CoChat
Sign Up
Cited by 109Herpesvirus Infections and TreatmentsInfectious Encephalopathies and EncephalitisCytomegalovirus and herpesvirus research

The DOI matches its Crossref record; 41 of the 42 references it cites were found in a registry or an index.

Herpes simplex and varicella zoster CNS infections: clinical presentations, treatments and outcomes

Kaewpoowat, Quanhathai, Salazar, Lucrecia, Aguilera, Elizabeth, Wootton, Susan H., Hasbun, Rodrigo·2016·Infection
DOI 10.1007/s15010-015-0867-6
Open this paper in CoChat — free account

Abstract

Objectives To describe the clinical manifestations, cerebrospinal fluid (CSF) characteristics, imaging studies and prognostic factors of adverse clinical outcomes (ACO) among adults with herpes simplex virus (HSV) or varicella zoster virus (VZV) CNS infections.Methods Retrospective review of adult patients with positive HSV or VZV polymerase chain reaction on CSF from an observational study of meningitis or encephalitis in Houston, TX (2004-2014), and New Orleans, LA (1999-2008).Results Ninety-eight adults patients were identified; 25 had encephalitis [20 (20.4 %) HSV, 5 (5.1 %) VZV], and 73 had meningitis [60 (61.1 %) HSV and 13 (13.3 %) VZV]. HSV and VZV had similar presentations except for nausea (P < 0.01) and rash (P < 0.001). The CSF profile did not differ between HSV and VZV infection. Abnormal neuroimaging findings were found in 11.6 % (10/86) brain CTs and 21.3 % (16/75) brain MRIs. The EEG was abnormal in 57.9 % (11/19). Sixteen patients (16.3 %) had an ACO (10 HSV encephalitis, 3 VZV encephalitis and 3 VZV meningitis). Intravenous acyclovir administered within 48 h was protective against an ACO [OR 0.19 (0.04-0.80), P = 0.02). However, on logistic regression only Charlson comorbidity score >1 and an encephalitis presentation were independently associated with an ACO. The treatment for HSV meningitis was variable, and all patients had a good clinical outcome.Conclusion Alpha herpes CNS infections due to HSV and VZV infections have similar clinical and laboratory manifestations. ACO was observed more frequently in those patients with comorbidities and an encephalitis presentation.

Overview

Integrity signals

Registry

Crossref · 10.1007/s15010-015-0867-6

Cites

41 of 41 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Show all 42 references

Cited by

Sorted by citations

Related

See all

Metadata

Authors
Kaewpoowat, Q., Salazar, L., Aguilera, E., Wootton, S. H., & Hasbun, R.
Affiliations
The University of Texas Health Science Center at Houston (US)
Corresponding author
Kaewpoowat, Quanhathai
ORCID
Venue
Infection
Publisher
Springer Science and Business Media LLC
Published
2015-12-17
Volume
44
Issue
3
Pages
337-345
ISSN
  • 0300-8126 (ISSN-L)
  • 1439-0973
DOI
10.1007/s15010-015-0867-6
OpenAlex
W2216932999
Cited by
109
References
42
Citations by year
2026: 2 · 2025: 16 · 2024: 6 · 2023: 9 · 2022: 12 · 2021: 9 · 2020: 8 · 2019: 11 · 2018: 12 · 2017: 14 · 2016: 9
FWCI
9.16
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Infection (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Grant A Starr Foundation
  • National Center for Research Resources (NIH-1 K23 RR018929-01A2)
Topics
  • Health Sciences › Medicine › Infectious Diseases › Herpesvirus Infections and Treatments
  • Health Sciences › Medicine › Infectious Diseases › Infectious Encephalopathies and Encephalitis
  • Health Sciences › Medicine › Epidemiology › Cytomegalovirus and herpesvirus research
Keywords
herpes simplex virus, varicella-zoster virus, herpes simplex encephalitis, adverse clinical outcomes, acyclovir, intravenous antiviral therapy, neuroimaging findings, EEG abnormalities, Charlson Comorbidity Index, prognostic factors, adults
MeSH terms
Adolescent, Adult, Aged, Aged, 80 and over, Female, Humans, Male, Meningitis, Viral, Middle Aged, Retrospective Studies, Herpesvirus 3, Human, Treatment Outcome, Simplexvirus, Encephalitis, Herpes Simplex, Young Adult

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review