Debates regarding lean patients with polycystic ovary syndrome: a narrative review
Open accessAbstract
Polycystic ovary syndrome (PCOS) is a complex syndrome showing the clinical features of an endocrine/metabolic disorder, including hyperinsulinemia and hyperandrogenism. Two phenotypes are present, either lean or obese, with different biochemical, hormonal, and metabolic profiles. Evidence suggests many treatment modalities that can be applied. However, many of these modalities were found to be not suitable for the lean phenotype of PCOS. Much contradictory research was found regarding lean patients with PCOS. The aim of this narrative review is to shed light on the debate prevailing regarding characteristics, as well as metabolic, hematological, and potential management modalities. Literature review was performed from January 1, 2000 to March 31, 2017 with specific word search such as lean PCOS, hormonal abnormalities in lean PCOS, and the management of lean PCOS. All retrieved articles were carefully assessed, and data were obtained. We could conclude that the debate is still prevailing regarding this specific lean population with PCOS, especially with regard to their characteristics and management modalities. Further studies are still required to resolve this debate on the presence of PCOS in lean women.
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There is a lack of evidence regarding the effect of lifestyle intervention on improving glucose tolerance or lipid profiles and assessing clinical reproductive outcomes such as quality of life and treatment satisfaction.
“However, there is a lack of evidence regarding the effect of this lifestyle intervention on improving glucose tolerance or lipid profiles and assessing clinical reproductive outcomes, such as quality of life and treatment satisfaction [63].”
From PCOS and nutritional approaches: Differences between lean and obese phenotype (2021) · cites this paper as [63]
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Hao (2015) · doi:10.1002/14651858 · Cited by 11,321 · see citing works
Lifestyle changes in women with polycystic ovary syndrome
Lim, S. S., Hutchison, S. K., Van Ryswyk, E., Norman, R. J., Teede, H. J., & Moran, L. J. (2019) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd007506.pub4 · Cited by 725 · see citing works
Consensus on infertility treatment related to polycystic ovary syndrome
The Thessaloniki ESHRE/ASRM-Sponsored PCOS Consensus Workshop Group March 2–3, 2. (2008) · Fertility and Sterility · doi:10.1016/j.fertnstert.2007.09.041 · Cited by 719 · see citing works
Drug Design, Development and Therapy
(2020) · Drug Design Development and Therapy · doi:10.2147/dddt · Cited by 566 · see citing works
Nestler, J. E., & Jakubowicz, D. J. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.82.12.4431 · Cited by 394 · see citing works
Goodman, N. F., Cobin, R. H., Futterweit, W., Glueck, J. S., Legro, R. S., & Carmina, E. (2015) · Endocrine Practice · doi:10.4158/ep15748.dscpt2 · Cited by 361 · see citing works
Carmina, E., Bucchieri, S., Esposito, A., Del Puente, A., Mansueto, P., Orio, F., Di Fede, G., & Rini, G. (2007) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-2725 · Cited by 317 · see citing works
Lifestyle changes in women with polycystic ovary syndrome
Moran, L. J., Hutchison, S. K., Norman, R. J., & Teede, H. J. (2011) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd007506.pub3 · Cited by 292 · see citing works
Kirchengast, S. (2001) · Human Reproduction · doi:10.1093/humrep/16.6.1255 · Cited by 291 · see citing works
Yıldırım, B., Sabir, N., & Kaleli̇, B. (2003) · Fertility and Sterility · doi:10.1016/s0015-0282(03)00265-6 · Cited by 195 · see citing works
Arentz, S., Abbott, J. A., Smith, C. A., & Bensoussan, A. (2014) · BMC Complementary and Alternative Medicine · doi:10.1186/1472-6882-14-511 · Cited by 191 · see citing works
Barber, T. M., Golding, S. J., Alvey, C., Wass, J. A. H., Karpe, F., Franks, S., & McCarthy, M. I. (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2007-2117 · Cited by 179 · see citing works
Lean polycystic ovary syndrome (PCOS): an evidence-based practical approach
Toosy, S., Sodi, R., & Pappachan, J. M. (2018) · Journal of Diabetes & Metabolic Disorders · doi:10.1007/s40200-018-0371-5 · Cited by 154 · see citing works
Insulin Sensitivity in Women with Polycystic Ovary Syndrome
Vrbíková, J., Cibula, D., Dvor̆áková, K., Stanická, S., Šindelka, G., Hill, M., Fanta, M., Vondra, K., & Škrha, J. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-031378 · Cited by 145 · see citing works
Yilmaz, M., Bukan, N., Ayvaz, G., Karakoç, A., Törüner, F., Çakir, N., & Arslan, M. (2005) · Human Reproduction · doi:10.1093/humrep/dei258 · Cited by 138 · see citing works
Consensus on infertility treatment related to polycystic ovary syndrome.
Hong, K. (2008) · Human Reproduction · doi:10.1093/humrep/dem426 · Cited by 117 · see citing works
Al‐Azemi, M., Omu, F. E., & Omu, A. E. (2003) · Archives of Gynecology and Obstetrics · doi:10.1007/s00404-003-0537-2 · Cited by 116 · see citing works
Tan, S., Hahn, S., Benson, S., Dietz, T., Lahner, H., Moeller, L. C., Schmidt, M., Elsenbruch, S., Kimmig, R., Mann, K., et al. (2007) · European Journal of Endocrinology · doi:10.1530/eje-07-0294 · Cited by 112 · see citing works
Dietary intake, physical activity, and obesity in women with polycystic ovary syndrome
Wright, C. E., Zborowski, J. V., Talbott, E. O., McHugh-Pemu, K., & Youk, A. (2004) · International Journal of Obesity · doi:10.1038/sj.ijo.0802661 · Cited by 107 · see citing works
Metformin monotherapy in lean women with polycystic ovary syndrome
Kumari, A., Haq, A., Jayasundaram, R., Abdel-Wareth, L., al Haija, S., & Alvares, M. (2005) · Reproductive BioMedicine Online · doi:10.1016/s1472-6483(10)60809-7 · Cited by 96 · see citing works
Faloia, E., Canibus, P., Gatti, C., Frezza, F., Santangelo, M., Garrapa, G., & Boscaro, M. (2004) · Journal of Endocrinological Investigation · doi:10.1007/bf03345285 · Cited by 96 · see citing works
Serum total L-carnitine levels in non-obese women with polycystic ovary syndrome
Fenkçi, S. M., Fenkçi, V., Öztekin, Ö., Rota, S., & Karagenç, N. (2008) · Human Reproduction · doi:10.1093/humrep/den109 · Cited by 92 · see citing works
Pizzo, A., Laganà, A. S., & Barbaro, L. (2014) · Gynecological Endocrinology · doi:10.3109/09513590.2013.860120 · Cited by 90 · see citing works
Trolle, B., Flyvbjerg, A., Kesmodel, U., & Lauszus, F. F. (2007) · Human Reproduction · doi:10.1093/humrep/dem271 · Cited by 90 · see citing works
Li, S., Chu, Q., Ma, J., Sun, Y. W., Tao, T., Huang, R., Liao, Y., Yue, J., Zheng, J., Wang, L., et al. (2016) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2016-2692 · Cited by 90 · see citing works
Önalan, G., Göktolga, Ü., Ceyhan, T., Bağış, T., Önalan, R., & Pabuçcu, R. (2005) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/j.ejogrb.2005.05.010 · Cited by 71 · see citing works
Ezeh, U., Pall, M., Mathur, R., & Azziz, R. (2014) · Human Reproduction · doi:10.1093/humrep/deu096 · Cited by 71 · see citing works
Metformin in the treatment of infertility in polycystic ovarian syndrome: an alternative perspective
Nestler, J. E. (2008) · Fertility and Sterility · doi:10.1016/j.fertnstert.2008.04.073 · Cited by 69 · see citing works
Resistance exercise impacts lean muscle mass in women with polycystic ovary syndrome
KOGURE, G. S., MIRANDA-FURTADO, C. L., SILVA, R. C., MELO, A. S., FERRIANI, R. A., DE SÁ, M. F. S., & REIS, R. M. D. (2016) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000000822 · Cited by 68 · see citing works
CONCERN: Does ovary need D-chiro-inositol?
Isabella, R., & Raffone, E. (2012) · Journal of Ovarian Research · doi:10.1186/1757-2215-5-14 · Cited by 67 · see citing works
Horejsi, R., Möller, R., Rackl, S., Giuliani, A., Freytag, U., Crailsheim, K., Sudi, K. M., & Tafeit, E. (2003) · American Journal of Physical Anthropology · doi:10.1002/ajpa.10364 · Cited by 67 · see citing works
Assessment of insulin resistance in lean women with polycystic ovary syndrome
Morciano, A., Romani, F., Sagnella, F., Scarinci, E., Palla, C., Moro, F., Tropea, A., Policola, C., Della Casa, S., Guido, M., et al. (2014) · Fertility and Sterility · doi:10.1016/j.fertnstert.2014.04.004 · Cited by 62 · see citing works
Neve-Dolfing, J. G., Stassen, C. M., van Haard, P. M. M., Wolffenbuttel, B. H. R., & Schweitzer, D. H. (2011) · Human Reproduction · doi:10.1093/humrep/der070 · Cited by 62 · see citing works
Tehrani, H. G., Mostajeran, F., & Shahsavari, S. (2014) · PubMed · Cited by 55 · see citing works
Marciniak, A., Nawrocka-Rutkowska, J., Brodowska, A., Wiśniewska, B., & Starczewski, A. (2016) · Annals of Agricultural and Environmental Medicine · doi:10.5604/12321966.1226842 · Cited by 51 · see citing works
Polycystic ovarian syndrome during puberty and adolescence
Williams, R. M., Ong, K. K., & Dunger, D. B. (2013) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2013.01.005 · Cited by 50 · see citing works
Adiponectin and leptin in overweight/obese and lean women with polycystic ovary syndrome
Chen, C.-I., Hsu, M.-I., Lin, S., Chang, Y.-C. I., Hsu, C.-S., & Tzeng, C. (2014) · Gynecological Endocrinology · doi:10.3109/09513590.2014.984676 · Cited by 49 · see citing works
Livadas, S., Κόλλιας, Α., Panidis, D., & Diamanti‐Kandarakis, E. (2014) · European Journal of Endocrinology · doi:10.1530/eje-13-1007 · Cited by 45 · see citing works
Oxidative stress and inflammation in lean and obese subjects with polycystic ovary syndrome.
Blair, S. A., Tun, T. K., Young, I. S., Phelan, N., Gibney, J., & McEneny, J. (2013) · PubMed · Cited by 43 · see citing works
Sharma, S., & Majumdar, A. (2015) · Journal of Human Reproductive Sciences · doi:10.4103/0974-1208.170394 · Cited by 42 · see citing works
Plasma L -carnitine levels of obese and non-obese polycystic ovary syndrome patients
Çelik, F., Köse, M., Yılmazer, M., Köken, G., Arıöz, D. T., & Pektas, M. K. (2017) · Journal of Obstetrics and Gynaecology · doi:10.1080/01443615.2016.1264375 · Cited by 40 · see citing works
Genazzani, A. D., Santagni, S., Ricchieri, F., Campedelli, A., Rattighieri, E., Chierchia, E., Marini, G. M. F., Despini, G., Prati, A., & Simoncini, T. (2014) · Journal of obstetrics and gynaecology research · doi:10.1111/jog.12319 · Cited by 31 · see citing works
Ganie, M. A., Marwaha, R. K., Dhingra, A., Nisar, S., Mani, K., Masoodi, S. R., Chakraborty, S., & Rashid, A. (2016) · Gynecological Endocrinology · doi:10.3109/09513590.2016.1141879 · Cited by 28 · see citing works
Ovarian stimulation in polycystic ovary syndrome patients: the role of body mass index
Orvieto, R., Nahum, R., Meltcer, S., Homburg, R., Rabinson, J., Anteby, E. Y., & Ashkenazi, J. (2009) · Reproductive BioMedicine Online · doi:10.1016/s1472-6483(10)60090-9 · Cited by 26 · see citing works
Şahin, S., Eroğlu, M., Selcuk, S., Turkgeldi, L. S., Kozalı, Ş., Davutoğlu, S., & Muhçu, M. (2014) · PubMed · Cited by 26 · see citing works
Saydam, B. Ö., Has, A. C., Bozdağ, G., Oğuz, K. K., & Yıldız, B. O. (2017) · Gynecological Endocrinology · doi:10.1080/09513590.2017.1295440 · Cited by 23 · see citing works
Metabolic effects of polycystic ovary syndrome in adolescents
Han, Y., Kim, H. S., Lee, H.-J., Oh, J.-Y., & Sung, Y.-A. (2015) · Annals of Pediatric Endocrinology & Metabolism · doi:10.6065/apem.2015.20.3.136 · Cited by 22 · see citing works
Yıldızhan, B., İlhan, G. A., & Pekin, T. (2016) · Journal of Obstetrics and Gynaecology · doi:10.3109/01443615.2016.1168376 · Cited by 21 · see citing works
Komarowska, H., Stangierski, A., Warmuz‐Stangierska, I., Lodyga, M., Wachowiak-Ochmańska, K., Waśko, R., Wanic-Kossowska, M., & Ruchała, M. (2013) · PubMed · Cited by 20 · see citing works
Kumbak, B., & Kahraman, S. (2009) · Acta Obstetricia Et Gynecologica Scandinavica · doi:10.1080/00016340902835919 · Cited by 18 · see citing works
Treatment strategies for infertile women with polycystic ovary syndrome.
Vitek, W., Hoeger, K. M., & Legro, R. S. (2016) · PubMed · Cited by 18 · see citing works
Metformin increases pressure pain threshold in lean women with polycystic ovary syndrome
Кялка, М., Milewicz, T., Sztefko, K., Rogatko, I., & Majewska, R. (2016) · Drug Design Development and Therapy · doi:10.2147/dddt.s109086 · Cited by 18 · see citing works
Physical Properties of Blood Are Altered in Young and Lean Women with Polycystic Ovary Syndrome
Simmonds, M. J., Milne, N., Ong, K. J., Brotherton, E. J., McNamee, A. P., Horobin, J. T., & Sabapathy, S. (2016) · PLoS ONE · doi:10.1371/journal.pone.0167290 · Cited by 18 · see citing works
Erol, O. Ö., Özel, M. K., Elli̇dağ, H. Y., Toptaş, T., Uysal, A., & Yılmaz, N. (2017) · Journal of Obstetrics and Gynaecology · doi:10.1080/01443615.2017.1286464 · Cited by 18 · see citing works
Tu, J., Lin, G., Lu, C., & Gong, F. (2013) · Gynecological Endocrinology · doi:10.3109/09513590.2013.860121 · Cited by 17 · see citing works
Vitagliano, A., Quaranta, M., Noventa, M., & Gizzo, S. (2015) · Archives of Gynecology and Obstetrics · doi:10.1007/s00404-015-3662-9 · Cited by 16 · see citing works
Scott, D. S., Joham, A. E., Teede, H. J., Gibson‐Helm, M. E., Harrison, C. L., Cassar, S., Hutchison, S. K., Ebeling, P. R., Stepto, N. K., & de Courten, B. V. (2016) · Nutrients · doi:10.3390/nu8120774 · Cited by 16 · see citing works
Li, L., Zhang, F., Cui, J., Shi, Y., Xiang, J., Wang, X., Zhao, N., Yan, Q.-W., Greenberg, A. S., Peng, Y., et al. (2016) · Gynecological Endocrinology · doi:10.1080/09513590.2016.1252743 · Cited by 16 · see citing works
Trolle, B., Flyvbjerg, A., Kesmodel, U., & Lauszus, F. F. (2008) · Obstetrical & Gynecological Survey · doi:10.1097/01.ogx.0000300471.31456.ea · Cited by 14 · see citing works
β-endorphins Plasma Level is Higher in Lean Polycystic Ovary Syndrome (PCOS) Women
Кялка, М., Milewicz, T., Spałkowska, M., Krzyczkowska-Sendrakowska, M., Wasyl, B., Pełka, A., & Krzysiek, J. (2016) · Experimental and Clinical Endocrinology & Diabetes · doi:10.1055/s-0035-1564094 · Cited by 14 · see citing works
Should insulin resistance be screened in lean hirsute women?
Arduç, A., SARIÇAM, O., Dogan, B. A., Tuna, M. M., Tütüncü, Y., Işık, S., Berker, D. S., Sennaroğlu, E., & Güler, S. (2015) · Gynecological Endocrinology · doi:10.3109/09513590.2014.994598 · Cited by 12 · see citing works
Mioni, R., Cà, A. D., Turra, J., Azzolini, S., Xamin, N., Bleve, L., Maffei, P., Vettor, R., & Fallo, F. (2016) · Endocrine · doi:10.1007/s12020-016-0958-x · Cited by 12 · see citing works
Galletta, M., Grasso, S., Vaiarelli, A., & Roseff, S. (2011) · PubMed · Cited by 11 · see citing works
Circulating levels of vitamin D 3 and leptin in lean infertile women with polycystic ovary syndrome
Dawood, A. S., Elgergawy, A. E.-S., & Elhalwagy, A. (2018) · Journal of Human Reproductive Sciences · doi:10.4103/jhrs.jhrs_40_18 · Cited by 10 · see citing works
Кялка, М., Milewicz, T., Mrozińska, S., Rogatko, I., Sztefko, K., & Majewska, R. (2017) · Minerva Endocrinology · doi:10.23736/s0391-1977.16.02494-9 · Cited by 9 · see citing works
The role of metformin in the treatment of infertile women with polycystic ovary syndrome
Atiomo, W., & Sinha, A. (2004) · The Obstetrician & Gynaecologist · doi:10.1576/toag.6.3.145.26996 · Cited by 8 · see citing works
Rakuša, M., Jensterle, M., Mijovski, M. B., & Janež, A. (2017) · Metabolic Syndrome and Related Disorders · doi:10.1089/met.2016.0148 · Cited by 7 · see citing works
Ovulation induction by metformin in lean and obese women with polycystic ovary syndrome
Popova, P., Ivanova, L., Каронова, Т. Л., & Grineva, E. N. (2011) · 13th European Congress of Endocrinology · Cited by 6 · see citing works
Know your Enemy: The Rationale of Using Inositol in the Treatment of Polycystic Ovary Syndrome
Laganà, A. S. (2013) · Endocrinology & Metabolic Syndrome · doi:10.4172/2161-1017.1000e121 · Cited by 6 · see citing works
Basic and Meal Stimulated Plasma GIP Levels are Higher in Lean PCOS Women with FAI over 5
Milewicz, T., Migacz, K., Кялка, М., Rogatko, I., Kowalczuk, A., Spałkowska, M., Mrozińska, S., Czajkowska, Z., & Sztefko, K. (2016) · Experimental and Clinical Endocrinology & Diabetes · doi:10.1055/s-0042-101165 · Cited by 6 · see citing works
Kialka, M., Milewicz, T., Mrozinska, S., Sztefko, K., Rogatko, I., & Majewska, R. (2016) · Endocrine Abstracts · doi:10.1530/endoabs.41.ep751 · Cited by 6 · see citing works
Metabolic risks of the lean PCOS woman
Kar, S. (2013) · Fertility and Sterility · doi:10.1016/j.fertnstert.2013.07.848 · Cited by 5 · see citing works
Ovulation Induction: Evidence Based Guidelines for Daily Practice
Cohlen, B., van Santbrink, E., & Laven, J. (2016) · EUR Research Repository (Erasmus University Rotterdam) · Cited by 3 · see citing works
Krohn, M., Sparks, A. E., & Shah, D. K. (2015) · Proceedings in Obstetrics and Gynecology · doi:10.17077/2154-4751.1288 · Cited by 1 · see citing works
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- [16]Kirchengast S Huber J Body composition characteristics and body fat distribution in lean women with polycystic ovary syndrome Hum Reprod 2001 16 1255 60 11387301
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Dapas, M., Lin, F. T. J., Nadkarni, G. N., Sisk, R., Legro, R. S., Urbanek, M., Hayes, M. G., & Dunaif, A. (2020) · PLOS Medicine · doi:10.1371/journal.pmed.1003132 · Cited by 297 · see citing works
Saadia, Z. (2020) · Medical Archives · doi:10.5455/medarh.2020.74.289-293 · Cited by 209 · see citing works
Lean polycystic ovary syndrome (PCOS): an evidence-based practical approach
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PCOS and nutritional approaches: Differences between lean and obese phenotype
Barrea, L., Frias-Toral, E., Verde, L., Ceriani, F., Cucalón, G., Garcia-Velasquez, E., Moretti, D., Savastano, S., Colao, A., & Muscogiuri, G. (2021) · Metabolism Open · doi:10.1016/j.metop.2021.100123 · Cited by 86 · see citing works
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Pratama, G., Wiweko, B., Asmarinah, A., Widyahening, I. S., Andraini, T., Bayuaji, H., & Hestiantoro, A. (2024) · Scientific Reports · doi:10.1038/s41598-024-58064-0 · Cited by 87 · see citing works
Machine-aided self-diagnostic prediction models for polycystic ovary syndrome: observational study
Zigarelli, A., Jia, Z., & Lee, H. (2022) · JMIR Formative Research · doi:10.2196/29967 · Cited by 74 · see citing works
Obesity and Polycystic Ovary Syndrome
Kim, J. (2024) · Journal of Obesity & Metabolic Syndrome · doi:10.7570/jomes24035 · Cited by 53 · see citing works
Batarfi, A. A., Filimban, N., Bajouh, O. S., Dallol, A., Chaudhary, A., & Bakhashab, S. (2019) · BMC Medical Genetics · doi:10.1186/s12881-019-0876-x · Cited by 34 · see citing works
Weight management strategies for patients with PCOS: current perspectives
Ozgen Saydam, B., & Yildiz, B. O. (2021) · Expert Review of Endocrinology & Metabolism · doi:10.1080/17446651.2021.1896966 · Cited by 33 · see citing works
Key Genes Associated With Non-Alcoholic Fatty Liver Disease and Polycystic Ovary Syndrome
Chen, Y., Ma, L., Ge, Z., Pan, Y., & Xie, L. (2022) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2022.888194 · Cited by 34 · see citing works
Socioeconomic status in Danish women with polycystic ovary syndrome: A register‐based cohort study
Rubin, K. H., Andersen, M., Abrahamsen, B., & Glintborg, D. (2018) · Acta Obstetricia Et Gynecologica Scandinavica · doi:10.1111/aogs.13514 · Cited by 32 · see citing works
Jerobin, J., Ramanjaneya, M., Bettahi, I., Parammal, R., Siveen, K. S., Alkasem, M., Aye, M., Sathyapalan, T., Skarulis, M. C., Atkin, S. L., et al. (2021) · Lipids in Health and Disease · doi:10.1186/s12944-021-01463-3 · Cited by 29 · see citing works
Ott, J., Robin, G., Hager, M., & Dewailly, D. (2024) · Human Reproduction Update · doi:10.1093/humupd/dmae030 · Cited by 27 · see citing works
Berbrier, D. E., Leone, C. A., Adler, T. E., Bender, J. R., Taylor, H. S., Stachenfeld, N. S., & Usselman, C. W. (2023) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00583.2022 · Cited by 27 · see citing works
Idicula‐Thomas, S., Gawde, U., Bhaye, S., Pokar, K., & Bader, G. D. (2020) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2020.06.023 · Cited by 26 · see citing works
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Lu, K.-T., Ho, Y., Chang, C., Lan, K., Wu, C., & Su, Y. (2022) · Biomedicines · doi:10.3390/biomedicines10123197 · Cited by 19 · see citing works
Artimani, T., & Najafi, R. (2020) · Cell Biology International · doi:10.1002/cbin.11367 · Cited by 19 · see citing works
Polycystic ovary syndrome: Pathways and mechanisms for possible increased susceptibility to COVID-19
Ilias, Ι., Goulas, S., & Zabulienė, L. (2021) · World Journal of Clinical Cases · doi:10.12998/wjcc.v9.i12.2711 · Cited by 15 · see citing works
Jin, Y., Fei, S., Yang, A., Yu, X., Li, Y., Liang, S., Jing, X., Wang, K., Zhang, L., Xiao, S., et al. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1279717 · Cited by 15 · see citing works
Tharayil, S. P., Rasal, S., Gawde, U., Mukherjee, S., Patil, A. D., Joshi, B. N., Idicula‐Thomas, S., & Shukla, P. (2024) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2024.112386 · Cited by 14 · see citing works
The role of dietitian in the multidisciplinary treatment of PCOS
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Stefanaki, C., Bacopoulou, F., Kandaraki, E., Boschiero, D., & Diamanti‐Kandarakis, E. (2019) · Nutrients · doi:10.3390/nu11092055 · Cited by 13 · see citing works
ART outcomes in lean compared to obese phenotypes of polycystic ovarian syndrome
Fouks, Y., Neuhausser, W., Ryley, D. A., Penzias, A. S., Sakkas, D., & Vaughan, D. A. (2023) · Journal of Assisted Reproduction and Genetics · doi:10.1007/s10815-023-02804-0 · Cited by 11 · see citing works
Kotipalli, R. S. S., Patnaik, S. S., Kumar, J. M., Sistla, R., & Kathirvel, M. (2023) · Life Sciences · doi:10.1016/j.lfs.2023.121795 · Cited by 11 · see citing works
Lee, I. O., Kim, J. C., Seo, J. W., Pak, H. Y., & Chung, J. E. (2021) · Journal of Obstetrics and Gynaecology · doi:10.1080/01443615.2020.1849071 · Cited by 11 · see citing works
Circulating levels of vitamin D 3 and leptin in lean infertile women with polycystic ovary syndrome
Dawood, A. S., Elgergawy, A. E.-S., & Elhalwagy, A. (2018) · Journal of Human Reproductive Sciences · doi:10.4103/jhrs.jhrs_40_18 · Cited by 10 · see citing works
Lean Polycystic Ovary Syndrome: A Narrative Review
Elnashar, A. M. (2024) · Clinical and Experimental Obstetrics & Gynecology · doi:10.31083/j.ceog5106142 · Cited by 9 · see citing works
Zheng, C., Lin, Y., Zhang, Z., Ye, J., Lin, Y., & Tian, J. (2025) · Frontiers in Endocrinology · doi:10.3389/fendo.2025.1680685 · Cited by 10 · see citing works
Insulin sensitivity and obstructive sleep apnea in adolescents with polycystic ovary syndrome
Underland, L., Kenigsberg, L., AGARWAL, C., Sin, S., Punjabi, N. P., Heptulla, R. A., & Arens, R. (2022) · Minerva Endocrinology · doi:10.23736/s2724-6507.22.03619-3 · Cited by 7 · see citing works
Rakuša, M., Jensterle, M., Mijovski, M. B., & Janež, A. (2017) · Metabolic Syndrome and Related Disorders · doi:10.1089/met.2016.0148 · Cited by 7 · see citing works
Arunachalam, R., Priya, K., Brindha, R., & Parthiban, K. (2024) · Journal of Family Medicine and Primary Care · doi:10.4103/jfmpc.jfmpc_1425_23 · Cited by 6 · see citing works
Navigating the Future of PCOS Treatment: The Precision Medicine Paradigm
Sunil, A. T., Jo, C., Sanigha, P. S., Kolasseri, A. E., Tamizhselvi, R., & Jayanthi, S. (2024) · Current pharmacogenomics and personalized medicine (Online)/Current pharmacogenomics and personalized medicine · doi:10.2174/0118756921331801240820115132 · Cited by 4 · see citing works
Arusoğlu, G. (2020) · Journal of Nutrition and Metabolism · doi:10.1155/2020/9191505 · Cited by 4 · see citing works
Bone mass density in lean and overweight women with polycystic ovary syndrome
Mørch, N. F., Aziz, M., & Svendsen, P. F. (2022) · Scandinavian Journal of Clinical and Laboratory Investigation · doi:10.1080/00365513.2022.2049359 · Cited by 4 · see citing works
Gu, R., & Syed, N. (2023) · Undergraduate Research in Natural and Clinical Science and Technology (URNCST) Journal · doi:10.26685/urncst.417 · Cited by 3 · see citing works
Unmet need: specific pcos-diagnostic
Eckert-Krause, M. (2018) · International Journal of Family & Community Medicine · doi:10.15406/ijfcm.2018.02.00033 · Cited by 3 · see citing works
Aziz, M. (2023) · Undergraduate Research in Natural and Clinical Science and Technology (URNCST) Journal · doi:10.26685/urncst.473 · Cited by 2 · see citing works
The hyperemic response to exercise is blunted in females with polycystic ovary syndrome
Huckins, W., Delage, S. I., Berbrier, D. E., Skolnik, D. A., Keightley, H. S. A., & Usselman, C. W. (2025) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00263.2024 · Cited by 3 · see citing works
Prayitno, G. D., Sartika, C. R., Djuwantono, T., Wijaya, A., Muharam, R., Hidayat, Y. M., Haifa, R., Zahrah, A., & Lestari, K. (2026) · Journal of Clinical Medicine · doi:10.3390/jcm15051707 · Cited by 2 · see citing works
Decreased serum profile of the interleukin-36α in polycystic ovary syndrome
Eroğlu, S., & Çakmaklıoğulları, E. K. (2021) · Taiwanese Journal of Obstetrics and Gynecology · doi:10.1016/j.tjog.2021.09.012 · Cited by 2 · see citing works
Jin, Y., Zhang, L., Yu, X., Yang, A., Wang, X., Qi, B., Yang, T., Sun, M., Zhao, G., & Gao, B. (2025) · Diabetes & Metabolic Syndrome Clinical Research & Reviews · doi:10.1016/j.dsx.2025.103277 · Cited by 2 · see citing works
Diagonostic parameters of polycystic ovarian syndrome in outpatient setting
Jesmin, Z. F., Saha, E., Yasmin, F., Ara, A., & Khaliduzmnan, S. (2021) · Bangladesh Medical Journal Khulna · doi:10.3329/bmjk.v53i1-2.54884 · Cited by 2 · see citing works
(2020) · Systematic Reviews in Pharmacy · doi:10.31838/srp.2020.4.82 · Cited by 2 · see citing works
Nahidi, F., Tehrani, F. R., Ghodsi, D., Jafari, M., Majd, H. A., & Abdolahian, S. (2021) · Journal of Education and Health Promotion · doi:10.4103/jehp.jehp_15_21 · Cited by 2 · see citing works
Татарчук, Т. Ф., Tutchenko, T. М., & Бурка, О. А. (2022) · IntechOpen eBooks · doi:10.5772/intechopen.103808 · Cited by 2 · see citing works
Comparison of Endocrine and Metabolic Profile of Obese and Lean PCOS Women with Infertility
Ak, A., Pandey, A., Kumar, N., Gupta, P., Agrawal, S., & Ali, W. (2022) · International Journal of Infertility & Fetal Medicine · doi:10.5005/jp-journals-10016-1290 · Cited by 2 · see citing works
Mendpara, V. A., Ganampet, N. R., Afroze, S., Gnanasekaran, S., Sahu, S., Atikah, R., Rajpal, S., Raghavan, P., Ajith, K., Parmar, M. P., et al. (2023) · Research Square · doi:10.21203/rs.3.rs-3360467/v1 · Cited by 2 · see citing works
Ijaz, A., Khadim, S., Sahi, I. A., Akbar, A., Saeed, S., Ahmed, F., Muhammad, K., & Waheed, Y. (2025) · Middle East Fertility Society Journal · doi:10.1186/s43043-025-00225-w · Cited by 1 · see citing works
Hou, J., Duan, Y., Zhao, W., Sun, Q., & Wang, J. (2026) · Frontiers in Endocrinology · doi:10.3389/fendo.2026.1760541 · Cited by 1 · see citing works
Clinical and Hormonal Profile in Non Obese Women of Polycystic Ovarian Syndrome
Bindal, D. J. (2018) · Journal of Medical Science And clinical Research · doi:10.18535/jmscr/v6i8.74 · Cited by 1 · see citing works
Depression in Polycystic Ovary Syndrome
Barry, J. A. (2019) · Springer eBooks · doi:10.1007/978-3-030-30290-0_2 · Cited by 1 · see citing works
Elkhyat, A., Elsokary, A., & Elshwaikh, S. L. (2024) · Journal of Obstetrics Gynecology and Cancer Research · doi:10.30699/jogcr.9.1.70 · Cited by 1 · see citing works
Introduction to Biological and Psychobiological Aspects of PCOS
Barry, J. A. (2019) · Springer eBooks · doi:10.1007/978-3-030-30290-0_1 · Cited by 1 · see citing works
Lipidstoffwechsel in normgewichtigen PCOS-Patientinnen
Radan, A. (2019) · Journal für Gynäkologische Endokrinologie/Schweiz · doi:10.1007/s41975-019-0091-3
Khan, S. H., Gul, A. A., Manzoor, R., Baig, A., Anwar, R., & Chaudhry, T. (2019) · Journal Of Obesity Management · doi:10.14302/issn.2574-450x.jom-19-3000
Anxiety and Other Psychological Issues in PCOS
Barry, J. A. (2019) · Springer eBooks · doi:10.1007/978-3-030-30290-0_3
Altered cooperativeness in patients with polycystic ovary syndrome
Aksu, E., Beyazyüz, E., Albayrak, Y., Potas, N., Durankuş, F., Uvaçin, G., & Beyazyüz, M. (2019) · Psychiatry and Clinical Psychopharmacology · doi:10.1080/24750573.2019.1691357
Infertility Management in Lean Versus Obese PCOS
Shah, D., & Patil, M. (2021) · ISGE series · doi:10.1007/978-3-030-63650-0_9
Kyrou, I., Kahal, H., Weickert, M. O., Barber, T. M., & Randeva, H. S. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-823045-9.00029-8
Depressionen beim polyzystischen Ovarialsyndrom
Barry, J. A. (2023) · Springer eBooks · doi:10.1007/978-3-031-24461-2_2
Einführung in biologische und psychobiologische Aspekte des PCOS
Barry, J. A. (2023) · Springer eBooks · doi:10.1007/978-3-031-24461-2_1
Ängste und andere psychologische Probleme beim PCOS
Barry, J. A. (2023) · Springer eBooks · doi:10.1007/978-3-031-24461-2_3
Pugliese, G., de Alteriis, G., & Savastano, S. (2023) · L Endocrinologo · doi:10.1007/s40619-023-01355-x
Pate, D., John, J. A., Bodepudi, R., Seher, S., Khan, S. A., Emmanuel, S. Y. W., Shantha, V., Nerella, R., Shaman, B., & Hamid, P. (2024) · Journal For International Medical Graduates · doi:10.56570/jimgs.v1i1.149
Causes of Polycystic Ovarian Syndrome
Panda, S., Das, R., Konar, L., & Singh, M. (2024) · Obstetrics and gynecology. · doi:10.5772/intechopen.113877
Polycystic Ovary Syndrome: Facts beyond Reproduction. A Short Review
Ghunaim, S. S., & Ghazeeri, G. S. (2018) · Journal of genitourinary disorders. · doi:10.47739/2641-7790.genitourinarydisorders.1007
Polycystic ovary syndrome and cardiovascular disease risk
Друк, И. В., Друк, И. В., & Мамедов, М. Н. (2026) · Rational Pharmacotherapy in Cardiology · doi:10.20996/1819-6446-2025-3183
Hormone anti-müllérienne, métabolisme et ovaires polykystiques
Bourgneuf, C. (2020) · theses.fr (ABES) · doi:10.70675/49adc908zd64cz461azbc64z6e8c73917684
Shao, D., Zheng, Z., Cai, R., Zou, D., Chen, P., & Diao, X. (2026) · Complementary Medicine Research · doi:10.1159/000553497
- Authors
- Dawood, A., & Goyal, M.
- Affiliations
- All India Institute of Medical Sciences (IN)
- Venue
- Journal of Human Reproductive Sciences
- Published
- 2017
- Volume
- 10
- Issue
- 3
- Pages
- 154
- ISSN
- 0974-1208 (ISSN-L)
- PMC
- PMC5672719
- OpenAlex
- W2766966628
- Cited by
- 72
- References
- 72
- Citations by year
- 2026: 4 · 2025: 4 · 2024: 10 · 2023: 11 · 2022: 10 · 2021: 9 · 2020: 8 · 2019: 9 · 2018: 6 · 2017: 1
- FWCI
- 1.07
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- cc-by-nc-sa
- Locations
- Journal of Human Reproductive Sciences (publishedVersion, cc-by-nc-sa)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion, cc-by-nc-sa)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Keywords
- polycystic ovary syndrome, lean PCOS, PCOS phenotypes, hyperinsulinemia, hyperandrogenism, endocrine disorders, PCOS management, metabolic profile, hematological profile
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