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Lean polycystic ovary syndrome (PCOS): an evidence-based practical approach
Open accessAbstract
Background Polycystic ovary syndrome (PCOS) is a common endocrinopathy affecting women of reproductive age. Common features include menstrual irregularities, hyperandrogenism and polycystic ovarian morphology although the presentation can be heterogeneous. Insulin resistance is thought to be responsible for the hormonal and metabolic derangements observed. PCOS has two phenotypes, overweight/obese and lean, the latter being a much less common presentation of the syndrome.Aims The aim of the present review is to summarise cardinal features, and to devise diagnostic and treatment algorithms for lean PCOS based on recent literature.Methods We searched PubMed, EBSCOhost and Google Scholar using search terms such as 'lean polycystic ovary syndrome' OR 'lean polycystic ovarian syndrome' OR 'lean PCOS' OR 'lean polycystic ovary disease' OR 'lean polycystic ovarian disease' OR 'lean PCOD' OR 'hyperandrogenism' AND 'low BMI OR 'low body mass index' to identify potential articles to be included in the review. Citation searches were subsequently performed in order to find relevant literature.Results Hormonal, metabolic and haematological profiles were altered in lean women with PCOS compared to healthy counterparts. However, the derangements were either comparable or less obvious compared to obese women with the syndrome. Insulin resistance seemed inherent in PCOS independent of obesity. Treatment options included weight maintenance, restoration of ovulation with insulin-sensitizers such as metformin, relief of symptoms such as hirsutism, acne and menstrual dysfunction, and assisted reproductive technologies in refractory cases, all of which showed promising results. The literature with evidence on lean PCOS is of low to moderate quality and there are still some uncertainties in the evidence base.Conclusion Carefully designed randomised controlled trials are required to confirm findings of previous studies in lean PCOS and to consolidate diagnostic and management algorithms proposed in this review. This paper will aid health professionals to improve their clinical approach in managing lean women with PCOS.
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“The majority of women with PCOS are overweight or obese and evidence indicates that the microbiome of obese individuals is capable of extracting more energy from the host diet compared with the microbiome of lean individuals [132].”
From Polycystic Ovary Syndrome: An Evolutionary Adaptation to Lifestyle and the Environment (2022) · cites this paper as [152]
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“Physiological regulation of insulin function can be viewed as an adaptive mechanism to regulate the metabolic pathway of insulin signaling (PI-3K), in response to changing environmental conditions [starvation, fear, stress] [164,165] or during normal alterations of internal states (pregnancy, lactation, adolescence) [65,146,152].”
From Polycystic Ovary Syndrome: An Evolutionary Adaptation to Lifestyle and the Environment (2022) · cites this paper as [152]
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“When the physiology of insulin function is considered to be a quantitative or continuous variable from an evolutionary perspective, it is likely that all women with PCOS, whether obese or lean, have reduced insulin sensitivity [152,155,166].”
From Polycystic Ovary Syndrome: An Evolutionary Adaptation to Lifestyle and the Environment (2022) · cites this paper as [152]
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“Also, important risen low-density lipoprotein (LDL) and total cholesterol have been associated in lean PCOS women versus controls [1,30,55].”
From PCOS and nutritional approaches: Differences between lean and obese phenotype (2021) · cites this paper as [30]
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“reported prevalence rates in obese and lean women vary widely [147,152]”
From Polycystic Ovary Syndrome: An Evolutionary Adaptation to Lifestyle and the Environment (2022) · cites this paper as [152]
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“Several reports showed the different metabolic disturbances characteristics in PCOS patients, like increased plasma insulin levels 2 h after glucose administration to lean PCOS patients, correlated with the lean, healthy participants.”
From PCOS and nutritional approaches: Differences between lean and obese phenotype (2021) · cites this paper as [30]
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“These lean PCOS patients may or may not have the cardinal symptoms such as irregular menstrual cycles and acne [30].”
From PCOS and nutritional approaches: Differences between lean and obese phenotype (2021) · cites this paper as [30]
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Citations
Cites
(2004) · Fertility and Sterility · doi:10.1016/j.fertnstert.2003.10.004 · Cited by 9,050
Yamauchi, T., Kamon, J., Waki, H., Terauchi, Y., Kubota, N., Hara, K., Mori, Y., Ide, T., Murakami, K., Tsuboyama-Kasaoka, N., et al. (2001) · Nature Medicine · doi:10.1038/90984 · Cited by 4,915
Yamauchi, T., Kamon, J., Minokoshi, Y., Ito, Y., Waki, H., Uchida, S., Yamashita, S., Noda, M., Kita, S., Ueki, K., et al. (2002) · Nature Medicine · doi:10.1038/nm788 · Cited by 4,238
A role for ghrelin in the central regulation of feeding
Nakazato, M., Murakami, N., Date, Y., Kojima, M., Matsuo, H., Kangawa, K., & Matsukura, S. (2001) · Nature · doi:10.1038/35051587 · Cited by 3,443
The Diagnosis of Polycystic Ovary Syndrome during Adolescence
Witchel, S. F., Oberfield, S., Rosenfield, R. L., Codner, E., Bonny, A., Ibáñez, L., Pena, A., Horikawa, R., Gomez-Lobo, V., Joel, D., et al. (2015) · Hormone Research in Paediatrics · doi:10.1159/000375530 · Cited by 3,113
The Prevalence and Features of the Polycystic Ovary Syndrome in an Unselected Population
Azziz, R., Woods, K. S., Reyna, R., Key, T. J., Knochenhauer, E. S., & Yıldız, B. O. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-032046 · Cited by 2,715
Men at risk: occupation and male infertility.
Claman, P. (2004) · Fertility and Sterility · doi:10.1016/s0015-0282(03)01188-9 · Cited by 2,219
Azziz, R., Carmina, E., Dewailly, D., Diamanti-Kandarakis, E., Escobar-Morreale, H. F., Futterweit, W., Janssen, O. E., Legro, R. S., Norman, R. J., Taylor, A. E., et al. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-0178 · Cited by 2,143
Diamanti-Kandarakis, E., & Dunaif, A. (2012) · Endocrine Reviews · doi:10.1210/er.2011-1034 · Cited by 1,947
Legro, R. S., Arslanian, S. A., Ehrmann, D. A., Hoeger, K. M., Murad, M. H., Pasquali, R., & Welt, C. K. (2013) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2013-2350 · Cited by 1,919
Cited by
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Siddiqui, S., Mateen, S., Ahmad, R., & Moin, S. (2022) · Journal of Assisted Reproduction and Genetics · doi:10.1007/s10815-022-02625-7 · Cited by 404
Fundamental Concepts and Novel Aspects of Polycystic Ovarian Syndrome: Expert Consensus Resolutions
Aversa, A., Vignera, S. L., Rago, R., Gambineri, A., Nappi, R. E., Calogero, A. E., & Ferlin, A. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.00516 · Cited by 159
Polycystic Ovary Syndrome: An Evolutionary Adaptation to Lifestyle and the Environment
parker, J., O'Brien, C., Hawrelak, J., & Gersh, F. (2021) · doi:10.20944/preprints202112.0088.v1 · Cited by 113
Polycystic Ovary Syndrome: An Evolutionary Adaptation to Lifestyle and the Environment
Parker, J., O’Brien, C., Hawrelak, J., & Gersh, F. L. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph19031336 · Cited by 114
“Physiological regulation of insulin function can be viewed as an adaptive mechanism to regulate the metabolic pathway of insulin signaling (PI-3K), in response to changing environmental conditions (starvation, fear, stress) (163,164) or during normal alterations of internal states (pregnancy, lactation, adolescence) (…”
BackgroundInfluentialPolycystic Ovary Syndrome Fuels Cardiovascular Inflammation and Aggravates Ischemic Cardiac Injury
Gao, L., Zhao, Y., Wu, H., Lin, X.-H., Guo, F., Li, J., Long, Y., Zhou, B., She, J., Zhang, C., et al. (2023) · Circulation · doi:10.1161/circulationaha.123.065827 · Cited by 109
Predicting polycystic ovary syndrome with machine learning algorithms from electronic health records
Zad, Z., Jiang, V. S., Wolf, A. T., Wang, T., Cheng, J. J., Paschalidis, I. C., & Mahalingaiah, S. (2024) · Frontiers in Endocrinology · doi:10.3389/fendo.2024.1298628 · Cited by 97
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Kicińska, A. M., Maksym, R., Zabielska-Kaczorowska, M. A., Stachowska, A., & Babińska, A. (2023) · Biomedicines · doi:10.3390/biomedicines11061567 · Cited by 108
PCOS and nutritional approaches: Differences between lean and obese phenotype
Barrea, L., Frias-Toral, E., Verde, L., Ceriani, F., Cucalón, G., Garcia-Velasquez, E., Moretti, D., Savastano, S., Colao, A., & Muscogiuri, G. (2021) · Metabolism Open · doi:10.1016/j.metop.2021.100123 · Cited by 86
Machine-aided self-diagnostic prediction models for polycystic ovary syndrome: observational study
Zigarelli, A., Jia, Z., & Lee, H. (2022) · JMIR Formative Research · doi:10.2196/29967 · Cited by 74
“Toosy et al [8] noted that a smaller proportion of women with lean PCOS had a normal or low BMI (≤25 kg/m2) and may or may not have symptoms, which makes diagnosis more challenging.”
BackgroundInfluentialEmanuel, R. H. K., Roberts, J., Docherty, P. D., Lunt, H., Campbell, R. E., & Möller, K. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.1017468 · Cited by 87
Debates regarding lean patients with polycystic ovary syndrome: a narrative review
Dawood, A., & Goyal, M. (2017) · Journal of Human Reproductive Sciences · doi:10.4103/jhrs.jhrs_77_17 · Cited by 72
Insulin Metabolism in Polycystic Ovary Syndrome: Secretion, Signaling, and Clearance
Herman, R., Sikonja, J., Jensterle, M., Janez, A., & Dolzan, V. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24043140 · Cited by 69
Clinical Presentation and Diagnosis of Polycystic Ovarian Syndrome
LENTSCHER, J. A., & DeCherney, A. H. (2020) · Clinical Obstetrics & Gynecology · doi:10.1097/grf.0000000000000563 · Cited by 73
Reproductive risk factors across the female lifecourse and later metabolic health
Nichols, A. R., Chavarro, J. E., & Oken, E. (2024) · Cell Metabolism · doi:10.1016/j.cmet.2024.01.002 · Cited by 66
Higher risk of type 2 diabetes in women with hyperandrogenic polycystic ovary syndrome
Persson, S., Elenis, E., Türkmen, Ş., Kramer, M. S., Yong, E., & Poromaa, I. S. (2021) · Fertility and Sterility · doi:10.1016/j.fertnstert.2021.04.018 · Cited by 57
Shirazi, F. K. H., Khodamoradi, Z., & Jeddi, M. (2021) · BMC Endocrine Disorders · doi:10.1186/s12902-021-00710-z · Cited by 58
Parker, J. (2023) · Life · doi:10.3390/life13041056 · Cited by 43
Zhu, J., Pujol‐Gualdo, N., Wittemans, L. B. L., Lindgren, C. M., Laisk, T., Hirschhorn, J. N., & Chan, Y.-M. (2021) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgab838 · Cited by 45
Insulin resistance, metabolic syndrome and polycystic ovaries: an intriguing conundrum
Prosperi, S., & Chiarelli, F. (2025) · Frontiers in Endocrinology · doi:10.3389/fendo.2025.1669716 · Cited by 58
Yang, S., Liu, C., Ma, S., Chang, W.-H., Chen, Y., Lee, W.-L., & Wang, P. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph19159094 · Cited by 35
Yang, S., Zhao, L., He, W., & Mi, Y. (2022) · Drugs · doi:10.1007/s40265-022-01779-z · Cited by 33
Weight management strategies for patients with PCOS: current perspectives
Ozgen Saydam, B., & Yildiz, B. O. (2021) · Expert Review of Endocrinology & Metabolism · doi:10.1080/17446651.2021.1896966 · Cited by 33
Dietary Approaches to Women’s Sexual and Reproductive Health
Kudesia, R., Alexander, M., Gulati, M., Kennard, A., & Tollefson, M. (2021) · American Journal of Lifestyle Medicine · doi:10.1177/15598276211007113 · Cited by 38
Idicula‐Thomas, S., Gawde, U., Bhaye, S., Pokar, K., & Bader, G. D. (2020) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2020.06.023 · Cited by 27
Patel, J. K., Chaudhary, H., Panchal, S., Joshi, R. G., & Joshi, R. G. (2024) · Reproductive Toxicology · doi:10.1016/j.reprotox.2024.108562 · Cited by 26
Shukla, P., & Melkani, G. C. (2023) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-023-09789-2 · Cited by 24
Effect of Dietary Regimen on the Development of Polycystic Ovary Syndrome: A Narrative Review
Alomran, S., & Estrella, E. D. (2023) · Cureus · doi:10.7759/cureus.47569 · Cited by 23
Glintborg, D., Ollila, M., Møller, J. K., Pesonen, P., Persson, S., Elenis, E., Rubin, K. H., Gissler, M., Andersen, M., Poromaa, I. S., et al. (2024) · Human Reproduction · doi:10.1093/humrep/deae124 · Cited by 25
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Ou, M., Xu, P., Lin, H., Ma, K., & Liu, M. (2021) · International Journal of Endocrinology · doi:10.1155/2021/9511772 · Cited by 26
Camajani, E., Feraco, A., Verde, L., Moriconi, E., Marchetti, M., Colao, A., Caprio, M., Muscogiuri, G., & Barrea, L. (2023) · Current Obesity Reports · doi:10.1007/s13679-023-00516-1 · Cited by 25
Balkrishna, A., Rana, M., Mishra, S., Srivastava, D., Bhardwaj, R., Singh, S., Rajput, S. K., & Arya, V. (2023) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2023/3705508 · Cited by 31
Endocrine and metabolic effects of GLP-1 receptor agonists on women with PCOS, a narrative review
Monney, M., Mavromati, M., Leboulleux, S., & Gariani, K. (2025) · Endocrine Connections · doi:10.1530/ec-24-0529 · Cited by 26
Menstrual Disorders Related to Eating Disorders
Milano, W., Ambrosio, P., Carizzone, F., Biasio, V. D., Foia, M. G., Saetta, B., Milano, M. F., & Capasso, A. (2021) · Endocrine Metabolic & Immune Disorders - Drug Targets · doi:10.2174/1871530321666210625145345 · Cited by 20
Gestational diabetes and other adverse pregnancy outcomes in polycystic ovary syndrome
Selen, D. J., & Powe, C. E. (2022) · Current Opinion in Endocrinology Diabetes and Obesity · doi:10.1097/med.0000000000000769 · Cited by 23
Assessment of Type 2 Diabetes Risk in Young Women with Polycystic Ovary Syndrome
Livadas, S., Paparodis, R. D., Anagnostis, P. G., Gambineri, A., Μacut, D., Petrović, T., Yıldız, B. O., Micić, D., Mastorakos, G. P., & Μacut, D. (2023) · Diagnostics · doi:10.3390/diagnostics13122067 · Cited by 23
Towards Hormone Health: An Autoethnography of Long-Term Holistic Tracking to Manage PCOS
Kang, D., Li, J., Leshed, G., Rzeszotarski, J. M., & Lu, X. (2025) · CHI Conference on Human Factors in Computing Systems · doi:10.1145/3706598.3713619 · Cited by 20
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Glintborg, D., Kolster, N. D., Ravn, P., & Andersen, M. (2022) · Biomedicines · doi:10.3390/biomedicines10061455 · Cited by 18
Adipose-androgen crosstalk in polycystic ovary syndrome: mechanisms and therapeutic implications
Ni, M., Lei, H., Ye, T., & Wang, Y. (2025) · Frontiers in Endocrinology · doi:10.3389/fendo.2025.1731179 · Cited by 25
Silva, K. D., Demmer, R. T., Jönsson, D., Mousa, A., Teede, H. J., Forbes, A. B., & Enticott, J. (2022) · PLoS ONE · doi:10.1371/journal.pone.0269191 · Cited by 16
Lee, H. J., Jo, H. N., Noh, H. K., Kim, S. H., & Joo, J. K. (2022) · Ginekologia Polska · doi:10.5603/gp.a2021.0239 · Cited by 15
The role of dietitian in the multidisciplinary treatment of PCOS
Nemchikova, O., & Frontoni, S. (2022) · Nutrition, Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2022.01.003 · Cited by 14
Bila, J. S., Dotlić, J., Andjić, M., Ivanović, K., Micić, J., Tulić, L., Pupovac, M., Stojnić, J., Vuković, I., & Ivanovic, S. (2025) · Journal of Clinical Medicine · doi:10.3390/jcm14165642 · Cited by 22
Li, Y., Wang, Y., Liu, H., Zhang, S., & Zhang, C. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1117996 · Cited by 14
Bushell, A., & Crespi, B. J. (2024) · Frontiers in Reproductive Health · doi:10.3389/frph.2024.1475132 · Cited by 16
Arora, S., Vedpal, & Chauhan, N. (2024) · Multimedia Tools and Applications · doi:10.1007/s11042-024-19707-6 · Cited by 17
Stefanaki, C., Bacopoulou, F., Kandaraki, E., Boschiero, D., & Diamanti‐Kandarakis, E. (2019) · Nutrients · doi:10.3390/nu11092055 · Cited by 13
Bir, A., Ghosh, A., & Chowdhury, S. (2023) · Journal of Education and Health Promotion · doi:10.4103/jehp.jehp_1605_22 · Cited by 13
Gudović, A., Bukumirić, Z., Milinčić, M., Pupovac, M., Andjić, M., Ivanović, K., & Spremović-Radjenović, S. (2024) · Biomedicines · doi:10.3390/biomedicines12020349 · Cited by 17
Abdo, N. M., Ahmad, H., Loney, T., Zarmakoupis-Zavos, P. N., Aslam, I., Irfan, S., Grivna, M., Ahmed, L. A., & Al‐Rifai, R. H. (2023) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph20031692 · Cited by 13
ART outcomes in lean compared to obese phenotypes of polycystic ovarian syndrome
Fouks, Y., Neuhausser, W., Ryley, D. A., Penzias, A. S., Sakkas, D., & Vaughan, D. A. (2023) · Journal of Assisted Reproduction and Genetics · doi:10.1007/s10815-023-02804-0 · Cited by 11
Corrie, L., Kommineni, N., Kaur, J., Awasthi, A., Gundaram, R., & Kukati, L. (2023) · Current Radiopharmaceuticals · doi:10.2174/0118744710258313231105072931 · Cited by 11
Zhao, H., Zhang, J., Xing, C., Cheng, X., & He, B. (2024) · Journal of Ovarian Research · doi:10.1186/s13048-024-01367-7 · Cited by 14
Zhu, Y., Lin, S., Zhang, Y., Yu, J., Fu, J., Li, Y., Shan, C., Cai, J., Liu, W. X., & Tao, T. (2024) · Scientific Reports · doi:10.1038/s41598-024-77645-7 · Cited by 13
Zheng, C., Lin, Y., Zhang, Z., Ye, J., Lin, Y., & Tian, J. (2025) · Frontiers in Endocrinology · doi:10.3389/fendo.2025.1680685 · Cited by 10
Kolnikaj, T. S., Herman, R., Janež, A., & Jensterle, M. (2022) · Life · doi:10.3390/life12111906 · Cited by 10
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Moharir, S. R., Talamadla, M. K., Bhardwaj, P., Banerjee, A., Dey, R. J., & Sekhar, K. V. G. C. (2025) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2025.118361 · Cited by 11
GnRH pulse generator activity in mouse models of polycystic ovary syndromePreprint
Zhou, Z., Han, S. Y., Pardo-Navarro, M., Wall, E. G., Desai, R., Vas, S., Handelsman, D. J., & Herbison, A. E. (2024) · eLife · doi:10.7554/elife.97179.3 · Cited by 15
Glintborg, D., Ollila, M., Koskenkari, N. V. S., Møller, J. K., Calla, D., Gyllenberg, F., Rubin, K. H., Pesonen, P., Andersen, M., Poromaa, I. S., et al. (2025) · European Journal of Endocrinology · doi:10.1093/ejendo/lvaf266 · Cited by 9
Kim, J., Kim, O., Jung, H., Pang, Y., & Dan, H. (2021) · Health Care For Women International · doi:10.1080/07399332.2021.1939348 · Cited by 9
Liu, X., Zhang, C., Huang, J., Liu, H., Li, B., Zhang, F., & Xu, C. (2024) · Clinica Chimica Acta · doi:10.1016/j.cca.2024.117860 · Cited by 8
Pourghazi, F., Eslami, M., Mohammadi, S., Ghoreshi, R., Ejtahed, H., & Qorbani, M. (2023) · BMC Endocrine Disorders · doi:10.1186/s12902-023-01490-4 · Cited by 8
Kian, M., Hosseini, E., Abdizadeh, T., Langaee, T. Y., Khajouei, A., & Ghasemi, S. (2021) · EXCLI journal · doi:10.17179/excli2021-4534 · Cited by 10
Kogure, G. S., Ribeiro, V. B., Mendes, M. C., Ferriani, R. A., Furtado, C. L. M., & dos Reis, R. M. (2023) · Archives of Endocrinology and Metabolism · doi:10.20945/2359-3997000000627 · Cited by 8
Harrath, A. H., Jalouli, M., Al-Zharani, M. M., & Rahaman (2026) · Biomolecules · doi:10.3390/biom16050626 · Cited by 8
Liu, S., Zhou, X., Jie, H., Zheng, Z., Cai, B., Mai, Q., & Zhou, C. (2024) · International Journal of Women s Health · doi:10.2147/ijwh.s445021 · Cited by 7
Thaller, M., Homer, V., Abbott, S., Hazlehurst, J., Mollan, S. P., & Sinclair, A. J. (2024) · Neuro-Ophthalmology · doi:10.1080/01658107.2024.2341775 · Cited by 7
Carosso, A. R., Conforti, A., Cimadomo, D., Spadoni, V., Zacà, C., Massarotti, C., Vaiarelli, A., Venturella, R., Vitagliano, A., Busnelli, A., et al. (2025) · Journal of Assisted Reproduction and Genetics · doi:10.1007/s10815-024-03379-0 · Cited by 6
Ashraf, A., Singh, R., Ganai, B. A., & Shahnawaz, M. (2024) · Archives of Gynecology and Obstetrics · doi:10.1007/s00404-023-07326-9 · Cited by 5
Long, J. R., Parker, M., Jumani, S., Ahmed, A. S., Huynh, V., & Gomez‐Lobo, V. (2024) · Journal of Pediatric and Adolescent Gynecology · doi:10.1016/j.jpag.2024.11.003 · Cited by 7
Singh, J. R., Jain, A., Wadhwa, N., Tilak, H. R., & Ahirwar, A. K. (2022) · Advances in Laboratory Medicine / Avances en Medicina de Laboratorio · doi:10.1515/almed-2022-0050 · Cited by 4
Clinical management of androgen excess and defect in women
Rosato, E., Sciarra, F., Minnetti, M., Degjoni, A., & Venneri, M. A. (2023) · Expert Review of Endocrinology & Metabolism · doi:10.1080/17446651.2023.2279537 · Cited by 4
Shah, A. K., Yadav, B. K., Shah, A. K., Suri, A., & Deo, S. K. (2022) · Journal of Laboratory Physicians · doi:10.1055/s-0042-1750066 · Cited by 4
Intrauterine androgen exposure impairs gonadal adipose tissue functions of adult female rats
Ferrer, M. J., Abruzzese, G. A., Heber, M. F., Ferreira, S. R., Arboccó, F. C. V., & Motta, A. B. (2022) · Theriogenology · doi:10.1016/j.theriogenology.2022.12.035 · Cited by 4
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Tilak, J. R., Jain, A., Wadhwa, N., Tilak, H. R., & Ahirwar, A. K. (2022) · Advances in Laboratory Medicine / Avances en Medicina de Laboratorio · doi:10.1515/almed-2021-0098 · Cited by 3
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Low serum hepcidin levels in women with polycystic ovary syndrome: evidence from meta-analysis
Nong, J., Li, H., Yang, Y., Qing-hong, L., Sun, Y., Yin, Q., & Hongying, H. (2024) · Gynecological Endocrinology · doi:10.1080/09513590.2024.2375568 · Cited by 5
Diagnosis Experiences in Individuals With Lean Polycystic Ovary Syndrome
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Liu, L., Liu, B., Li, M., & Qin, L. (2025) · Journal of Ovarian Research · doi:10.1186/s13048-025-01884-z · Cited by 2
Nowak, J., Jabczyk, M., Borszcz, J., Jagielski, P., & Zubelewicz‐Szkodzińska, B. (2026) · Frontiers in Endocrinology · doi:10.3389/fendo.2025.1756679 · Cited by 3
Prayitno, G. D., Sartika, C. R., Djuwantono, T., Wijaya, A., Muharam, R., Hidayat, Y. M., Haifa, R., Zahrah, A., & Lestari, K. (2026) · Journal of Clinical Medicine · doi:10.3390/jcm15051707 · Cited by 2
Weidner, A. E., Vann, K., Hodowanec, A. I., Ivey, D., Roy, A., Sechrist, Z. R., Cole, C. L., & Astapova, O. (2026) · Endocrinology · doi:10.1210/endocr/bqag025 · Cited by 2
Gao, A., & Wen, J.-R. (2024) · Undergraduate Research in Natural and Clinical Science and Technology (URNCST) Journal · doi:10.26685/urncst.525 · Cited by 2
Emanuel, R. H. K., Docherty, P. D., Lunt, H., Murray, R., & Campbell, R. E. (2024) · Intelligence-Based Medicine · doi:10.1016/j.ibmed.2024.100135 · Cited by 2
Różańska-Smuszkiewicz, G., Smuszkiewicz-Różański, P., Kmiotek, W., Ragan, D., Oronowicz, R., Staszczak, P., Jaworska, B., Długosz, J., Bara, M., & Jama, G. (2024) · Quality in Sport · doi:10.12775/qs.2024.19.53209 · Cited by 4
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Nahidi, F., Tehrani, F. R., Ghodsi, D., Jafari, M., Majd, H. A., & Abdolahian, S. (2021) · Journal of Education and Health Promotion · doi:10.4103/jehp.jehp_15_21 · Cited by 5
Sun, F., Cun, J., Huang, R., Chen, Y., Verwoerd, G., & Yu, Y. (2022) · Reproductive Biology · doi:10.1016/j.repbio.2022.100649 · Cited by 2
Atnil, E., Hestiantoro, A., Riayati, O., Febri, R. R., & Muna, N. (2022) · Majalah Obstetri & Ginekologi · doi:10.20473/mog.v30i22022.66-71 · Cited by 2
Mendpara, V. A., Ganampet, N. R., Afroze, S., Gnanasekaran, S., Sahu, S., Atikah, R., Rajpal, S., Raghavan, P., Ajith, K., Parmar, M. P., et al. (2023) · Research Square · doi:10.21203/rs.3.rs-3360467/v1 · Cited by 2
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Lumezi, B. G., & Lokaj‐Berisha, V. (2024) · American Journal of Case Reports · doi:10.12659/ajcr.945814 · Cited by 1
Dhumad, M. M., Hamdan, F. B., & Al-Mayah, Q. S. (2025) · Italian Journal of Medicine · doi:10.4081/itjm.2025.2085 · Cited by 1
Berbrier, D. E., Huckins, W., Delage, S. I., Berkel, E. K. V., Hannaian, S. J., Myara, R., Okafor, O. N., Chung, T. H., Tulandi, T., Reinblatt, S. L., et al. (2026) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00453.2025 · Cited by 1
Seale, L., Bates, N., Tumin, D., & Sutton, J. (2026) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/j.ejogrb.2026.115140 · Cited by 1
Wangikar, P. P., Vinodkumar, K., Agarwal, K., Sunder, A. V., Sahasrabuddhe, D., Kulkarni, B., Kamath, M. S., Malhotra, N., & Kapoor, N. (2026) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2026.102129 · Cited by 1
Ravat, F. K., Nair, S. M., Gandhi, M., Ninama, P. G., Punjabi, S., Shah, D., Sheth, D. B., Patel, B., Maheriy, B. K., & Thummar, K. N. (2026) · Steroids · doi:10.1016/j.steroids.2026.109831 · Cited by 1
Meghana, G., Seth, A., Singh, P., Jana, P., Singh, R., Aggarwal, K., & Mendiratta, V. (2026) · The Indian Journal of Pediatrics · doi:10.1007/s12098-026-06338-y · Cited by 1
Ho, V. N. A., Pham, T. D., Nguyen, N. T., Hoang, H. L. T., Ho, T. M., & Vuong, L. N. (2022) · Daehan saengsik uihak hoeji/Clinical and experimental reproductive medicine · doi:10.5653/cerm.2022.05204 · Cited by 1
Pal, R. S., Pal, Y., Chaitanya, M., Kumar, R., Tyagi, P. K., & Srivastava, P. (2023) · Current Women s Health Reviews · doi:10.2174/0115734048262284230927191823 · Cited by 1
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Mukherjee, S., Rai, D., Ghoshal, D., Chakraborty, T., & Karati, D. (2024) · Current Women s Health Reviews · doi:10.2174/0115734048268656231127064615 · Cited by 1
Metadata
- Authors
- Toosy, S., Sodi, R., & Pappachan, J. M.
- Affiliations
- Lancaster University (GB)
- University Hospitals of Morecambe Bay NHS Foundation Trust (GB)
- Pilgrim Hospital (GB)
- Corresponding author
- Pappachan, Joseph M.
- Venue
- Journal of Diabetes & Metabolic Disorders
- Published
- 2018-11-13
- Volume
- 17
- Issue
- 2
- Pages
- 277-285
- ISSN
- 2251-6581 (ISSN-L)
- PMC
- PMC6405408
- OpenAlex
- W2900701301
- Cited by
- 154
- References
- 78
- Citations by year
- 2026: 28 · 2025: 21 · 2024: 34 · 2023: 27 · 2022: 22 · 2021: 16 · 2020: 3 · 2019: 2
- FWCI
- 5.59
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Diabetes & Metabolic Disorders (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Keywords
- polycystic ovary syndrome, hyperandrogenism, insulin resistance, menstrual irregularity, PCOS phenotypes, metformin, ovulation induction, hirsutism, acne, assisted reproduction, diagnostic algorithm, treatment algorithm, low body mass index
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