CoChat
Sign Up
Cited by 5Nutrition and Health in AgingNutrition and Health StudiesSkin Protection and Aging

Cutaneous Signs of Nutritional Deficiencies

Open access
Park, Sarah E., Williams, Madison, Crew, Ashley B., Hsiao, Jennifer L.·2024·Current Geriatrics Reports
DOI 10.1007/s13670-024-00425-8
Open this paper in CoChat — free accountOpen PDF

Abstract

Purpose of Review: This review article highlights cutaneous findings of nutritional deficiencies with a particular focus on conditions that impact the elderly population, who are at higher risk of developing these deficiencies. Recent Findings: An increasing number of studies demonstrate the importance of adequate nutrition intake in regulating aging processes and the progression of key age-related illnesses. Summary: Early recognition of dermatological manifestations associated with nutritional disorders can prompt appropriate supplementation and help prevent sequelae of cutaneous and systemic complications.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1007/s13670-024-00425-8

Cites

5 of 5 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Protein deficiency may manifest through peripheral edema, loss of muscle mass, thinning and fragility of hair, brittle nails, and delayed wound healing.

    “Protein Deficiency: Protein deficiency may manifest through peripheral edema, loss of muscle mass, thinning and fragility of hair, brittle nails, and delayed wound healing [31].”

    From The Seven Methods for the Evaluation of Nutritional Status—ABCDEFG: Narrative Review (2026) · cites this paper as [31]

    The Protein Deficiency section links low protein to muscle wasting, kwashiorkor to edema, and marasmus to thin hair and fissured nails. It does not describe hair fragility or brittle nails as protein-deficiency signs. The Introduction associates slowed wound healing with malnutrition generally, not protein deficiency specifically. (LLM, conf=0.86)

    Experimental — accuracy not yet measured

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Research works printed but not linked: 56

  1. Wong CY, Chu DH. Cutaneous signs of nutritional disorders. Int J Womens Dermatol. 2021;7:647-52. https:// doi. org/ 10. 1016/j. ijwd. 2021. 09. 003. · DOI
  2. Kaur D, Rasane P, Singh J, et al. Nutritional Interventions for Elderly and Considerations for the Development of Geriatric Foods. Curr Aging Sci. 2019;12(1):15-27. https:// doi. org/ 10. 2174/ 18746 09812 66619 05211 10548. · DOI
  3. Sanford AM. Anorexia of aging and its role for frailty. Curr Opin Clin Nutr Metab Care. 2017;20(1):54-60. https:// doi. org/ 10. 1097/ MCO. 00000 00000 000336. · DOI
  4. Donini LM, Poggiogalle E, Piredda M, et al. Anorexia and Eating Patterns in the Elderly. PLoS ONE. 2013;8(5):e63539. https:// doi. org/ 10. 1371/ journ al. pone. 00635 39. · DOI
  5. de Boer A, Ter Horst GJ, Lorist MM. Physiological and psycho- social age-related changes associated with reduced food intake in older persons. Ageing Res Rev. 2013;12(1):316-28. https:// doi. org/ 10. 1016/j. arr. 2012. 08. 002. · DOI
  6. Gana W, De Luca A, Debacq C, et al. Analysis of the Impact of Selected Vitamins Deficiencies on the Risk of Disability in Older People. Nutrients. 2021;13(9):3163. https:// doi. org/ 10. 3390/ nu130 93163. · DOI
  7. Azzini E, Raguzzini A, Polito A. A Brief Review on Vitamin B12 Deficiency Looking at Some Case Study Reports in Adults. Int J Mol Sci. 2021;22(18):9694. https:// doi. org/ 10. 3390/ ijms2 21896 94. · DOI
  8. Nosewicz J, Spaccarelli N, Roberts KM, et al. The epidemiol- ogy, impact, and diagnosis of micronutrient nutritional derma- toses part 1: Zinc, selenium, copper, vitamin A, and vitamin C. J Am Acad Dermatol. 2022;86(2):267-78. https:// doi. org/ 10. 1016/j. jaad. 2021. 07. 079. · DOI
  9. Briefel RR, Bialostosky K, Kennedy-Stephenson J, McDowell MA, Ervin RB, Wright JD. Zinc Intake of the U.S. Population: Findings from the Third National Health and Nutrition Examination Survey, 1988-1994. The Journal of Nutrition. 2000;130(5):1367S-1373S. https:// doi. org/ 10. 1093/ jn/ 130.5. 1367S. · DOI · Paper page
  10. Santos CA, Fonseca J, Lopes MTM, Carolino E, Guerreiro AS. Serum zinc evolution in dysphagic patients that underwent endo- scopic gastrostomy for long term enteral feeding. Asia Pac J Clin Nutr. 2017;26(2):227-33. https:// doi. org/ 10. 6133/ apjcn. 022016. 03. · DOI
  11. McAlpine SG, Culton DA. Oral Diseases in the Geriatric Popu- lation. Curr Geri Rep. Published online May 29, 2024. https:// doi. org/ 10. 1007/ s13670-024-00416-9 · DOI
  12. Manzoni APD da S, Weber MB. Skin changes after bariatric surgery. An Bras Dermatol. 2015;90(2):157-166. https:// doi. org/ 10. 1590/ abd18 06-4841. 20153 139 · DOI
  13. Abbaspour N, Hurrell R, Kelishadi R. Review on iron and its importance for human health. J Res Med Sci. 2014;19(2):164-74.
  14. Smith DL. Anemia in the Elderly. afp. 2000;62(7):1565-1572.
  15. Oyedeji CI, Artz AS, Cohen HJ. How I treat anemia in older adults. Blood. 2024;143(3):205-13. https:// doi. org/ 10. 1182/ blood. 20220 17626. · DOI
  16. E R, N K, M K, et al. Are we giving too much iron? Low-dose iron therapy is effective in octogenarians. The American journal of medi- cine. 2005;118(10). https:// doi. org/ 10. 1016/j. amjmed. 2005. 01. 065 · DOI
  17. Keller U. Nutritional Laboratory Markers in Malnutrition. J Clin Med. 2019;8(6):775. https:// doi. org/ 10. 3390/ jcm80 60775. · DOI · Paper page
  18. Aşkın Ö, Uzunçakmak TKÜ, Altunkalem N, Tüzün Y. Vita- min deficiencies/hypervitaminosis and the skin. Clin Dermatol. 2021;39(5):847-57. https:// doi. org/ 10. 1016/j. clind ermat ol. 2021. 05. 010. · DOI
  19. Vitamin A deficiency. Accessed February 28, 2024. https://www. who.int/data/nutrition/nlis/info/vitamin-a-deficiency 27. Roche FC, Harris-Tryon TA. Illuminating the Role of Vitamin A in Skin Innate Immunity and the Skin Microbiome: A Narrative Review. Nutrients. 2021;13(2):302. https:// doi. org/ 10. 3390/ nu130 20302. · DOI
  20. Verheyden MJ, Howard V, Gupta M. Phrynoderma: an under- recognised condition reflecting nutritional deficiency. Med J Aust. 2024;221(2):86-7. https:// doi. org/ 10. 5694/ mja2. 52362. · DOI
  21. Boucher BJ. The Problems of Vitamin D Insufficiency in Older People. Aging Dis. 2012;3(4):313-29.
  22. Lips P, Bouillon R, van Schoor NM, et al. Reducing frac- ture risk with calcium and vitamin D. Clin Endocrinol (Oxf). 2010;73(3):277-85. https:// doi. org/ 10. 1111/j. 1365-2265. 2009. 03701.x. · DOI
  23. Roider E, Ruzicka T, Schauber J, Vitamin D. the Cutaneous Barrier, Antimicrobial Peptides and Allergies: Is There a Link? Allergy Asthma Immunol Res. 2013;5(3):119-28. https:// doi. org/ 10. 4168/ aair. 2013.5. 3. 119. · DOI
  24. Saini K, Mysore V. Role of vitamin D in hair loss: A short review. J Cosmet Dermatol. 2021;20(11):3407-14. https:// doi. org/ 10. 1111/ jocd. 14421. · DOI
  25. Mosekilde L. Vitamin D and the elderly. Clin Endocrinol (Oxf). 2005;62(3):265-81. https:// doi. org/ 10. 1111/j. 1365-2265. 2005. 02226.x. · DOI
  26. Holick MF, Binkley NC, Bischoff-Ferrari HA, et al. Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 2011;96(7):1911-30. https:// doi. org/ 10. 1210/ jc. 2011-0385. · DOI
  27. Card DJ, Gorska R, Harrington DJ. Laboratory assessment of vita- min K status. J Clin Pathol. 2020;73(2):70-5. https:// doi. org/ 10. 1136/ jclin path-2019-205997. · DOI
  28. Barthelemy H, Chouvet B, Cambazard F. Skin and mucosal manifes- tations in vitamin deficiency. J Am Acad Dermatol. 1986;15(6):1263- 74. https:// doi. org/ 10. 1016/ s0190-9622(86) 70301-0. · DOI
  29. Nicolov M, Cocora M, Buda V, et al. Hydrosoluble and Lipo- soluble Vitamins: New Perspectives through ADMET Analysis. Medicina (Kaunas). 2021;57(11):1204. https:// doi. org/ 10. 3390/ medic ina57 111204. · DOI
  30. Miller SJ. Nutritional deficiency and the skin. J Am Acad Dermatol. 1989;21(1):1-30. https:// doi. org/ 10. 1016/ s0190-9622(89) 70144-4. · DOI
  31. Hrubša M, Siatka T, Nejmanová I, et al. Biological Properties of Vitamins of the B-Complex, Part 1: Vitamins B1, B2, B3, and B5. Nutrients. 2022;14(3):484. https:// doi. org/ 10. 3390/ nu140 30484. · DOI
  32. Pourhassan M, Biesalski HK, Angersbach B, Lueg G, Klimek C, Wirth R. Prevalence of thiamine deficiency in older hospitalized patients. Clin Interv Aging. 2018;13:2247-50. https:// doi. org/ 10. 2147/ CIA. S1831 02. · DOI
  33. Nath A, Shope TR, Koch TR. Chapter 51 -Thiamine (Vitamin B1) After Weight Loss Bariatric Surgery. In: Rajendram R, Martin CR, Preedy VR, eds. Metabolism and Pathophysiology of Bari- atric Surgery. Academic Press; 2017:479-489. https:// doi. org/ 10. 1016/ B978-0-12-804011-9. 00037-6 · DOI
  34. Okafor C, Nimmagadda M, Soin S, Lanka L. Non-alcoholic Wernicke encephalopathy: great masquerader. BMJ Case Rep. 2018;11(1):e227731. https:// doi. org/ 10. 1136/ bcr-2018-227731. · DOI
  35. Folate I of M (US) SC on the SE of DRI and its P on, Vita- mins OB, Choline A. Thiamin. In: Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline. National Academies Press (US); 1998. Accessed March 1, 2024. https:// www. ncbi. nlm. nih. gov/ books/ NBK11 4331/
  36. Nosewicz J, Spaccarelli N, Roberts KM, et al. The epidemiology, impact, and diagnosis of micronutrient nutritional dermatoses. Part 2: B-complex vitamins. Journal of the American Academy of Der- matology. 2022;86(2):281-92. https:// doi. org/ 10. 1016/j. jaad. 2021. 06. 900. · DOI
  37. Friedli A, Saurat JH. Oculo-Orogenital Syndrome -A Deficiency of Vitamins B2 and B6. N Engl J Med. 2004;350(11):1130-1130. https:// doi. org/ 10. 1056/ NEJMi cm980 412. · DOI
  38. Gasperi V, Sibilano M, Savini I, Catani MV. Niacin in the Central Nervous System: An Update of Biological Aspects and Clinical Applications. Int J Mol Sci. 2019;20(4):974. https:// doi. org/ 10. 3390/ ijms2 00409 74. · DOI
  39. Prabhu D, Dawe RS, Mponda K. Pellagra a review exploring causes and mechanisms, including isoniazid-induced pellagra. Photodermatol Photoimmunol Photomed. 2021;37(2):99-104. https:// doi. org/ 10. 1111/ phpp. 12659. · DOI
  40. Elgharably N, Al Abadie M, Al Abadie M, Ball PA, Morrissey H. Vitamin B group levels and supplementations in dermatology. Derma- tol Reports. 2022;15(1):9511. https:// doi. org/ 10. 4081/ dr. 2022. 9511. · DOI
  41. Kjeldby IK, Fosnes GS, Ligaarden SC, Farup PG. Vitamin B6 deficiency and diseases in elderly people -a study in nursing homes. BMC Geriatr. 2013;13:13. https:// doi. org/ 10. 1186/ 1471-2318-13-13. · DOI
  42. Stover PJ, Field MS. Vitamin B-6. Adv Nutr. 2015;6(1):132-3. https:// doi. org/ 10. 3945/ an. 113. 005207. · DOI
  43. Zempleni J, Hassan YI, Wijeratne SS. Biotin and biotinidase defi- ciency. Expert Rev Endocrinol Metab. 2008;3(6):715-24. https:// doi. org/ 10. 1586/ 17446 651.3. 6. 715. · DOI
  44. Sealey WM, Teague AM, Stratton SL, Mock DM. Smok- ing accelerates biotin catabolism in women. Am J Clin Nutr. 2004;80(4):932-5. https:// doi. org/ 10. 1093/ ajcn/ 80.4. 932. · DOI
  45. Visentin M, Diop-Bove N, Zhao R, Goldman ID. The Intestinal Absorption of Folates. Annu Rev Physiol. 2014;76(1):251-74. https:// doi. org/ 10. 1146/ annur ev-physi ol-020911-153251. · DOI
  46. Lambie DG, Johnson RH. Drugs and Folate Metabolism. Drugs. 1985;30(2):145-55. https:// doi. org/ 10. 2165/ 00003 495-19853 0020-00003. · DOI
  47. Ma F, Wu T, Zhao J, et al. Plasma Homocysteine and Serum Folate and Vitamin B12 Levels in Mild Cognitive Impairment and Alzheimer's Disease: A Case-Control Study. Nutrients. 2017;9(7):725. https:// doi. org/ 10. 3390/ nu907 0725. · DOI
  48. Bender A, Hagan KE, Kingston N. The association of folate and depression: A meta-analysis. J Psychiatr Res. 2017;95:9-18. https:// doi. org/ 10. 1016/j. jpsyc hires. 2017. 07. 019. · DOI · Paper page
  49. Li Y, Huang T, Zheng Y, Muka T, Troup J, Hu FB. Folic Acid Supplementation and the Risk of Cardiovascular Diseases: A Meta- Analysis of Randomized Controlled Trials. J Am Heart Assoc. 2016;5(8):e003768. https:// doi. org/ 10. 1161/ JAHA. 116. 003768. · DOI
  50. McDonald I, Connolly M, Tobin AM. A review of pso- riasis, a known risk factor for cardiovascular disease and its impact on folate and homocysteine metabolism. J Nutr Metab. 2012;2012:965385. https:// doi. org/ 10. 1155/ 2012/ 965385. · DOI
  51. Green R, Datta MA. Megaloblastic Anemias: Nutritional and Other Causes. Med Clin North Am. 2017;101(2):297-317. https:// doi. org/ 10. 1016/j. mcna. 2016. 09. 013. · DOI
  52. Dutta RR, Kumar T, Ingole N. Diet and Vitiligo: The Story So Far. Cureus. 2022;14(8):e28516. https:// doi. org/ 10. 7759/ cureus. 28516. · DOI
  53. Carr AC, Spencer E, Heenan H, Lunt H, Vollebregt M, Prickett TCR. Vitamin C Status in People with Types 1 and 2 Diabetes Mellitus and Varying Degrees of Renal Dysfunction: Relationship to Body Weight. Antioxidants (Basel). 2022;11(2):245. https:// doi. org/ 10. 3390/ antio x1102 0245. · DOI
  54. McCall SJ, Clark AB, Luben RN, Wareham NJ, Khaw KT, Myint PK. Plasma Vitamin C Levels: Risk Factors for Deficiency and Association with Self-Reported Functional Health in the Euro- pean Prospective Investigation into Cancer-Norfolk. Nutrients. 2019;11(7):1552. https:// doi. org/ 10. 3390/ nu110 71552. · DOI · Paper page
  55. Scurvy LD. Can Fam Physician. 2008;54(10):1403-6.
  56. Yeung LK, Alschuler DM, Wall M, et al. Multivitamin Supple- mentation Improves Memory in Older Adults: A Randomized Clinical Trial. Am J Clin Nutr. 2023;118(1):273-82. https:// doi. org/ 10. 1016/j. ajcnut. 2023. 05. 011. · DOI

Cited by

Sorted by citations

Authors
Park, S. E., Williams, M., Crew, A. B., & Hsiao, J. L.
Affiliations
  • University of California, Los Angeles (US)
  • Washington State University (US)
  • University of Southern California (US)
Corresponding author
Hsiao, Jennifer L.
ORCID
Venue
Current Geriatrics Reports
Publisher
Springer Science and Business Media LLC
Published
2024-08-31
Volume
13
Issue
4
Pages
189-199
ISSN
2196-7865 (ISSN-L)
DOI
10.1007/s13670-024-00425-8
OpenAlex
W4402081136
Cited by
5
References
5
Citations by year
2026: 3 · 2025: 2
FWCI
1.43
Type
journal article
Language
en
Open access
Licence
Locations
Current Geriatrics Reports (publishedVersion, cc-by)
Funders
University of Southern California
Topics
  • Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutrition and Health Studies
  • Health Sciences › Medicine › Dermatology › Skin Protection and Aging
Keywords
nutritional deficiency, cutaneous manifestations, older adults, aging, age-related diseases, dietary supplementation

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review