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Fully automated liquid extraction‐based surface sampling and ionization using a chip‐based robotic nanoelectrospray platform
Abstract
A fully automated liquid extraction‐based surface sampling device utilizing an Advion NanoMate chip‐based infusion nanoelectrospray ionization system is reported. Analyses were enabled for discrete spot sampling by using the Advanced User Interface of the current commercial control software. This software interface provided the parameter control necessary for the NanoMate robotic pipettor to both form and withdraw a liquid microjunction for sampling from a surface. The system was tested with three types of analytically important sample surface types, viz., spotted sample arrays on a MALDI plate, dried blood spots on paper, and whole‐body thin tissue sections from drug dosed mice. The qualitative and quantitative data were consistent with previous studies employing other liquid extraction‐based surface sampling techniques. Published in 2009 by John Wiley & Sons, Ltd.
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Cited by
Ambient Sampling/Ionization Mass Spectrometry: Applications and Current Trends
Harris, G. A., Galhena, A. S., & Fernández, F. M. (2011) · Analytical Chemistry · doi:10.1021/ac200918u · Cited by 527
Zhang, J., Rector, J., Lin, J. Q., Young, J. H., Sans, M., Katta, N., Giese, N., Yu, W., Nagi, C., Suliburk, J., et al. (2017) · Science Translational Medicine · doi:10.1126/scitranslmed.aan3968 · Cited by 406
Therapeutic Drug Monitoring by Dried Blood Spot: Progress to Date and Future Directions
Wilhelm, A. J., den Burger, J. C. G., & Swart, E. L. (2014) · Clinical Pharmacokinetics · doi:10.1007/s40262-014-0177-7 · Cited by 342
Mass spectrometry imaging for drug distribution studies
Prideaux, B., & Stoeckli, M. (2012) · Journal of Proteomics · doi:10.1016/j.jprot.2012.07.028 · Cited by 279
Native Mass Spectrometry of Membrane Proteins
Keener, J. E., Zhang, G., & Marty, M. T. (2021) · Analytical Chemistry · doi:10.1021/acs.analchem.0c04342 · Cited by 126
Metadata
- Authors
- Kertesz, V., & Van Berkel, G. J.
- Venue
- Journal of Mass Spectrometry
- Publisher
- Wiley
- Published
- 2009-12-17
- Volume
- 45
- Issue
- 3
- Pages
- 252-260
- ISSN
- 1076-5174 (ISSN-L)
- 1096-9888
- OpenAlex
- W2035212554
- Cited by
- 350
- References
- 0
- FWCI
- 7.44
- Type
- journal article
- Language
- en
- Open access
- closed
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