bray, G. A., Chen, H., Clark, J. M., Coday, M., Dutton, G. R., Egan, C., Espeland, M. A., Evans, M. E., et al. (2020) · Diabetes Care · doi:10.2337/dc20-0358 · Cited by 22
Self-citation
Structured lifestyle modification as an adjunct to obesity pharmacotherapy: there is much to learn
Murphy, E. E., & Finucane, F. M. (2024) · International Journal of Obesity · doi:10.1038/s41366-024-01499-2 · Cited by 22
Obesity-related neuropathy: the new epidemic
Elafros, M. A., Reynolds, E. L., & Callaghan, B. C. (2024) · Current Opinion in Neurology · doi:10.1097/wco.0000000000001292 · Cited by 23
Changes in household diet: Determinants and predictability
Hut, S., & Oster, E. F. (2022) · Journal of Public Economics · doi:10.1016/j.jpubeco.2022.104620 · Cited by 21
American Medical Society for Sports Medicine Position Statement on the Care of the Athlete and Athletic Person With Diabetes
Trojian, T. H., Colberg, S., Harris, G., Oh, R., Dixit, S., Gibson, M., Corcoran, M., Ramey, L., & Berg, P. V. (2021) · Clinical Journal of Sport Medicine · doi:10.1097/jsm.0000000000000906 · Cited by 21
Effect of GLP-1 receptor agonists on weight and cardiovascular outcomes: A review
Raza, F. A., Altaf, R., Bashir, T., Asghar, F., Altaf, R., Tousif, S., Goyal, A., Mohammed, A., Mohammad, M. F., Anan, M., et al. (2024) · Medicine · doi:10.1097/md.0000000000040364 · Cited by 27
Class 3 Obesity in a Multidisciplinary Metabolic Weight Management Program: The Effect of Preexisting Type 2 Diabetes on 6-Month Weight Loss
Medveczky, D., Kodsi, R., Skelsey, K., Grudzinskas, K., Bueno, F. R., Ho, V., Kormas, N., & Piya, M. K. (2020) · Journal of Diabetes Research · doi:10.1155/2020/9327910 · Cited by 20
Pharmacotherapy for obesity: recent evolution and implications for cardiovascular risk reduction
Maki, K. C., Kirkpatrick, C. F., Allison, D. B., & Gadde, K. M. (2023) · Expert Review of Endocrinology & Metabolism · doi:10.1080/17446651.2023.2209176 · Cited by 19
Diabetes Mellitus and Noncardiac Atherosclerotic Vascular Disease—Pathogenesis and Pharmacological Treatment Options
Muzurović, E. M., & Mikhailidis, D. P. (2020) · Journal of Cardiovascular Pharmacology and Therapeutics · doi:10.1177/1074248420941675 · Cited by 17
The long-term effect of intentional weight loss on changes in bone mineral density in persons with type 2 diabetes: results from the Look AHEAD randomized trial
Johnson, K., Anderson, A., Beavers, K. M., Crandall, C. J., Hazuda, H. P., Lewis, C. E., Lipkin, E. W., Schwartz, A. V., Pi-Sunyer, X., & Zhao, Q. (2023) · Archives of Osteoporosis · doi:10.1007/s11657-023-01303-0 · Cited by 16
Self-citation
Introduction to the dietary management of obesity in adults
Lee, V. (2023) · Clinical Medicine · doi:10.7861/clinmed.2023-0157 · Cited by 18
Personalized intervention to improve stress and sleep patterns for glycemic control and weight management in obese Emirati patients with type 2 diabetes: a randomized controlled clinical trial
Mussa, B. M., Schauman, M., Ramalingam, V., Skaria, S., & Abusnana, S. (2019) · Diabetes Metabolic Syndrome and Obesity · doi:10.2147/dmso.s201142 · Cited by 15
Prehabilitation: metabolic considerations
Chabot, K., Gillis, C., & Carli, F. (2020) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0000000000000663 · Cited by 15
Precision behavioral medicine: Implications of genetic and genomic discoveries for behavioral weight loss treatment.
McCaffery, J. M. (2018) · American Psychologist · doi:10.1037/amp0000253 · Cited by 15
Type 2 diabetes care: Improvement by standardization at a diabetes rehabilitation clinic. An observational report
Haslacher, H., Fallmann, H., Waldhäusl, C., Hartmann, E., Wagner, O. F., & Waldhäusl, W. K. (2019) · PLoS ONE · doi:10.1371/journal.pone.0226132 · Cited by 15
Diagnosis and Non-Invasive Treatment of Obesity in Adults with Type 2 Diabetes Mellitus: A Review of Guidelines
Łuniewski, M., Matyjaszek‐Matuszek, B., & Lenart-Lipińska, M. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12134431 · Cited by 15
The Association of Prior Intensive Lifestyle Intervention and Diabetes Support and Education With Frailty Prevalence at Long-Term Follow-Up in the Action for Health in Diabetes Extension Study
Espinoza, S. E., Hazuda, H. P., Maruthur, N. M., Bray, G. A., Johnson, K., Synyer, X. P., Newman, A. B., Wing, R. R., Yanovski, S. Z., Gaussoin, S. A., et al. (2021) · The Journals of Gerontology Series A · doi:10.1093/gerona/glab312 · Cited by 14
Weight-centric pharmacological management of type 2 diabetes mellitus – An essential component of cardiovascular disease prevention
Muzurović, E. M., Dragnić, S., Medenica, S., Smolović, B., Bulajić, P., & Mikhailidis, D. P. (2020) · Journal of Diabetes and its Complications · doi:10.1016/j.jdiacomp.2020.107619 · Cited by 16
Association of a lifestyle score with cardiometabolic markers among individuals with diabetes: a cross-sectional study
Bächle, C., Lang, A., Straßburger, K., Kuß, O., Burkart, V., Szendroedi, J., Müssig, K., Weber, K. S., Schrauwen‐Hinderling, V. B., Herder, C., et al. (2023) · BMJ Open Diabetes Research & Care · doi:10.1136/bmjdrc-2023-003469 · Cited by 13
Osteoarthritis progression: is diabetes a culprit?
Kirkman, M. S. (2015) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2015.03.030 · Cited by 13
The effect of a combined lifestyle intervention with and without protein drink on inflammation in older adults with obesity and type 2 diabetes
Memelink, R. G., Njemini, R., Kuil, M. J. J. D. B., Wopereis, S., den Bosch, J. D. V., Schoufour, J. D., Tieland, M., Weijs, P. J. M., & Bautmans, I. (2024) · Experimental Gerontology · doi:10.1016/j.exger.2024.112410 · Cited by 13
Effects of meal replacement therapy on metabolic outcomes in Thai patients with type 2 diabetes: A randomized controlled trial
Boonyavarakul, A., Leelawattana, R., Pongchaiyakul, C., Buranapin, S., Phanachet, P., & Pramyothin, P. (2018) · Nutrition and Health · doi:10.1177/0260106018800074 · Cited by 10
The past decade in type 2 diabetes and future challenges
HADDAD, J. A., & Haddad, A. N. (2018) · HORMONES · doi:10.1007/s42000-018-0080-y · Cited by 11
Roux-en-Y gastric bypass in the elderly: is age a determining factor in our outcomes?
Turchi, M., Kingma, B. F., Laborda, N., Montanelli, A., Maldonado, J. M., & Fiolo, F. E. (2020) · Surgery for Obesity and Related Diseases · doi:10.1016/j.soard.2020.05.015 · Cited by 11
A geriatrics walking clinic improves hemoglobin A1c and timed gait in older veterans with type 2 diabetes
Jiwani, R. B., Wang, C.-P., Orsak, B., MacCarthy, D., Kellogg, D. L., Powers, B., Wang, J., Padala, P. R., Padala, K. P., & Espinoza, S. E. (2020) · Geriatric Nursing · doi:10.1016/j.gerinurse.2020.10.001 · Cited by 12
Weight Loss Interventions and Skeletal Health in Persons with Diabetes
Zhao, Q., Khedkar, S. V., & Johnson, K. (2022) · Current Osteoporosis Reports · doi:10.1007/s11914-022-00744-9 · Cited by 12
Changes in Body Weight Among People With Type 2 Diabetes Mellitus in the United States, NHANES 2005-2012
Wang, Y., Bolge, S. C., Lopez, J. M. S., Zhu, V. J., & Stang, P. (2016) · The Science of Diabetes Self-Management and Care · doi:10.1177/0145721716640096 · Cited by 11
Predictive modeling of lean body mass, appendicular lean mass, and appendicular skeletal muscle mass using machine learning techniques: A comprehensive analysis utilizing NHANES data and the Look AHEAD study
Olshvang, D., Harris, C., Chellappa, R., & Santhanam, P. (2024) · PLoS ONE · doi:10.1371/journal.pone.0309830 · Cited by 10
Lifestyle intervention for obesity: a call to transform the clinical care delivery system in Mexico
Díaz-Zavala, R. G., Candia-Plata, M. D. C., Martínez-Contreras, T. D. J., & Esparza‐Romero, J. (2019) · Diabetes Metabolic Syndrome and Obesity · doi:10.2147/dmso.s208884 · Cited by 13
Structured Lifestyle Modification Prior to Bariatric Surgery: How Much is Enough?
Brazil, J., & Finucane, F. M. (2021) · Obesity Surgery · doi:10.1007/s11695-021-05573-w · Cited by 10
Association of physical activity on blood glucose in individuals with type 2 diabetes
Wang, Y., Dzubur, E., James, R. A., Fakhouri, T. M., Brunning, S., Painter, S. L., Madan, A., & Shah, B. R. (2021) · Translational Behavioral Medicine · doi:10.1093/tbm/ibab159 · Cited by 11
Adverse effects of obesity on overall health, quality of life, and related physical health metrics: A cross‐sectional and longitudinal study from the All of Us Research Program
Yao, Z., Tchang, B. G., Chae, K., Albert, M. H., Clark, J. M., & Blaha, M. J. (2025) · Journal of Internal Medicine · doi:10.1111/joim.20083 · Cited by 11
Efficacy and Sustainability of Diabetes-Specific Meal Replacement on Obese and Overweight Type-2 Diabetes Mellitus Patients: Study Approaches for a Randomised Controlled Trial and Impact of COVID-19 on Trial Progress
Chen, L. L., Ludin, A. F. M., Shahar, S., Manaf, Z. A., & Tohit, N. M. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph19074188 · Cited by 8
Low physical activity is associated with impaired endothelial function in patients with type 2 diabetes and controls after 5 years of follow-up
Baier, J. M., Funck, K. L., Vernstrøm, L., Laugesen, E., & Poulsen, P. L. (2021) · BMC Endocrine Disorders · doi:10.1186/s12902-021-00857-9 · Cited by 10
Weight Management in Adults With Obesity
Yanovski, S. Z. (2018) · JAMA · doi:10.1001/jama.2018.11031 · Cited by 9
Tailoring Exercise Prescription for Effective Diabetes Glucose Management
Lewis, C. J., Rafi, E., Dobbs, B., Barton, T., Hatipoğlu, B., & Malin, S. K. (2025) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgae908 · Cited by 8
Evidence generated from a realist synthesis of trials on educational weight loss interventions in type 2 diabetes mellitus
Maula, A., Kendrick, D., Kai, J., & Griffiths, F. E. (2020) · Diabetic Medicine · doi:10.1111/dme.14394 · Cited by 10
Changing the dietary composition improves inflammation but not adipocyte thermogenesis in diet-induced obese mice
Folie, S., Radlinger, B., Goebel, G., Salzmann, K., Staudacher, G., Ress, C., Tilg, H., & Kaser, S. (2021) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2021.108837 · Cited by 9
Addressing people and place microenvironments in weight loss disparities (APP-Me): Design of a randomized controlled trial testing timely messages for weight loss behavior in low income Black and White Women
Clark, D. O., Srinivas, P., Bodke, K., Keith, N. R., Hood, S. M., & Tu, W. (2018) · Contemporary Clinical Trials · doi:10.1016/j.cct.2018.01.006 · Cited by 9
James Lind Alliance research priorities: should diet and exercise be used as an alternative to drugs for the management of type 2 diabetes or alongside them?
England, C. Y., & Andrews, R. C. (2019) · Diabetic Medicine · doi:10.1111/dme.14217 · Cited by 8
The 10-Year Effects of Intensive Lifestyle Intervention on Kidney Outcomes
Lavenburg, L.-M. U., Schaubel, D. E., Chao, A. M., Reese, P. P., & Cohen, J. B. (2024) · Kidney Medicine · doi:10.1016/j.xkme.2024.100814 · Cited by 7
Factors influencing adults to drop out of intensive lifestyle interventions for weight loss
Ruelas, A. L., Martínez-Contreras, T. D. J., Esparza‐Romero, J., Díaz-Zavala, R. G., Plata, M. D. C. C., Hingle, M. D., Armenta-Guirado, B. I., & Haby, M. M. (2023) · Translational Behavioral Medicine · doi:10.1093/tbm/ibac112 · Cited by 6
Type 1 diabetes care: Improvement by standardization in a diabetes rehabilitation clinic. An observational report
Haslacher, H., Fallmann, H., Waldhäusl, C., Hartmann, E., Wagner, O. F., & Waldhäusl, W. K. (2018) · PLoS ONE · doi:10.1371/journal.pone.0194135 · Cited by 6
Effectiveness of Online Aftercare Programs Following Intragastric Balloon Placement for Obesity Is Similar to Traditional Follow-up: a Large Propensity Matched US Multicenter Study
Vargas, E. J., Bazerbachi, F., Storm, A. C., Rizk, M., Acosta, A. J., Grothe, K. B., Clark, M. M., Mundi, M. S., Pesta, C. M., Bali, A. H., et al. (2019) · Obesity Surgery · doi:10.1007/s11695-019-04102-0 · Cited by 6
Can Weight Loss Improve the Cardiovascular Outcomes of Patients with Obesity and Obstructive Sleep Apnea?
Alruwaily, A., Alruwaili, H., Garvey, J., & le Roux, C. W. (2022) · Hearts · doi:10.3390/hearts3020008 · Cited by 7
Effect of aerobic exercise and low-carbohydrate high-fat diet on glucose tolerance and android/gynoid fat in overweight/obese women: A randomized controlled trial
Valsdottir, T. D., Øvrebø, B., Kornfeldt, T. M., Litleskare, S., Johansen, E. I., Henriksen, C., & Jensen, J. (2023) · Frontiers in Physiology · doi:10.3389/fphys.2023.1056296 · Cited by 7
Long‐term preservation of lean mass and sustained loss of fat mass after completion of an intensive lifestyle intervention in older adults with obesity and type 2 diabetes
Memelink, R. G., Hijlkema, A., Valentin, B., Streppel, M. T., Pasman, W. J., Wopereis, S., den Bosch, J. D. V., Tieland, M., Schoufour, J. D., Bautmans, I., et al. (2024) · Lifestyle Medicine · doi:10.1002/lim2.103 · Cited by 6
Does the impact of intensive lifestyle intervention on cognitive function vary depending baseline level of frailty? An ancillary study to the Action for Health in Diabetes (Look AHEAD) Trial
Simpson, F. R., Carmichael, O. T., Hayden, K. M., Hugenschmidt, C. E., McCaffery, J. M., Yaşar, S., Pajewski, N. M., & Espeland, M. A. (2021) · Journal of Diabetes and its Complications · doi:10.1016/j.jdiacomp.2021.107909 · Cited by 5
Differential effects of lifestyle interventions on continuous glucose monitoring metrics in persons with type 2 diabetes: Potential for personalised treatment
de Hoogh, I. M., Snel, T., Kamstra, R. J. M., Krone, T., de Graaf, A. A., & Pijl, H. (2025) · Diabetes Obesity and Metabolism · doi:10.1111/dom.16654 · Cited by 5
Community Engagement in Behavioral Medicine: A Scoping Review
Persad-Clem, R., Ventura, L. M., Lyons, T., Keinath, C. M., Graves, K. D., Schneider, M. L., Shelton, R. C., & Rosas, L. G. (2023) · International Journal of Behavioral Medicine · doi:10.1007/s12529-023-10242-6 · Cited by 5

Authors: Pi-Sunyer, X.
Venue: Current Nutrition Reports
Publisher: Springer Science and Business Media LLC
Published: 2014-09-28
Volume: 3
Issue: 4
Pages: 387-391
ISSN: 2161-3311 (ISSN-L)
DOI: 10.1007/s13668-014-0099-x
PMC: PMC4339027
OpenAlex: W2077801798
Cited by: 176
References: 35
Citations by year: 2026: 14 · 2025: 13 · 2024: 19 · 2023: 21 · 2022: 21 · 2021: 13 · 2020: 23 · 2019: 16 · 2018: 14 · 2017: 12 · 2016: 4 · 2015: 6
FWCI: 5.90
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
Locations: Current Nutrition Reports (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of Diabetes and Digestive and Kidney Diseases (U01DK057178)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Education
Keywords: Look AHEAD trial, intensive lifestyle intervention, type 2 diabetes, obesity, overweight, diabetes support and education, cardiovascular disease, weight loss, physical fitness, sleep apnea, liver fat, insulin sensitivity, kidney disease, depression, urinary incontinence, quality of life, cost-effectiveness

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

The Look AHEAD Trial: A Review and Discussion of Its Outcomes

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks