Cited by 229Antimicrobial agents and applicationsInfection Control in HealthcareInfection Control and Ventilation

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Rapid and effective virucidal activity of povidone-iodine products against middle east respiratory syndrome coronavirus (MERS-CoV) and modified vaccinia virus ankara (MVA).

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Eggers, Maren, Eickmann, Markus, Zorn, Juergen·2015·Infectious Diseases and Therapy

DOI 10.1007/s40121-015-0091-9PMC PMC4675768

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Abstract

INTRODUCTION: Since the first case of Middle East Respiratory Syndrome coronavirus (MERS-CoV) infection was reported in 2012, the virus has infected more than 1300 individuals in 26 countries, and caused more than 480 deaths. Human-to-human transmission requires close contact, and has typically occurred in the healthcare setting. Improved global awareness, together with improved hygiene practices in healthcare facilities, has been highlighted as key strategies in controlling the spread of MERS-CoV. This study tested the in vitro efficacy of three formulations of povidone iodine (PVP-I: 4% PVP-I skin cleanser, 7.5% PVP-I surgical scrub, and 1% PVP-I gargle/mouthwash) against a reference virus (Modified vaccinia virus Ankara, MVA) and MERS-CoV. METHODS: According to EN14476, a standard suspension test was used to assess virucidal activity against MVA and large volume plating was used for MERS-CoV. All products were tested under clean (0.3 g/L bovine serum albumin, BSA) and dirty conditions (3.0 g/L BSA + 3.0 mL/L erythrocytes), with application times of 15, 30, and 60 s for MVA, and 15 s for MERS-CoV. The products were tested undiluted, 1:10 and 1:100 diluted against MVA, and undiluted against MERS-CoV. RESULTS: A reduction in virus titer of ≥4 log10 (corresponding to an inactivation of ≥99.99%) was regarded as evidence of virucidal activity. This was achieved versus MVA and MERS-CoV, under both clean and dirty conditions, within 15 s of application of each undiluted PVP-I product. CONCLUSION: These data indicate that PVP-I-based hand wash products for potentially contaminated skin, and PVP-I gargle/mouthwash for reduction of viral load in the oral cavity and the oropharynx, may help to support hygiene measures to prevent transmission of MERS-CoV. FUNDING: Mundipharma Research GmbH & Co.

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Authors: Eggers, M., Eickmann, M., & Zorn, J.
Affiliations: Philipps University of Marburg (DE)
Mundipharma (Germany) (DE)
Corresponding author: Zorn, Juergen
ORCID: Eggers, Maren
Venue: Infectious Diseases and Therapy
Publisher: Springer Science and Business Media LLC
Published: 2015-09-28
Volume: 4
Issue: 4
Pages: 491-501
ISSN: 2193-6382 (ISSN-L)
2193-8229
DOI: 10.1007/s40121-015-0091-9
PMC: PMC4675768
OpenAlex: W2106483552
Cited by: 229
References: 21
Citations by year: 2026: 2 · 2025: 3 · 2024: 8 · 2023: 17 · 2022: 29 · 2021: 54 · 2020: 108 · 2019: 2 · 2018: 3 · 2017: 2 · 2016: 1
FWCI: 0.91
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by-nc
Locations: Infectious Diseases and Therapy (publishedVersion, cc-by-nc)
PubMed Central (publishedVersion, cc-by-nc)
PubMed (publishedVersion)
Funders: Philipps-Universität Marburg
Topics: Life Sciences › Immunology and Microbiology › Applied Microbiology and Biotechnology › Antimicrobial agents and applications
Health Sciences › Medicine › Infectious Diseases › Infection Control in Healthcare
Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Infection Control and Ventilation
Keywords: povidone-iodine, MERS-CoV, modified vaccinia Ankara, virucidal activity, hand hygiene, surgical scrubbing, mouthwash, skin disinfection, viral load reduction, nosocomial transmission

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Rapid and effective virucidal activity of povidone-iodine products against middle east respiratory syndrome coronavirus (MERS-CoV) and modified vaccinia virus ankara (MVA).

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