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Cited by 435

The DOI matches its Crossref record; 79 of the 79 references it cites were found in a registry or an index.

Vitamin D and Multiple Sclerosis: A Comprehensive Review

Open access
Sintzel, Martina B., Rametta, Mark, Reder, Anthony T.·2018·Neurology and Therapy
DOI 10.1007/s40120-017-0086-4
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Abstract

Numerous observational studies have suggested that there is a correlation between the level of serum vitamin D and MS risk and disease activity. To explore this hypothesis, a literature search of large, prospective, observation studies, epidemiological studies, and studies using new approaches such as Mendelian randomization was conducted. Available data and ongoing research included in this review suggest that the level of serum vitamin D affects the risk of developing MS and also modifies disease activity in MS patients. Newer Mendelian randomization analyses suggest there is a causal relationship between low vitamin D level and the risk of MS. Post-hoc evaluations from two phase 3 studies, BENEFIT and BEYOND, support the findings of observational trials. Study limitations identified in this review recognize the need for larger controlled clinical trials to establish vitamin D supplementation as the standard of care for MS patients. Though there is increasing evidence indicating that lower vitamin D levels are associated with increased risk of MS and with greater clinical and brain MRI activity in established MS, the impact of vitamin D supplementation on MS activity remains inadequately investigated.

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Metadata

Authors
Sintzel, M. B., Rametta, M., & Reder, A. T.
Venue
Neurology and Therapy
Publisher
Springer Science and Business Media LLC
Published
2017-12-14
Volume
7
Issue
1
Pages
59-85
ISSN
  • 2193-6536 (ISSN-L)
  • 2193-8253
DOI
10.1007/s40120-017-0086-4
OpenAlex
W2775648299
Cited by
435
References
79
FWCI
16.87
Type
journal article
Language
en
Open access
gold

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CoChat. (2026). Citation check: Vitamin D and Multiple Sclerosis: A Comprehensive Review. https://app.cochat.ai/papers/10.1007/s40120-017-0086-4
The paper
Sintzel, M. B., Rametta, M., & Reder, A. T. (2018). Vitamin D and Multiple Sclerosis: A Comprehensive Review. Neurology and Therapy. https://doi.org/10.1007/s40120-017-0086-4

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.