Cited by 91Traumatic Brain Injury and Neurovascular DisturbancesTraumatic Brain Injury ResearchAutomotive and Human Injury Biomechanics

Traumatic Brain Injury in the Elderly: Is it as Bad as we Think?

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Mak, Calvin H. K., Wong, Stephen K. H., Wong, George K., Ng, Stephanie, Wang, Kevin K. W., Lam, Ping Kuen, Poon, Wai Sang·2012·Current Translational Geriatrics and Experimental Gerontology Reports

Abstract

Traumatic brain injury in elderly patients is a neglected global disease burden. The main cause is fall, followed by motor vehicle accidents. This review article summarizes different aspects of geriatric traumatic brain injury, including epidemiology, pathology, and effects of comorbidities and pre-injury medications such as antiplatelets and anticoagulants. Functional outcome with or without surgical intervention, cognitive outcome, and psychiatric complications are discussed. Animal models are also reviewed in attempt to explain the relationship of aging and outcome, together with advances in stem cell research. Though elderly people in general did fare worse after traumatic brain injury, certain "younger elderly" people, aged 65-75 years, could have a comparable outcome to younger adults after minor to moderate head injury.

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  • Elderly individuals are at greater risk to suffer significant cognitive impairment and early morbidity following TBI, potentially due to an already present dysfunction in the microglial compartment.

    “Elderly individuals are at greater risk to suffer significant cognitive impairment and early morbidity following TBI, potentially due to an already present dysfunction in the microglial compartment [109,122,123].”

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Authors
Mak, C. H. K., Wong, S. K. H., Wong, G. K., Ng, S., Wang, K. K. W., Lam, P. K., & Poon, W. S.
Affiliations
Chinese University of Hong Kong (HK)
Corresponding author
Poon, Wai Sang
Venue
Current Translational Geriatrics and Experimental Gerontology Reports
Published
2012-07-06
Volume
1
Issue
3
Pages
171-178
ISSN
2162-4941 (ISSN-L)
OpenAlex
W2060325639
Cited by
91
References
89
Citations by year
2026: 5 · 2025: 8 · 2024: 8 · 2023: 5 · 2022: 7 · 2021: 9 · 2020: 9 · 2019: 8 · 2018: 10 · 2017: 10 · 2016: 5 · 2015: 2 · 2014: 5
FWCI
0.31
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • Current Translational Geriatrics and Experimental Gerontology Reports (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Neurology › Traumatic Brain Injury and Neurovascular Disturbances
  • Health Sciences › Medicine › Epidemiology › Traumatic Brain Injury Research
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Automotive and Human Injury Biomechanics
Keywords
traumatic brain injury, older adults, falls, motor vehicle accidents, comorbidities, antiplatelet agents, anticoagulants, functional outcome, cognitive outcomes, psychiatric complications, animal models of aging, stem cell therapy

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