The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.
Therapeutic Drug Monitoring by Dried Blood Spot: Progress to Date and Future Directions
Open accessAbstract
This article discusses dried blood spot (DBS) sampling in therapeutic drug monitoring (TDM). The most important advantages of DBS sampling in TDM are the minimally invasive procedure of a finger prick (home sampling), the small volume (children), and the stability of the analyte. Many assays in DBS have been reported in the literature over the previous 5 years. These assays and their analytical techniques are reviewed here. Factors that may influence the accuracy and reproducibility of DBS methods are also discussed. Important issues are the correlation with plasma/serum concentrations and the influence of hematocrit on spot size and recovery. The different substrate materials are considered. DBS sampling can be a valid alternative to conventional venous sampling. However, patient correlation studies are indispensable to prove this. Promising developments are dried plasma spots using membrane and hematocrit correction using the potassium concentration.
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Cites
Development, Characterization, and Application of Paper Spray Ionization
Liu, J., Wang, H., Manicke, N. E., Lin, J.-M., Cooks, R. G., & Ouyang, Z. (2010) · Analytical Chemistry · doi:10.1021/ac902854g · Cited by 711
Dried Blood Spot Methods in Therapeutic Drug Monitoring: Methods, Assays, and Pitfalls
Edelbroek, P. M., Heijden, J. V. D., & Stolk, L. M. L. (2009) · Therapeutic Drug Monitoring · doi:10.1097/ftd.0b013e31819e91ce · Cited by 512
Kertesz, V., & Van Berkel, G. J. (2010) · Journal of Mass Spectrometry · doi:10.1002/jms.1709 · Cited by 350
Castillo-Mancilla, J. R., Zheng, J.-H., Rower, J. E., Meditz, A., Gardner, E. M., Predhomme, J., Fernandez, C., Langness, J., Kiser, J. J., Bushman, L. R., et al. (2013) · AIDS Research and Human Retroviruses · doi:10.1089/aid.2012.0089 · Cited by 315
European Medicines Agency Guideline on Bioanalytical Method Validation: What More Is There to Say?
Smith, G. (2012) · Bioanalysis · doi:10.4155/bio.12.44 · Cited by 308
Hemato-Critical Issues in Quantitative Analysis of Dried Blood Spots: Challenges and Solutions
De Kesel, P. M., Sadones, N., Capiau, S., Lambert, W. E., & Stove, C. P. (2013) · Bioanalysis · doi:10.4155/bio.13.156 · Cited by 277
Manicke, N. E., Abu‐Rabie, P., Spooner, N., Ouyang, Z., & Cooks, R. G. (2011) · Journal of the American Society for Mass Spectrometry · doi:10.1007/s13361-011-0177-x · Cited by 232
Therapeutic drug monitoring of tacrolimus with the dried blood spot method
Hoogtanders, K., van der Heijden, J., Christiaans, M., Edelbroek, P., van Hooff, J. P., & Stolk, L. M. L. (2007) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2006.11.023 · Cited by 186
EBF Recommendation on the Validation of Bioanalytical Methods for Dried Blood Spots
Timmerman, P., White, S., Globig, S., et al. (2011) · Bioanalysis · doi:10.4155/bio.11.132 · Cited by 184
Capiau, S., Stove, V. V., Lambert, W. E., & Stove, C. P. (2012) · Analytical Chemistry · doi:10.1021/ac303014b · Cited by 157
Cited by
Consensus Guidelines for Therapeutic Drug Monitoring in Neuropsychopharmacology: Update 2017
Hiemke, C., Bergemann, N., Clement, H., Conca, A., Deckert, J., Domschke, K., Eckermann, G., Egberts, K., Gerlach, M., Greiner, C., et al. (2018) · Pharmacopsychiatry · doi:10.1055/s-0043-116492 · Cited by 1,446
Nemoto, O., Hayashi, N., Kitahara, Y., Furue, M., Hojo, S., Nomoto, M., Shima, S., & The Japanese E6005 Study Investigators (2016) · The Journal of Dermatology · doi:10.1111/1346-8138.13231 · Cited by 45
Feasibility of and patients’ perspective on nilotinib dried blood spot self-sampling
Boons, C. C. L. M., Timmers, L., Janssen, J. J. W. M., Swart, E. L., Hugtenburg, J. G., & Hendrikse, N. H. (2019) · European Journal of Clinical Pharmacology · doi:10.1007/s00228-019-02640-1 · Cited by 36
Self-citation
Metadata
- Authors
- Wilhelm, A. J., den Burger, J. C. G., & Swart, E. L.
- Venue
- Clinical Pharmacokinetics
- Published
- 2014-09-10
- Volume
- 53
- Issue
- 11
- Pages
- 961-973
- ISSN
- 0312-5963 (ISSN-L)
- 1179-1926
- OpenAlex
- W2042516926
- Cited by
- 342
- References
- 38
- FWCI
- 11.41
- Type
- journal article
- Language
- en
- Open access
- hybrid
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